keyword
https://read.qxmd.com/read/38351345/crosstalk-between-endothelial-progenitor-cells-and-hcc-through-periostin-ccl2-cd36-supports-formation-of-the-pro-metastatic-microenvironment-in-hcc
#21
JOURNAL ARTICLE
Tuo Deng, Jungang Zhao, Yifan Tong, Ziyan Chen, Bangjie He, Jiacheng Li, Bo Chen, Rizhao Li, Liming Deng, Haitao Yu, Baofu Zhang, Tan Zhang, Zhehao Shi, Boyang Gao, Junyan Jiang, Yunfeng Shan, Zhengping Yu, Yuepeng Jin, Yi Wang, Jinglin Xia, Gang Chen
Metastasis causes most cancer-related deaths, and the role and mechanism of periostin (POSTN) in the metastasis of hepatocellular carcinoma (HCC) remain undiscovered. In this study, DEN and HTVi HCC models were performed in hepatic-specific Postn ablation and Postn knock-in mouse to reveal the role of POSTN in HCC metastasis. Furthermore, POSTN was positively correlated with circulating EPCs level and promoted EPC mobilization and tumour infiltration. POSTN also mediated the crosstalk between HCC and EPCs, which promoted metastasis ability and upregulated CD36 expression in HCC through indirect crosstalk...
February 13, 2024: Oncogene
https://read.qxmd.com/read/38347567/extracellular-vesicles-produced-by-irradiated-endothelial-or-glioblastoma-stem-cells-promote-tumor-growth-and-vascularization-modulating-tumor-microenvironment
#22
JOURNAL ARTICLE
Giorgia Castellani, Mariachiara Buccarelli, Quintino Giorgio D'Alessandris, Ramona Ilari, Andrea Cappannini, Francesca Pedini, Alessandra Boe, Valentina Lulli, Isabella Parolini, Stefano Giannetti, Mauro Biffoni, Vincenzo Zappavigna, Giovanna Marziali, Roberto Pallini, Lucia Ricci-Vitiani
BACKGROUND: Glioblastoma (GBM) is the most lethal primary brain tumor in adult, characterized by highly aggressive and infiltrative growth. The current therapeutic management of GBM includes surgical resection followed by ionizing radiations and chemotherapy. Complex and dynamic interplay between tumor cells and tumor microenvironment drives the progression and contributes to therapeutic resistance. Extracellular vesicles (EVs) play a crucial role in the intercellular communication by delivering bioactive molecules in the surrounding milieu modulating tumor microenvironment...
February 12, 2024: Cancer Cell International
https://read.qxmd.com/read/38308345/pdk4-inhibits-osteoarthritis-progression-by-activating-the-ppar-pathway
#23
JOURNAL ARTICLE
Zhengnan Li, Lifeng Xie, Hui Zeng, Yaohong Wu
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease caused by the deterioration of cartilage. However, the underlying mechanisms of OA pathogenesis remain elusive. METHODS: Hub genes were screened by bioinformatics analysis based on the GSE114007 and GSE169077 datasets. The Sprague-Dawley (SD) rat model of OA was constructed by intra-articular injection of a mixture of papain and L-cysteine. Hematoxylin-eosin (HE) staining was used to detect pathological changes in OA rat models...
February 2, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38307091/periostin-promotes-the-proliferation-differentiation-and-mineralization-of-osteoblasts-from-ovariectomized-rats
#24
JOURNAL ARTICLE
Jun Yan, Zidong Wang, Li Xian, Dawei Wang, Yunzhen Chen, Jie Bai, Hai-Juan Liu
Perimenopausal period causes a significant amount of bone loss, which results in primary osteoporosis (OP). The Periostin (Postn) may play important roles in the pathogenesis of OP after ovariectomized (OVX) rats. To identify the roles of Postn in the bone marrow mesenchymal stem cell derived osteoblasts (BMSC-OB) in OVX rats, we investigated the expression of Wnt/β-catenin signaling pathways in BMSC-OB and the effects of Postn on bone formation by development of BMSC-OB cultures. Twenty-four female Sprague-Dawley rats at 6 months were randomized into 3 groups: sham-operated (SHAM) group, OVX group and OVX+Postn group...
