keyword
https://read.qxmd.com/read/38533071/machine-learning-for-the-early-prediction-of-acute-respiratory-distress-syndrome-ards-in-patients-with-sepsis-in-the-icu-based-on-clinical-data
#1
JOURNAL ARTICLE
Zhenzhen Jiang, Leping Liu, Lin Du, Shanshan Lv, Fang Liang, Yanwei Luo, Chunjiang Wang, Qin Shen
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a fatal outcome of severe sepsis. Machine learning models are helpful for accurately predicting ARDS in patients with sepsis at an early stage. OBJECTIVE: We aim to develop a machine-learning model for predicting ARDS in patients with sepsis in the intensive care unit (ICU). METHODS: The initial clinical data of patients with sepsis admitted to the hospital (including population characteristics, clinical diagnosis, complications, and laboratory tests) were used to predict ARDS, and screen out the crucial variables...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509149/plasma-renin-as-a-novel-prognostic-biomarker-of-sepsis-associated-acute-respiratory-distress-syndrome
#2
JOURNAL ARTICLE
Anjali Chakradhar, Rebecca M Baron, Mayra Pinilla Vera, Prasad Devarajan, Lakhmir Chawla, Peter C Hou
Sepsis-associated acute respiratory distress syndrome (ARDS) is a life-threatening condition in critical care medicine for which there is a substantial need for early prognostic biomarkers of outcome. The present study seeks to link plasma renin levels and 30-day mortality in sepsis-associated ARDS patients treated at our institution. The Registry of Critical Illness (RoCI) prospectively enrolled patients from the intensive care units (ICU) within a single academic medical center, and a convenience sample of patients with sepsis-associated ARDS was analyzed from this cohort...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38506971/cerebral-microbleeds-in-critically-ill-patients-with-respiratory-failure-or-sepsis-a-scoping-review
#3
JOURNAL ARTICLE
Bing Yu Chen, Johnny Dang, Sung-Min Cho, Mary Pat Harnegie, Ken Uchino
BACKGROUND: Cerebral microbleeds (CMBs) have been described in critically ill patients with respiratory failure, acute respiratory distress syndrome (ARDS), or sepsis. This scoping review aimed to systematically summarize existing literature on critical illness-associated CMBs. METHODS: Studies reporting on adults admitted to the intensive care unit for respiratory failure, ARDS, or sepsis with evidence of CMBs on magnetic resonance imaging were included for review following a systematic search across five databases (MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and Web of Science) and a two-stage screening process...
March 20, 2024: Neurocritical Care
https://read.qxmd.com/read/38505705/editorial-ai-and-data-science-in-pulmonary-and-critical-care-physiology-and-medicine
#4
EDITORIAL
Yuh-Chin Huang, Paresh Giri, Octavian Ioachimescu, An-Kwok Ian Wong
No abstract text is available yet for this article.
2024: Frontiers in Physiology
https://read.qxmd.com/read/38471792/patient-stratification-using-plasma-cytokines-and-their-regulators-in-sepsis-relationship-to-outcomes-treatment-effect-and-leucocyte-transcriptomic-subphenotypes
#5
JOURNAL ARTICLE
David Benjamin Antcliffe, Yuxin Mi, Shalini Santhakumaran, Katie L Burnham, A Toby Prevost, Josie K Ward, Timothy J Marshall, Claire Bradley, Farah Al-Beidh, Paula Hutton, Stuart McKechnie, Emma E Davenport, Charles J Hinds, Cecilia M O'Kane, Daniel Francis McAuley, Manu Shankar-Hari, Anthony C Gordon, Julian C Knight
RATIONALE: Heterogeneity of the host response within sepsis, acute respiratory distress syndrome (ARDS) and more widely critical illness, limits discovery and targeting of immunomodulatory therapies. Clustering approaches using clinical and circulating biomarkers have defined hyper-inflammatory and hypo-inflammatory subphenotypes in ARDS associated with differential treatment response. It is unknown if similar subphenotypes exist in sepsis populations where leucocyte transcriptomic-defined subphenotypes have been reported...
