keyword
https://read.qxmd.com/read/38387901/-inhibitory-effect-of-metformin-and-arsenic-trioxide-on-kg1a-cell-proliferation
#1
JOURNAL ARTICLE
Wen-Hui Huang-Li, Meng Liu, Shu-Min Gui, Ming-Ming Feng, Hui Liu, Xiao-Hui Si, Xin-Qing Niu
OBJECTIVE: To investigate the effect of metformin and arsenic trioxide on KG1a cells proliferation of acute myeloid leukemia and its possible mechanism. METHODS: CCK-8 method was used to detect the killing effect of metformin, arsenic trioxide and combined application on KG1a cells. Annexin V-FITC/PI Dual Stain Flow Cytometry was used to detect the effect of combined application on apoptosis of KG1a cells. Western blot was used to detect the expression of intracellular apoptosis-,autophagy-related protein...
February 2024: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/38345595/metformin-mediated-fast-charge-reversal-nanohybrid-for-deep-penetration-piezocatalysis-augmented-chemodynamic-immunotherapy-of-cancer
#2
JOURNAL ARTICLE
Yuan Wang, Qingshuang Tang, Ruiqi Wu, Shiyuan Yang, Zhishuai Geng, Ping He, Xiaoda Li, Qingfeng Chen, Xiaolong Liang
Immune checkpoint blockade (ICB) therapy still suffers from insufficient immune response and adverse effect of ICB antibodies. Chemodynamic therapy (CDT) has been demonstrated to be an effective way to synergize with ICB therapy. However, a low generation rate of reactive oxygen species and poor tumor penetration of CDT platforms still decline the immune effects. Herein, a charge-reversal nanohybrid Met@BF containing both Fe3 O4 and BaTiO3 nanoparticles in the core and Metformin (Met) on the surface was fabricated for tumor microenvironment (TME)- and ultrasound (US)-activated piezocatalysis-chemodynamic immunotherapy of cancer...
February 12, 2024: ACS Nano
https://read.qxmd.com/read/38123081/predicting-the-occurrence-of-antagonism-within-ternary-guanidine-mixture-pollutants-based-on-the-concentration-ratio-of-components
#3
JOURNAL ARTICLE
Jian-Ping Zeng, Jin Zhang, Jun-Hua Hong, Yuan-Fan Zhao, Jing Zhang, Ying Zhang, Xian-Huai Huang, Fa-Zhi Xie
The widespread prevalence and coexistence of diverse guanidine compounds pose substantial risks of potential toxicity interactions, synergism or antagonism, to environmental organisms. This complexity presents a formidable challenge in assessing the risks associated with various pollutants. Hence, a method that is both accurate and universally applicable for predicting toxicity interactions within mixtures is crucial, given the unimaginable diversity of potential combinations. A toxicity interaction prediction method (TIPM) developed in our past research was employed to predict the toxicity interaction, synergism or antagonism, within guanidine compound mixtures...
December 18, 2023: Science of the Total Environment
https://read.qxmd.com/read/38066653/comparison-of-the-efficacy-of-anti-diabetic-medications-as-add-on-to-metformin-in-type-2-diabetes-mellitus-from-a-real-world-database
#4
JOURNAL ARTICLE
Ryosuke Ono, Chika Ogami, Chihiro Hasegawa, Hideto To, Yoshiaki Matsumoto, Yasuhiro Tsuji
BACKGROUND: Metformin is recommended as a first-line drug in the guidelines of the treatment for type 2 diabetes mellitus. However, high-quality evidence from clinical trials directly comparing the degree of hypoglycemic effect of combination therapy of metformin and a hypoglycemic agent with a different mechanism of action with that of monotherapy of a hypoglycemic drug is lacking. We aimed to examine whether combination therapy of hypoglycemic agents with metformin showed antagonism, addition, or synergism compared to monotherapy with hypoglycemic agents other than metformin regarding hemoglobin A1c levels...
December 9, 2023: BMC Pharmacology & Toxicology
https://read.qxmd.com/read/38035560/metformin-regulates-the-mir-205-vegfa-axis-in-renal-cell-carcinoma-cells-exploring-a-clinical-synergism-with-tyrosine-kinase-inhibitors
#5
JOURNAL ARTICLE
Markus Krebs, Mischa J Kotlyar, Julian Fahl, Sudha Janaki Raman, Florian Röhrig, André Marquardt, Hubert Kübler, Burkhard Kneitz, Almut Schulze, Charis Kalogirou
INTRODUCTION: Metformin (MF) intake could be associated with a favorable outcome in Sunitinib (SUT)- and Axitinib (AX)-treated clear cell renal cell carcinoma (ccRCC) patients. Functionally, MF induces miR-205, a microRNA serving as a tumor suppressor in several cancers. METHODS: qRT-PCR, viability assays and Western blotting analyzed MF and SUT/AX effects in RCC4 and 786-O cells. A tetracycline-inducible overexpression model was used to study the role of miR-205 and its known target gene VEGFA...
