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Ovarian transplantation

Catherine Poirot, Anne Fortin, Nathalie Dhédin, Pauline Brice, Gérard Socié, Jean-Marc Lacorte, Jean-Paul Akakpo, Catherine Genestie, Jean-Paul Vernant, Thierry Leblanc, Jean Gabarre, Alain Delmer, Yasmina Badachi, Véronique Drouineaud, Céline Chalas, Sophie Egels, Philippe Touraine, Marc Dommergues, Géraldine Lebègue, Jean-Philippe Wolf, Frédérique Capron, Gilles Lefebvre, Nicolas Boissel
No abstract text is available yet for this article.
February 14, 2019: Haematologica
Zehua Wang, Jianwen Gao, Jiabing Zhou, Haiou Liu, Congjian Xu
OBJECTIVE: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP inhibitor, has an anti-tumor effect on high grade serous ovarian cancer, but its effects on cellular senescence have not been reported. This study intends to explore the role of olaparib in the regulation of senescence in ovarian cancer cells. METHODS: The effects of olaparib on the senescence of ovarian cancer cells were detected by using the senescence-associated β-galactosidase (SA-β-Gal) and senescence-associated heterochromatin aggregation (SAHF)...
November 22, 2018: Journal of Gynecologic Oncology
Ahmed Fayed, Ahmed Soliman, Mervat Naguib, Mahmoud Soliman, M Salaheldin
BACKGROUND: Women with chronic kidney disease commonly have menstrual irregularities and fertility abnormalities. Antimüllerian hormone (AMH) and antral follicle count (AFC) are well-recognized indicators of ovarian reserve. AIMS: To assess AMH level and total AFC in women who are on hemodialysis and after successful kidney transplantation (KTx). METHODS: Sixty women with end-stage kidney disease (ESKD) on regular hemodialysis were included in this study with 20 patients of them were going to have renal transplant...
February 8, 2019: International Urology and Nephrology
Jana Liebenthron, Markus Montag, Jochen Reinsberg, Maria Köster, Vladimir Isachenko, Katrin van der Ven, Hans van der Ven, Jan-Steffen Krüssel, Michael von Wolff
RESEARCH QUESTION: Is overnight transportation of ovarian tissue before cryopreservation in a centralized cryobank from the FertiPROTEKT network feasible? DESIGN: Data from 1810 women with cryopreserved ovarian tissue after overnight transportation from December 2000 to December 2017 were analysed with a focus on transportation, tissue activity parameters and pregnancy, and delivery rates after transplantation. RESULTS: A total of 92.4% of tissue samples arrived at ideal temperatures of 2-8°C, 0...
January 19, 2019: Reproductive Biomedicine Online
John B Liao, Cynthia E Fisher, Margaret M Madeleine
Solid organ transplant (SOT) recipients have approximately 2-fold greater risk of developing and dying from a malignancy compared to the general population. Among the gynecologic cancers, including uterine, cervical, vaginal, vulvar, and ovarian, the HPV-related cancers are known to increase among women post-transplantation compared to women in the general population, but less is known about the risk of uterine and ovarian cancers. This review will provide an overview of the epidemiology of gynecologic cancers after SOT, as well as their pathophysiology, management, and specific risk factors...
February 6, 2019: American Journal of Transplantation
Min Zheng, Gaoge Zuo, Jing Tong, Zi-Jiang Chen, Wei-Ping Li, Cong Zhang
PURPOSE: Melatonin is an important factor in regulating numerous processes in human female reproduction. The aim of the present study was to compare melatonin levels in the follicular fluid (FF) of ovarian hyperstimulation syndrome (OHSS) women with those of non-OHSS women undergoing in vitro fertilization (IVF)-embryo transfer and to evaluate the relationship between FF melatonin levels and IVF outcomes in these women. METHODS: We determined FF melatonin levels in 20 OHSS women and 23 non-OHSS women on oocyte retrieval day...
February 6, 2019: Archives of Gynecology and Obstetrics
Roman Franěk, Tomáš Tichopád, Christoph Steinbach, Xuan Xie, Jelena Lujić, Zoran Marinović, Ákos Horváth, Vojtěch Kašpar, Martin Pšenička
Several experiments were conducted in order to develop an optimal protocol for slow-rate freezing (-1 °C/min) and short-term storage (-80 or 4 °C) of common carp ovarian tissue fragments with an emphasis on oogonial stem cells (OSCs). Dimethyl sulfoxide (Me2 SO) with concentration of 1.5 M was identified as the best cryoprotectant in comparison to propylene glycol and methanol. When comparing supplementation of sugars (glucose, trehalose, sucrose) in different concentrations (0.1, 0.3, 0.5 M), glucose and trehalose in 0...
