keyword
https://read.qxmd.com/read/38533990/primary-and-secondary-intracerebral-hemorrhage-in-pregnant-and-nonpregnant-young-adults-by-smash-up-criteria
#1
JOURNAL ARTICLE
Mehriban Sariyeva, Noora Haghighi, Amanda Mitchell, Whitney A Booker, Nils H Petersen, Andrea D Shields, Shivani Ghoshal, Sachin Agarwal, Soojin Park, Jan Claassen, E Sander Connolly, David J Roh, Eliza C Miller
BACKGROUND: Intracerebral hemorrhage (ICH) is a major cause of maternal morbidity, but its pathophysiology is poorly characterized. We investigated characteristics of pregnancy-associated ICH (P-ICH), compared with ICH in similar aged nonpregnant adults of both sexes. METHODS AND RESULTS: We performed a retrospective analysis of 134 adults aged 18 to 44 years admitted to our center with nontraumatic ICH from January 1, 2012, to December 31, 2021. We compared ICH characteristics among 3 groups: those with P-ICH (pregnant or within 12 months of end of pregnancy); nonpregnant women; and men...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38527423/posterior-reversible-encephalopathy-syndrome-in-eclamptic-patients-the-relationship-between-blood-pressure-cranial-involvement-and-seizure-recurrence
#2
JOURNAL ARTICLE
Musa Temel, Merve Durmuş, Şeyma Eroğlu Durmaz, Deniz Güvenir, Erdem Gürkaş
OBJECTIVES: Posterior reversible encephalopathy syndrome(PRES) is a clinic radiological disorder characterized by headache, epileptic seizure, encephalopathy, visual impairment, and focal neurological deficits. Gestational hypertension, which is a significant risk factor for PRES, may cause significant morbidity and mortality among pregnant women. DESIGN: Twenty-four patients with PRES caused by eclampsia who were admitted to our hospital in the last 5 years were included in this study...
March 25, 2024: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/38515998/hepatic-encephalopathy-precipitated-by-preeclampsia-in-the-setting-of-cirrhosis-a-case-report
#3
Mary E Fang, Nicholas A Peoples, Alison N Goulding, Mary C Tolcher
Preeclampsia and decompensated chronic liver disease are known triggers of acute hepatic dysfunction in pregnancy, rarely including hepatic encephalopathy. Differentiating the driver of acute hepatic dysfunction in patients with concomitant preeclampsia and preexisting liver disease presents a diagnostic challenge with important management implications. A 42-year-old woman, gravida 3 para 0201, at 24 1/7 weeks of gestation presented with hepatic encephalopathy, transaminitis, and hyperbilirubinemia in the setting of cirrhosis and severe new-onset preeclampsia...
March 2024: Case Reports in Women's Health
https://read.qxmd.com/read/38509184/real-world-comparison-of-terlipressin-vs-octreotide-as-an-adjuvant-treatment-in-the-management-of-variceal-bleeding
#4
REVIEW
H Rehman, S T Rehman, S Zulfiqar, S Awan, Shahab Abid
Variceal bleeding is a major complication and the leading cause of death in patients with cirrhosis and portal hypertension. This study aims to compare the efficacy and safety of terlipressin vs octreotide as an adjuvant to endoscopic management of patients with esophageal variceal bleeding in a real-time scenario. We reviewed the medical records of patients with esophageal variceal bleeding from January 2005 to December 2020 at our tertiary care Aga Khan University Hospital. Mortality was assessed after 6 weeks...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38496121/role-of-portosystemic-shunt-and-portal-vein-stent-in-managing-portal-hypertension-due-to-hematological-diseases
#5
JOURNAL ARTICLE
Ji Hoon Kim, Suho Kim, Hee-Chul Nam, Chang Wook Kim, Jae-Sung Yoo, Ji Won Han, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Ho-Jong Chun, Sung-Eun Lee, Jung-Suk Oh, Pil Soo Sung
INTRODUCTION: Patients with hematological diseases experience complications related to portal hypertension, including life-threatening complications such as variceal bleeding. METHODS: We analyzed the prognosis of patients with hematological diseases and portal hypertension treated with transjugular intrahepatic portosystemic shunts (TIPS) or portal vein stents. We retrospectively assessed patients with hematological diseases and portal hypertension who had variceal bleeding...