November 30, 2023: Urologia Internationalis
https://read.qxmd.com/read/37970441/synergic-effects-of-trigonella-foenum-graecum-ribes-rubrum-lavandula-angustifolia-and-arctium-lappa-extracts-mixture-on-learning-and-memory-deficits-in-streptozocin-induced-diabetic-rats
#6
JOURNAL ARTICLE
Mona Sadat Hosseini Arya, Samaneh Kakhki, Farimah Beheshti, Mohammad Hadi Ebrahimzadeh, Jalil Farzadmehr
OBJECTIVES: The present study aimed to assess the efficacy of some known extracts on learning and memory impairment induced by streptozocin (STZ) in male rats. MATERIALS AND METHODS: Eighty male rats were randomly divided: 1) control, 2) STZ (50 mg/kg), 3) STZ+ Trigonella foenum-graecum (200 mg/kg), 4) STZ+ Ribes rubrum (500 mg/kg), 5) STZ+ Lavandula angustifolia (400 mg/kg), 6) STZ+ Arctium Lappa (200 mg/kg), 7) STZ+mix of extracts (quarter dose of each extract), and 8) STZ+metformin (100 mg/kg)...
2023: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/37738800/diclofenac-and-metformin-synergistic-dose-dependent-inhibition-of-hamster-fibrosarcoma-rescued-with-mebendazole
#7
JOURNAL ARTICLE
Dušica J Popović, Kosta J Popović, Dejan Miljković, Jovan K Popović, Dušan Lalošević, Mihalj Poša, Zana Dolićanin, Ivan Čapo
We examined whether combinig diclofenac and metformin in doses equivalent to human doses would synergize their anticancer activity on fibrosarcoma inoculated to hamsters and in vitro. Rescue experiment was performed to examine whether the prosurvival NF-κB stimulation by mebendazole can reverse anticancer effects of the treatment. BHK-21/C13 cell culture was subcutaneously inoculated to Syrian golden hamsters randomly divided into groups (6 animals per group): 1) untreated control; treated daily with 2) diclofenac; 3) metformin; 4) combinations of diclofenac and metformin at various doses; 5) combination of diclofenac, metformin and mebendazole; 6) mebendazole...
September 20, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37717372/boningmycin-induces-ampk-mediated-endoplasmic-reticulum-associated-degradation-of-pd-l1-protein-in-human-cancer-cells
#8
JOURNAL ARTICLE
Juan Zhang, Jincai Wang, Yue Shang, Yang Chen, Shuzhen Chen, Qiyang He
Anti-PD-1/PD-L1 monoclonal antibodies have displayed remarkable clinical benefits and revolutionized the treatment of multiple tumor types, but the low response rates and immune-related adverse events limit their application, which promoting the development of small molecule agents to improve the efficacy of PD-1/PD-L1 blockade therapy. Boningmycin (BON), a new small molecule belonging to bleomycin (BLM) family, exhibits potent anticancer activity in vitro and in vivo, as well as negligible lung toxicity, thereby can be an alternative of BLM...
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37565233/retracted-metformin-synergizes-with-pd-l1-monoclonal-antibody-enhancing-tumor-immune-response-in-treating-non-small-cell-lung-cancer-and-its-molecular-mechanism-investigation
#9
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2022/5983959.].
2023: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/37409755/metformin-sensitizes-aml-cells-to-venetoclax-through-endoplasmic-reticulum-stress-chop-pathway
#10
JOURNAL ARTICLE
Lei Hua, Nianhui Yang, Yue Li, Kexiu Huang, Xinya Jiang, Fangshu Liu, Zhi Yu, Jie Chen, Jing Lai, Juan Du, Hui Zeng
Venetoclax inhibits acute myeloid leukaemia by inhibiting BCL-2 targeting, and a combination regimen with venetoclax has been explored. Although these regimens produce better clinical results, the vast majority of patients still suffer from disease recurrence or primary drug resistance. Metformin has been demonstrated to induce apoptosis in cancer cells. However, whether it can synergize with venetoclax and the underlying mechanisms of metformin-induced apoptosis are not fully understood. In this study, we investigated the effect of metformin and venetoclax on the growth of AML cells in vitro and in vivo...
