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Cardiopulmonary test prediction

Craig A Williams, Kyle C A Wedgwood, Hossein Mohammadi, Katie Prouse, Owen W Tomlinson, Krasimira Tsaneva-Atanasova
Cystic fibrosis (CF) is a debilitating chronic condition, which requires complex and expensive disease management. Exercise has now been recognised as a critical factor in improving health and quality of life in patients with CF. Hence, cardiopulmonary exercise testing (CPET) is used to determine aerobic fitness of young patients as part of the clinical management of CF. However, at present there is a lack of conclusive evidence for one limiting system of aerobic fitness for CF patients at individual patient level...
2019: PloS One
Cosimo Carriere, Ugo Corrà, Massimo Piepoli, Alice Bonomi, Elisabetta Salvioni, Simone Binno, Alessandra Magini, Susanna Sciomer, Beatrice Pezzuto, Piero Gentile, Mauro Schina, Gianfranco Sinagra, Piergiuseppe Agostoni
BACKGROUND: During cardiopulmonary exercise test, the isocapnic buffering period ranges between anaerobic threshold (AT) and respiratory compensation point (RCP). We investigated whether oxygen uptake (VO2 ) increase during the isocapnic buffering period (ΔVO2 AT-RCP) is related to heart failure severity and prognosis. METHODS: We retrospectively analysed reduced ejection fraction heart failure patients who attained RCP at cardiopulmonary exercise test. The study endpoint was the composite of cardiovascular mortality and urgent heart transplantation/left ventricular assist device implantation...
February 12, 2019: European Journal of Preventive Cardiology
Shingo Tsujinaga, Hiroyuki Iwano, Miwa Sarashina, Taichi Hayashi, Michito Murayama, Ayako Ichikawa, Masahiro Nakabachi, Hisao Nishino, Shinobu Yokoyama, Arata Fukushima, Takashi Yokota, Kazunori Okada, Sanae Kaga, Pavlos P Vlachos, Toshihisa Anzai
BACKGROUND: Although the enhancement of early-diastolic intra-left ventricular pressure difference (IVPD) during exercise is considered to maintain exercise capacity, little is known about their relationship in heart failure (HF). METHODS AND RESULTS: Cardiopulmonary exercise testing and exercise-stress echocardiography were performed in 50 HF patients (left ventricular (LV) ejection fraction 39±15%). Echocardiographic images were obtained at rest, submaximal, and peak exercise...
February 9, 2019: Journal of Cardiac Failure
Philippe Grieshaber, Sina Möller, Borros Arneth, Peter Roth, Bernd Niemann, Harald Renz, Andreas Böning
BACKGROUND:  Prediction, early diagnosis, and therapy of cardiac surgery-associated acute kidney injury (CSA-AKI) are challenging. We prospectively tested a staged approach to identify patients at high risk for CSA-AKI combining clinical risk stratification and early postoperative quantification of urinary biomarkers for AKI. METHODS:  All patients, excluding those on chronic hemodialysis, undergoing scheduled surgery with cardiopulmonary bypass between August 2015 and July 2016 were included...
February 11, 2019: Thoracic and Cardiovascular Surgeon
Anna Kuo, Joshua J Todd, Jessica W Witherspoon, Tokunbor A Lawal, Jeffery Elliott, Irene C Chrismer, Monique O Shelton, Muslima S Razaqyar, Minal S Jain, Ruhi Vasavada, Melissa Waite, Bart Drinkard, Darren Michael, Alicia Richarte, Carsten G Bönnemann, Katherine G Meilleur
BACKGROUND: RYR1-related disorders (RYR1-RD), are a spectrum of genetic neuromuscular disorders. Affected individuals frequently experience fatigue yet appropriate tools to assess RYR1-RD-associated fatigue remain underdeveloped. OBJECTIVE: This study assessed the reliability and validity of two self-report questionnaires, the multidimensional fatigue inventory (MFI-20) and adult/pediatric functional assessment of chronic illness-fatigue (FACIT-F/Peds-FACIT-F) as potential fatigue measures in RYR1-RD affected individuals...
2019: Journal of Neuromuscular Diseases
Yi-Jen Chen, Hung-Pin Tu, Chia-Ling Lee, Wei-Chun Huang, Jin-Shiou Yang, Cyuan-Fong Li, Chia-Hsin Chen, Ko-Long Lin
Background: The 6-minute walk test (6MWT) and cardiopulmonary exercise test (CPET) are exercise tests associated with physical function, quality of life and hemodynamic data in patients with pulmonary arterial hypertension (PAH). This study was conducted to assess correlations between exercise capacity, quality of life and disease functional classification, and to analyze the value of comprehensive assessments in predicting mortality in patients with PAH. Methods: Fifty-four patients with PAH were enrolled...
