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Brain metastasis lung cancer

Suheil Albert Atallah-Yunes, Jackson Clark, Shazia Samanani, Myat Soe
BACKGROUND Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as secondary adrenal insufficiency. Although pituitary gland metastasis is rare, it is underestimated, as it is commonly misdiagnosed with pituitary gland adenoma due to the lack of clear radiological criteria differentiating between both...
February 17, 2019: American Journal of Case Reports
Paolo Borghetti, Marco Lorenzo Bonù, Rachele Giubbolini, Niccolo' Giaj Levra, Rosario Mazzola, Marco Perna, Luca Visani, Fiammetta Meacci, Maria Taraborrelli, Luca Triggiani, Davide Franceschini, Carlo Greco, Alessio Bruni, Stefano Maria Magrini, Vieri Scotti
PURPOSE: To investigate the role of radiotherapy (RT) in the management of EGFR- or ALK-mutated metastatic non-small cell lung cancer (NSCLC) treated with TKI. MATERIALS AND METHODS: Clinical data of 106 patients (pts) from five Institutions treated with RT concomitant to TKI were retrospectively revised. Overall survival (OS) and toxicities were analyzed as endpoints of the study. RESULTS: Median age of pts was 65 years. TKIs were given for EGFR (81%)- or ALK (19%)-mutated metastatic NSCLC...
February 15, 2019: La Radiologia Medica
Wen-Ya Li, Ting-Ting Zhao, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yunan Han, Yong-Xi Song, Jian-Hua Wu, Hao Xu, Song-Cheng Yin, Xing-Yu Liu, Zhi-Feng Miao
BACKGROUND: The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and overall survival (OS) in NSCLC patients with brain metastases. METHODS: Searches were performed in PubMed, EmBase, and the Cochrane Library to identify studies evaluating the association of EGFR mutation with OS in NSCLC patients through September 2017...
February 13, 2019: BMC Cancer
S Yesmin, M Sanyal, M J Hasan
Breast cancer in male is rare which accounts about 1% of all malignant breast neoplasm cases. Since paraneoplastic syndrome is unusual with male breast cancer, very few reported cases are found. A72- year-old gentleman presented with proximal myopathy in all four limbs was referred to Dr. Sirajul Islam Medical College and Hospital in April 2017. He had generalized wasting with reduced tone and reflexes. Planter responses were normal with intact sensory. There were typical Heliotrope rash bilaterally. In background, he had history of radical mastectomy due to stage IIA ductal carcinoma of left breast 7 years back...
January 2019: Mymensingh Medical Journal: MMJ
Zhe Wang, Shu-Geng Gao, Qi Xue, Xiao-Tong Guo, Li-Xu Wang, Xin Yu, Yi-Kun Yang, Ju-Wei Mu
Background: Previous studies have demonstrated that survival of patients with non-small cell lung cancer (NSCLC) with oligometastasis may benefit from local treatment. The purpose of this study was to compare the efficacy of local surgical treatment with systematic chemoradiotherapy in NSCLC with oligometastasis. Methods: Data from a total of 172 patients with NSCLC with oligometastasis were collected at our Cancer Hospital from January 2006 to December 2016. The patients were divided into two groups: group A (82 cases) underwent primary surgical treatment and adjuvant chemotherapy was performed after operation, while group B (90 cases) received systematic chemotherapy and local radiotherapy...
December 2018: Journal of Thoracic Disease
Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit, Federico Mayor
Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on ACKR3. This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation of tumour cell proliferation and migration, tumour angiogenesis or resistance to drugs, thus contributing to cancer progression and metastasis occurrence. Here we focus on the clinical significance and potential mechanisms underlying the pathological role of ACKR3 in breast, lung and brain cancer and discuss its possible relevance as prognostic factor and potential therapeutic target in these contexts...
February 11, 2019: Molecular Pharmacology
Hidenao Kayawake, Norihito Okumura, Keiji Yamanashi, Ayuko Takahashi, Satoshi Itasaka, Hiroshige Yoshioka, Takashi Nakashima, Tomoaki Matsuoka
OBJECTIVES: When induction therapy followed by surgery for locally advanced non-small cell lung cancer results in pathological complete response, the prognosis is excellent; however, relapses can occur. We analyzed the predictive factors for achieving pathological complete response and reviewed the clinicopathological features and surgical outcomes of locally advanced non-small cell lung cancer with pathological complete response. METHODS: Between March 2005 and January 2015, 145 resections after induction therapy for locally advanced non-small cell lung cancer were performed; 38 cases achieved pathological complete response...
