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David A Edwards, Traci L Hedrick, Jennifer Jayaram, Charles Argoff, Padma Gulur, Stefan D Holubar, Tong J Gan, Michael G Mythen, Timothy E Miller, Andrew D Shaw, Julie K M Thacker, Matthew D McEvoy
Enhanced recovery pathways have quickly become part of the standard of care for patients undergoing elective surgery, especially in North America and Europe. One of the central tenets of this multidisciplinary approach is the use of multimodal analgesia with opioid-sparing and even opioid-free anesthesia and analgesia. However, the current state is a historically high use of opioids for both appropriate and inappropriate reasons, and patients with chronic opioid use before their surgery represent a common, often difficult-to-manage population for the enhanced recovery providers and health care team at large...
February 12, 2019: Anesthesia and Analgesia
Kirti Arora, Gitanjali Goyal, Divya Soin, Sumit Kumar, Hobinder Arora, Cheenu Garg
Parathyroid hormone (PTH) is the main regulator of calcium, phosphate, magnesium, sodium, and potassium homeostasis. Therefore, this study was conducted to evaluate the relationship between PTH and aforementioned minerals in end-stage renal disease (ESRD) patients. Aim: The aim of this study was to estimate serum intact parathormone (iPTH) and other biochemical parameters in ESRD patients and to find correlation between serum iPTH and biochemical parameters in the study group. Results: This cross-sectional study included 60 clinically diagnosed patients of ESRD of age (>18 years), either sex...
November 2018: Indian Journal of Endocrinology and Metabolism
Mario E Lacouture, David J Kopsky, Raphael Lilker, Fiona Damstra, Mecheline H M van der Linden, Azael Freites-Martinez, Mischa P M Nagel
Cancer is one of the leading causes of mortality and morbidity worldwide. Recent improved therapies have resulted in more patients surviving cancer and living longer. Despite these advances, the majority of patients will develop adverse events from anticancer therapies. Foot alterations, including nail toxicities, hand-foot syndrome, edema, xerosis, hyperkeratosis, and neuropathy, are frequent among cancer patients. These untoward conditions may negatively impact quality of life, and in some cases may result in the interruption or discontinuation of cancer treatments...
November 2018: Journal of the American Podiatric Medical Association
Eli Y Adashi, I Glenn Cohen, Jacob H Hanna, Azim M Surani, Katsuhiko Hayashi
The implications of scientific breakthroughs are rarely faced up to in advance of their realization. Stem cell-derived human gametes, a disruptive technology in waiting, are likely to recapitulate this historic pattern absent active intervention. Herein we call for the conduct of thoughtful ante hoc deliberations on the prospect of stem cell-derived human gametes with an eye toward minimizing potential untoward post hoc regulatory or statutory impositions.
February 6, 2019: Trends in Molecular Medicine
Seema Elina Punnoose, John Victor, Produl Hazarika, Marla Ss
C-MAC® video-laryngoscope is often used by anesthetists in difficult intubation scenarios primarily in adults. Using this C-MAC® device in two of our pediatric cases, we successfully removed the laryngeal foreign body, while the anesthetist provided the apneic technique. A systematic review of PubMed and Google Scholar for similar cases was conducted. We found only one such case report of pediatric airway foreign body removal via video-laryngoscope in the English literature. The use of this high-quality, magnified video-laryngoscope in children in an emergency scenario is often not adequately applied...
2019: SAGE Open Medical Case Reports
Deok-Bog Moon, Sung-Gyu Lee, Shin Hwang, Chul-Soo Ahn, Ki-Hun Kim, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Young-In Yoon, Hwui-Dong Cho, Jae-Hyun Kwon, Yong-Kyu Jung, Su-Min Ha
Simultaneous splenectomy (SSPX) in adult living donor liver transplantation (ALDLT) has definitely beneficial roles such as portal flow modulation in small-for-size graft and correction of hypersplenism-related pancytopenia, and so on, but disastrous complications after SSPX often occur. For the first time, we devised unique and innovative splenic devascularization (SDV) procedure to alleviated untoward effects of SSPX but to maintain its benefits for the indicated patients. From April 2013 to December 2014, 520 recipients underwent ALDLT, and the SSPX and SDV were simultaneously performed in 62 (11...
