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Inhalant allergy

Arielle L Langer, Andrew Leader, Seunghee Kim-Schulze, Yelena Ginzburg, Miriam Merad, Jeffrey Glassberg
Inhaled mometasone was shown to improve pain scores and decrease soluble vascular cell adhesion molecule (sVCAM) concentration in a randomized controlled trial of nonasthmatic patients with sickle cell disease. We sought to explore potential changes in systemic inflammation as a mechanism underlying this effect. Serum samples from 41 trial participants (15 placebo- and 26 mometasone-treated) were analyzed using a 92 inflammatory marker panel at baseline and after 8 weeks of mometasone therapy. Individual marker analysis and correlation analysis were conducted...
February 20, 2019: Annals of Hematology
Agnieszka Kubik-Komar, Krystyna Piotrowska-Weryszko, Elżbieta Weryszko-Chmielewska, Izabela Kuna-Broniowska, Kazimiera Chłopek, Dorota Myszkowska, Małgorzata Puc, Piotr Rapiejko, Monika Ziemianin, Katarzyna Dąbrowska-Zapart, Agnieszka Lipiec
During the spring period, Betula pollen is the main cause of inhalant allergies in Poland and therefore it is important to monitor and forecast airborne pollen concentrations of this taxon. This study conducted a comparative analysis of the basic characteristics of Betula pollen seasons at the regional scale. The study was carried out from 2001 to 2016 in five cities in Poland: Lublin, Warsaw, Cracow, Sosnowiec, and Szczecin. To find the attributes of birch pollen seasons that mostly differentiated the individual cities, a general discriminant analysis (GDA) was performed, while a principal component analysis (PCA) allowed us to reduce the data space and present a scatterplot of PCA scores in order to compare pollen seasons in the individual cities...
April 10, 2019: Science of the Total Environment
Francesca Cipriani, Salvatore Tripodi, Valentina Panetta, Serena Perna, Ekaterina Potapova, Arianna Dondi, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Carla Mastrorilli, Viviana Moschese, Simone Pelosi, Ifigenia Sfika, Elena Varin, Valeria Villella, Anna Maria Zicari, Giulia Brindisi, Giampaolo Ricci, Paolo Maria Matricardi
BACKGROUND: Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross-sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. We investigated predictive biomarkers of disease evolution in a large cohort of children with SAR. METHODS: During 2015-2017 (follow-up), we re-examined 401 patients from those enrolled in 2009-2011 (baseline) by the "Panallergens in Pediatrics" study, a large multicenter survey of Italian children with SAR...
February 7, 2019: Pediatric Allergy and Immunology
Yan Guan, Hui-Juan Shen, Jian Shen, Yong-Liang Jia, Xin-Wei Dong, Ya-Chao Jin, Qiang-Min Xie
Various studies have shown that flavones have several pharmacological activities including anti-allergy activities. However, the bioavailability of oral flavones is very low, and whether inhaled administration can improve efficacy in respiratory disease models is unclear. In the present study, the anti-allergic activities of inhaling 5,7-dimethoxy-3,4'-dihydroxyflavone (MHF), a synthetic flavonoid, was investigated by comparison with disodium cromoglycate (DSCG) and nedocromil sodium (NS) in rat allergic models...
January 29, 2019: European Journal of Pharmacology
Željka Babić, Sanja Kežić, Jelena Macan
BACKGROUND: The significance of individual risk factors in the development of contact allergy, such as genetic variation in cytokine genes and atopy, is still not clearly defined. OBJECTIVES: The aim of this study was to investigate the association between TNFα 308G>A polymorphism or atopy and contact sensitization (CS) in a cohort from the general Croatian population. MATERIALS & METHODS: The study involved 312 first-year students from the University of Zagreb (median age: 19 years)...
January 28, 2019: European Journal of Dermatology: EJD
Chang Keun Kim, Zak Callaway, Jungi Choi, Hyo Bin Kim, Eun Mi Kwon, Yoon Seok Chang, Yeong Ho Rha, Soo Jong Hong, Jae Won Oh, Hyun Hee Kim, Dae Hyun Lim, Sung Won Kim, Kang Seo Park, Yong Hoon Cho, Hai Lee Chung, Hee Ju Park, Sang Gun Jung, Im Joo Kang, Myung Chul Hyun, Moo Young Oh, Jin A Jung, Myung Sung Kim, Jung Yeon Shim, Jin Tack Kim, Young Yull Koh
PURPOSE: Adherence is a major component of successful medical treatment. However, non-adherence remains a barrier to effective delivery of healthcare worldwide. METHODS: Twenty healthcare facilities (secondary or tertiary hospitals) belonging to the Korean Academy of Pediatric Allergy and Respiratory Diseases (KAPARD) participated. Questionnaires were given to patients currently receiving treatment in the form of inhalant useor oral intake or transdermal patch for mild to moderate asthma...
