keyword
https://read.qxmd.com/read/38541922/the-prepetrous-segment-of-the-internal-carotid-artery-as-a-neglected-site-of-symptomatic-atherosclerosis-a-single-center-series
#1
JOURNAL ARTICLE
Marialuisa Zedde, Ilaria Grisendi, Federica Assenza, Manuela Napoli, Claudio Moratti, Lara Bonacini, Giovanna Di Cecco, Serena D'Aniello, Claudio Pavone, Giovanni Merlino, Jukka Putaala, Franco Valzania, Rosario Pascarella
(1) Background: Non-stenotic complicated plaques are a neglected cause of stroke, in particular in young patients. Atherosclerosis has some preferential sites in extracranial arteries and the prepetrous segment of the internal carotid artery has been rarely described as site of atheroma in general and of complicated atheroma in stroke patients. The aim of this study is to describe the rate of the prepetrous internal carotid artery's (ICA) involvement in a single-center case series of young stroke patients. (2) Methods: All patients < 50 years old with acute ischemic stroke admitted to a single-center Stroke Unit during two time periods (the first one from 1 January 2018 to 31 December 2019, and the second one from 1 January 2021 to 30 June 2022), were prospectively investigated as part of a screening protocol of the Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO) study [ClinicalTrials...
March 15, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38534972/pediatric-hemangiomas-in-the-female-genital-tract-a-literature-review
#2
REVIEW
Lucia Merlino, Agnese Immacolata Volpicelli, Franco Anglana, Giulia D'Ovidio, Mattia Dominoni, Marianna Francesca Pasquali, Barbara Gardella, Paolo Inghirami, Pietro Lippa, Roberto Senatori
BACKGROUND: Hemangiomas are aberrant proliferations of blood vessels and the most frequent benign pediatric soft tissue tumors. Although they are common, genital localization is rare. This study aimed to assist doctors in the diagnosis, management, and treatment of pediatric vulvovaginal hemangiomas by conducting a review of the literature. METHODS: We conducted a literature review including papers published between August 2009 and May 2023. RESULTS: While most hemangiomas are usually indolent and resolve with time, in some cases, especially cervicovaginal and uterine ones, they might present with severe symptoms like heavy bleeding and need further instrumental investigation for diagnosis, like CT or MRI...
February 28, 2024: Diseases (Basel)
https://read.qxmd.com/read/38525705/pulsed-radiofrequency-for-auriculotemporal-neuralgia-a-case-report
#3
Yan Tereshko, Enrico Belgrado, Christian Lettieri, Simone Dal Bello, Giovanni Merlino, Gian Luigi Gigli, Mariarosaria Valente
Auriculotemporal neuralgia is a rare facial pain disorder with no therapeutic evidence for refractory cases. We described a male patient with right auriculotemporal neuralgia, refractory to anesthetic nerve blocks and botulinum toxin type A injections, who was successfully treated with pulsed radiofrequency without adverse events. Pulsed radiofrequency may be an effective and safe treatment for refractory auriculotemporal neuralgia.
March 12, 2024: Neurology International
https://read.qxmd.com/read/38500754/predictors-of-atrial-fibrillation-detection-in-embolic-stroke-of-undetermined-source-patients-with-implantable-loop-recorder
#4
JOURNAL ARTICLE
Lucio D'Anna, Roberta La Cava, Ashni Khetarpal, Abeer Karjikar, Ahmad Almohtadi, Michele Romoli, Matteo Foschi, Raffaele Ornello, Federico De Santis, Simona Sacco, Samir Abu-Rumeileh, Simone Lorenzut, Daisy Pavoni, Mariarosaria Valente, Giovanni Merlino, Soraia Almeida, Asha Barnard, Jianqun Guan, Soma Banerjee, Phang Boon Lim
BACKGROUND: Covert atrial fibrillation (AF) is a predominant aetiology of embolic stroke of undetermined source (ESUS). Evidence suggested that AF is more frequently detected by implantable loop recorder (ILR) than by conventional monitoring. However, the predictive factors associated with occult AF detected using ILRs are not well established yet. In this study we aim to investigate the predictors of AF detection in patients with ESUS undergoing an ILR. METHODS: This observational multi-centre study included consecutive ESUS patients who underwent ILR implantation...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38487322/isolated-insular-stroke-topography-is-the-answer-with-respect-to-outcome-and-cardiac-involvement
#5
JOURNAL ARTICLE