February 3, 2019: Transplant International: Official Journal of the European Society for Organ Transplantation
Nicola Veronese, Cyrus Cooper, Jean-Yves Reginster, Marc Hochberg, Jaime Branco, Olivier Bruyère, Roland Chapurlat, Nasser Al-Daghri, Elaine Dennison, Gabriel Herrero-Beaumont, Jean-François Kaux, Emmanuel Maheu, René Rizzoli, Roland Roth, Lucio C Rovati, Daniel Uebelhart, Mila Vlaskovska, André Scheen
OBJECTIVES: Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases that frequently co-exist, along with overweight/obesity. While the mechanical impact of excess body weight on joints may explain lower limb OA, we sought to explore whether T2DM is linked to OA outside of excess weight and whether T2DM may play a role in OA pathophysiology. The consequence of T2DM on OA outcomes is a question of research interest. METHODS: We conducted a critical review of the literature to explore the association between T2DM and OA, whether any association is site-specific for OA, and whether the presence of T2DM impacts on OA outcomes...
January 11, 2019: Seminars in Arthritis and Rheumatism
Mahmoud H Alabbad, Mohammed Z AlMussalam, Ahmed M AlMusalmi, Mohammad M Alealiwi, Ali I Alresasy, Haidar N Alyaseen, Ahmed Badar
BACKGROUND: Energy drinks contain stimulants mainly caffeine. The use of these drinks by university students is on the rise despite concerns about their safety. This study identified the determinants of the consumption of energy drinks in a cohort of Saudi university students. MATERIALS AND METHODS: This cross-sectional study was carried out at Imam Abdulrahman Bin Faisal University in Saudi Arabia. The students who volunteered to participate ( n = 1255) were asked to complete a pretested questionnaire soliciting information on gender, marital status, class and college of study, pattern of energy drinks use, reasons for use, any benefits as well as any untoward effects experienced...
January 2019: Journal of Family & Community Medicine
G S Yan, L L Li, S L Jiang, S Meng, C C Wu
Objective: To investigate the effects of two different sorbents(Carbon perfusion apparatus and Resin perfusion apparatus)in Double plasma molecular absorb syetem for liver failure treatment. Methods: A total of 152 cases with liver failure who were admitted to The Sixth People's Hospital of Zhengzhou, from June 2016 to May 2018 were selected and divided into DPMARS Carbon group (77 cases) and Resin group (75 cases). The two groups were observed in terms of liver function, prothrombin activity(PTA),Plasma albumin ,tumor necrosis factor alpha and interleukin-6 were detected and compared between the two groups before and after treatment...
January 20, 2019: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
A Jelmer Brüggemann, Camilla Forsberg, Robert Thornberg
BACKGROUND: There is a growing body of international research that displays the prevalence and character of abuse in health care. Even though most of these studies are conducted from a patient perspective little is known about how patients conceptualize their agency in relation to such situations. This study aimed to explore how patients reason about their potential to act in abusive situations. METHODS: Qualitative interviews were conducted with thirteen patients in Sweden...
January 23, 2019: BMC Health Services Research
Derrick J Sanderson, John Rutkowski, Bashir Attuwaybi, Abeer Eddib
Introduction and Hypothesis: In the United States, vesicovaginal fistula (VVF) most often results from gynecologic surgery causing significant morbidity and distress to both the patient and surgeon. The use of tissue interposition at time of primary repair has been advocated to decrease the risk of recurrence. The aim of this study is to describe our experience with interposition of sigmoid epiploica during robotic extravesical repair of supratrigonal VVF. Methods: This is a retrospective case series from June 2015 to September 2016...
October 2018: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Katelyn B Detweiler, Fei He, Heather F Mangian, Gary M Davenport, Maria R C de Godoy
Soybean hulls (SBH) are a fiber-rich co-product of the soybean oil extraction process that corresponds to 8% of the soybean seed. Despite being readily available and priced competitively, SBH are underutilized in monogastric nutrition. Thus, the objective of this study was to evaluate SBH as a dietary fiber in canine diets. Four diets were formulated with either SBH, beet pulp (BP), or cellulose (CL) as the main source of dietary fiber (15% total dietary fiber [TDF]), with the control diet formulated with no supplemental fiber (NF)...
January 10, 2019: Journal of Animal Science
Zuleyha Karaca, Aysa Hacioglu, Fahrettin Kelestimur
INTRODUCTION: The prevalence of pituitary dysfunction is high following aneurysmal subarachnoid hemorrhage (aSAH) and when occurs it may contribute to residual symptoms of aSAH such as decreased cognition and quality of life. Hypopituitarism following aSAH may have non-specific, subtle symptoms and potentially serious consequences if remained undiagnosed. METHODS: We reviewed the literature on epidemiology, pathophysiology, diagnostic methods and management of neuroendocrine changes after aSAH as well as on the impact of pituitary dysfunction on outcome of the patient...