February 2024: Curēus
https://read.qxmd.com/read/38492713/the-simultaneous-occurrence-of-gestational-diabetes-and-hypertensive-disorders-of-pregnancy-affects-fetal-growth-and-neonatal-morbidity
#6
JOURNAL ARTICLE
Chioma Onuoha, Carolin C M Schulte, Tanayott Thaweethai, Sarah Hsu, Deepti Pant, Kaitlyn E James, Sarbattama Sen, Anjali Kaimal, Camille E Powe
BACKGROUND: Gestational diabetes (GDM) is associated with an increased risk of hypertensive disorders of pregnancy (HDP), but there are limited data on fetal growth and neonatal outcomes when both conditions are present. OBJECTIVES: We evaluated the risk of abnormal fetal growth and neonatal morbidity in pregnancies with co-occurrence of GDM and HDP. STUDY DESIGN: In a retrospective study of 47,093 singleton pregnancies, we compared the incidence of appropriate for gestational age birthweight (AGA) in pregnancies affected by GDM alone, HDP alone, or both GDM and HDP (GDM/HDP) to that in pregnancies affected by neither disorder using generalized estimating equations (covariates: maternal age, nulliparity, BMI, insurance type, race, marital status and prenatal care site)...
March 14, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38486673/novel-nurse-led-early-postdischarge-clinic-is-associated-with-fewer-readmissions-and-lower-mortality-following-hospitalisation-with-decompensated-cirrhosis
#7
JOURNAL ARTICLE
Benjamin Giles, Kirsty Fancey, Karen Gamble, Zeshan Riaz, Joanna K Dowman, Andrew J Fowell, Richard J Aspinall
OBJECTIVE: Patients hospitalised with decompensated cirrhosis have high rates of early unplanned readmission. Many readmissions are avoidable with secondary preventative strategies, but patients are often readmitted prior to outpatient review. To address this, we established a novel, nurse-led early postdischarge (EPD) clinic delivering goal-directed care for cirrhosis complications and evaluated the impact. METHODS: Retrospective cohort study comparing outcomes in 78 patients seen in the EPD clinic with 91 phenotypically matched controls receiving standard, consultant hepatologist care...
March 2024: Frontline Gastroenterology
https://read.qxmd.com/read/38482311/hyponatremia-induced-worsening-of-trigeminal-neuralgia-when-the-sodium-plays-the-game
#8
Mohammad Z Ansari, Rashmi Singh, Bijaya Mohanty, Sarita Kumari, Ashok Sunder
A 78-year-old elderly male who was on treatment for trigeminal neuralgia and hypertension was brought to the emergency with altered sensorium. His vital parameters were within normal limits; however, the arterial blood gas analysis showed severe hyponatremia. He was admitted to the ward, where further workup was carried out and hyponatremia correction started. He had a sudden worsening in his facial pain before he landed in encephalopathy. His medications (oxcarbazepine and chlorthalidone) that could cause hyponatremia were stopped, and judicious correction of hyponatremia was done...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38463101/reversible-cerebral-vasoconstriction-syndrome-and-posterior-reversible-encephalopathy-syndrome-following-vaccination-analysis-of-the-vaers-database-and-systematic-review
#9
JOURNAL ARTICLE
Bahadar S Srichawla, Ton Fang, Vincent Kipkorir, Maria A Garcia-Dominguez
OBJECTIVES: This study aimed to analyze the Vaccine Adverse Event Reporting System (VAERS) database and systematically review the literature to provide a comprehensive analysis of reversible cerebral vasoconstriction syndrome (RCVS) and posterior reversible encephalopathy syndrome (PRES) secondary to vaccination. METHODS: The authors analyzed the VAERS database and conducted a systematic review following PRISMA guidelines. The inclusion criteria for VAERS data were a score of ≥3 on the RCVS2 score and/or radiographic findings consistent with the diagnosis of RCVS or PRES...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38452930/venous-congestive-encephalopathy-secondary-to-arteriovenous-fistula-aggravated-by-cerebrospinal-fluid-shunt
#10
Juan Casado Pellejero, Silvia Vázquez Sufuentes, Laura Beatriz López López, Rosario Barrena Caballo
We present a unique clinical case of venous congestive encephalopathy in the context of a cerebral arteriovenous fistula with clinical worsening secondary to valvular overdrainage. ICP monitoring, the different pressure settings of the programable CSF shunt and the detailed clinical description that is carried out offer us enough data to understand that this case provides important pathophysiological knowledge to a little-known disease.
March 5, 2024: Neurocirugía (English Edition)
https://read.qxmd.com/read/38444690/improving-outcomes-in-hepatorenal-syndrome-acute-kidney-injury-with-early-diagnoses-and-implementation-of-approved-treatment-regimens
#11
JOURNAL ARTICLE
Nikolaos T Pyrsopoulos, David Bernstein, Marcelo Kugelmas, Emily J Owen, K Rajender Reddy, Nancy Reau, Sammy Saab, Hani M Wadei
Decompensated cirrhosis, defined by the overt manifestations of liver failure and portal hypertension (eg, ascites, hepatic encephalopathy, variceal bleeding), is the inflection point associated with increased morbidity and mortality in chronic liver disease. Acute kidney injury in the setting of cirrhosis (hepatorenal syndrome-acute kidney injury [HRS-AKI]) is a severe and often fatal complication. The goals of treatment of HRS-AKI are to reverse renal failure and prolong survival in these critically ill patients or perhaps to allow the transplant team to complete the pretransplant evaluation and bridge the patient to transplant...