February 6, 2019: General Thoracic and Cardiovascular Surgery
Lobna Ouldamer, Sofiane Bendifallah, Gilles Body, Cyril Touboul, Olivier Graesslin, Emilie Raimond, Pierre Collinet, Charles Coutant, Alexandre Bricou, Vincent Lavoué, Jean Lévêque, Emile Daraï, Marcos Ballester
Patterns of distant metastatic failure of endometrial cancer (EC) by specific anatomic site are not well described in the literature. In this manuscript, we evaluated the metastatic patterns of EC cancer and analysed the potential distribution of metastatic disease in this malignancy. METHODS: A total of 1444 women with EC were identified. Of which we extracted women with locoregional and distant recurrence or with distant recurrence alone. Women were scored based on first site of metastasis: multiple versus one site: bone, brain, lung, liver or sus diaphragmatic lymph nodes...
January 19, 2019: European Journal of Surgical Oncology
Yadong Guo, Shiyu Mao, Aihong Zhang, Ruiliang Wang, Ziwei Zhang, Junfeng Zhang, Longsheng Wang, Wentao Zhang, Yuan Wu, Lin Ye, Bin Yang, Xudong Yao
Objective: This study compared the clinicopathological features and survival of metastatic prostate cancer (mPCa) after stratification by age and non-bone-related metastasis to identify prognostic factors. Methods: Patients with mPCa between 2010 and 2015 were identified from the Surveillance, Epidemiology and End Results database and analyzed. The overall survival (OS) rate was assessed using the Kaplan-Meier curve and log-rank test as well as multivariate Cox regression analysis. Results: Among the 10147 patients with mPCa, 5378 were classified as young (≤70 years), 3140 were classified as middle-aged (70-82 years), and 1629 were classified as elderly (> 82 years)...
2019: Journal of Cancer
Vaishali Aggarwal, Dharambir Kashyap, Katrin Sak, Hardeep Singh Tuli, Aklank Jain, Ashun Chaudhary, Vivek Kumar Garg, Gautam Sethi, Mukerrem Betul Yerer
Tocotrienols, found in several natural sources such as rice bran, annatto seeds, and palm oil have been reported to exert various beneficial health promoting properties especially against chronic diseases, including cancer. The incidence of cancer is rapidly increasing around the world not only because of continual aging and growth in global population, but also due to the adaptation of Western lifestyle behaviours, including intake of high fat diets and low physical activity. Tocotrienols can suppress the growth of different malignancies, including those of breast, lung, ovary, prostate, liver, brain, colon, myeloma, and pancreas...
February 2, 2019: International Journal of Molecular Sciences
Koichi Saruwatari, Tokunori Ikeda, Sho Saeki, Naoki Shingu, Kosuke Imamura, Taiyou Komatu, Sunao Ushijima, Hirotaka Maruyama, Kosuke Kashiwabara, Yusuke Tomita, Hidenori Ichiyasu, Kazuhiko Fujii, Takuro Sakagami
BACKGROUND/AIM: The optimal treatment strategy for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) has not yet been fully determined. The aim of this study was to investigate the optimal management of EGFR-mutant NSCLC patients with BM. PATIENTS AND METHODS: A multicenter retrospective study was performed on the clinical outcomes of 81 advanced/recurrent EGFR-mutant NSCLC patients with BM treated with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) (gefitinib n=52 or erlotinib n=29)...
February 2019: Anticancer Research
Yuhao Huang, Kevin K H Chow, Jacqueline V Aredo, Sukhmani K Padda, Summer S Han, Bina W Kakusa, Melanie Hayden Gephart
BACKGROUND: Few prognostic markers are available for NSCLC patients undergoing neurosurgical resection of symptomatic brain metastases. OBJECTIVE: We investigated whether tumor mutation status (EGFR, KRAS, ALK, ROS1, BRAF) and treatment history were associated with survival after neurosurgery. METHODS: We reviewed the electronic health records of 104 NSCLC patients with genomic profiling who underwent neurosurgical resection for symptomatic brain metastases at an academic institution between January 2000 and January 2018...
January 30, 2019: World Neurosurgery
Vasco Branco, José Pimentel, Maria Alexandra Brito, Cristina Carvalho
BACKGROUND: Central Nervous System (CNS) tumors have a poor survival prognosis due to their invasive and heterogeneous nature, in addition to the resistance to multiple treatments. OBJECTIVE: In this paper, the main aspects of brain tumor biology and pathogenesis are reviewed both for primary tumors of the brain, (i.e. gliomas) and for metastasis from other malignant tumors, namely lung cancer, breast cancer and malignant melanoma which account for a high percentage of overall malignant brain tumors...
January 31, 2019: Current Medicinal Chemistry
Takeshi Takayasu, Fumiyuki Yamasaki, Takeo Shishido, Motoki Takano, Hirofumi Maruyama, Kazuhiko Sugiyama, Kaoru Kurisu
We present the case of a 68-year-old man with brain metastasis from lung cancer and a history of immune checkpoint inhibitor administration, with overlapping abscess within the metastatic lesion. He initially received antibiotic treatment under a diagnosis of brain abscess because of a hyper-intense area on diffusion-weighted imaging inside the gadolinium-enhanced wall. The size of the enhanced lesion did not change much, but the extent of perifocal edema decreased after antibiotic treatment. After 2-4 months, the lesion gradually enlarged, and imaging characteristics changed from single cyst to multiple cysts...
