Lei Hua, Nianhui Yang, Yue Li, Kexiu Huang, Xinya Jiang, Fangshu Liu, Zhi Yu, Jie Chen, Jing Lai, Juan Du, Hui Zeng
Venetoclax inhibits acute myeloid leukaemia by inhibiting BCL-2 targeting, and a combination regimen with venetoclax has been explored. Although these regimens produce better clinical results, the vast majority of patients still suffer from disease recurrence or primary drug resistance. Metformin has been demonstrated to induce apoptosis in cancer cells. However, whether it can synergize with venetoclax and the underlying mechanisms of metformin-induced apoptosis are not fully understood. In this study, we investigated the effect of metformin and venetoclax on the growth of AML cells in vitro and in vivo...
July 6, 2023: British Journal of Haematology