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Bin Lu, Dao-Yu Zhu, Jun-Hui Yin, He Xu, Changqing Zhang, Qin-Fei Ke, You-Shui Gao, Ya-Ping Guo
Hierarchically porous structures and bioactive compositions of artificial biomaterials play a positive role in bone defect healing and new bone regeneration. Herein, cerium oxide nanoparticles-modified bioglass (Ce-BG) scaffolds were firstly constructed by the incorporation of hollow mesoporous Ce-BG microspheres in CTS via a freeze-drying technology. The interconnected macropores in Ce-BG scaffolds facilitated the in-growth of bone cells/tissues from material surfaces into the interiors, while the hollow cores and mesopore shells in Ce-BG microspheres provides more active sites for bone mineralization...
February 12, 2019: Biofabrication
Alicja Porenczuk, Bartłomiej Jankiewicz, Magdalena Naurecka, Bartosz Bartosewicz, Bartosz Sierakowski, Dariusz Gozdowski, Jerzy Kostecki, Barbara Nasiłowska, Agnieszka Mielczarek
BACKGROUND: The accessibility of the remineralizing ions in teeth's environment is essential for their incorporation into caries-affected dentin. Novel bioglass-reinforced materials capable of releasing fluoride, calcium and phosphates may be particularly useful in the tissue remineralization process. A novel restorative material, ACTIVA BioActive-Restorative (Pulpdent Corp., Watertown, USA), is a hydrophilic resin-modified glassionomer cement (RMGIC) enriched with bioglass particles and fortified with a patented rubberized polymer resin...
February 8, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
M Nivedhitha Sundaram, Sivashanmugam Amirthalingam, Ullas Mony, Praveen Kerala Varma, RangasamyJayakumar
Effective bleeding control is a major concern in trauma and major surgeries. Chitosan (Ch) as hemostatic agent has been widely used and when applied at the site of injury it acts by aggregating blood cells and forming a plug. Our prime interest is to enhance the blood clotting potential of Ch hydrogel. Incorporation of nano bioglass (nBG) with silica (activate coagulation factor XII), calcium (activate intrinsic pathway) and phosphate (initiates extrinsic pathway) ions into Ch hydrogel (protonated amine group) would act simultaneously on mechanisms involved in hemostasis and bring about effective bleeding control...
February 6, 2019: International Journal of Biological Macromolecules
Ye Meng, Wenjiang Qiang, Jingqin Pang
Hydroxyapatite (HAP) has excellent biocompatibility with living bone tissue and does not cause defensive body reactions, therefore, it has become one of the most widely used calcium phosphate materials in dental and medical fields. However, its poor mechanical properties have been a substantial challenge in the application of HAP for the replacement of load-bearing or large bone defects. Laminated HAP⁻45S5 bioglass ceramics composites were prepared by the spark plasma sintering (SPS) technique. The interface structures between the HAP and 45S5 bioglass layers and the mechanical properties of the laminated composites were investigated...
February 4, 2019: Materials
Bruna M B de Oliveira, Izabelle E Agostini, Mauro L Baesso, Rafael Menezes-Silva, Ana Flávia S Borges, Maria Fidela L Navarro, John W Nicholson, Sharanbir K Sidhu, Renata C Pascotto
OBJECTIVE: To evaluate the influence of external energy sources on the dynamic setting process of glass-ionomer restorative materials. METHODS: Eighteen brands of GIC were studied: Bioglass R (Biodinâmica; G1), Chemfil Rock (Dentsply; G2), Equia Forte (GC; G3), Gold Label 2 (GC; G4), Gold Label 9 (GC; G5), Glass Ionomer Cement Type II - (Shofu; G6), Ionglass R (Maquira; G7), Ion Z (FGM; G8), Ionomaster (Wilcos; G9), Ionofil Plus (Voco; G10), Ionostar Plus (Voco; G11), Ketac Molar easymix (3M ESPE; G12), Magic Glass R (Vigodent; G13), Maxxion R (FGM; G14), Riva Self Cure (SDI; G15), Vidrion R (SS White; G16), Vitro Fil R (Nova DFL; G17) and Vitro Molar (Nova DFL; G18)...
January 29, 2019: Dental Materials: Official Publication of the Academy of Dental Materials
Basam A E Ben-Arfa, Sofia Neto, Isabel M Miranda Salvado, Robert C Pullar, José M F Ferreira
This research details the successful fabrication of scaffolds by robocasting from high silica sol-gel glass doped with Cu2+ or La3+ . The parent HSSGG composition within the system SiO2 -CaO-Na2 O-P2 O5 [67% Si - 24% Ca - 5% Na - 4% P (mol%)] was doped with 5 wt.% Cu2+ or La3+ (Cu5 and La5). The paper sheds light on the importance of copper and lanthanum in improving the mechanical properties of the 3-D printed scaffolds. 1 h wet milling was sufficient to obtain a bioglass powder ready to be used in the preparation of a 40 vol...
