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Lupus diet

Maria-Magdalena Constantin, Iuliana Elena Nita, Rodica Olteanu, Traian Constantin, Stefana Bucur, Clara Matei, Anca Raducan
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology, although its mechanisms involve genetic, epigenetic and environmental risk factors. Considering that SLE pathogenesis is yet to be explored, recent studies aimed to investigate the impact of diet, in terms of triggering or altering the course of the disease. To study the impact of diet on SLE pathogenesis, we conducted a search on Pubmed using the keywords 'diet and autoimmune diseases', 'diet and lupus', 'caloric restriction and lupus', 'polyunsaturated fatty acids and lupus', 'vitamin D and lupus', 'vitamin C and lupus' 'vitamin E and lupus' 'vitamin A and lupus' 'vitamin B and lupus', 'polyphenols and lupus', 'isoflavones and lupus', 'minerals and lupus', 'aminoacids and lupus', 'curcumin and lupus' and found 10,215 papers, from which we selected 47 relevant articles...
February 2019: Experimental and Therapeutic Medicine
Tyson R Chiaro, June L Round
Few studies have analyzed how diet-induced changes in the microbiota influence lupus. In this issue of Cell Host & Microbe, Zegarra-Ruiz et al. (2019) find that translocation of Lactobacillus reuteri from the gut to systemic organs worsens lupus. However, diets with resistant starch restrict L. reuteri growth and ameliorate disease.
January 9, 2019: Cell Host & Microbe
Cyril Milleret, Andrés Ordiz, Guillaume Chapron, Harry Peter Andreassen, Jonas Kindberg, Johan Månsson, Aimee Tallian, Petter Wabakken, Camilla Wikenros, Barbara Zimmermann, Jon E Swenson, Håkan Sand
Identifying how sympatric species belonging to the same guild coexist is a major question of community ecology and conservation. Habitat segregation between two species might help reduce the effects of interspecific competition and apex predators are of special interest in this context, because their interactions can have consequences for lower trophic levels. However, habitat segregation between sympatric large carnivores has seldom been studied. Based on monitoring of 53 brown bears ( Ursus arctos ) and seven sympatric adult gray wolves ( Canis lupus ) equipped with GPS collars in Sweden, we analyzed the degree of interspecific segregation in habitat selection within their home ranges in both late winter and spring, when their diets overlap the most...
December 2018: Ecology and Evolution
Daniel F Zegarra-Ruiz, Asmaa El Beidaq, Alonso J Iñiguez, Martina Lubrano Di Ricco, Silvio Manfredo Vieira, William E Ruff, Derek Mubiru, Rebecca L Fine, John Sterpka, Teri M Greiling, Carina Dehner, Martin A Kriegel
Western lifestyle is linked to autoimmune and metabolic diseases, driven by changes in diet and gut microbiota composition. Using Toll-like receptor 7 (TLR7)-dependent mouse models of systemic lupus erythematosus (SLE), we dissect dietary effects on the gut microbiota and find that Lactobacillus reuteri can drive autoimmunity but is ameliorated by dietary resistant starch (RS). Culture of internal organs and 16S rDNA sequencing revealed TLR7-dependent translocation of L. reuteri in mice and fecal enrichment of Lactobacillus in a subset of SLE patients...
December 7, 2018: Cell Host & Microbe
Bruce Richardson
Systemic lupus erythematosus flares when genetically predisposed people encounter environmental agents that cause oxidative stress, such as infections and sunlight. How these modify the immune system to initiate flares is unclear. Drug induced lupus models demonstrate that CD4+ T cells epigenetically altered with DNA methylation inhibitors cause lupus in animal models, and similar T cells are found in patients with active lupus. How infections and sun exposure inhibit T cell DNA methylation is unclear. DNA methylation patterns are replicated each time a cell divides in a process that requires DNA methyltransferase one (Dnmt1), which is upregulated as cells enter mitosis, as well as the methyl donor S-adenosylmethionine, created from dietary sources...
November 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Khalil Karimov, Shannon M Kachel, Klaus Hackländer
Long recognized as a threat to wildlife, livestock grazing in protected areas has the potential to undermine conservation goals, via competition, habitat degradation, human-carnivore conflict and disruption of predator-prey relationships. In the Strictly Protected Area Zorkul in Tajikistan (Zorkul Reserve), grazing is commonplace despite official prohibition, with potentially detrimental effects on local fauna, in particular, snow leopard Panthera uncia, wolf Canis lupus, brown bear Ursus arctos, argali sheep Ovis ammon, Asiatic ibex Capra sibirica, and long-tailed marmot Marmota caudata...