February 1, 2019: Cryobiology
Kazutoshi Komori, Koichi Hirabayashi, Daisuke Morita, Yosuke Hara, Takashi Kurata, Shoji Saito, Miyuki Tanaka, Ryu Yanagisawa, Kazuo Sakashita, Kenichi Koike, Yozo Nakazawa
BACKGROUND: The spectrum of late sequelae after hematopoietic stem cell transplantation (HSCT) includes infertility, which is the most frequent complication. Some reports suggested that ovarian function may be better preserved in females undergoing HSCT with reduced-intensity conditioning (RIC) than with conventional myeloablative conditioning (MAC). However, the impact of HSCT after 8-Gy TBI-based reduced-toxicity MAC (RTMAC), whose efficacy is between those of conventional MAC and RIC, on ovarian function remains unclear...
February 3, 2019: Pediatric Transplantation
Laura Curr Beamer
OBJECTIVES: To review heredity cancer syndromes involving the breasts, ovaries, or breast and ovaries. To recommend useful professional and patient resources on cancer genetics. A case study of germline BRCA genetic testing after allogeneic bone marrow transplant is presented. DATA SOURCES: National guidelines, evidence-based summaries, peer-reviewed studies, editorials, and professional Web sites. CONCLUSION: Advancing genetic/genomic technology in oncology has led to a renaissance of information about hereditary cancer syndromes...
January 30, 2019: Seminars in Oncology Nursing
Jessica J Martin, Dori C Woods, Jonathan L Tilly
A now large body of evidence supports the existence of mitotically active germ cells in postnatal ovaries of diverse mammalian species, including humans. This opens the possibility that adult stem cells naturally committed to a germline fate could be leveraged for the production of female gametes outside of the body. The functional properties of these cells, referred to as female germline or oogonial stem cells (OSCs), in ovaries of women have recently been tested in various ways, including a very recent investigation of the differentiation capacity of human OSCs at a single cell level...
January 28, 2019: Cells
Matthias W Beckmann, Laura Lotz, Bettina Toth, Dunja Maria Baston-Büst, Tanja Fehm, Torsten Frambach, Ariane Germeyer, Maren Goeckenjan, Felix Häberlin, Melanie Henes, Jens Hirchenhain, Stephanie Hübner, Matthias Korell, Jan-Steffen Krüssel, Andreas Müller, Jochen Reinsberg, Roxana Schwab, Stephan Seitz, Marc Sütterlin, Hans van der Ven, Katrin van der Ven, Katharina Winkler-Crepaz, Pauline Wimberger, Michael von Wolff, Jana Liebenthron, Ralf Dittrich
The cryopreservation of ovarian tissue with subsequent transplantation of the tissue represents an established method of fertility protection for female patients who have to undergo gonadotoxic therapy. The procedure can be performed at any point in the cycle and thus generally does not lead to any delay in oncological therapy. With the aid of this procedure, more than 130 births to date worldwide have been able to be recorded. The birth rate is currently approximately 30% and it can be assumed that this will increase through the further optimisation of the cryopreservation and surgical technique...
January 2019: Geburtshilfe und Frauenheilkunde
Li Ling, Xiushan Feng, Tianqin Wei, Yan Wang, Yaping Wang, Ziling Wang, Dongyuan Tang, Yanjing Luo, Zhengai Xiong
BACKGROUND: Chemotherapy can induce premature ovarian insufficiency (POI) and reduce fertility in young female patients. Currently, there is no effective therapy for POI. Human amnion-derived mesenchymal stem cells (hAD-MSCs) may be a promising seed cell for regenerative medicine. This study investigated the effects and mechanisms of hAD-MSC transplantation on chemotherapy-induced POI in rats. METHODS: Chemotherapy-induced POI rat models were established by intraperitoneal injection of cyclophosphamide...
January 25, 2019: Stem Cell Research & Therapy
Raffaella Fabbri, Maria Macciocca, Rossella Vicenti, Roberto Paradisi, Stefani Rossi, Elena Sabattini, Anna Gazzola, Renato Seracchioli
This case report describes the first Italian live birth obtained by cryopreserved ovarian tissue transplantation in a woman affected by non-Hodgkin's lymphoma. Before anticancer treatments, several fertility preservation options were proposed. At 29 years the patient underwent laparoscopy for ovarian tissue cryopreservation. After treatments she experienced premature ovarian failure (POF) and asked for cryopreserved ovarian tissue transplantation. Before transplantation, ovarian samples were analyzed to assess neoplastic contamination and tissue quality...
December 2018: International Journal of Hematologic Oncology
Ludmila Szabova, Baktiar Karim, Melanie Gordon, Lucy Lu, Nathan Pate, Zoe Weaver Ohler
Nongestational choriocarcinoma is a rare malignancy in humans with poor prognosis. Naturally occurring choriocarcinoma is also rare in laboratory mice, and no genetic mouse model accurately recapitulates the features of this cancer. Here we report development of a genetically engineered mouse (GEM) model with alterations in Brca2, Trp53, and RB that develops ovarian tumors. Most of the ovarian tumors displayed histological characteristics of nongestational choriocarcinoma of the ovary (NGCO) (47%) with abundant syncytiotrophoblasts and cytotrophoblasts, positive immunolabeling for human chorionic gonadotropin, and positive periodic acid-Schiff reaction...