January 25, 2019: Acta Biomaterialia
João Henrique Lopes, Otto Mao Vargas Machuca Bueno, Italo Odone Mazali, Celso Aparecido Bertran
In this research, the mechanism of an efficient strategy for the synthesis of 58S bioglass with high structural homogeneity by a citric acid assisted sol-gel route was investigated. This is an interesting approach to prepare bioactive glass via the sol-gel method with application potential in bone tissue engineering and also for the development of new biomedical devices. Herein, 58S bioglass was synthesized by two routes: conventional sol-gel method (CSG) and citric acid assisted sol-gel route coupled to the self-propagating combustion method (SPC)...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
Boonlom Thavornyutikarn, Bryce Feltis, Paul F A Wright, Terence W Turney
The silicate glass 45S5 Bioglass® (BG) is a potential scaffold material for bone regeneration because of its excellent bioactivity, biocompatibility and ability to form a strong bond with bone tissues, via the formation of an apatite layer on its surface. The evaluation of in vitro bioactivity in physiological body fluids, whilst challenging, can offer some insights for developing the bone-bonding ability of these glasses in vivo. In this study, we investigated the influence of three different cell culture and tissue fluid-like solutions on the dissolution and calcium-phosphate (CaP) based re-precipitation behaviour at the glass-liquid interface...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
Sungho Lee, Aira Matsugaki, Toshihiro Kasuga, Takayoshi Nakano
During the bone regeneration process, the anisotropic microstructure of bone tissue (bone quality) recovers much later than bone mass (bone quantity), resulting in severe mechanical dysfunction in the bone. Hence, restoration of bone microstructure in parallel with bone mass is necessary for ideal bone tissue regeneration; for this, development of advanced bifunctional biomaterials, which control both the quality and quantity in regenerated bone, is required. We developed novel oriented bioactive glass / poly(lactic acid) composite scaffolds by introducing an effective methodology for controlling cell alignment and proliferation, which play important roles for achieving bone anisotropy and bone mass, respectively...
January 24, 2019: Journal of Biomedical Materials Research. Part A
Ahmet Engin Pazarceviren, Zafer Evis, Dilek Keskin, Aysen Tezcaner
Guided bone regeneration (GBR) is a therapeutic modality applied prior to dental implant placement to increase bone density at the defect site or during placement for directing bone growth around implant. In this study, an asymmetric, bilayer structure was prepared by covalently bonding a dense polycaprolactone - polyethylene glycol - polycaprolactone (PCEC) membrane layer with a hydrogel layer of bismuth doped bioactive glass (BG, 45S5) and graphene oxide (GO) particles incorporated gelatin. Structural and mechanical properties (surface morphology and chemistry, thickness, tensile strength, degradation rate of GBR membranes) were studied...
January 21, 2019: Biomedical Materials
Djurdja Vukajlovic, Julie Parker, Oana Bretcanu, Katarina Novakovic
Composite scaffolds formed from polymers and bioglasses have been widely explored for applications in regenerative medicine as they have suitable organic/inorganic structures and properties similar to human hard tissue. Yet, these materials have only been used for non-load-bearing or low load-bearing purposes as they have limited mechanical strength while research is focused on improving their properties. One method of improving mechanical strength is by covalently bonding the organic and inorganic phases. This has been successfully achieved in Class ll hybrids which have covalent bonding between polymers and bioglasses...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
Iman Manavitehrani, Thi Y L Le, Sean Daly, Yiwei Wang, Peter K Maitz, Aaron Schindeler, Fariba Dehghani
Polyester-based scaffolds have been employed in tissue engineering due to their biocompatibility, biodegradability, microstructure, and affordability. However, the acidic degradation byproducts of most common polyesters have the potential to cause inflammation and/or necrosis. In this study, we introduce a porous scaffold with benign degradation byproducts fabricated by gas-foaming based on poly(propylene carbonate) (PPC) blended with starch and bioglass particles. The pore sizes ranged from 100 to 500 μm...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
Devis Bellucci, Roberta Salvatori, Alexandre Anesi, Luigi Chiarini, Valeria Cannillo
A novel bioglass composition (BGMS10), containing strontium and magnesium and characterized by an ultra-high crystallization temperature, is here employed for the first time to produce different composites with the addition of specific amounts of hydroxyapatite. After an investigation of the samples' bioactivity in vitro in a simulated body fluid solution (SBF) - according to a widely used protocol -, the biocompatibility of the new materials was tested with respect to murine fibroblasts both by direct and indirect tests, in order to evaluate possible cytotoxic effects of the materials' eluates...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
Martin T Matter, Lea Furer, Fabian H L Starsich, Giuseppino Fortunato, Sotiris E Pratsinis, Inge K Herrmann
Despite its use as a highly efficient and reusable catalyst in research and industrial settings, cerium oxide nanoparticles or nanoceria have yet to gain a foothold in the biomedical field. A variety of beneficial effects of nanoceria have been demonstrated, including its use as an inorganic nanoenzyme to mimic antioxidant enzymes, to protect mammalian cells and to suppress microbial growths. While these properties are of high interest for wound-management applications, literature offers contradicting reports on toxicity and enzymatic activity of nanoceria...