March 12, 2024: Thorax
https://read.qxmd.com/read/38442923/-review-and-prospects-of-international-clinical-research-in-critical-care-medicine-in-2023
#6
JOURNAL ARTICLE
Ziqi Rong, Pengyu Lu, Wei Huang
The main clinical research advances of critical care in 2023 includes: new trials of Chinese herbal medicine, hydroxocobalamin (vitamin B12), methylene blue as well glucocorticoids have shown the potential to improve outcomes of patients with sepsis and septic shock; international committees launched new global definition and managing recommendations for acute respiratory distress syndrome (ARDS). Besides, a cluster of new evidences has emerged in many aspects as following: fluid control strategy in sepsis (restrictive/liberative), antibiotic infusion strategy (continuous/intermittent), oxygen-saturation targets for mechanical ventilation (conservative/liberative), blood pressure targets after resuscitation from out-of-hospital cardiac arrest (hypotension/hypertension), blood pressure targets after successful stroke thrombectomy (intensive/conventional), and nutritional support strategies (low protein-calories/conventional protein-calories, fasting/persistent feeding before extubation)...
February 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38438849/attributable-mortality-of-ards-among-critically-ill-patients-with-sepsis-a-multicenter-retrospective-cohort-study
#7
MULTICENTER STUDY
Dong-Hui Wang, Hui-Miao Jia, Xi Zheng, Xiu-Ming Xi, Yue Zheng, Wen-Xiong Li
BACKGROUND: Both sepsis and acute respiratory distress syndrome (ARDS) are common severe diseases in the intensive care unit (ICU). There is no large-scale multicenter study to clarify the attributable mortality of ARDS among septic patients. This study aimed to evaluate the excess mortality of ARDS in critically ill patients with sepsis. METHODS: The data were obtained from a multicenter, prospective cohort study in 18 Chinese ICUs between January 2014 and August 2015...
March 4, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38415021/sequential-extracorporeal-therapy-of-pathogen-removal-followed-by-cell-directed-extracorporeal-therapy-in-streptococcal-toxic-shock-syndrome-refractory-to-venoarterial-extracorporeal-membrane-oxygenation-a-case-report
#8
Stephen J Amerson, McKenna Hoffman, Fadi Abouzahr, Mohammad Ahmad, Rachel K Sterling, Hitesh Gidwani, Linda E Sousse, Jeffrey D Dellavolpe
BACKGROUND: Streptococcal toxic shock syndrome (STSS) is a fulminant complication of predominantly invasive group A streptococcal infections. STSS is often characterized by influenza-like symptoms, including fever, chills, and myalgia that can quickly progress to sepsis with hypotension, tachycardia, tachypnea, and multiple organ failure (kidney, liver, lung, or blood). Mortality can exceed 50% depending on the severity of symptoms. CASE SUMMARY: Here, we describe a novel, multi-extracorporeal intervention strategy in a case of severe septic shock secondary to STSS...
March 2024: Critical care explorations
https://read.qxmd.com/read/38404046/improved-survival-in-covid-19-related-sepsis-and-ards-treated-with-a-unique-triple-therapy-including-therapeutic-plasma-exchange-a-single-center-retrospective-analysis
#9
JOURNAL ARTICLE
Philip Keith, Rebecca Inez Caldino Bohn, Trung Nguyen, L Keith Scott, Monty Richmond, Matthew Day, Carol Choe, Linda Perkins, Rebecca Burnside, Richard Pyke, Ben Rikard, Amanda Guffey, Arun Saini, H J Park, Joseph Carcillo
BACKGROUND: Throughout the COVID-19 pandemic, the mortality of critically ill patients remained high. Our group developed a treatment regimen targeting sepsis and ARDS which we labeled "triple therapy" consisting of (1) corticosteroids, (2) therapeutic plasma exchange (TPE), and (3) timely intubation with lung protective ventilation. Our propensity analysis assesses the impact of triple therapy on survival in COVID-19 patients with sepsis and ARDS. METHODS: Retrospective propensity analysis comparing triple therapy to no triple therapy in adult critically ill COVID-19 patients admitted to the Intensive Care Unit at Lexington Medical Center from 1 March 2020 through 31 October 2021...
