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Multitrigger wheeze

Matteo Bonato, Erica Bazzan, Deborah Snijders, Mariaenrica Tinè, Davide Biondini, Graziella Turato, Elisabetta Balestro, Alberto Papi, Manuel G Cosio, Angelo Barbato, Simonetta Baraldo, Marina Saetta
RATIONALE: Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to predict if early wheeze will become asthma is still a matter of vivid debate. AIM: To assess the clinical and pathological factors possibly predicting the future development of asthma in children. METHODS: 80 children (mean age 3.8±1 yrs) undergoing a clinically indicated bronchoscopy were followed prospectively for a median of 5 yrs...
May 29, 2018: American Journal of Respiratory Cell and Molecular Biology
Ben D Spycher, Cara Cochrane, Raquel Granell, Jonathan A C Sterne, Michael Silverman, Eva Pedersen, Erol A Gaillard, John Henderson, Claudia E Kuehni
The distinction between episodic viral wheeze (EVW) and multitrigger wheeze (MTW) is used to guide management of preschool wheeze. It has been questioned whether these phenotypes are stable over time. We examined the temporal stability of MTW and EVW in two large population-based cohorts.We classified children from the Avon Longitudinal Study of Parents and Children (n=10 970) and the Leicester Respiratory Cohorts ((LRCs), n=3263) into EVW, MTW and no wheeze at ages 2, 4 and 6 years based on parent-reported symptoms...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Prithi Sureka Mummidi, Radha Tripathy, Bhagirathi Dwibedi, Amarendra Mahapatra, Suryakanta Baraha
BACKGROUND & OBJECTIVES: Wheezing is a common problem in children under five with acute respiratory infections (ARIs). Viruses are known to be responsible for a considerable proportion of ARIs in children. This study was undertaken to know the viral aetiology of wheezing among the children less than five years of age, admitted to a tertiary care hospital in eastern India. METHODS: Seventy five children, under the age of five years admitted with wheezing, were included in the study...
February 2017: Indian Journal of Medical Research
Katja Landgraf-Rauf, Bettina Anselm, Bianca Schaub
Asthma represents the most common chronic childhood disease worldwide. Whereas preschool children present with wheezing triggered by different factors (multitrigger and viral wheeze), clinical asthma manifestation in school children has previously been classified as allergic and non-allergic asthma. For both, the underlying immunological mechanisms are not yet understood in depth in children. Treatment is still prescribed regardless of underlying mechanisms, and children are not always treated successfully...
December 2016: Molecular and Cellular Pediatrics
J Just, P Saint Pierre, F Amat, R Gouvis-Echraghi, N Lambert-Guillemot, T Guiddir, I Annesi Maesano
'Phenotyping' asthma by multivariate analyses and more recently by unsupervised analysis has been performed in children cohorts. We describe the key findings that have emerged from these cohorts. It would appear that there are three wheeze phenotypes in children of preschool age: the mild episodic viral wheeze phenotype; the multitrigger atopic wheeze; and, less often encountered, the severe non-atopic wheeze. Early onset of allergy in asthma (more prevalent in boys) is associated with poor prognosis unlike the severe non-atopic wheeze phenotype which has a female predominance...
June 2015: Pediatric Allergy and Immunology
Hugo P Van Bever, Eugene Han, Lynette Shek, Seo Yi Chng, Daniel Goh
Asthma is considered a chronic disease, but not all preschool wheezing is asthma since most will eventually grow out of their symptoms. Although still a matter of debate, preschool wheezing can be classified in 2 major groups: virus-induced wheezing and multitrigger wheezing, having a different prognosis and a different treatment approach. Virus-induced wheezing is the most common phenotype of preschool wheezing and is usually associated with a good prognosis. Treatment should be conservative, but if preventive treatment is required, leukotriene-receptor antagonists might be the first choice treatment...
November 2010: World Allergy Organization Journal
Luca Bertelli, Andrea Gentili, Cecilia Modolon, Ilaria Corsini, Salvatore Cazzato
We report a child with a history of recurrent episodes of wheezing. At 3 months of age, the frequency of these episodes began to increase. Wheezing was associated with persistent cough and dyspnea with nocturnal awakening. The skin prick test was positive for pollen and pet dander. Airway endoscopy revealed the presence of a peanut, which obstructed the left main bronchus. Chronic cough and recurrent wheezing with symptoms between acute exacerbations could be signs not only of asthma but also of other disorders...
December 2012: Pediatric Emergency Care
Luis Garcia-Marcos, Fernando D Martinez
No abstract text is available yet for this article.
September 2010: Journal of Allergy and Clinical Immunology
Graziella Turato, Angelo Barbato, Simonetta Baraldo, Maria Elena Zanin, Erica Bazzan, Kim Lokar-Oliani, Fiorella Calabrese, Cristina Panizzolo, Deborah Snijders, Piero Maestrelli, Renzo Zuin, Leonardo M Fabbri, Marina Saetta
RATIONALE: Epidemiologic studies have shown that, in atopic children, wheezing is more likely to persist into adulthood, eventually becoming asthma, whereas it appears to resolve by adolescence in nonatopic children. OBJECTIVES: To investigate whether among children with multitrigger wheeze responsive to bronchodilators the airway pathology would be different in nonatopic wheezers, who are often considered nonasthmatic, compared with atopic wheezers, who are more frequently diagnosed as having asthma...
September 1, 2008: American Journal of Respiratory and Critical Care Medicine
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