March 2019: Allergy, Asthma & Immunology Research
Chalerat Direkwattanachai, Chalermthai Aksilp, Pantipa Chatchatee, Orathai Jirapongsananuruk, Haruthai Kamalaporn, Wasu Kamchaisatian, Sorasak Lochindarat, Lina Ngamtrakulpanit, Orapan Poachanukoon, Muthita Trakultivakorn, Jamaree Teeratakulpisarn, Kanokporn Udomittipong, Mukda Vangveeravong, Jitladda Deerojanawong
BACKGROUND: Acute asthmatic exacerbation in children causes economic burdens both directly and indirectly. The GINA guideline does mention the use of inhaled or oral corticosteroids in the treatment of asthmatic exacerbation, it provides little practical guidance on the use of nebulized corticosteroid. OBJECTIVE: To review and recommend the practical considerations in the use of nebulized corticosteroid in children with acute asthmatic exacerbation. METHODS: This consensus was developed by a group of expert pediatricians in respiratory and allergy fields in Thailand...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
I Pali-Schöll, S Blank, K Verhoeckx, R S Mueller, J Janda, E Marti, A A Seida, C Rhyner, D J DeBoer, E Jensen-Jarolim
Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion animals to those in people. With few exceptions, the situation in human insect allergy is better documented than in animals. We focus on a review of recent literature, and give overviews of the epidemiology and clinical signs...
January 15, 2019: Allergy
Marjolein Wentink, Daphne Peeters, Mirjam van der Burg, Clementien Vermont, Liesbeth Duijts, Gertjan J Driessen
A 3-year-old girl was referred to a pediatric pulmonologist for dyspnea and recurrent upper respiratory tract infections (RTIs). The patient was born full term to unrelated Dutch parents after an uneventful pregnancy and birth. The year before presentation, she had suffered from pneumonia and > 10 upper RTIs. Apart from the recurrent RTIs, which started in infancy, her medical history was not significant and did not include allergies or eczema. An adenotonsillectomy was performed at the age of 2 years, and she was treated with multiple antibiotic regimens and inhalation therapy with salbutamol and corticosteroids, with no relief of symptoms...
January 2019: Chest
Y DI, R L Yu, H DU, L Li, W J Yan, J G Liu, X Y Wang, J S Yin
Objective: To investigate the incidence of plant food allergy in patients with pollinosis and the effect of food allergens on the clinical symptoms of pollinosis patients. Method: A total of 40 patients with pollinosis and food allergy attended to the allergy Department of Duolun People's Hospital of Inner Mongolia were accepted skin prick test of inhaled allergens while the rhino conjunctivitis quality of life questionnaire(RQLQ) were also completed. The patients were divided into A and B groups randomly. Patients in group A were required for avoiding allergic plant foods intake but not them in group B...
December 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Z Z Cao, H J Xiang, J J Gao, S Y Huang, B Zheng, X Zhan, R R Chen, B B Chen
Objective: To explore the prevalence of allergy in patients with acute rhinosinusitis (ARS) and evaluate the severity of symptoms in ARS children with or without allergy. Method: Two hundred and seven children (4-12 years of age) with ARS and 85 children of control group were included in our research from June, 2016 to January, 2018. We use questionaire to collect the basic information of pediatric patients. The results of skin prick test (SPT) were recorded. Mothers were required to complete the Sinus and Nasal Quality-of-Life Survey (SN-5)...
September 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Petra Bacher, Alexander Scheffold
Forkhead box P3-positive regulatory T (Treg) cells are essential mediators of tolerance against self-antigens and harmless exogenous antigens. Treg cell deficiencies result in multiple autoimmune and allergic syndromes in neonates. How Treg cells affect conventional allergies against aeroantigens, which are restricted to a few specific proteins released from inhaled particles, remains controversial. The hallmarks of antigen-specific loss of tolerance are allergen-specific TH 2 cells and IgE. However, difficulties in identifying the rare allergen-specific Treg cells have obscured the cellular basis of tolerance to aeroallergens, which is also a major obstacle for the rational design of novel and more efficient allergen-specific immunotherapies...