February 2024: Journal of Clinical Apheresis
https://read.qxmd.com/read/38403808/pattern-of-fluid-overload-and-its-impact-on-mortality-among-mechanically-ventilated-children-secondary-analysis-of-the-relisch-trial
#10
JOURNAL ARTICLE
Shubham Charaya, Suresh Kumar Angurana, Karthi Nallasamy, Arun Bansal, Jayashree Muralidharan
OBJECTIVES: To assess the pattern of fluid overload (FO) and its impact on mortality among mechanically ventilated children. METHODS: In this secondary analysis of an open-label randomized controlled trial (ReLiSCh trial, October 2020-September 2021), hemodynamically stable mechanically ventilated children (n = 100) admitted to a tertiary level pediatric intensive care unit (PICU) in North India were enrolled. The primary outcome was pattern of FO (FO% >10% and cumulative FO% from day 1-7); and secondary outcomes were pattern of FO among survivors and non-survivors, and prescription practices of maintenance fluid...
February 26, 2024: Indian Journal of Pediatrics
https://read.qxmd.com/read/38354980/epidemiology-and-outcomes-of-infections-during-extracorporeal-membrane-oxygenation-in-adult-patients-with-covid-19-ards-a-single-center-study
#11
JOURNAL ARTICLE
Divya Rakesh Joshi, Ram Gopalakrishnan, C Selvi, Nandini Sethuraman, V R Yamunadevi, V Ramasubramanian, P Senthur Nambi, M Yogesh, Thangaraj Paul Ramesh
BACKGROUND: There is a scarcity of data regarding nosocomial infections in patients with COVID-19 treated with ECMO. This observational study from India aims to describe the epidemiology and microbiology of infections in patients with COVID-19 associated ECMO. METHODS: This is an ambi-directional observational study of COVID-19 ECMO patients admitted from April 2021 to June 2022 in a tertiary care hospital. The total number of sepsis episodes for each patient was recorded and were categorized as bloodstream infections (BSI), pneumonias, skin and soft tissue infections (SSTI), invasive candidiasis (IC), catheter associated urinary tract infection (CAUTI), intra-abdominal infections (IAI), and Clostridioides difficile infections...
February 12, 2024: Indian Journal of Medical Microbiology
https://read.qxmd.com/read/38347890/complications-associated-with-the-use-of-resuscitative-endovascular-balloon-occlusion-of-the-aorta-reboa-an-updated-review
#12
REVIEW
Marcelo Augusto Fontenelle Ribeiro Junior, Salman M Salman, Sally M Al-Qaraghuli, Farah Makki, Riham A Abu Affan, Shahin Reza Mohseni, Megan Brenner
Resuscitative endovascular balloon occlusion of the aorta (REBOA) has become part of the arsenal to temporize patients in shock from severe hemorrhage. REBOA is used in trauma to prevent cardiovascular collapse by preserving heart and brain perfusion and minimizing distal hemorrhage until definitive hemorrhage control can be achieved. Significant side effects, including death, ischemia and reperfusion injuries, severe renal and lung damage, limb ischemia and amputations have all been reported. The aim of this article is to provide an update on complications related to REBOA...
2024: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/38341938/different-ventilation-intensities-among-various-categories-of-patients-ventilated-for-reasons-other-than-ards-a-pooled-analysis-of-4-observational-studies
#13
JOURNAL ARTICLE
Simon Corrado Serafini, David M P van Meenen, Luigi Pisani, Ary Serpa Neto, Lorenzo Ball, Marcelo Gama de Abreu, Anna Geke Algera, Luciano Azevedo, Giacomo Bellani, Arjen M Dondorp, Eddy Fan, John G Laffey, Tai Pham, Edda M Tschernko, Marcus J Schultz, Margaretha C E van der Woude
PURPOSE: We investigated driving pressure (ΔP) and mechanical power (MP) and associations with clinical outcomes in critically ill patients ventilated for reasons other than ARDS. MATERIALS AND METHODS: Individual patient data analysis of a pooled database that included patients from four observational studies of ventilation. ΔP and MP were compared among invasively ventilated non-ARDS patients with sepsis, with pneumonia, and not having sepsis or pneumonia...
