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METs- metabolic syndrome

Trevor Tapiwa Nyakudya, Simon Isaiah, Ademola Ayeleso, Ashwell Rungano Ndhlala, Emmanuel Mukwevho, Kennedy Honey Erlwanger
Nutritional manipulations in the neonatal period are associated with the development of negative or positive health outcomes later in life. Excessive fructose consumption has been attributed to the increase in the global prevalence of metabolic syndrome (MetS) and the development of oxidative stress. Oleanolic acid (OA) has anti-diabetic and anti-obesity effects. We investigated the protective potential of orally administering OA in the neonatal period, to prevent fructose-induced oxidative stress, adverse health outcomes and maturation of the gastrointestinal tract (GIT) in suckling rats...
February 13, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Hui Wang, Yingjie Yu, Xu Tian
Rising frequency of eating-away-from-home (EAFH) is suspected to be correlated with several non-communicable diseases. This study adopted the Chinese Health and Nutrition Survey (CHNS) 2009 data to investigate the association between being diagnosed with the metabolic syndrome (MetS) and EAFH at different ages. Results showed that the association between EAFH and MetS varied at different ages and differed for males and females. EAFH was positively associated with a higher risk of getting MetS for males, especially for those aged between 45 and 60; while it was negatively associated with the risk of getting MetS for young females (<45) (all p < 0...
February 16, 2019: International Journal of Environmental Research and Public Health
Ying Lian, Qun Yuan, Gangpu Wang, Fang Tang
Sleep quality has been suggested to play an important role in development of metabolic syndrome (MetS). However, the results have been inconsistent. A systematic review of observational studies aimed to evaluate the association between sleep quality and MetS. A comprehensive search was conducted in PubMed and EMBASE. The pooled odd ratios (ORs) were calculated using random effects models. The construction of funnel plot was used to explore publication bias, with further application of Egger's test. 22 studies were included...
February 1, 2019: Psychiatry Research
Shihui Lin, Xi Yue, Hua Wu, Ting-Li Han, Jing Zhu, Chuanjiang Wang, Ming Lei, Mu Zhang, Qiong Liu, Fang Xu
OBJECTIVES: The aim of this study was to analyse the metabolomics of patients with acute respiratory distress syndrome (ARDS) for the identification of metabolic markers with potential diagnostic and prognostic value. METHODS: The enrolled subjects included adult patients with ARDS that met the Berlin definition and healthy controls matched based on age, gender, and body mass index (BMI). Plasma samples were collected from 37 patients with ARDS and 28 healthy controls...
February 16, 2019: Clinical Biochemistry
Yuan-Yuei Chen, Wen-Hui Fang, Chung-Ching Wang, Tung-Wei Kao, Yaw-Wen Chang, Chen-Jung Wu, Yi-Chao Zhou, Yu-Shan Sun, Wei-Liang Chen
Emerging studies have shed light on the association between Helicobacter pylori (HP) infection and cardiometabolic risk. However, there is no evidence to support a causal link for the relationship in the general population. Our aim was to determine whether HP infection is associated with the risks of incident type II diabetes mellitus (DM) in a population-based cohort consisting of adults from the general population. A total of 69235 adults enrolled in the study obtained health examinations at the Tri-Service General Hospital in Taiwan from 2010 to 2016...
2019: PloS One
D Rico, A B Martín-Diana, C Martínez-Villaluenga, L Aguirre, J M Silván, M Dueñas, D A De Luis, A Lasa
The potential bioactivities for alleviating Metabolic Syndrome associated risk factors were evaluated in carob ( Ceratonia siliqua L.) fruit by-products, i.e. seed peel, germ and pod. Carob germ and seed peel showed higher phenolic content than pod (99.72, 80.24 and 47.06 μmol GAE g-1 , respectively). Pod mostly contained gallic acid and gallotannins; seed peel and germ's showed as most abundant polyphenols quercetin and apigenin derivatives. Carob pod and seed peel revealed stronger antioxidant capacities compared to germ...
January 2019: Heliyon
Farideh Mohsenzadeh-Ledari, Ziba Taghizadeh, Zahra Motaghi, Afsaneh Keramat, Mahmood Moosazadeh, Ali Najafi
Metabolic syndrome (MetS), a series of symptoms, including abdominal obesity, impaired glucose tolerance and insulin metabolism, hypertension, and dyslipidemia, is considered as the risk of developing cardiovascular disease and diabetes that can predispose a pregnant women to serious health problem, women in the developed as well as the developing countries. This study was aimed to investigate the effects of appropriate interventions on pregnant women with indicators of MetS to further improve the outcome of pregnancy...