February 2, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38297310/plasma-fibroblast-activation-protein-is-decreased-in-acute-heart-failure-despite-cardiac-tissue-upregulation
#25
JOURNAL ARTICLE
Marta Delgado-Arija, Patricia Genovés, Lorena Pérez-Carrillo, Irene González-Torrent, Isaac Giménez-Escamilla, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón, Esther Roselló-Lletí
BACKGROUND: Cardiac fibroblast activation protein (FAP) has an emerging role in heart failure (HF). A paradoxical reduction in its levels in pathological conditions associated with acute processes has been observed. We aimed to identify FAP cardiac tissue expression and its relationship with the main cardiac fibrosis-related signaling pathways, and to compare plasma FAP levels in acute and chronic HF patients. METHODS: Transcriptomic changes were assessed via mRNA/ncRNA-seq in left ventricle tissue from HF patients (n = 57) and controls (n = 10)...
February 1, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38280891/single-cell-rna-sequencing-reveals-the-epithelial-cell-fibroblast-and-key-gene-alterations-in-chronic-rhinosinusitis-with-nasal-polyps
#26
JOURNAL ARTICLE
Yakun Wang, Zufei Li, Jun Lu
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the nasal mucosa, and epithelial-mesenchymal transition (EMT) is thought to be an essential process in the pathogenesis of CRSwNP. However, the mechanisms of epithelial and fibroblastic changes at the single-cell level are unclear. In this study, we investigated the epithelial cell, fibroblast, and key gene alterations in the development of CRSwNP. We revealed major cell types involved in CRSwNP and nasal mucosal inflammation formation, then mapped epithelial and fibroblast subpopulations...
January 27, 2024: Scientific Reports
https://read.qxmd.com/read/38280140/spatial-transcriptomics-in-a-case-of-follicular-thyroid-carcinoma-reveals-clone-specific-dysregulation-of-genes-regulating-extracellular-matrix-in-the-invading-front
#27
JOURNAL ARTICLE
Vincenzo Condello, Johan O Paulsson, Jan Zedenius, Anders Näsman, C Christofer Juhlin
Follicular thyroid carcinoma (FTC) is recognized by its ability to invade the tumor capsule and blood vessels, although the exact molecular signals orchestrating this phenotype remain elusive. In this study, the spatial transcriptional landscape of an FTC is detailed with comparisons between the invasive front and histologically indolent central core tumor areas. The Visium spatial gene expression platform allowed us to interrogate and visualize the whole transcriptome in 2D across formalin-fixated paraffin-embedded (FFPE) tissue sections...
January 27, 2024: Endocrine Pathology
https://read.qxmd.com/read/38275881/deficiency-of-stabilin-1-in-the-context-of-hepatic-melanoma-metastasis
#28
JOURNAL ARTICLE
Sebastian A Wohlfeil, Ana Olsavszky, Anna Lena Irkens, Verena Häfele, Bianca Dietsch, Niklas Straub, Sergij Goerdt, Cyrill Géraud
BACKGROUND: This study analyzed the role of Stabilin-1 on hepatic melanoma metastasis in preclinical mouse models. METHODS: In Stabilin-1-/- mice (Stab1 KO), liver colonization of B16F10 luc2 and Wt31 melanoma was investigated. The numbers, morphology, and vascularization of hepatic metastases and the hepatic microenvironment were analyzed by immunofluorescence. RESULTS: While hepatic metastasis of B16F10 luc2 or Wt31 melanoma was unaltered between Stab1 KO and wildtype (Ctrl) mice, metastases of B16F10 luc2 tended to be smaller in Stab1 KO...