2018: PloS One
Chelsea A O'Driscoll, Leah A Owens, Erica J Hoffmann, Madeline E Gallo, Amin Afrazi, Mei Han, John H Fechner, James J Schauer, Christopher A Bradfield, Joshua D Mezrich
BACKGROUND: Autoimmune diseases have increased in incidence and prevalence worldwide. While genetic predispositions play a role, environmental factors are a major contributor. Atmospheric particulate matter (PM) is a complex mixture composed of metals, nitrates, sulfates and diverse adsorbed organic compounds like polycyclic aromatic hydrocarbons (PAHs) and dioxins. Exposure to atmospheric PM aggravates autoimmune diseases such as type 1 diabetes, rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus, among others...
January 2019: Environmental Research
G Pocovi-Gerardino, M Correa-Rodríguez, J-L Callejas Rubio, R Ríos Fernández, N Ortego-Centeno, B Rueda-Medina
BACKGROUND AND AIMS: C-reactive protein (CRP) is commonly used as a biomarker for inflammation. Mild elevations of CRP have been seen in chronic autoimmune diseases like systemic lupus erythematosus (SLE), and CRP has been linked to an increased risk of cardiovascular events. Diet quality and certain dietary factors seem to influence CRP levels in healthy subjects. To date, the effect of diet on serum CRP in SLE has not been studied. Our aim was to investigate the relationship between dietary nutrients, antioxidant intake, and serum CRP in SLE...
October 3, 2018: Biological Research for Nursing
Mark A Ditmer, John R Fieberg, Ron A Moen, Steve K Windels, Seth P Stapleton, Tara R Harris
Predators directly impact prey populations through lethal encounters, but understanding nonlethal, indirect effects is also critical because foraging animals often face trade-offs between predator avoidance and energy intake. Quantifying these indirect effects can be difficult even when it is possible to monitor individuals that regularly interact. Our goal was to understand how movement and resource selection of a predator (wolves; Canis lupus ) influence the movement behavior of a prey species (moose; Alces alces )...
September 2018: Ecology and Evolution
Dusanka Janezic, Lorentz Jantschi, Sorana D Bolboaca
Several studies report the effects of excessive use of sugars and sweeteners in the diet. These include obesity, cardiac diseases, diabetes, and even lymphomas, leukemias, cancers of the bladder and brain, chronic fatigue syndrome, Parkinson's disease, Alzheimer's disease, multiple sclerosis, autism, and systemic lupus. On the other hand, each sugar and sweetener has a distinct metabolic assimilation process, and its chemical structure plays an important role in this process. Several scientific papers present the biological effects of the sugars and sweeteners in relation to their chemical structure...
September 26, 2018: Current Medicinal Chemistry
Melissa A Bates, Peyman Akbari, Kristen N Gilley, James G Wagner, Ning Li, Anna K Kopec, Kathryn A Wierenga, Daven Jackson-Humbles, Christina Brandenberger, Andrij Holian, Abby D Benninghoff, Jack R Harkema, James J Pestka
Ectopic lymphoid structures (ELS) consist of B-cell and T-cell aggregates that are initiated de novo in inflamed tissues outside of secondary lymphoid organs. When organized within follicular dendritic cell (FDC) networks, ELS contain functional germinal centers that can yield autoantibody-secreting plasma cells and promote autoimmune disease. Intranasal instillation of lupus-prone mice with crystalline silica (cSiO2 ), a respirable particle linked to human lupus, triggers ELS formation in the lung, systemic autoantibodies, and early onset of glomerulonephritis...
2018: Frontiers in Immunology
Yuehai Wang, Ziyang Huang, Ling Lin, Guangyong Huang, Weitao Liu, Yuzeng Xue
Fas knockout (Fas-/- ) mice are a model for systemic lupus erythematosus (SLE) -like autoimmune syndromes. We aimed to induce atherosclerosis (AS) in Fas-/- mice. Sixteen male Fas-/- mice were included in the study, sex-matched C57B6/L (B6) and apolipoprotein E-knockout (ApoE-/- ) mice were negative and positive AS controls, respectively. A silica collar was placed around the right carotid artery of each mouse to induce AS development. All mice were fed a 24-week high-fat diet, and investigated for AS lesions...
September 20, 2018: Clinical and Experimental Hypertension: CHE
Kassem Sharif, Howard Amital, Yehuda Shoenfeld
Autoimmune diseases are a group of heterogeneous condition that occur secondary to the intrinsic loss of tolerance to self- antigens. In genetically susceptible individuals, the complex interplay of environmental factors and epigenetic deregulations have been proposed to drive disease etiopathogenesis. Various environmental variables have been identified including viral infections, exposure to pollutants, stress and dietary factors. Sodium, a major constituent of salt is essential for mammalian physiology. However, high salt intake may play a role in the development of autoimmune diseases...
