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Pulmonary test AI

Marko Topalovic, Nilakash Das, Pierre-Régis Burgel, Marc Daenen, Eric Derom, Christel Haenebalcke, Rob Janssen, Huib A M Kerstjens, Giuseppe Liistro, Renaud Louis, Vincent Ninane, Christophe Pison, Marc Schlesser, Piet Vercauter, Claus F Vogelmeier, Emiel Wouters, Jokke Wynants, Wim Janssens
The interpretation of pulmonary function tests (PFTs) to diagnose respiratory diseases is built on expert opinion which relies on the recognition of patterns and clinical context for the detection of specific diseases. In the study, we aimed to explore the accuracy and inter-rater variability of pulmonologists when interpreting PFTs and compared it against that of artificial intelligence (AI)-based software which was developed and validated in more than 1500 historical patient cases.120 pulmonologists from 16 European hospitals evaluated 50 cases comprising with PFT and clinical information resulting in 6000 independent interpretations...
February 14, 2019: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Joseph J Smolich, Jonathan P Mynard
As prior work has shown that reducing lung liquid volume 1) increases pulmonary arterial (PA) blood flow, 2) augments right ventricular (RV) output/power, and 3) decreases left atrial (LA) pressure, we tested the hypothesis that this perturbation has global cardiovascular effects. Ten anesthetized, open-chest fetal lambs (gestation 128±2d, term=147d) were acutely instrumented with 1) LA and right atrial (RA) catheters, 2) aortic and pulmonary trunk catheters, 3) brachiocephalic trunk (BCT), aortic isthmus (AI), ductal and left PA flow probes to obtain left ventricular (LV) and RV outputs and hydraulic power, and flow in the descending thoracic aorta (DTA), and 4) an endotracheal tube to remove lung liquid...
January 9, 2019: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Yan L Ge, Cong H Liu, Meng H Wang, Zhen Z Li, Hong L Li, Zi Y Cui, Hai F Zhang, Xiao Y Zhu, Xue Zhang, Hua L Yu, Ai S Fu, Hong Y Wang
<i>Background:</i> Cryptococcal pneumonia is an uncommon lesion in immune-competent adults. Histological evidence of Cryptococcus neoformans is a gold criterion for diagnosis. Here we report a case firstly misdiagnosed as tuberculosis from a lung biopsy. <i>Methods:</i> Chest computed tomography (CT) scan and CT-guided puncture were performed for diagnosis and blood tests explored for the latent etiology. <i>Results:</i> Chest CT scan images showed multiple nodules in the left peripheral lower lobe...
October 31, 2018: Clinical Laboratory
Brock G Bennion, Harshad Ingle, Teresa L Ai, Cathrine A Miner, Derek J Platt, Amber M Smith, Megan T Baldridge, Jonathan J Miner
We previously generated STING N153S knockin mice that have a human disease-associated gain-of-function mutation in STING. Patients with this mutation (STING N154S in human) develop STING-associated vasculopathy with onset in infancy (SAVI), a severe pediatric autoinflammatory disease characterized by pulmonary fibrosis. Since this mutation promotes up-regulation of antiviral type I interferon-stimulated genes (ISGs), we hypothesized that STING N153S knockin mice may develop more severe autoinflammatory disease in response to a virus challenge...
November 21, 2018: Journal of Virology
Wen Wen, Lei Gu, Guo Qing Yu, Ai Ming Wang, Hua Zeng, Ping Yu, Wei Liu, De Sheng Jia, Wen Jie Xia, Guo Xiang Lai, Wei Liu
BACKGROUND: Mycoplasmal pneumonia is a common type of adult community-acquired pneumonia in China, but round/spherical pneumonia caused by mycoplasma pneumoniae has rarely been reported. Here, we report an outbreak of mycoplasmal round pneumonia in a military dormitory in China. METHODS: We analysed epidemiological, clinical, imaging and laboratory data from a series of adults affected by an outbreak of mycoplasmal round pneumonia in the dormitory of a military hospital (Fuzhou General Hospital) in Fuzhou, China...
December 2018: Clinical Respiratory Journal
Ramandeep Singh, Mannudeep K Kalra, Chayanin Nitiwarangkul, John A Patti, Fatemeh Homayounieh, Atul Padole, Pooja Rao, Preetham Putha, Victorine V Muse, Amita Sharma, Subba R Digumarthy
BACKGROUND: Deep learning (DL) based solutions have been proposed for interpretation of several imaging modalities including radiography, CT, and MR. For chest radiographs, DL algorithms have found success in the evaluation of abnormalities such as lung nodules, pulmonary tuberculosis, cystic fibrosis, pneumoconiosis, and location of peripherally inserted central catheters. Chest radiography represents the most commonly performed radiological test for a multitude of non-emergent and emergent clinical indications...