January 2019: NMC case report journal
Arpitha A, Pallavi V R, Uttam D Bafna, Praveen S Rathod, Vijay C R, Shobha K, Rajshekar Kundargi
OBJECTIVES: To assess the importance of salvage therapy in the management of high-risk gestational trophoblastic neoplasia (HR GTN) after failure of first line multiagent chemotherapy. METHODS: This retrospective study involving women with HR GTN treated at Kidwai cancer institute from 2000 to 2015. Initial chemotherapy consisted of etoposide, methotrexate with folinic acid, actinomycin D, cyclophosphamide and vincristine (EMA-CO). Thirty one patients who had incomplete response or relapsed were treated with various drug combinations employing etoposide and platinum agents...
January 29, 2019: International Journal of Gynecological Cancer
Hyesun Park, Suzanne E Dahlberg, Christine A Lydon, Tetsuro Araki, Hiroto Hatabu, Michael S Rabin, Bruce E Johnson, Mizuki Nishino
BACKGROUND: The 8th edition of TNM staging of non-small cell lung cancer (NSCLC) has revised M classification and defined M1b disease with single extrathoracic metastasis, which is distinguished from M1c with multiple extrathoracic metastases. We investigated the prevalence, characteristics, and overall survival (OS) of M1b disease in patients with stage IV NSCLC. METHODS: The study reviewed the medical records and imaging studies of 567 patients with stage IV NSCLC to determine M stage using the 8th edition of TNM staging...
January 29, 2019: Oncologist
Yuki Yokota, Yoshito Tomimaru, Takashi Iwazawa, Kozo Noguchi, Hirotsugu Nagase, Takayuki Ogino, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Shingo Noura, Tomono Kawase, Hiroshi Imamura, Kenzo Akagi, Keizo Dono
A 72-year-old man received chemoradiotherapy for lung squamous cell carcinoma(T4N2M0, Stage Ⅲb). Nine months after the start of chemoradiotherapy, a 60 mm sized mass was identified in the spleen on abdominal CT. FDG-PET/CT examination revealed abnormal FDG accumulation in the tumor, and no obvious accumulation was observed in other sites. By endoscopic ultrasound-guided fine needle aspiration cytology, the tumor was diagnosed as splenic metastasis from lung cancer. Since the primary lung tumor was well controlled by the chemoradiotherapy and no metastatic lesions were found except in the spleen, laparoscopic excision of the splenic metastasis was planned...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Binnari Kim, Yun-Jeong Jang, Sujin Park, Jung-Il Lee, Hong Kwan Kim, Joungho Han
BACKGROUND: Studies have shown that 30-50% of non-small cell lung cancer (NSCLC) patients develop brain metastasis (BM). Since BM shortens overall survival and decreases the quality of life, early detection and treatment of BM are vital. While data are available for clinical risk factors of NSCLC with BM, histopathological factors are not well understood. Therefore, we evaluated the histopathological related factors which will help early detection and selection of effective treatment options...
January 18, 2019: Pathology, Research and Practice
Jian Chen, Jiade J Lu, Ningyi Ma, Jingfang Zhao, Chang Chen, Min Fan, Guoliang Jiang, Jingfang Mao
BACKGROUND: To evaluate the safety and efficacy of particle therapy (PT) using pencil beam scanning (PBS) technique for early stage non-small cell lung cancer (NSCLC). METHODS: From 08/2014 to 03/2018, 31 consecutive patients with sum of the longest diameters of primary tumor and hilar lymph node < 5 cm, N0-1, M0 NSCLC treated with PT were retrospectively analyzed. Gating/active breathing control techniques were used to control tumor motion in 20 and 7 patients...
January 25, 2019: Radiation Oncology
Ting Li, Shan-Bing Wang, Kai-Jian Lei, Mao-Qiong Jiang, Yu-Ming Jia
RATIONALE: The potential efficacy of apatinib in patients with advanced triple-negative breast cancer (TNBC) has been observed in a previous phase II clinical study. However, there is no study to evaluate its efficacy and safety in TNBC patients with brain metastasis (BM). Here we report one case that apatinib exhibited excellent antitumor effects in a breast cancer patient with brain metastasis, with no serious treatment-associated with adverse event. PATIENT CONCERNS: In this case report, one Chinese woman who was diagnosed with stage IV TNBC with multiple bone, lung, and brain metastases was unable to tolerate chemotherapy and refused whole-brain radiation therapy (WBRT) due to her poor physical condition...
January 2019: Medicine (Baltimore)
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