July 6, 2023: British Journal of Haematology
https://read.qxmd.com/read/37364322/metformin-as-a-booster-of-cancer-immunotherapy
#11
REVIEW
Jutatip Panaampon, Yubin Zhou, Charupong Saengboonmee
Metformin, a biguanide antidiabetic, has been studied for its repurposing effects in oncology. Although a modest effect was observed in a single-agent regimen, metformin can synergize the anti-tumor effects of other modalities. The promising combination for cancer treatment is with immunotherapy. Despite high efficacy for some cancers, immunotherapy could be limited by modulation of the tumor immune microenvironment and the immune exhaustion of cytotoxic immune cells. Combining immunotherapy with metformin, thus, exerted a rescuing effect of immunotherapy and potentiated the anti-tumor effects of each other...
August 2023: International Immunopharmacology
https://read.qxmd.com/read/37305656/targeting-the-adpkd-methylome-using-nanoparticle-mediated-combination-therapy
#12
JOURNAL ARTICLE
Annie Trinh, Yi Huang, Hanjuan Shao, Aparna Ram, Julien Morival, Jonathan Wang, Eun Ji Chung, Timothy L Downing
DNA methylation aberrancies are found in autosomal dominant polycystic kidney disease (ADPKD), which suggests the methylome to be a promising therapeutic target. However, the impact of combining DNA methylation inhibitors (DNMTi) and ADPKD drugs in treating ADPKD and on disease-associated methylation patterns has not been fully explored. To test this, ADPKD drugs, metformin and tolvaptan (MT), were delivered in combination with DNMTi 5-aza-2'-deoxycytidine (Aza) to 2D or 3D cystic Pkd1 heterozygous renal epithelial cells (PKD1-Het cells) as free drugs or within nanoparticles to enable direct delivery for future in vivo applications...
June 2023: APL Bioengineering
https://read.qxmd.com/read/37261532/a-phase-ii-study-of-metformin-plus-pemetrexed-and-carboplatin-in-patients-with-non-squamous-non-small-cell-lung-cancer-metalung
#13
JOURNAL ARTICLE
S Verma, S Chitikela, V Singh, S Khurana, D Pushpam, D Jain, S Kumar, Y Gupta, P S Malik
Immune checkpoint inhibitors (ICIs) ± chemotherapy is the standard treatment for driver mutation-negative non-small cell lung cancer (NSCLC). However, accessibility to ICIs in LMICs is limited due to high cost, and platinum-based chemotherapy remains the mainstay of treatment. Metformin has anticancer properties, and studies suggest synergism between metformin and pemetrexed. Based on preclinical evidence, this combination may be more beneficial for STK11-mutated NSCLC, a subgroup, inherently resistant to ICIs...
June 1, 2023: Medical Oncology
https://read.qxmd.com/read/37147018/metformin-improves-cancer-immunotherapy-by-directly-rescuing-tumor-infiltrating-cd8-t-lymphocytes-from-hypoxia-induced-immunosuppression
#14
JOURNAL ARTICLE
Veronica Finisguerra, Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck, Lionel Mignion, Bernard Gallez, Benoit J Van den Eynde
BACKGROUND: Despite their revolutionary success in cancer treatment over the last decades, immunotherapies encounter limitations in certain tumor types and patients. The efficacy of immunotherapies depends on tumor antigen-specific CD8 T-cell viability and functionality within the immunosuppressive tumor microenvironment, where oxygen levels are often low. Hypoxia can reduce CD8 T-cell fitness in several ways and CD8 T cells are mostly excluded from hypoxic tumor regions. Given the challenges to achieve durable reduction of hypoxia in the clinic, ameliorating CD8 T-cell survival and effector function in hypoxic condition could improve tumor response to immunotherapies...
May 2023: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/37143025/dual-a-1-and-a-2a-adenosine-receptor-antagonists-methoxy-substituted-2-benzylidene-1-indanone-suppresses-intestinal-postprandial-glucose-and-attenuates-hyperglycaemia-in-fructose-streptozotocin-diabetic-rats
#15
JOURNAL ARTICLE
Olakunle Sanni, Gisella Terre'Blanche
BACKGROUND/AIM: Recent research suggests that adenosine receptors (ARs) influence many of the metabolic abnormalities associated with diabetes. A non-xanthine benzylidene indanone derivative 2-(3,4-dihydroxybenzylidene)-4-methoxy-2,3-dihydro-1 H-inden-1-one (2-BI), has shown to exhibit higher affinity at A1 /A2A ARs compared to caffeine. Due to its structural similarity to caffeine, and the established antidiabetic effects of caffeine, the current study was initiated to explore the possible antidiabetic effect of 2-BI...