2019: International Journal of Preventive Medicine
Azza Gaber Antar Farag, Eman Ae Badr, Abdel Monem A Eltorgoman, Mohamed Fa Assar, Eman N Elshafey, Nermin Reda Tayel, Hossam Ea Aboutaleb
Background: 11β HSD1 generates cortisol from cortisone. 11β HSD1 single-nucleotide polymorphism (SNP) was associated with metabolic syndrome (MeTS). Although the relation of acne vulgaris (AV) and skin tags (STs) with MeTS has been reported, the relationship between 11β HSD 1 SNP and cortisol activity in those patients has not studied till now. Aims: To investigate, two 11β-HSD1 SNPs (rs846910 and rs12086634), serum lipid profile and cortisol levels in patients with AV and STs in an Egyptian population...
2019: Clinical, Cosmetic and Investigational Dermatology
Ah Reum Khang, Hye Won Lee, Dongwon Yi, Yang Ho Kang, Seok Man Son
Purpose: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and it is the hepatic manifestation of metabolic syndrome (MetS). We aimed to estimate the prevalence of NAFLD defined by the fatty liver index (FLI), in order to investigate the association between FLI and metabolic disorders and to determine the cutoff value of FLI to screen for MetS. Subjects and methods: This study utilized a national representative sample of Korean adults (the Korean National Health and Nutrition Examination Surveys) which was conducted in 2010-2011...
2019: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Xiaoli Guo, Qiaoyun Yang, Wei Zhang, Yujiao Chen, Jing Ren, Ai Gao
Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the mechanism underlying this effect are poorly understood. A preliminary cross-sectional study was conducted in 2015. Significantly higher blood concentrations of lead (Pb), cadmium (Cd), copper (Cu), and selenium (Se) were observed in the MetS group. With a priori adjustment for age, the concentration of Cu and Se in the blood was associated with a 2.56 - fold [95% confidence interval (CI), 1...
February 6, 2019: Environmental Pollution
Li Qi, Yu Tian, Yongsheng Chen
It is commonly held that the gallbladder (GB) is not indispensable for life. However, recent studies strongly suggest that GB removal can lead to the development of metabolic syndrome (MetS). With the recent recognition of the role of bile acids (BAs) in systemic metabolic regulation, it is worthwhile to re-examine the function of the GB, which can be regarded as the physiological 'pacemaker' of BA flow. Thus in the present study, we review the role of the GB in BA flow regulation, describe the epidemiologic evidence that associates cholecystectomy with various components of MetS, and discuss the possible mechanism behind these connections, in order to demonstrate the pivotal role that GB plays in metabolic regulation...
February 15, 2019: Diabetes/metabolism Research and Reviews
Ye Bi, Ji-Lan Wang, Ming-Long Li, Jie Zhou, Xiang-Lan Sun
OBJECTIVES: Pancreas steatosis is the description of fat accumulation in the pancreatic gland. The prevalence and development mechanisms of pancreatic steatosis in patients with metabolic disorders still remain unclear. The aim of this study is to systematically review the association between pancreatic steatosis and metabolic co-morbidities. METHODS: We performed a systematic search strategy using three electronic databases (MEDLINE, Scopus, and Embase) for relevant studies concerning the associations of pancreatic steatosis with metabolic syndrome (MetS) and its clinical relevance from inception until September 30, 2018...
February 14, 2019: Diabetes/metabolism Research and Reviews
Maureen Jepkorir Cheserek, Yonghui Shi, Guowei Le
Background: The relationship between metabolic syndrome (MetS) and hyperuricemia is not fully understood. Objective: To examine the association of hyperuricemia with MetS and the component of MetS that is mostly influenced by hyperuricemia among university workers. Methods: Anthropometric measurements, blood pressure, glucose, lipid profiles, renal function tests were measured in 1198 male and 1075 female (22-60 years old) workers on annual medical examination...
December 2018: African Health Sciences
Hongmei Li, Qiu Zhang, Yan He, Jijun Shi, Weidong Hu, Hao Peng
Soluble corin has been associated with cardiovascular disease and its risk factors, but whether it is associated with metabolic syndrome (MetS), a cluster of cardiometabolic disorders, remains unclear. We aimed to examine the association between soluble corin and MetS in Chinese men and women. We examined serum soluble corin using immunoassays in 962 men (mean age, 53 years) and 1536 women (mean age, 54 years) free of cardiovascular disease. Logistic regression was applied to examine the association between soluble corin and MetS in men and women...