January 13, 2019: Veterinary Pathology
R Fabbri, R Seracchioli, R Vicenti, R Paradisi, S Rossi, L De Meis, M Ciccarone, G Caprara, N A Martino, M Macciocca
In this case report, we describe the outcomes of two heterotopic transplantations of cryopreserved ovarian tissue performed in a patient with HL, after 11 and 15 years of storage. At the age of 30, the patient underwent laparoscopy to collect ovarian tissue for cryopreservation before chemotherapy and radiotherapy. Eleven years later she experienced premature ovarian failure (POF). As the patient was only interested in endocrine function recovery, two heterotopic ovarian tissue transplantations were performed in the abdominal wall above the rectus muscle respectively 11 and 15 years after cryopreservation...
January 2, 2019: Gynecological Endocrinology
Belinda K M Lo, Sairah Sheikh, Suzannah A Williams
Follicle development requires complex and coordinated interactions between both the oocyte and its associated somatic cells. In ovarian dysfunction, follicle development may be abnormal due to defective somatic cell function; for example, premature ovarian insufficiency or malignancies. Replacing defective somatic cells, using the reaggregated ovary (RO) technique, may 'rescue' follicle development. ROs containing mature follicles have been generated when transplanted to a host mouse to develop. We have developed a RO culture technique and the aims were to determine how follicle development differed between transplanted and cultured ROs, and the influence of ovarian age (P2 vs P6)...
February 1, 2019: Reproduction: the Official Journal of the Society for the Study of Fertility
Shailesh Puntambekar, Seema Puntambekar, Milind Telang, Pankaj Kulkarni, Shardul Date, Mangesh Panse, Ravindra Sathe, Nikhil Agarkhedkar, Neeta Warty, Sandesh Kade, Manoj Manchekar, Mihir Chitale, Hirav Parekh, Kajal Parikh, Mehul Mehta, Bhushan Kinholkar, Joy Shankar Jana, Avinash Pare, Shailendra Kanade, Abhay Sadre, Shirish Hardikar, Advait Jathar, Tejashree Bakre, Meenakshi Chate, Raviraj Tiruke
STUDY OBJECTIVE: To evaluate 2 cases of uterine transplant surgery that used utero-ovarian veins as outflow channels, internal iliac arteries for perfusion, and the organ harvest surgery performed laparoscopically. DESIGN: Case study (Canadian Task Force Classification III). SETTING: An urban, private, tertiary care hospital. PATIENTS: Two patients, ages 30 and 24 years, diagnosed with absolute uterine factor infertility secondary to Mayer-Rokitansky-Küster-Hauser syndrome underwent related living donor uterine transplants; donors were their mothers with normal menses...
December 29, 2018: Journal of Minimally Invasive Gynecology
Callista L Mulder, Lotte L Eijkenboom, Catharina C M Beerendonk, Didi D M Braat, Ronald Peek
STUDY QUESTION: Is it possible to eliminate metastasized cancer cells from ovarian cortex fragments prior to autotransplantation without compromising the ovarian tissue or follicles? SUMMARY ANSWER: Ex vivo pharmacological inhibition of YAP/TAZ by Verteporfin enabled us to efficiently eradicate experimentally induced small tumours, derived from leukaemia and rhabdomyosarcoma, from human ovarian tissue fragments. WHAT IS KNOWN ALREADY: Autotransplantation of ovarian tissue fragments that contain metastasized tumour cells may reintroduce the malignancy to the recipient...
December 28, 2018: Human Reproduction
Yilu Chen, Junzhao Zhao, Huina Zhang
BACKGROUND The aim of this study was to evaluate the efficacy of specific in vitro fertilization (IVF) protocols for patients with polycystic ovary syndrome (PCOS), and therefore, analyze the first-rank intention IVF protocol. MATERIAL AND METHODS In this study, 408 PCOS patients (464 treatment cycles) were enrolled and assigned to one of 3 groups: group 1 [oral contraceptive long-term regimen group (OC-L protocol group, n=91)], group 2 (GnRH antagonist protocol, n=80), and group 3 [follicular phase long-term regimen group, C₁-L protocol group n=293]...
December 28, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Paul G Werthmann, Robert Kempenich, Gunver S Kienle
INTRODUCTION: Epithelial ovarian cancer (EOC) has a poor prognosis in advanced stages. High-dose chemotherapy (HDC) was pursued in the 1990s but was not found to improve survival of patients with EOC in larger studies. Many patients with cancer use Viscum album extracts (VAE). Also called European mistletoe, Viscum album can lead to improved quality of life and reduced chemotherapy side effects and may have synergistic cytotoxic and proliferation-inhibiting effects when used together with chemotherapy...
2018: Permanente Journal
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