December 20, 2018: ACS Applied Materials & Interfaces
Elia Marin, Satoshi Horiguchi, Matteo Zanocco, Francesco Boschetto, Alfredo Rondinella, Wenliang Zhu, Ryan M Bock, Bryan J McEntire, Tetsuya Adachi, B Sonny Bal, Giuseppe Pezzotti
The surfaces of silicon nitride ( β -Si3 N4 ) and zirconia toughened alumina (ZTA) were patterned using a high-energy laser source, which operated at a wavelength of 1064 nm. The patterning procedure yielded a series regular, cylindrical cavities 500 and 300 μm in diameter and depth, respectively. These cavities were subsequently filled with bioglass mixed with different fractions of Si3 N4 powder (0, 5, and 10 mol.%) to obtain bioactive functionalized bioceramic surfaces. The laser-patterned samples were first characterized using several spectroscopic techniques before and after functionalization, and then tested in vitro with respect to their osteoconductivity using a human osteosarcoma cell line (SaOS-2)...
December 2018: Heliyon
Hugo R Fernandes, Anuraag Gaddam, Avito Rebelo, Daniela Brazete, George E Stan, José M F Ferreira
The discovery of bioactive glasses (BGs) in the late 1960s by Larry Hench et al. was driven by the need for implant materials with an ability to bond to living tissues, which were intended to replace inert metal and plastic implants that were not well tolerated by the body. Among a number of tested compositions, the one that later became designated by the well-known trademark of 45S5 Bioglass® excelled in its ability to bond to bone and soft tissues. Bonding to living tissues was mediated through the formation of an interfacial bone-like hydroxyapatite layer when the bioglass was put in contact with biological fluids in vivo...
December 12, 2018: Materials
Kartikeya Dixit, Niraj Sinha
45S5 Bioglass® has been used quite extensively in the form of particulate as synthetic bone graft. However, 45S5 glass has certain limitations such as difficulty in sintering and slow and partial conversion to hydroxy carbonated apatite. In pursuit of overcoming these limitations, bioactive glasses (13-93B1) containing increased amount of B₂O₃ by partial replacement of SiO₂ have been prepared using sol-gel technique in this study. Since bioactive glasses are brittle in nature, therefore, they are unsuitable for load bearing sites...
May 1, 2019: Journal of Nanoscience and Nanotechnology
Ioana Lese, David Alexander Graf, Catherine Tsai, Adriano Taddeo, Martin Tobias Matter, Mihai A Constantinescu, Inge Katrin Herrmann, Radu Olariu
BACKGROUND: Distal flap necrosis is a frequent complication of perforator flaps. Advances in nanotechnology offer exciting new therapeutic approaches. Anti-inflammatory and neo-angiogenic properties of certain metal oxides within the nanoparticles, including bioglass and ceria, may promote flap survival. Here, we explore the ability of various nanoparticle formulations to increase flap survival in a rat model. MATERIALS AND METHODS: A 9 x 3 cm dorsal flap based on the posterior thigh perforator was raised in 32 Lewis rats...
2018: PloS One
Manz Andrea Stefanie, Attin Thomas, Sener Beatrice, Sahrmann Philipp
BACKGROUND: Dentine hypersensitivity is especially frequent in patients with pronounced periodontal attachment loss. Aim of the treatment is an obstruction of the dentine tubules in order to inhibit liquid or osmotic motion, which is considered as trigger for pain sensations. Novel approaches aim for obstruction by calcium phosphate compounds in order to rely on biocompatible compounds. It was the aim of the study to optically investigate the morphology and to assess the fluid permeability of treated dentine surfaces...
November 21, 2018: BMC Oral Health
A Sleibi, A Tappuni, D Mills, G R Davis, A Baysan
OBJECTIVES: The objective of this in vitro study was to quantify the amount of mineral change in demineralized dentin at pH 5.5 after the application of dental varnishes containing fluoride with casein phosphopeptide-amorphous calcium phosphate, fluoride and bioglass, or fluoride alone. METHODS AND MATERIALS: A total of 12 extracted human sound mandibular premolar root samples were coated with an acid-resistant varnish, leaving a 2 × 3 mm window at the outer root surface...
November 2018: Operative Dentistry
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