December 2023: Gastroenterology & Hepatology
https://read.qxmd.com/read/38443649/incidence-and-costs-of-clinically-significant-events-with-systemic-therapy-in-patients-with-unresectable-hepatocellular-carcinoma-a-retrospective-cohort-study
#12
JOURNAL ARTICLE
Daniel J Simmons, Stephen J Valerio, Darren S Thomas, Marcus J Healey, Zhuoxin Jiang, Jesica M Levingston Mac Leod, Yian Lin, Janvi Sah
INTRODUCTION: Systemic therapies have been associated with clinically significant events (CSEs) in patients with unresectable hepatocellular carcinoma (uHCC). We evaluated the incidence of CSEs (bleeding, clotting, encephalopathy, and portal hypertension), and their impact on healthcare resource utilization (HCRU) and costs, in patients with uHCC treated with first-line (1L) atezolizumab plus bevacizumab (A + B), lenvatinib (LEN), or sorafenib (SOR) in the USA. METHODS: A retrospective cohort study was performed using medical/pharmacy claims from Optum® Clinformatics® Data Mart...
March 5, 2024: Advances in Therapy
https://read.qxmd.com/read/38438672/prognosis-of-lspd-versus-tips-for-the-treatment-of-esophagogastric-variceal-bleeding-in-cirrhosis
#13
JOURNAL ARTICLE
Biao Chen, Jingxuan Wang, Weiyong Sheng, Bingqing Ma, Peng Xu, Xing Cheng, Weiyi Cheng, Chengjun Cai, Guoliang Wang, Wenming Pan, Chidan Wan, Chuansheng Zheng, Ping Cheng, Jinxiang Zhang
BACKGROUND: This study aimed to compare postoperative complications in patients with esophagogastric variceal bleeding (EVB) who underwent laparoscopic splenectomy combined with pericardial devascularization (LSPD) versus transjugular intrahepatic portosystemic shunt (TIPS) procedures. METHODS: A retrospective collection of medical records was conducted from January 2014 to May 2020 at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology...
March 4, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38422816/generation-of-induced-pluripotent-stem-cells-ucli024-a-from-a-patient-with-argininosuccinate-lyase-deficiency-carrying-a-homozygous-c-437g%C3%A2-%C3%A2-a-p-arg146gln-mutation
#14
JOURNAL ARTICLE
Claire Duff, Madeha Islam, Onelia Gagliano, Hema Pramod, Hassan Rashidi, Manju Kurian, Paul Gissen, Julien Baruteau
Argininosuccinic aciduria (ASA) is a rare inherited metabolic disease caused by argininosuccinate lyase (ASL) deficiency. Patients with ASA present with hyperammonaemia due to an impaired urea cycle pathway in the liver, and systemic disease with epileptic encephalopathy, chronic liver disease, and arterial hypertension. A human induced pluripotent stem cell (iPSC) line from the fibroblasts of a patient with ASA with homozygous pathogenic c.437G > A mutation of hASL was generated. Characterization of the cell line demonstrated pluripotency, differentiation potential and normal karyotype...
February 28, 2024: Stem Cell Research
https://read.qxmd.com/read/38410311/acute-encephalopathy-in-a-10-year-old-patient-with-maple-syrup-urine-disease-a-challenging-diagnosis
#15
Pedro Miragaia, Ana Grangeia, Esmeralda Rodrigues, Raquel Sousa, Augusto Ribeiro
Maple syrup urine disease (MSUD) is a rare autosomal recessive metabolic disorder characterized by a deficiency in the branched-chain alpha-keto acid dehydrogenase complex, leading to the toxic accumulation of leucine, isoleucine and valine. Acute encephalopathy (AE) is a severe neurological disorder with diverse etiologies, demanding prompt identification and intervention. We present a unique case of a previously healthy teenage patient who developed AE during an influenza infection. Despite initial inconclusive investigations, the patient's condition rapidly deteriorated, requiring pediatric intensive care unit (PICU) admission...