January 19, 2024: Cancers
https://read.qxmd.com/read/38272440/the-chromatin-remodeling-protein-brg1-mediates-ang-ii-induced-pro-fibrogenic-response-in-renal-fibroblasts
#29
JOURNAL ARTICLE
Wenxuan Hong, Yuwen Zhu, Yanshan Lin, Shifan Tang, Jinsi Chen, Lei Xu, Jie Jiang, Yuting Zong, Yongchen Zhang, Aijun Sun, Xiaoyan Wu
AIMS: Renal fibrosis is an important pathophysiological process commonly observed in patients chronic kidney disease (CKD). Angiotensin II (Ang II) is a major risk factor for CKD in part by promoting renal fibrosis. In the present study we investigated Brahma-Related Gene 1 (BRG1, encoded by Smarca4) in Ang II induced pro-fibrogenic response in renal fibroblasts. METHODS AND MATERIALS: Renal fibrosis was induced by chronic angiotensin II infusion. Fibroblast- and myofibroblast-specific BRG1 deletion was achieved by crossing the BRG1f/f mice to the Col1a1-CreERT2 mice and the Postn-CreERT2 mice, respectively...
January 23, 2024: Life Sciences
https://read.qxmd.com/read/38255321/expression-of-the-pro-fibrotic-marker-periostin-in-a-mouse-model-of-duchenne-muscular-dystrophy
#30
JOURNAL ARTICLE
Jessica Trundle, Viktorija Cernisova, Alexis Boulinguiez, Ngoc Lu-Nguyen, Alberto Malerba, Linda Popplewell
Duchenne muscular dystrophy (DMD) is characterised by fibrotic tissue deposition in skeletal muscle. We assessed the role of periostin in fibrosis using mdx mice, an established DMD murine model, for which we conducted a thorough examination of periostin expression over a year. RNA and protein levels in diaphragm (DIA) muscles were assessed and complemented by a detailed histological analysis at 5 months of age. In dystrophic DIAs, periostin ( Postn) mRNA expression significantly exceeded that seen in wildtype controls at all timepoints analysed, with the highest expression at 5 months of age ( p < 0...
January 18, 2024: Biomedicines
https://read.qxmd.com/read/38246584/single-cell-rna-sequencing-reveals-dysregulated-postn-wnt5a-fibroblast-subclusters-in-prurigo-nodularis
#31
JOURNAL ARTICLE
Jay R Patel, Marina Z Joel, Kevin K Lee, Anusha Kambala, Hannah Cornman, Olusola Oladipo, Matthew Taylor, Brenda Umenita Imo, Emily Z Ma, Jaya Manjunath, Alexander L Kollhoff, June Deng, Varsha Parthasarathy, Karen Cravero, Melika Marani, Mindy Szeto, Ryan Zhao, Sreenidhi Sankararaman, Ruixiang Li, Shanae Henry, Thomas Pritchard, Vito Rebecca, Madan M Kwatra, Won Jin Ho, Xinzhong Dong, Sewon Kang, Shawn G Kwatra
Prurigo nodularis (PN) is an intensely pruritic, inflammatory skin disease with a poorly understood pathogenesis. We performed single-cell transcriptomic profiling of 28,695 lesional and non-lesional PN cells. Lesional PN has increased dysregulated fibroblasts (FBs) and myofibroblasts. FBs in lesional PN were shifted towards a cancer-associated fibroblast (CAF)-like phenotype, with POSTN+WNT5A+ CAFs increased in PN, and similarly so in squamous cell carcinoma. A multi-center cohort study revealed an increased risk of SCC and CAF-associated malignancies (breast and colorectal) in PN patients...
January 19, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38218364/profibrotic-subsets-of-spp1-macrophages-and-postn-fibroblasts-contribute-to-fibrotic-scarring-in-acne-keloidalis
#32
JOURNAL ARTICLE
Yi-Kai Hong, Daw-Yang Hwang, Chao-Chun Yang, Siao Muk Cheng, Peng-Chieh Chen, Wilson Jr Aala, Hans I-Chen Harn, Spencer T Evans, Alexandros Onoufriadis, Si-Lin Liu, Yu-Chen Lin, Yi-Han Chang, Tzu-Kun Lo, Kuo-Shu Hung, Yi-Chao Lee, Ming-Jer Tang, Kurt Q Lu, John A McGrath, Chao-Kai Hsu
Acne keloidalis (AK) is a primary scarring alopecia characterized by longstanding inflammation in the scalp causing keloid-like scar formation and hair loss. Histologically, AK is characterized by mixed leukocytic infiltrates in the acute stage followed by a granulomatous reaction and extensive fibrosis in the later stages. To further explore its pathogenesis, bulk RNA-sequencing, single-cell RNA-sequencing, and spatial transcriptomics were applied to occipital scalp biopsy specimens of lesional and adjacent non-lesional skin in patients with clinically active disease...