Fedra Kuris, Sara Tartaglia, Roberto Sperotto, Laura Ceccarelli, Daniele Bagatto, Simone Lorenzut, Giovanni Merlino, Francesco Janes, Carolina Gentile, Roberto Marinig, Lorenzo Verriello, Mariarosaria Valente, Giada Pauletto
BACKGROUND AND PURPOSE: Isolated insular strokes (IIS) are a rare occurrence due to the frequent concomitant involvement of adjacent territories, supplied by the M2 segment of the middle cerebral artery (MCA), and clinical aspects are sometimes contradictory. We aimed to describe clinical and radiological characteristics of a pure IIS case series, focusing on its functional outcome and cardiac involvement. METHODS: We identified 15 isolated insular ischemic strokes from a pool of 563 ischemic strokes occurred between January 2020 and December 2021...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38482850/a-comprehensive-update-on-the-admet-considerations-for-%C3%AE-2%C3%AE-calcium-channel-ligand-medications-for-treating-restless-legs-syndrome
#6
REVIEW
Gaia Pellitteri, Salvatore Versace, Giovanni Merlino, Annacarmen Nilo, Gian Luigi Gigli, Mariarosaria Valente
INTRODUCTION: Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a sleep-related sensory-motor disorder associated with poor sleep quality and impaired daily functioning. In patients affected by chronic RLS/WED, a pharmacological therapy is recommended. International guidelines suggest to start the treatment with a α2δ calcium channel ligand in most cases, unless contraindicated. AREAS COVERED: The present review is based on an extensive Internet and PubMed search from 1986 to 2024...
March 15, 2024: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/38422864/neural-thyroid-hormone-metabolism-integrates-seasonal-changes-in-environmental-temperature-with-the-neuroendocrine-reproductive-axis
#7
JOURNAL ARTICLE
Deborah I Lutterschmidt, Kalera Stratton, Treven J Winters, Stephanie Martin, Lauren J Merlino
We asked if environmental temperature alters thyroid hormone metabolism within the hypothalamus, thereby providing a neuroendocrine mechanism by which temperature could be integrated with photoperiod to regulate seasonal rhythms. We used immunohistochemistry to assess the effects of low-temperature winter dormancy at 4 °C or 12 °C on thyroid-stimulating hormone (TSH) within the infundibulum of the pituitary as well as deiodinase 2 (Dio2) and 3 (Dio3) within the hypothalamus of red-sided garter snakes (Thamnophis sirtalis)...
February 28, 2024: Hormones and Behavior
https://read.qxmd.com/read/38398479/reply-to-ronsivalle-s-di-luca-m-exploring-the-choice-of-graft-materials-in-tympanoplasty-a-perspective-on-the-use-of-temporalis-fascia-and-cartilage-grafts-comment-on-ferlito-et-al-type-1-tympanoplasty-outcomes-between-cartilage-and-temporal-fascia-grafts-a
#8
JOURNAL ARTICLE
https://read.qxmd.com/read/38381985/evaluation-with-a-coordinate-measuring-machine-of-dimensional-accuracy-of-the-abutment-duplication-technique-in-cement-retained-implant-restoration
#9
JOURNAL ARTICLE
Luciano Malchiodi, Filippo Scartozzoni, Lisa Merlino, Alberto Borsi, Pier Francesco Nocini
PURPOSE: To evaluate the effectiveness and accuracy of a proposed duplication technique in terms of one- and three-dimensional discrepancies between an original abutment and polyurethane duplicates obtained through a conventional workflow in single-implant rehabilitation. MATERIALS AND METHODS: A titanium, shoulderless abutment was chosen for a single-implant cemented rehabilitation. The master cast was made using a plastic-based die system, and the implant portion was separated...
February 21, 2024: International Journal of Prosthodontics
https://read.qxmd.com/read/38380076/differences-in-run-up-take-off-and-flight-characteristics-successful-vs-unsuccessful-high-jump-attempts-at-the-iaaf-world-championships
#10
JOURNAL ARTICLE
Gareth Nicholson, Gaspar Epro, Stéphane Merlino, Josh Walker, Athanassios Bissas
Studies previously conducted on high jump have yielded important information regarding successful performance. However, analyses in competitive scenarios have often disregarded athletes' unsuccessful attempts. This study aimed to investigate the biomechanical differences between successful and unsuccessful jumps during competition. High-speed video footage (200 Hz) was obtained from 11 athletes during the 2018 Men's World Athletics Indoor Championship Final. From each athlete, one successful (SU) and one unsuccessful (UN) jump at the same bar height were included in the analysis, leaving seven athletes in total...
