Sara La Manna, Concetta Di Natale, Valeria Panzetta, Marilisa Leone, Flavia A Mercurio, Irene Cipollone, Maria Monti, Paolo A Netti, Giarita Ferraro, Aarón Terán, Ana E Sánchez-Peláez, Santiago Herrero, Antonello Merlino, Daniela Marasco
The physical and chemical properties of paddlewheel diruthenium compounds are highly dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare the ability of two diruthenium compounds, [Ru2 Cl(D- p -FPhF)(O2 CCH3 )3 ]·H2 O ( 1 ) (D- p -FPhF- = N,N' -bis(4-fluorophenyl)formamidinate) and K3 [Ru2 (O2 CO)4 ]·3H2 O ( 2 ), to act as inhibitors of amyloid aggregation of the Aβ1-42 peptide and its peculiar fragments, Aβ1-16 and Aβ21-40 . A wide range of biophysical techniques has been used to determine the inhibition capacity against aggregation and the possible mechanism of action of these compounds (Thioflavin T fluorescence and autofluorescence assays, UV-vis absorption spectroscopy, circular dichroism, nuclear magnetic resonance, mass spectrometry, and electron scanning microscopy)...
December 20, 2023: Inorganic Chemistry