February 10, 2024: Journal of Critical Care
https://read.qxmd.com/read/38337417/assessment-of-pulmonary-circulation-of-critically-ill-patients-based-on-critical-care-ultrasound
#14
REVIEW
Shiyi Gong, Xin Ding, Xiaoting Wang
Pulmonary circulation is crucial in the human circulatory system, facilitating the oxygenation of blood as it moves from the right heart to the lungs and then to the left heart. However, during critical illness, pulmonary microcirculation can be vulnerable to both intrapulmonary and extrapulmonary injuries. To assess these potential injuries in critically ill patients, critical point-of-care ultrasound can be used to quantitatively and qualitatively evaluate the right atrium, right ventricle, pulmonary artery, lung, pulmonary vein, and left atrium along the direction of blood flow...
January 26, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38320026/laying-the-groundwork-for-physiology-guided-precision-medicine-in-the-critically-ill
#15
EDITORIAL
Chad H Hochberg, Sarina K Sahetya
Canonical critical care syndromes such as sepsis and acute respiratory distress syndrome (ARDS) include patients with markedly heterogeneous biology.1 This, paired with decades of randomized controlled trials (RCTs) that were traditionally viewed as "negative," has stalled progress in improving patient outcomes.2 However, emerging awareness of sub-phenotypes based on differences in biomarker profiles and resulting heterogeneous treatment effects have led to calls for precision medicine in which therapies are targeted to those most likely to benefit...
May 2023: NEJM Evid
https://read.qxmd.com/read/38304431/nucleated-red-blood-cells-are-a-late-biomarker-in-predicting-intensive-care-unit-mortality-in-patients-with-covid-19-acute-respiratory-distress-syndrome-an-observational-cohort-study
#16
JOURNAL ARTICLE
Götz Schmidt, Arnd Martens, Christian Koch, Melanie Markmann, Emmanuel Schneck, Ulrich Matt, Matthias Hecker, Khodr Tello, Matthias Wolff, Michael Sander, István Vadász
BACKGROUND: Nucleated red blood cells (nRBC) are precursor cells of the erythropoiesis that are absent from the peripheral blood under physiological conditions. Their presence is associated with adverse outcomes in critically ill patients. This study aimed to evaluate the predictive value of nRBC on mortality in intensive care unit (ICU) patients with COVID-19 acute respiratory distress syndrome (ARDS). MATERIAL AND METHODS: This retrospective, observational cohort study analyzed data on 206 ICU patients diagnosed with COVID-19 ARDS between March 2020 and March 2022...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38286691/protocol-for-fever-control-using-external-cooling-in-mechanically-ventilated-patients-with-septic-shock-sepsiscool-ii-randomised-controlled-trial
#17
JOURNAL ARTICLE
Armelle Guénégou-Arnoux, Juliette Murris, Stéphane Bechet, Camille Jung, Johann Auchabie, Julien Dupeyrat, Nadia Anguel, Pierre Asfar, Julio Badie, Dorothée Carpentier, Benjamin Chousterman, Jeremy Bourenne, Agathe Delbove, Jérôme Devaquet, Nicolas Deye, Guillaume Dumas, Anne-Florence Dureau, Jean-Baptiste Lascarrou, Stephane Legriel, Christophe Guitton, Caroline Jannière-Nartey, Jean-Pierre Quenot, Jean-Claude Lacherade, Julien Maizel, Armand Mekontso Dessap, Bruno Mourvillier, Philippe Petua, Gaetan Plantefeve, Jean-Christophe Richard, Alexandre Robert, Clément Saccheri, Ly Van Phach Vong, Sandrine Katsahian, Frédérique Schortgen
INTRODUCTION: Fever treatment is commonly applied in patients with sepsis but its impact on survival remains undetermined. Patients with respiratory and haemodynamic failure are at the highest risk for not tolerating the metabolic cost of fever. However, fever can help to control infection. Treating fever with paracetamol has been shown to be less effective than cooling. In the SEPSISCOOL pilot study, active fever control by external cooling improved organ failure recovery and early survival...