2024: Frontiers in sports and active living
https://read.qxmd.com/read/38356756/vns-health-and-hss-partner-to-reduce-length-of-stay-after-total-joint-arthroplasty-implications-for-home-care-providers
#11
JOURNAL ARTICLE
Joseph Gallagher, Sandy Merlino
No abstract text is available yet for this article.
February 2024: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://read.qxmd.com/read/38287601/structural-insights-and-aggregation-propensity-of-a-super-stable-monellin-mutant-a-new-potential-building-block-for-protein-based-nanostructured-materials
#12
JOURNAL ARTICLE
Rosanna Lucignano, Roberta Spadaccini, Antonello Merlino, Diletta Ami, Antonino Natalello, Giarita Ferraro, Delia Picone
Protein fibrillation is commonly associated with pathologic amyloidosis. However, under appropriate conditions several proteins form fibrillar structures in vitro that can be used for biotechnological applications. MNEI and its variants, firstly designed as single chain derivatives of the sweet protein monellin, are also useful models for protein fibrillary aggregation studies. In this work, we have drawn attention to a protein dubbed Mut9, already characterized as a "super stable" MNEI variant. Comparative analysis of the respective X-ray structures revealed how the substitutions present in Mut9 eliminate several unfavorable interactions and stabilize the global structure...
January 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38285632/development-and-nanoparticle-mediated-delivery-of-novel-mdm2-mdm4-heterodimer-peptide-inhibitors-to-enhance-5-fluorouracil-nucleolar-stress-in-colorectal-cancer-cells
#13
JOURNAL ARTICLE
Francesco Merlino, Annalisa Pecoraro, Giuseppe Longobardi, Greta Donati, Francesco Saverio Di Leva, Chiara Brignola, Rebecca Piccarducci, Simona Daniele, Claudia Martini, Luciana Marinelli, Giulia Russo, Fabiana Quaglia, Claudia Conte, Annapina Russo, Valeria La Pietra
Colorectal cancer (CRC) often involves wild-type p53 inactivation by MDM2 and MDM4 overexpression, promoting tumor progression and resistance to 5-fluoruracil (5-FU). Disrupting the MDM2/4 heterodimer can proficiently reactivate p53, sensitizing cancer cells to 5-FU. Herein, we developed 16 peptides based on Pep3 ( 1 ), the only known peptide acting through this mechanism. The new peptides, notably 3 and 9 , showed lower IC50 values than 1 . When incorporated into tumor-targeted biodegradable nanoparticles, these exhibited cytotoxicity against three different CRC cell lines...
January 29, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38275111/lorenzutcomparison-of-pharmacokinetic-properties-of-alteplase-and-tenecteplase-the-future-of-thrombolysis-in-acute-ischemic-stroke
#14
REVIEW
Alessandro Marè, Simone Lorenzut, Francesco Janes, Carolina Gentile, Roberto Marinig, Yan Tereshko, Gian Luigi Gigli, Mariarosaria Valente, Giovanni Merlino
INTRODUCTION: The drug most frequently used for thrombolysis in cases of acute ischemic stroke (AIS) is alteplase. However, there is moderate-to-high-quality evidence that tenecteplase has similar or higher efficacy and safety. With improved pharmacokinetic properties over alteplase, tenecteplase could be a significant advantage in treating AIS. AREAS COVERED: After conducting an extensive search on Scopus and PubMed, this manuscript reviews and compares the pharmacokinetic properties of alteplase and tenecteplase...
January 26, 2024: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/38270175/on-the-mechanism-of-action-of-arsenoplatins-arsenoplatin-1-binding-to-a-b-dna-dodecamer
#15
JOURNAL ARTICLE
Romualdo Troisi, Gabriella Tito, Giarita Ferraro, Filomena Sica, Lara Massai, Andrea Geri, Damiano Cirri, Luigi Messori, Antonello Merlino
The reaction of Pt-based anticancer agents with arsenic trioxide affords robust complexes known as arsenoplatins. The prototype of this family of anticancer compounds is arsenoplatin-1 (AP-1) that contains an As(OH)2 fragment linked to a Pt(II) moiety derived from cisplatin. Crystallographic and spectrometric studies of AP-1 binding to a B-DNA double helix dodecamer are presented here, in comparison with cisplatin and transplatin. Results reveal that AP-1, cisplatin and transplatin react differently with the DNA model system...