2018: PloS One
Xiao-Mei Zhang, Ai-Zhen Lu, Hao-Wei Yang, Li-Ling Qian, Li-Bo Wang, Xiao-Bo Zhang
BACKGROUND: Limited data are available in relation to the clinical features of PIBO undergoing prolonged nebulization treatment with budesonide, terbutaline and ipratropium bromide. This retrospective study aimed to outline the features of clinical, high-resolution computed tomography (HRCT) and pulmonary function test (PFT) of PIBO, undergoing maintenance therapy utilizing a triple nebulization treatment and to determine the factors associated with prognosis. METHODS: Children diagnosed with PIBO were followed up between April 2014 and March 2017...
October 2018: World Journal of Pediatrics: WJP
Naohisa Urabe, Susumu Sakamoto, Go Sano, Ai Ito, Sakae Homma
BACKGROUND: We occasionally treat patients with clinically suspected pulmonary Mycobacterium avium complex (MAC) infection and negative MAC culture on bronchoscopy. OBJECTIVE: This study aimed to investigate the usefulness of bronchoscopy in patients with suspected MAC lung disease with nodular bronchiectasis on chest computed tomography (CT) and to clarify the clinical characteristics of these patients. METHODS: We reviewed the records of 71 patients with clinically suspected pulmonary MAC infection on chest CT who underwent bronchoscopy...
October 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
M J Li, C Chang, X H Wang, J Wang, Y Liang, Q Zhu
Objective: To evaluate the correlation of CT small airway measurement with clinical and inflammatory factors in asthma patients. Methods: From November 2014 to December 2015, a total of 20 patients with asthma were recruited in outpatient department of Peking University Third Hospital. All underwent asthma control test (ACT), CT and pulmonary function test. Serum leptin, immunoglobulin E(IgE) and transforming growth factor-β1(TGF-β1), induced sputum eosinophil percentage(Eos%) and matrix metalloproteinase(MMP-9) results were collected...
July 17, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Chuan-Zhong Huang, Ai-Min Huang, Jing-Feng Liu, Bin Wang, Ke-Can Lin, Yun-Bin Ye
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is a major threat to human health. The condition carries a high risk of death; 45% of new cases occur in China. Surgical resection is the first choice for treatment of HCC, but 30.9% of patients experience recurrence within 6 months after the operation. To improve patient survival, we must determine how to reduce the probability of recurrence and metastasis and elucidate the underlying mechanism of disease. We therefore studied the effect of somatostatin octapeptide (octreotide) on the invasion and metastasis of HCC...
2018: Cellular Physiology and Biochemistry
Hai-Bo Ding, Kai-Xiong Liu, Jie-Feng Huang, Da-Wen Wu, Jun-Ying Chen, Qing-Shi Chen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a multicomponent disorder characterized by inflammation, representing a significant leading cause of chronic morbidity and mortality. Reports have implicated hydrogen sulfide (H2 S) in both the pathology and treatment of COPD. The present study aimed to explore the effects involved with exogenous H2 S on endoplasmic reticulum stress (ERS) and pulmonary artery endothelial cells (PAECs) in a rat model of COPD. METHODS: Rat models of COPD were successfully established by means of passive smoke exposure and intratracheal injection with lipopolysaccharide (LPS)...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Duilio Divisi, Mirko Barone, Luca Bertolaccini, Gino Zaccagna, Francesca Gabriele, Roberto Crisci
Background: In the setting of solitary pulmonary nodules (SPNs), fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) is considered a useful non-invasive diagnostic tool though false positive (FP) and false negative (FN) results affects accuracy due to different conditions, such as inflammatory diseases or low-uptake neoplasms. Aim of this study is to evaluate overall diagnostic performance of 18 F-FDG-PET/CT for malignant pulmonary nodules...
April 2018: Journal of Thoracic Disease
Sébastien Préville-Ratelle, Adèle Coriati, Aurélie Ménard, Isabelle Bourdeau, François Tremblay, Yves Berthiaume
Background: The prevalence of adrenal insufficiency (AI) in cystic fibrosis (CF) is unknown. The frequent use of glucocorticoids (inhaled or systemic) may induce the long-term suppression of the hypothalamic-pituitary-adrenal axis. Methods: We reviewed the results of adrenocorticotropic hormone (ACTH) stimulation tests done over a 10-year period to evaluate adrenal function in 69 CF patients of the CHUM CF clinic. Clinical characteristics of AI patients were compared to adrenal-sufficient (AS) patients...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Xin-Bo Ai, Zhen-Jiang Wang, Qi-Chao Dong, Xu Lin, Yu-Ping Chen, Fei-Yue Gong, Hui Liang
Gastrointestinal histoplasmosis (GIH) without pulmonary and bone marrow involvement is very rare worldwide. It can be misdiagnosed as intestinal tuberculosis or Crohn's disease. There are just few case reports of GIH in patients with a positive HIV antibody test. Here, we report a patient who presented to our hospital with repeated intestinal obstruction. The suspicious diagnosis was intestinal tuberculosis or Crohn's disease due to unspecific clinical manifestations and radiologic images. Our patient's HIV antibody test was negative...