January 11, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38214211/utx-inhibition-suppresses-proliferation-and-promotes-apoptosis-in-patient-derived-glioblastoma-stem-cells-by-modulating-periostin-expression
#33
JOURNAL ARTICLE
Yan Luan, Hanyue Zhang, Yingfei Liu, Jingwen Xue, Ke Wang, Bo Ma, Kaige Ma, Haixia Lu, Xinlin Chen, Yong Liu, Zhichao Zhang
Glioblastoma stem cells (GSCs) exert a crucial influence on glioblastoma (GBM) development, progression, resistance to therapy, and recurrence, making them an attractive target for drug discovery. UTX, a histone H3K27 demethylase, participates in regulating multiple cancer types. However, its functional role in GSCs remains insufficiently explored. This study aims to investigate the role and regulatory mechanism of UTX on GSCs. Analysis of TCGA data revealed heightened UTX expression in glioma, inversely correlating with overall survival...
January 12, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38203755/single-cell-transcriptome-sequence-profiling-on-the-morphogenesis-of-secondary-hair-follicles-in-ordos-fine-wool-sheep
#34
JOURNAL ARTICLE
Chenglan Li, Xue He, Yi Wu, Jianye Li, Rui Zhang, Xuejiao An, Yaojing Yue
The Ordos fine-wool sheep is a high-quality breed in China that produces superior natural textiles and raw materials such as wool and lamb meat. However, compared to the Australian Merino sheep, there is still a gap in terms of the wool fiber fineness and wool yield. The hair follicle is the main organ that controls the type of wool fiber, and the morphological changes in the secondary hair follicle are crucial in determining wool quality. However, the process and molecular mechanisms of hair follicle morphogenesis in Ordos fine-wool sheep are not yet clear...
January 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38193247/histological-parameters-and-stromal-desmoplastic-status-affecting-accurate-diagnosis-of-extraprostatic-extension-of-prostate-cancer-using-multi-parametric-magnetic-resonance-imaging
#35
JOURNAL ARTICLE
Kousuke Okano, Kosuke Miyai, Ayako Mikoshi, Hiromi Edo, Keiichi Ito, Hitoshi Tsuda, Hiroshi Shinmoto
OBJECTIVE: To investigate the clinicopathological factors affecting discrepancies between multi-parametric magnetic resonance imaging (mpMRI) and histopathological evaluation for diagnosis of extraprostatic extension (EPE) of prostate cancer. METHODS: One hundred-and-three lesions from 96 cases with suspected EPE on preoperative mpMRI, of which 60 and 43 showed bulging and frank capsular breach, respectively, were grouped according to pathological (p)EPE in radical prostatectomy specimens...
January 9, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
https://read.qxmd.com/read/38186856/endothelial-periostin-regulates-vascular-remodeling-by-promoting-endothelial-dysfunction-in-pulmonary-arterial-hypertension
#36
JOURNAL ARTICLE
Dawn Lee, Heeyoung Lee, Ha-Neul Jo, Eunsik Yun, Byung Su Kwon, Jongmin Kim, Aram Lee
Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated with extracellular matrix (ECM) deposition, vascular cell hyperproliferation, and neointima formation in the small pulmonary artery. Endothelial dysfunction is considered a key feature in the initiation of vascular remodeling. Although vasodilators have been used for the treatment of PAH, it remains a life-threatening disease. Therefore, it is necessary to identify novel therapeutic targets for PAH treatment. Periostin (POSTN) is a secretory ECM protein involved in physiological and pathological processes, such as tissue remodeling, cell adhesion, migration, and proliferation...