January 2019: Acta Cardiologica Sinica
Gerhard-Paul Diller, Aleksander Kempny, Sonya V Babu-Narayan, Marthe Henrichs, Margarita Brida, Anselm Uebing, Astrid E Lammers, Helmut Baumgartner, Wei Li, Stephen J Wort, Konstantinos Dimopoulos, Michael A Gatzoulis
Aims: To assess the utility of machine learning algorithms on estimating prognosis and guiding therapy in a large cohort of patients with adult congenital heart disease (ACHD) or pulmonary hypertension at a single, tertiary centre. Methods and results: We included 10 019 adult patients (age 36.3 ± 17.3 years) under follow-up at our institution between 2000 and 2018. Clinical and demographic data, ECG parameters, cardiopulmonary exercise testing, and selected laboratory markers where collected and included in deep learning (DL) algorithms...
January 26, 2019: European Heart Journal
Valérie Lemay, Maxime Caru, Mariia Samoilenko, Simon Drouin, Nathalie Alos, Geneviève Lefebvre, Emile Levy, Sarah Lippé, Valérie Marcil, Serge Sultan, Laurence Bertout, Maja Krajinovic, Caroline Laverdière, Marie-Josée Raboisson, Daniel Sinnett, Gregor Andelfinger, Daniel Curnier
BACKGROUND: Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice of physical activity and a good cardiorespiratory fitness have the potential to reduce the risk of chronic disease and improve quality of life. The aim of this study was to evaluate in a cohort of ALL survivors, the association between a good cardiorespiratory fitness or the respect of physical activity guidelines and major long-term health outcomes...
January 25, 2019: Journal of Pediatric Hematology/oncology
H Hilmisson, E Sveinsdottir, Neale Lange, S Magnusdottir
OBJECTIVE: To determine prevalence of comorbid undiagnosed sleep disordered breathing (SDB) in chronic insomnia patients, using two complementary methods, one standard and one novel. METHODS: Using prospective design, adult patients diagnosed with chronic insomnia, treated with prescription pharmacological agents for >3 months without prior objective sleep evaluation or diagnosis of SDB were invited to participate. All patients recorded their sleep for two consecutive nights using level 3 home-sleep-apnea-test (HSAT) device to derive Respiratory Event Index (REI) for OSA diagnosis...
January 24, 2019: European Journal of Internal Medicine
Vasileios Stavrou, Afroditi K Boutou, George D Vavougios, Chaido Pastaka, Konstantinos I Gourgoulianis, Yiannis Koutedakis, Zoe Daniil, Eleni Karetsi
The aim of this study was to investigate the relationship between cardiopulmonary exercise testing (CPET) and the presence of obstructive sleep apnea syndrome (OSAS) in order to provide an innovative tool to identify patients with OSAS. A prospective nested case control design was adopted. A consecutive population of male volunteers referred to a Sleep Unit was subjected to nocturnal polysomnography, full lung function testing and maximal CPET. A stepwise linear discriminant function analysis (DFA) was applied to construct a model which could identify individuals with moderate-to-severe OSAS from healthy controls...
January 23, 2019: Respiratory Physiology & Neurobiology
Bryant Priromprintr, Michael J Silka, Jonathan Rhodes, Anjan S Batra
BACKGROUND: The long-term benefits of Melody valve implant for right ventricular outflow tract conduit obstruction or insufficiency on exercise capacity are undefined. METHODS: As part of the Melody valve clinical trial, 136 patients with congenital heart disease underwent serial cardiopulmonary exercise testing prior to, 6 months after, and annually for up to 5 years postimplant. RESULTS: Mean age at Melody valve implantation was 22.4 ± 0...
December 29, 2018: American Heart Journal
Frederike Kruse, Bjoern E Kleibrink, Thomas Rabis, Yi Wang, Gerhard Weinreich, Markus Kamler, Christian Taube, Kurt Rasche, Urte Sommerwerck
The prevalence of sleep-disordered breathing (SDB) after lung transplantation (LTX) is high. It is well-established that SDB is associated with decreased health-related quality of life (HRQoL), but the impact of SDB on exercise capacity is less clear. In this study we investigated HRQoL and exercise capacity in LTX recipients with or without SDB. In addition, we also investigated associations between sleep parameters and both HRQoL and exercise capacity. There were 53 stable LTX recipients (age > 18 years, 31 males, time from LTX 9-120 months) enrolled into the study...
January 25, 2019: Advances in Experimental Medicine and Biology
Katelyn E Uithoven, Joshua R Smith, Jose R Medina-Inojosa, Ray W Squires, Erik H Van Iterson, Thomas P Olson
The measurement of peak oxygen uptake (VO2peak ) is an important metric for evaluating cardiac transplantation (HTx) eligibility. However, it is unclear which factors (e.g., recipient demographics, clinical parameters, cardiac rehabilitation (CR) participation) influence VO2peak following HTx. Consecutive HTx patients with cardiopulmonary exercise testing (CPET) between 2007⁻2016 were included. VO2peak was measured from CPET standard protocol. Regression analyses determined predictors of the highest post-HTx VO2peak (i...