December 2018: Journal of Allergy and Clinical Immunology
Min Hye Kim, Sang Heon Kim, So Young Park, Ga Young Ban, Joo Hee Kim, Jae Woo Jung, Ji Yong Moon, Woo Jung Song, Hyouk Soo Kwon, Jae Woo Kwon, Jae Hyun Lee, Hye Ryun Kang, Jong Sook Park, Tae Bum Kim, Heung Woo Park, Kwang Ha Yoo, Yeon Mok Oh, Young Il Koh, An Soo Jang, Byung Jae Lee, Young Joo Cho, Sang Heon Cho, Hae Sim Park, Choon Sik Park, Ho Joo Yoon, You Sook Cho
PURPOSE: Although mild to moderate asthma is much more common, the morbidity and mortality of severe asthma are much higher. This study was performed to identify and analyze the clinical characteristics of severe asthma in Korea. METHODS: We registered patients with severe refractory asthma into the Severe Asthma Registry supported by the Severe Asthma Work Group of the Korean Academy of Asthma, Allergy and Clinical Immunology. Patients were enrolled since 2010 from the 15 university hospitals nationwide in Korea...
January 2019: Allergy, Asthma & Immunology Research
S Kallio, A K Kukkonen, E Savilahti, M Kuitunen
BACKGROUND: The long-term effects of probiotic intervention for primary prevention of allergic diseases are not well known. We previously reported less eczema until 10 years in our probiotic intervention trial. OBJECTIVE: To investigate the effect of early probiotic intervention on the prevalence of allergic diseases up to 13 years of age. METHODS: Pregnant women (n=1223) carrying a child at a high risk of allergy (at least one parent with allergic disease) were randomised to receive a mixture of probiotics (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii) or placebo in a double-blind manner from 36 weeks of gestation until birth...
November 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Magda Yehia Elseify, Asmaa Alhusseiny Alsharkawy, Marwa Moustapha Al-Fahham, Mahmoud Muhamed ElHady
INTRODUCTION: Recurrent hypoxia makes asthmatics at risk for pulmonary hypertension and ventricular dysfunction. Early stages of these cardiovascular diseases cannot be detected by conventional echocardiography. Tissue Doppler imaging has been introduced recently as a more sensitive & more accurate tool for investigating cardiovascular diseases. OBJECTIVE: investigating ventricular functions in asymptomatic asthmatic children using tissue Doppler echocardiography...
November 24, 2018: Clinical Respiratory Journal
L Zhu, F Zhu, Z-K Zhang
The allergy symptoms could arise from variable organ systems and have fluctuating nature in severity as well as symptoms. Moreover, these symptoms could be related to multiple pathological states like common cold, chronic obstipation, diarrhea, etc. On the other hand, food allergy diagnosis that usually spread by IgE-mediated inhalant also poses a great challenge in front of the scientific fraternity. So far, many advances in the field of allergy diagnosis, as well as therapeutics, have been made. These advances include skin prick testing (SPT), serum specific IgE (sIgE) level test, component resolved diagnosis (CRD) test, etc...
November 2018: European Review for Medical and Pharmacological Sciences
Semra Demir, Fusun Erdenen, Asli Gelincik, Derya Unal, Muge Olgac, Raif Coskun, Bahauddin Colakoglu, Suna Buyukozturk
AIM: To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs. METHOD: The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. The patients were divided into an anaphylaxis group and a nonanaphylaxis group. The anaphylaxis group was diagnosed according to the criteria of the World Allergy Organization. Skin testing with culprit drugs was performed...
November 16, 2018: International Archives of Allergy and Immunology
Jihui Zhang, Jie Chen, Clive Robinson
Serodominant group 1 allergens of house dust mites (HDMs) are cysteine protease digestive enzymes. By increasing the detection of any allergen by dendritic antigen presenting cells, upregulating inflammatory signalling molecules, and activating cells crucial to the transition from innate to acquired immune responses, the proteolytic activity of these HDM allergens also underlies their behaviour as inhalant allergens. The significance of this property is underlined by the attenuation of allergic responses to HDMs by novel inhibitors in experimental models...
November 10, 2018: International Journal of Molecular Sciences
Stephanie C Erdle, Edmond S Chan, Hyungjun Yang, Bruce A Vallance, Christopher Mill, Tiffany Wong
Background: Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and Panax quinquefolius (American ginseng). Although cases of allergy due to Korean ginseng have been reported in adults, there are no reported cases of allergy to American ginseng, and no reported cases of ginseng allergy in pediatric patients...
2018: Allergy, Asthma, and Clinical Immunology
Enrico Heffler, Diego Bagnasco, Giorgio W Canonica
PURPOSE OF REVIEW: Severe asthmatics, despite the chronic use of high inhaled corticosteroids (ICS) doses and frequent intake of systemic corticosteroids, remains clinically and/or functionally uncontrolled. These patients are also often affected by rhinitis or chronic rhinosinusitis requiring frequent use of intranasal corticosteroids. Therefore, severe asthmatics are exposed to an overload of corticosteroids that is frequently associated with relevant and costly adverse events. This clinical problem and the strategies to overcome it are here summarized...
February 2019: Current Opinion in Allergy and Clinical Immunology
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