Takeshi Nabe, Yurie Kijitani, Yuriko Kitagawa, Emi Sakano, Tomoko Ueno, Masanori Fujii, Shintaro Nakao, Masaru Sakai, Shinji Takai
It has been reported that chymase activity was increased in allergic conjunctivitis patients and this activity was correlated with the severity of the disease. However, the precise roles of chymase in allergic conjunctivitis are unclear, and whether chymase inhibitors are effective for allergic conjunctivitis has not been reported even in experimental animal models. In this study, the roles of chymase in the pathogenesis were evaluated using a selective chymase inhibitor, ONO-WH-236, in a guinea pig model of allergic conjunctivitis induced by cedar pollen...
August 2013: Experimental Eye Research