January 2018: Case Reports in Gastroenterology
Bing-Fang Huang, Ya-Chi Chang, Ai-Ling Han, Hui-Tsung Hsu
The present study combined air sampling with pulmonary function tests (PFTs) to determine both the extent of air pollution proximal to an electric arc furnace (EAF) and its impact on human health. The mass concentrations of particulate matter with aerodynamic diameters less than 2.5 µm (PM2.5 ) in exposure areas were not significantly higher than the samples taken at a control area. However, the concentrations of five metal elements, Cd, Cr, Cu, Ni, and Zn in PM2.5 were significantly higher in the exposure area than that of the control area...
April 2018: Toxicology and Industrial Health
Ai Kagase, Masanori Yamamoto, Tetsuro Shimura, Atsuko Kodama, Seiji Kano, Yutaka Koyama, Norio Tada, Toru Naganuma, Motoharu Araki, Futoshi Yamanaka, Shinichi Shirai, Yusuke Watanabe, Kentaro Hayashida
BACKGROUND: Hyponatremia is associated with the increased risk of early and late mortality in patients with cardiac disease. This study aimed to assess the prognostic value of hyponatremia in patients who had undergone transcatheter aortic valve replacement (TAVR). METHODS: We investigated 1,215 consecutive patients (mean age: 84.4 ± 5.0 years) who underwent TAVR using data from the Optimized CathEter vAlvular iNtervention (OCEAN)-TAVR Japanese multicenter registry...
January 11, 2018: Catheterization and Cardiovascular Interventions
Thomas Phlips, Philippe Taghji, Milad El Haddad, Michael Wolf, Sébastien Knecht, Yves Vandekerckhove, René Tavernier, Mattias Duytschaever
Aims: We have recently shown that a contact force (CF)-guided ablation protocol respecting region-specific criteria of lesion contiguity and lesion depth ('CLOSE' protocol) is associated with high incidence of acute durable pulmonary vein (PV) isolation (PVI) and a high single-procedure arrhythmia-free survival at 1 year. In the present study, we compared efficiency, safety, and efficacy of 'CLOSE'-guided PVI to conventional CF-guided PVI (CONV-CF). Methods and results: Fifty consecutive paroxysmal atrial fibrillation (AF) patients underwent PV encircling using a CF-sensing catheter targeting an interlesion distance (ILD) ≤6 mm and ablation index (AI) ≥400 and ≥550 at posterior and anterior wall ('CLOSE' group)...
November 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Long Jiang, Dongrong Situ, Yongbin Lin, Xiaodong Su, Yan Zheng, Yigong Zhang, Hao Long
BACKGROUND: Effective strategies for managing patients with pulmonary focal Ground-glass Opacity (fGGO) depend on the pretest probability of malignancy. Estimating a clinical probability of malignancy in patients with fGGOs can facilitate the selection and interpretation of subsequent diagnostic tests. METHODS : Data from patients with pulmonary fGGO lesions, who were diagnosed at Sun Yat-sen University Cancer Center, was retrospectively collected. Multiple logistic regression analysis was used to identify independent clinical predictors for malignancy and to develop a clinical predictive model to estimate the pretest probability of malignancy in patients with fGGOs...
November 2013: Thoracic Cancer
Lei Ji, Yong-Liang Lou, Zhong-Xiu Wu, Jin-Qin Jiang, Xing-Li Fan, Li-Fang Wang, Xiao-Xiang Liu, Peng Du, Jie Yan, Ai-Hua Sun
BACKGROUND: Quick diagnosis of smear-negative pulmonary tuberculosis (TB) and extra-pulmonary TB are urgently needed in clinical diagnosis. Our research aims to investigate the usefulness of the interferon-γ release assay (IGRA) for the diagnosis of smear-negative pulmonary and extra-pulmonary TB. METHODS: We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients (including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients), 113 extra-pulmonary TB patients, 81 patients with other pulmonary diseases and 100 healthy controls...
September 1, 2017: Infectious Diseases of Poverty
Ying Wang, Li-Hui Zhu, Ai-Zheng Chen, Qiao Xu, Yu-Juan Hong, Shi-Bin Wang
A one-step method using a high-voltage electrostatic anti-solvent process was employed to fabricate poly-l-lactide (PLLA) porous microspheres (PMs). To address the simplification and control of the preparation process, a 2⁴ full factorial experiment was performed to optimize the operating process and analyze the effect of the factors on the morphology and aerodynamic properties of the PLLA PMs, and various characterization tests were also performed. The resulting PLLA PMs exhibited an even and porous morphology with a density less than 0...
May 13, 2016: Materials
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