May 4, 2023: BMC Endocrine Disorders
https://read.qxmd.com/read/37124202/synergistic-interaction-and-activation-of-the-opioid-receptor-no-cgmp-k-channel-pathway-on-peripheral-antinociception-induced-by-the-%C3%AE-bisabolol-diclofenac-combination
#16
JOURNAL ARTICLE
Mario I Ortiz
Introduction: The local peripheral combination of analgesic drugs with herbal derivatives may have beneficial effects. Information on the action mechanism of these interactions between drugs is scarce. Therefore, the main of the present study was to determine the pharmacological interaction and action mechanism of the combination α-Bisabolol and diclofenac. Methods: Rats were injected in the dorsal surface of the right hind paw with 1% formalin. Rats received subcutaneous injections in the dorsal surface of paw of vehicles or increasing doses of α-Bisabolol, diclofenac or their combination before formalin injection into the paw...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37119739/the-ameliorative-effect-of-zinc-acetate-with-caffeic-acid-in-the-animal-model-of-type-2-diabetes
#17
JOURNAL ARTICLE
Godfrey R Matowane, Samson S Mashele, Tshepiso J Makhafola, Chika I Chukwuma
Recently the complexation-mediated antioxidative and glycaemic control synergism between zinc(II) and caffeic acid was demonstrated in vitro. The present study evaluated the complexation-mediated antidiabetic and antioxidative synergism between zinc(II) and caffeic acid in diabetic rats and the possible underlying mechanisms. Male SD rats were induced with diabetes using 10% fructose and 40 mg/kg bw streptozotocin. The diabetic rats were treated with Zn(II)-caffeic acid complex and its precursors (caffeic acid and zinc acetate) for 4 weeks at predetermined doses...
April 27, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/36901764/a-novel-combination-of-sotorasib-and-metformin-enhances-cytotoxicity-and-apoptosis-in-kras-mutated-non-small-cell-lung-cancer-cell-lines-through-mapk-and-p70s6k-inhibition
#18
JOURNAL ARTICLE
Pedro Barrios-Bernal, José Lucio-Lozada, Maritza Ramos-Ramírez, Norma Hernández-Pedro, Oscar Arrieta
Novel inhibitors of KRAS with G12C mutation (sotorasib) have demonstrated short-lasting responses due to resistance mediated by the AKT-mTOR-P70S6K pathway. In this context, metformin is a promising candidate to break this resistance by inhibiting mTOR and P70S6K. Therefore, this project aimed to explore the effects of the combination of sotorasib and metformin on cytotoxicity, apoptosis, and the activity of the MAPK and mTOR pathways. We created dose-effect curves to determine the IC50 concentration of sotorasib, and IC10 of metformin in three lung cancer cell lines; A549 (KRAS G12S), H522 (wild-type KRAS), and H23 (KRAS G12C)...
February 22, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36873273/effect-of-metformin-alone-and-in-combination-with-etoposide-and-epirubicin-on-proliferation-apoptosis-necrosis-and-migration-of-b-cpap-and-sw-cells-as-thyroid-cancer-cell-lines
#19
JOURNAL ARTICLE
Ghazaleh Ghavami, Ramin Ebrahimi Kiasari, Faezeh Pakzad, Soroush Sardari
BACKGROUND AND PURPOSE: There has not been a comprehensive study on the simultaneous effects of metformin, etoposide, and epirubicin on thyroid cancer cells. Hence, the current research proposed the in vitro study on the effect of metformin alone and in combination with etoposide and epirubicin on the rate of proliferation, apoptosis, necrosis, and migration against B-CPAP and SW-1736 cells as thyroid cancer cell lines. EXPERIMENTAL APPROACH: MTT-based proliferation assay, combination index method, flow cytometry, and scratch wound healing assays were used to evaluate the simultaneous effects of the three approved drugs against thyroid cancer cells...
April 2023: Research in Pharmaceutical Sciences
https://read.qxmd.com/read/36703564/co-drug-development-of-gallic-acid-and-metformin-targeting-the-pro-inflammatory%C3%A2-cytokines-for-the-treatment-of-breast-cancer
#20
JOURNAL ARTICLE
Vikas Kumar, Kalicharan Sharma, Richa Sachan, Sultan Alhayyani, Fahd A Al-Abbasi, Richa Singh, Firoz Anwar
It is well-documented that pro-inflammatory cytokines and inflammation play a significant role in the expansion of cancer disease. Gallic acid (GA), a natural compound, and metformin (Met), a synthetic drug exhibit potent anticancer potential via the distinct molecular mechanism. However, whether both these compounds can act synergistically to preclude and treat cancer is still unknown. This prompted us to scrutinize, the synergism between GA and Met, and that of a new co-drug synthesizing of GA and Met (GA-Met) and investigated the chemo-protective effect against breast cancer with possible intervention of cytokines...
April 2023: Journal of Biochemical and Molecular Toxicology
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