January 19, 2019: Journal of Clinical Medicine
Filip Gawecki, Timothy Strangeways, Alisha Amin, Joseph Perks, Heidi Wolfenden, Saranya Thurainatnam, Abeer Rizvi, James E Jackson, Vatshalan Santhirapala, J Myers, J Brown, Luke S G E Howard, Hannah C Tighe, Claire L Shovlin
Background: Pulmonary arteriovenous malformations (PAVMs) generate a right-to-left shunt. Impaired gas exchange results in hypoxemia and impaired CO2 clearance. Most patients compensate effectively but a proportion are dyspneic, and these are rarely the most hypoxaemic. Aim: To test degrees of concurrent pathology influencing exercise capacity. Design: Replicate, sequential single centre, prospective studies. Methods: Cardiopulmonary exercise tests (CPET) were performed in 26 patients with PAVMs, including individuals with and without known airflow obstruction...
January 17, 2019: QJM: Monthly Journal of the Association of Physicians
Agnieszka Lemanska, Karen Poole, Jonathan J Aning, Bruce A Griffin, Ralph Manders, John M Saxton, Joe Wainwright, Sara Faithfull
Background: Assessing fitness and promoting regular physical activity can improve health outcomes and early recovery in prostate cancer. This is however, underutilised in clinical practice. The cardiopulmonary exercise test (CPET) is increasingly being used pre-treatment to measure aerobic capacity and peak oxygen consumption (VO2 peak - a gold standard in cardiopulmonary fitness assessment). However, CPET requires expensive equipment and may not always be appropriate. The Siconolfi step test (SST) is simpler and cheaper, and could provide an alternative...
2019: European Review of Aging and Physical Activity
N J Greco, A G Manocchio, A V Lombardi, S L Gao, J Adams, K R Berend
AIMS: Despite declining frequency of blood transfusion and electrolyte supplementation following total joint arthroplasty, postoperative blood analyses are still routinely ordered for these patients. This study aimed to determine the rate of blood transfusion and electrolyte restoration in arthroplasty patients treated with a perioperative blood conservation protocol and to identify risk factors that would predict the need for transfusion and electrolyte supplementation. PATIENTS AND METHODS: Patients undergoing primary total joint arthroplasty of the hip or knee between July 2016 and February 2017 at a single institution were included in the study...
January 2019: Bone & Joint Journal
Jason Coult, Jennifer Blackwood, Lawrence Sherman, Thomas D Rea, Peter J Kudenchuk, Heemun Kwok
BACKGROUND: Quantitative measures of the ventricular fibrillation (VF) ECG waveform can assess myocardial physiology and predict cardiac arrest outcomes, making these measures a candidate to help guide resuscitation. Chest compressions are typically paused for waveform measure calculation because compressions cause ECG artifact. However, such pauses contradict resuscitation guideline recommendations to minimize cardiopulmonary resuscitation interruptions. We evaluated a comprehensive group of VF measures with and without ongoing compressions to determine their performance under both conditions for predicting functionally-intact survival, the study's primary outcome...
January 2019: Circulation. Arrhythmia and Electrophysiology
Fernanda M Vendrusculo, João P Heinzmann-Filho, Natália E Campos, Mailise F Gheller, Ingrid S de Almeida, Márcio V F Donadio
BACKGROUND: Several tests may be used to assess exercise intolerance in cystic fibrosis (CF), including the gold standard cardiopulmonary exercise test (CPET) and the Modified Shuttle Test (MST). OBJECTIVE: To evaluate the use of the MST as a predictor of peak oxygen uptake (VO2 peak) and to compare VO2 peak and maximal heart rate (HRmax) obtained in both tests. METHODS: Cross-sectional study including individuals with CF aged between 6 and 20 years old...
January 6, 2019: Pediatric Pulmonology
Erik Björklund, Emma C Hansson, Birgitta S Romlin, Anders Jeppsson, Carl Johan Malm
OBJECTIVES: Preoperative testing of platelet function predicts bleeding risk in cardiac surgery patients treated with dual antiplatelet therapy, but the value of postoperative platelet function testing, reflecting both preoperative antiplatelet therapy and perioperative changes in platelet function, has not been evaluated. METHODS: Seventy-four patients with acute coronary syndrome treated with acetylsalicylic acid and ticagrelor within 5 days before cardiac surgery were included in a prospective observational study...
December 22, 2018: Interactive Cardiovascular and Thoracic Surgery
Maciej Turski, Magdalena Kocierz-Woźnowska, Maciej Wybraniec, Marek Grabka, Marcin Wita, Adrianna Berger-Kucza, Krystian Wita, Katarzyna Mizia-Stec
INTRODUCTION: ST elevation myocardial infarction (STEMI) is one of the main causes of congestive heart failure (CHF). The main symptom of CHF is exercise tolerance impairment. The aim of the study was to evaluate the prevalence and risk factors for impaired exercise tolerance in patients after STEMI. METHODS AND RESULTS: 84 patients with STEMI were analyzed in the study. Cardiopulmonary exercise test (CPET) was performed 6 months after STEMI. Impaired exercise tolerance defined as peak VO2 < 84% predicted for age and sex was present in 49 (58%) patients and was connected with lack of abciximab administration (91,4 vs 69%, p=0·02) and the presence of mitral regurgitation (47 vs...
December 27, 2018: Clinical Physiology and Functional Imaging
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