2024: Animal Cells and Systems
https://read.qxmd.com/read/38185763/changes-in-the-astronaut-serum-proteome-during-prolonged-spaceflight
#37
JOURNAL ARTICLE
Yayoi Kimura, Yusuke Nakai, Yoko Ino, Tomoko Akiyama, Kayano Moriyama, Tatsuya Aiba, Takashi Ohira, Kenji Egashira, Yu Yamamoto, Yuriko Takeda, Yutaka Inaba, Akihide Ryo, Tomoyuki Saito, Ken Kumagai, Hisashi Hirano
The molecular mechanisms associated with spaceflight-induced biological adaptations that may affect many healthy tissue functions remain poorly understood. In this study, we analyzed temporal changes in the serum proteome of six astronauts during prolonged spaceflight missions using quantitative comprehensive proteome analysis performed with the data-independent acquisition method of mass spectrometry (DIA-MS). All six astronauts participated in a spaceflight mission for approximately 6 months and showed a decreasing trend in T-scores at almost all sites where dual-energy X-ray absorptiometry scans were performed...
January 7, 2024: Proteomics
https://read.qxmd.com/read/38176898/histone-methyltransferase-suv39h1-regulates-hepatic-stellate-cell-activation-and-is-targetable-in-liver-fibrosis
#38
JOURNAL ARTICLE
Ming Kong, Junjing Zhou, Aoqi Kang, Yameng Kuai, Huihui Xu, Min Li, Xiulian Miao, Yan Guo, Zhiwen Fan, Yong Xu, Zilong Li
OBJECTIVE: Liver fibrosis is a prelude to a host of end-stage liver diseases. Hepatic stellate cells (HSCs), switching from a quiescent state to myofibroblasts, are the major source for excessive production of extracellular matrix proteins. In the present study, we investigated the role of Suv39h1, a lysine methyltransferase, in HSC-myofibroblast transition and the implication in liver fibrosis. DESIGN: HSC-specific or myofibroblast-specific Suv39h1 deletion was achieved by crossbreeding the Suv39h1 f/f mice to the Lrat -Cre mice or the Postn -CreERT2 mice...
January 4, 2024: Gut
https://read.qxmd.com/read/38170412/population-based-high-dimensional-analyses-identify-multiple-intrinsic-characters-for-cancer-vaccines-against-lung-squamous-cell-carcinoma
#39
JOURNAL ARTICLE
Longjin Zeng, Lingchen Li, Xingyun Liao, Lincheng Zhang, Chenrui Yin, Xiewan Chen, Jianguo Sun
In lung squamous cell carcinoma (LUSC), current cancer vaccines show promising effects, despite a lack of benefit for a large number of patients. We first identified the tumor antigens into shared and private antigens, and determined the population by clustering analysis in public datasets. For vaccine development, The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) were collected. WGCNA method was furthermore applied to construct a consensus gene co-expression network based on TCGA and CPTAC datasets...
January 3, 2024: Medical Oncology
https://read.qxmd.com/read/38168935/presence-of-onco-fetal-neighborhoods-in-hepatocellular-carcinoma-is-associated-with-relapse-and-response-to-immunotherapy
#40
JOURNAL ARTICLE
Ziyi Li, Rhea Pai, Saurabh Gupta, Jennifer Currenti, Wei Guo, Anna Di Bartolomeo, Hao Feng, Zijie Zhang, Zhizhen Li, Longqi Liu, Abhishek Singh, Yinqi Bai, Bicheng Yang, Archita Mishra, Katharine Yang, Liang Qiao, Michael Wallace, Yujia Yin, Qiang Xia, Jerry Kok Yen Chan, Jacob George, Pierce Kah-Hoe Chow, Florent Ginhoux, Ankur Sharma
Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in the tumor microenvironment, leading to immunosuppressive features. Here, we employed single-cell RNA sequencing, spatial transcriptomics and bulk RNA sequencing to delineate specific cell subsets involved in hepatocellular carcinoma (HCC) relapse and response to immunotherapy. We identified POSTN+ extracellular matrix cancer-associated fibroblasts (EM CAFs) as a prominent onco-fetal interacting hub, promoting tumor progression...
January 2, 2024: Nature Cancer
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