January 14, 2019: Pituitary
C Graham, S Reid, T C Lord, K H Taylor
NHS Improvement highlights the importance of providing consistently safe care within the NHS. For dental professionals, this particularly concerns the reporting and avoidance of never events such as wrong tooth extraction and other serious incidents. Within the authors' unit, a number of infrequent never events and the national drive to introduce safety frameworks (NatSSIPs) has led to a reassessment of our safety procedures. In this paper, as part of our safety improvements, we discuss the chronological changes made in safety procedures following untoward events...
January 11, 2019: British Dental Journal
M Arioka, X Zhang, Z Li, U S Tulu, Y Liu, L Wang, X Yuan, J A Helms
Osteoporosis is associated with decreased bone density and increased bone fragility, but how this disease affects alveolar bone healing is not clear. The objective of this study was to determine the extent to which osteoporosis affects the jaw skeleton and then to evaluate possible mechanisms whereby an osteoporotic phenotype might affect the rate of alveolar bone healing following tooth extraction. Using an ovariectomized mouse model coupled with micro-computed tomographic imaging, histologic, molecular, and cellular assays, we first demonstrated that the appendicular and jaw skeletons both develop osteoporotic phenotypes...
January 9, 2019: Journal of Dental Research
Sean Setzen, Michael Platt
BACKGROUND: Sneezing is an almost universal daily phenomenon as a reflex to evacuate irritants from the nasal cavities. An autonomic-controlled buildup of intrathoracic pressure against a closed glottis followed by sudden release results in a burst of 1 kPa of air through the upper airway. Active intervention to limit a sneeze can be deleterious. Closure of the airway during a sneeze can result in over 20 times the airway pressures resulting in a variety of untoward events. This review summarizes all reported injuries that occurred as the result of a sneeze...
January 8, 2019: American Journal of Rhinology & Allergy
C E Tanase, M Golozar, S M Best, R A Brooks
Plasma electrolytic oxidation (PEO) has been demonstrated to be an effective surface treatment for enhancing the osteoconduction and osseointegration of commercially pure α-Ti (CP α-Ti) dental implant materials for clinical application. To explore the feasibility of extending the application of PEO to low-modulus β-type titanium alloys for load-bearing orthopaedic implants, a thorough understanding of the effect of substrate material on the biological performance of the PEO-treated surface is required. A 10 kW 50 Hz KeroniteTM processing unit was used to modify the surface of low-modulus near β-Ti13Nb13Zr and β-Ti45Nb substrates...
December 26, 2018: Colloids and Surfaces. B, Biointerfaces
Fred Stephen Sarfo, Michelle Nichols, Benedict Agyei, Arti Singh, Eugenia Ennin, Adu Darko Nyantakyi, Shadrack Osei Asibey, Raelle Tagge, Mulugeta Gebregziabher, Carolyn Jenkins, Bruce Ovbiagele
BACKGROUND: The burden of cardiovascular disease (CVD) among people living with HIV (PLWH) in sub-Saharan Africa is projected to rise due to a rapid epidemiological transition and improved treatment of HIV infection on the sub-continent. OBJECTIVE: The Evaluation of Vascular Event Risk while on Long-term Anti-retroviral Suppressive Therapy (EVERLAST) Study sought to assess the extent of subclinical atherosclerosis and characterize the nature of CVD risk factors among HIV patients on Antiretroviral therapy (ART) in Ghana...
December 19, 2018: Journal of the Neurological Sciences
John Harman, Stan Govender, John Simpson, Benji Benjamin
In New Zealand, oncoplastic surgery is common, but partial breast reconstruction presents challenges for radiation therapy targeting. Tissue rearrangement creates ambiguity when targeting the tumor bed, with resultant overestimation of treatment volumes. Thus, adoption of advanced methods of radiation therapy have been hindered. This pilot study describes use of a novel three-dimensional implant that provides a scaffolding for tissue ingrowth during partial breast reconstruction and delineates the tumor bed more precisely to assist radiation planning and mammographic surveillance...
January 2019: Plastic and Reconstructive Surgery
Jun-Qiao Zhao, Tie-Ming Ma
OBJECTIVE: To evaluate the clinical efficacy and security of acupuncture therapy combined with conventional antipsychotics in the treatment of schizophrenia. METHODS: We first comprehensively retrieved papers about acupuncture or moxibustion treatment of schizophrenia published from the time of establishment of the database to April of 2017 in Chinese databases such as Chinese National Knowledge Infrastructure(CNKI), Chinese Science and Technology Periodical Database (VIP), Wanfang, and Chinese BioMedical Literature (CBM) by using keywords "acupuncture"moxibustion"acupuncture +moxibustion"acupuncture +medication"electroacupuncture"filiform needle"scalp-acupuncture"auricular acupuncture", etc...
December 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
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