January 29, 2024: BMJ Open
https://read.qxmd.com/read/38263962/extracorporeal-membrane-oxygenation-in-adult-patients-with-sepsis-and-septic-shock-why-how-when-and-for-whom
#18
REVIEW
Hongling Zhang, Youdong Xu, Xin Huang, Shunyin Yang, Ruiting Li, Yongran Wu, Xiaojing Zou, Yuan Yu, You Shang
Sepsis and septic shock remain the leading causes of death in intensive care units. Some patients with sepsis fail to respond to routine treatment and rapidly progress to refractory respiratory and circulatory failure, necessitating extracorporeal membrane oxygenation (ECMO). However, the role of ECMO in adult patients with sepsis has not been fully established. According to existing studies, ECMO may be a viable salvage therapy in carefully selected adult patients with sepsis. The choice of venovenous, venoarterial, or hybrid ECMO modes is primarily determined by the patient's oxygenation and hemodynamics (distributive shock with preserved cardiac output, septic cardiomyopathy (left, right, or biventricular heart failure), or right ventricular failure caused by acute respiratory distress syndrome)...
January 2024: J Intensive Med
https://read.qxmd.com/read/38240492/2024-focused-update-guidelines-on-use-of-corticosteroids-in-sepsis-acute-respiratory-distress-syndrome-and-community-acquired-pneumonia
#19
JOURNAL ARTICLE
Dipayan Chaudhuri, Andrea M Nei, Bram Rochwerg, Robert A Balk, Karim Asehnoune, Rhonda Cadena, Joseph A Carcillo, Ricardo Correa, Katherine Drover, Annette M Esper, Hayley B Gershengorn, Naomi E Hammond, Namita Jayaprakash, Kusum Menon, Lama Nazer, Tyler Pitre, Zaffer A Qasim, James A Russell, Ariel P Santos, Aarti Sarwal, Joanna Spencer-Segal, Nejla Tilouche, Djillali Annane, Stephen M Pastores
RATIONALE: New evidence is available examining the use of corticosteroids in sepsis, acute respiratory distress syndrome (ARDS) and community-acquired pneumonia (CAP), warranting a focused update of the 2017 guideline on critical illness-related corticosteroid insufficiency. OBJECTIVES: To develop evidence-based recommendations for use of corticosteroids in hospitalized adults and children with sepsis, ARDS, and CAP. PANEL DESIGN: The 22-member panel included diverse representation from medicine, including adult and pediatric intensivists, pulmonologists, endocrinologists, nurses, pharmacists, and clinician-methodologists with expertise in developing evidence-based Clinical Practice Guidelines...
January 19, 2024: Critical Care Medicine
https://read.qxmd.com/read/38240490/executive-summary-guidelines-on-use-of-corticosteroids-in-critically-ill-patients-with-sepsis-acute-respiratory-distress-syndrome-and-community-acquired-pneumonia-focused-update-2024
#20
JOURNAL ARTICLE
Dipayan Chaudhuri, Andrea M Nei, Bram Rochwerg, Robert A Balk, Karim Asehnoune, Rhonda S Cadena, Joseph A Carcillo, Ricardo Correa, Katherine Drover, Annette M Esper, Hayley B Gershengorn, Naomi E Hammond, Namita Jayaprakash, Kusum Menon, Lama Nazer, Tyler Pitre, Zaffer A Qasim, James A Russell, Ariel P Santos, Aarti Sarwal, Joanna Spencer-Segal, Nejla Tilouche, Djillali Annane, Stephen M Pastores
No abstract text is available yet for this article.
January 19, 2024: Critical Care Medicine
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