February 14, 2019: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Wenzhen Li, Dongming Wang, Xiaojun Wang, Yanhong Gong, Shiyi Cao, Xiaoxv Yin, Xianbo Zhuang, Wenhuan Shi, Zhihong Wang, Zuxun Lu
BACKGROUND: The metabolic syndrome (MetS) is related with cardiovascular disease. However, its relationship with diabetes mellitus (DM) has not been examined in Chinese population with a larger sample. We aimed to assess the relationship between metabolic syndrome (MetS) and its components, and DM, and to determine the best one from the available definitions of Mets when assessing the risk of DM. METHODS: This was a cross-sectional survey in a nationally representative sample of 109,551 Chinese adults aged ≥40 years in 2014-15...
February 14, 2019: BMC Public Health
Yen-Ting Chen, Ping-Huei Tseng, Fen-Yu Tseng, Yu-Chiao Chi, Der-Sheng Han, Wei-Shiung Yang
Spot 14 (S14) protein is primarily expressed in adipogenic tissues. Compared to wild type, S14 knockout mice had better resistance to diet-induced obesity and glucose tolerance. However, the association between serum S14 level and metabolic variables in humans has never been investigated. The objectives of this study were to evaluate the associations between serum S14 concentrations with components of metabolic syndrome (MetS). A total of 327 subjects were recruited in this cross-sectional study and categorized by presence of MetS...
2019: PloS One
Jeffrey I Mechanick, Alan J Garber, George Grunberger, Yehuda Handelsman, W Timothy Garvey
The American Association of Clinical Endocrinologists (AACE) has created a dysglycemia-based chronic disease (DBCD) multimorbidity care model consisting of four distinct stages along the insulin resistance-prediabetes-type 2 diabetes (T2D) spectrum that are actionable in a preventive care paradigm to reduce the potential impact of T2D, cardiometabolic risk, and cardiovascular events. The controversy of whether there is value, cost-effectiveness, or clinical benefit of diagnosing and/or managing the prediabetes state is resolved by regarding the problem, not in isolation, but as an intermediate stage in the continuum of a progressive chronic disease with opportunities for multiple concurrent prevention strategies...
November 2018: Endocrine Practice
Hyun Ji Kim, Heon Lee, Bora Lee, Jae Wook Lee, Kyung Eun Shin, Jon Suh, Hyun Woo Park, Jeong A Kim
There has been a marked increase in the use of low-dose computed tomography (LDCT) for lung cancer screening. However, the potential of LDCT to predict metabolic syndrome (MetS) has not been well-documented in this risk-sharing population. We assessed the reliability of epicardial fat volume (EFV) and epicardial fat area (EFA) measurements on chest LDCT for prediction of MetS.A total of 130 (mean age, 50.2 ± 10.77 years) asymptomatic male who underwent nonelectrocardiography (ECG)-gated LDCT were divided into 2 groups for the main analysis (n = 75) and validation (n = 55)...
February 2019: Medicine (Baltimore)
Selma Korkmaz, Gülben Sayılan Özgün
Background/aim: Adropin is a peptide-structure hormone that plays a role in preventing the development of insulin resistance, which has been linked to obesity and metabolic regulation. The purpose of this study is to assess serum adropin levels and their relationship with metabolic parameters in psoriasis vulgaris patients both with and without metabolic syndrome (MetS). Materials and methods: Fifty-three patients and 26 healthy controls were included in this study...
February 11, 2019: Turkish Journal of Medical Sciences
Ashti Morovati, Bahram Pourghassem Gargari, Parvin Sarbakhsh, Hushyar Azari, Lida Lotfi-Dizaji
Metabolic syndrome (MetS) is a cluster of interconnected serious disorders, which is a major health problem whose prevalence is increasing. Oxidative stress and inflammation contribute to the disease pathogenesis and its complications. The present study aimed to investigate the effect of Cuminum cyminum L. (which has antioxidant and anti-inflammatory properties) essential oil (CuEO) supplementation on inflammatory and antioxidant status in patients with MetS. In this clinical trial, 56 patients with MetS aged 18-60 years received either 75-mg CuEO or placebo soft gel, thrice daily, for 8 weeks...
February 14, 2019: Phytotherapy Research: PTR
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