January 25, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38183469/analysis-of-ultra-short-implants-with-different-angulations-a-retrospective-case-control-study-with-2-to-9%C3%A2-years-of-follow-up
#16
JOURNAL ARTICLE
Luciano Malchiodi, Antonino Fiorino, Lisa Merlino, Alessandro Cucchi, Francesca Zotti, Pier Francesco Nocini
OBJECTIVES: Does the angulation of ultrashort implants influence the stability of the peri-implant bone? The present study aimed to evaluate the effectiveness of non-axial ultrashort implants after 2 to 9 years of follow-up in resorbed alveolar ridges. MATERIALS AND METHODS: All partially edentulous patients with ultrashort implants (< 6 mm) used in the posterior region of an atrophic mandible or maxilla, to support partial dentures in conjunction with standard implants, were included in this study...
January 6, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38159684/botulinum-toxin-type-a-improves-pain-in-numb-chin-syndrome
#17
Yan Tereshko, Bruno Hector Ercole, Lettieri Christian, Enrico Belgrado, Simone Dal Bello, Merlino Giovanni, Gian Luigi Gigli, Mariarosaria Valente
Numb chin syndrome is a rare pain disorder characterized by decreased sensation and paresthesia in the territory of the mental nerve. Neuropathic pain is sometimes described in this setting, and the most common treatments include oral analgesics, gabapentinoids, and carbamazepine; however, botulinum toxin type A has never been used in this setting. We describe a case of bilateral numb chin syndrome, secondary to Burkitt lymphoma, associated with refractory and persistent burning neuropathic pain, effectively treated twelve times with subcutaneous Botulinum toxin type A (BoNT/A) injections...
December 28, 2023: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38123623/storage-protein-activator-controls-grain-protein-accumulation-in-bread-wheat-in-a-nitrogen-dependent-manner
#18
JOURNAL ARTICLE
Anne Plessis, Catherine Ravel, Thierry Risacher, Nathalie Duchateau, Mireille Dardevet, Marielle Merlino, François Torney, Pierre Martre
The expression of cereal grain storage protein (GSP) genes is controlled by a complex network of transcription factors (TFs). Storage protein activator (SPA) is a major TF acting in this network but its specific function in wheat (Triticum aestivum L.) remains to be determined. Here we generated an RNAi line in which expression of the three SPA homoeologs was reduced. In this line and its null segregant we analyzed GSP accumulation and expression of GSP and regulatory TF genes under two regimes of nitrogen availability...
December 20, 2023: Scientific Reports
https://read.qxmd.com/read/38117944/a-diruthenium-metallodrug-as-a-potent-inhibitor-of-amyloid-%C3%AE-aggregation-synergism-of-mechanisms-of-action
#19
JOURNAL ARTICLE
Sara La Manna, Concetta Di Natale, Valeria Panzetta, Marilisa Leone, Flavia A Mercurio, Irene Cipollone, Maria Monti, Paolo A Netti, Giarita Ferraro, Aarón Terán, Ana E Sánchez-Peláez, Santiago Herrero, Antonello Merlino, Daniela Marasco
The physical and chemical properties of paddlewheel diruthenium compounds are highly dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare the ability of two diruthenium compounds, [Ru2 Cl(D- p -FPhF)(O2 CCH3 )3 ]·H2 O ( 1 ) (D- p -FPhF- = N,N' -bis(4-fluorophenyl)formamidinate) and K3 [Ru2 (O2 CO)4 ]·3H2 O ( 2 ), to act as inhibitors of amyloid aggregation of the Aβ1-42 peptide and its peculiar fragments, Aβ1-16 and Aβ21-40 . A wide range of biophysical techniques has been used to determine the inhibition capacity against aggregation and the possible mechanism of action of these compounds (Thioflavin T fluorescence and autofluorescence assays, UV-vis absorption spectroscopy, circular dichroism, nuclear magnetic resonance, mass spectrometry, and electron scanning microscopy)...
December 20, 2023: Inorganic Chemistry
https://read.qxmd.com/read/38087683/large-language-models-llms-in-the-evaluation-of-emergency-radiology-reports-performance-of-chatgpt-4-perplexity-and-bard
#20
JOURNAL ARTICLE
A Infante, S Gaudino, F Orsini, A Del Ciello, C Gullì, B Merlino, L Natale, R Iezzi, E Sala
No abstract text is available yet for this article.
November 29, 2023: Clinical Radiology
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