January 2024: Curēus
https://read.qxmd.com/read/38395452/efficacy-of-tips-plus-extrahepatic-collateral-embolisation-in-real-world-data-a-validation-study
#16
JOURNAL ARTICLE
Lianhui Zhao, Jun Tie, Guangchuan Wang, Zhengjie Li, Jiao Xu, Yuzheng Zhuge, Feng Zhang, Hao Wu, Bo Wei, Hui Xue, Peijie Li, Wei Wu, Chao Chen, Qiong Wu, Yifu Xia, Xiubin Sun, Chunqing Zhang
OBJECTIVES: The efficacy of transjugular intrahepatic portosystemic shunt (TIPS) plus extrahepatic collateral embolisation (TIPS+E) in reducing rebleeding and hepatic encephalopathy (HE) post-TIPS was recently reported in a meta-analysis, but further validation is essential. This study aims to confirm the effectiveness of TIPS+E using real-world data. METHODS: The multicentre retrospective cohort included 2077 patients with cirrhosis who underwent TIPS±E (TIPS: 631, TIPS+E: 1446) between January 2010 and December 2022...
February 23, 2024: BMJ Open Gastroenterology
https://read.qxmd.com/read/38392918/updated-clinical-guidelines-on-the-management-of-hepatitis-c-infection-in-children
#17
REVIEW
Chaowapong Jarasvaraparn, Christopher Hartley, Wikrom Karnsakul
Children represent only a small proportion of those infected with the hepatitis C virus (HCV) compared to adults. Nevertheless, a substantial number of children have chronic HCV infection and are at risk of complications including cirrhosis, portal hypertension, hepatic decompensation with hepatic encephalopathy, and hepatocellular carcinoma in adulthood. The overall prevalence of the HCV in children was estimated to be 0.87% worldwide. The HCV spreads through the blood. Children born to women with chronic hepatitis C should be evaluated and tested for HCV due to the known risk of infection...
February 16, 2024: Pathogens
https://read.qxmd.com/read/38385421/tacrolimus-associated-posterior-reversible-encephalopathy-syndrome-in-renal-transplant-recipient-in-early-posttransplant-period-case-report
#18
Syed Mohd Azhar Hassan
Posterior reversible encephalopathy syndrome is an emergency medical condition with varied causes presenting as reversible subcortical vasogenic brain edema caused by endothelial injury, resulting from changes in blood pressure or direct effects of cytokines on endothelium. Posterior reversible encephalopathy syndrome is manifested by neurologic symptoms. Common causes include hypertensive emergency, renal disease, preeclampsia, eclampsia, and immunosuppressive drugs. In this case report, a 17-year-old female patient on hemodialysis as a result of lupus nephritis who had previously undergone deceased donor organ transplant and was on triple immunosuppression presented with neurological symptoms of posterior reversible encephalopathy syndrome in the early posttransplant period...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38383893/clinical-relevance-of-reversible-cerebral-vasoconstriction-syndrome-in-pregnant-women-with-posterior-reversible-encephalopathy-syndrome-review-of-case-reports-in-japan
#19
REVIEW
Hirotada Suzuki, Akihide Ohkuchi, Kenji Horie, Manabu Ogoyama, Rie Usui, Hironori Takahashi, Hiroyuki Fujiwara
We systematically reviewed case reports of posterior reversible encephalopathy syndrome (PRES), and investigated the characteristics of PRES in pregnant Japanese women and the clinical relevance of reversible cerebral vasoconstriction syndrome (RCVS) in pregnant women with PRES. Articles were collected using the PubMed/Medline and Ichushi-Web databases. This review was ultimately conducted on 121 articles (162 patients). The clinical characteristics of PRES, individual sites of PRES lesions, edema types, and clinical characteristics of RCVS in PRES cases were examined...
February 21, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38364832/cabozantinib-plus-atezolizumab-versus-sorafenib-for-advanced-hepatocellular-carcinoma-cosmic-312-final-results-of-a-randomised-phase-3-study
#20
JOURNAL ARTICLE
Thomas Yau, Ahmed Kaseb, Ann-Lii Cheng, Shukui Qin, Andrew X Zhu, Stephen L Chan, Tamar Melkadze, Wattana Sukeepaisarnjaroen, Valery Breder, Gontran Verset, Edward Gane, Ivan Borbath, Jose David Gomez Rangel, Baek-Yeol Ryoo, Tamta Makharadze, Philippe Merle, Fawzi Benzaghou, Steven Milwee, Zhong Wang, Dominic Curran, Robin Kate Kelley, Lorenza Rimassa
BACKGROUND: The aim of the COSMIC-312 trial was to evaluate cabozantinib plus atezolizumab versus sorafenib in patients with previously untreated advanced hepatocellular carcinoma. In the initial analysis, cabozantinib plus atezolizumab significantly prolonged progression-free survival versus sorafenib. Here, we report the pre-planned final overall survival analysis and updated safety and efficacy results following longer follow-up. METHODS: COSMIC-312 was an open-label, randomised, phase 3 study done across 178 centres in 32 countries...
February 13, 2024: Lancet. Gastroenterology & Hepatology
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