November 2018: Autoimmunity Reviews
Francisco Oliveira, Vinicius Schoeps, Wilson Sanvito, Berenice Valerio
As the celiac disease (CD), the non-celiac gluten sensitivity (NCGS) has also been associated with several autoimmune manifestations. It is rarely associated with myasthenia gravis (MG). This paper shall introduce the case of a young female patient, initially presenting a peripheral neuropathy framework. During clinical and neurological follow-up, she began to present symptoms of various immune-mediated morbidities. Diseases related to gluten represent a clinical spectrum of manifestations with a trigger in common, the ingestion of gluten...
April 2018: Revista da Associação Médica Brasileira
Linyu Geng, Shiying Wang, Xia Li, Dandan Wang, Haifeng Chen, Jinyun Chen, Yue Sun, Weiwei Chen, Genhong Yao, Xiang Gao, Wanjun Chen, Songtao Shi, Xuebing Feng, Lingyun Sun
Patients with systemic lupus erythematosus (SLE) have a tremendously increased risk for cardiovascular disease (CVD), which could not be accounted in entirety by traditional Framingham risk factors. To study whether the accelerated atherosclerosis in SLE patients is mediated by type I interferon (IFN-I) through the regulation of endothelial progenitor cells (EPCs), we created a line of C57BL/6 mice with deficiency in both apolipoprotein E (ApoE-/-) and fas ligand (FasL-/-, gld.). As expected, the resultant gld...
September 2018: Current Research in Translational Medicine
Tianshu Lyu, Guangshuai Liu, Huanxin Zhang, Lidong Wang, Shengyang Zhou, Huashan Dou, Bo Pang, Weilai Sha, Honghai Zhang
Wolves (Canis lupus) and their domesticated and close relatives, dogs (Canis lupus familiaris), have great differences in their diets and living environments. To the best of our knowledge, the fundamental question of how the abundance and function of the gut microbiota of domestic dogs evolved to adapt to the changes in host feeding habits has yet to be addressed. In this study, our comparative analyses of gut metagenomes showed that the abundance of gut microbiota between the two species have some significant differences...
August 2, 2018: AMB Express
Marina Aparicio-Soto, Sergio Montserrat-de la Paz, Marina Sanchez-Hidalgo, Ana Cardeno, Beatriz Bermudez, Francisco J G Muriana, Catalina Alarcon-de-la-Lastra
Monocytes and macrophages are critical effectors and regulators of inflammation and innate immune response, which appear altered in different autoimmune diseases such as systemic lupus erythematosus (SLE). Recent studies suggested that virgin olive oil (VOO) and particularly its phenol compounds might possess preventive effects on different immune-inflammatory diseases, including SLE. Here, we evaluated the effects of VOO (and sunflower oil) on lipopolysaccharide (LPS)-activated peritoneal macrophages from a model of pristane-induced SLE in BALB/c mice, as well as those of the phenol fraction (PF) from VOO on the immune-inflammatory activity and plasticity in monocytes and monocyte-derived macrophages from healthy volunteers...
September 2018: British Journal of Nutrition
Gabriela Pocovi-Gerardino, María Correa-Rodríguez, José Luis Callejas-Rubio, Raquel Ríos-Fernández, Norberto Ortego-Centeno, Blanca Rueda-Medina
INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Despite the influence of diet on inflammation, dietary habits in patients with systemic lupus erythematosus (SLE) are not well established. The study objective was to assess dietary intake and nutritional status in SLE patients. PATIENTS AND METHODS: A cross-sectional study was conducted in 92 patients with SLE. Nutritional status was determined by body mass index (BMI) and energy/nutrient distribution of diet was analyzed and compared to a control group...
November 2018: Endocrinología, Diabetes y Nutrición
Catherine J Andersen
Cellular cholesterol metabolism, lipid raft formation, and lipoprotein interactions contribute to the regulation of immune-mediated inflammation and response to pathogens. Lipid pathways have been implicated in the pathogenesis of bacterial and viral infections, whereas altered lipid metabolism may contribute to immune dysfunction in autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. Interestingly, dietary cholesterol may exert protective or detrimental effects on risk, progression, and treatment of different infectious and autoimmune diseases, although current findings suggest that these effects are variable across populations and different diseases...
June 13, 2018: Nutrients
Pushkar Mehra, Charles H Henry, Kamyar R Giglou
PURPOSE: To evaluate clinical outcomes in patients with autoimmune or connective tissue (CT) disease undergoing temporomandibular joint (TMJ) reconstruction. MATERIALS AND METHODS: Patients were divided into 2 groups based on type of TMJ reconstruction. Patients in group 1 (n = 9) underwent autogenous reconstruction and had a diagnosis of rheumatoid arthritis (5), lupus arthritis (1), and psoriatic arthritis (3). Patients in group 2 (n = 2l) had alloplastic reconstruction with a patient-fitted total joint prosthesis (TMJ Concepts, Ventura, CA) and had a diagnosis of rheumatoid arthritis (15), lupus (3), and psoriatic arthritis (3)...
August 2018: Journal of Oral and Maxillofacial Surgery
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