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GI intervention

Dejan Micic, John N Gaetano, Neha Nigam, Matthew Peller, Vijaya L Rao, Carol Semrad, Adam C Stein, Sonia S Kupfer
INTRODUCTION: A small bowel source is suspected when evaluation of overt gastrointestinal (GI) bleeding with upper and lower endoscopy is negative. Video capsule endoscopy (VCE) is the recommended next diagnostic test for small bowel bleeding sources. However, clinical or endoscopic predictive factors for small bowel bleeding in the setting of an overt bleeding presentation are unknown. We aimed to define predictive factors for positive VCE among individuals presenting with overt bleeding and a suspected small bowel source...
2019: PloS One
Deise Cristina Oliva Caramico-Favero, Zelita Caldeira Ferreira Guedes, Mauro Batista de Morais
BACKGROUND: Cerebral palsy may be associated with comorbidities such as undernutrition, impaired growth and gastrointestinal symptoms. Children with cerebral palsy exhibit eating problems due to the effect on the anatomical and functional structures involved in the eating function resulting in malnutrition. OBJECTIVE: The aim of this study was to investigate the association between food intake, nutritional status and gastrointestinal symptoms in children with cerebral palsy...
October 2018: Arquivos de Gastroenterologia
Chiara Giulia Fontanella, Claudia Salmaso, Ilaria Toniolo, Niccolò de Cesare, Alessandro Rubini, Giulia Maria De Benedictis, Emanuele Luigi Carniel
Bariatric surgery is performed on obese people aiming at reducing the capacity of the stomach and/or the absorbing capability of the gastrointestinal tract. A more reliable and effective approach to bariatric surgery may integrate different expertise, in the areas of surgery, physiology and biomechanics, availing of a strong cooperation between clinicians and engineers. This work aimed at developing a computational model of the stomach, as a computational tool for the physio-mechanical investigation of stomach functionality and the planning of bariatric procedures...
February 19, 2019: Annals of Biomedical Engineering
Rosalie H Bartels, Emmanuel Chimwezi, Victoria Watson, Leilei Pei, Isabel Potani, Benjamin Allubha, Kate Chidzalo, Duolao Wang, Queen Dube, Macpherson Mallewa, Angela Allen, Robert H J Bandsma, Wieger P Voskuijl, Stephen J Allen
Intestinal pathology in children with complicated severe acute malnutrition (SAM) persists despite standard management. Given the similarity with intestinal pathology in non-IgE mediated gastrointestinal food allergy and Crohn's disease, we tested whether therapeutic feeds effective in treating these conditions may benefit children with complicated SAM. After initial clinical stabilisation, 95 children aged 6-23 months admitted at Queen Elizabeth Central Hospital, Blantyre, Malawi between January 1st and December 31st , 2016 were allocated randomly to either standard feeds, an elemental feed or a polymeric feed for 14 days...
February 19, 2019: Scientific Reports
Suseela Somarajan, Nicole D Muszynski, Joseph D Olson, Leonard A Bradshaw, William O Richards
BACKGROUND: Acute mesenteric ischemia represents a life-threatening gastrointestinal condition. A noninvasive diagnostic modality that identifies mesenteric ischemia patients early in the disease process will enable early surgical intervention. Previous studies have identified significant changes in the small-bowel electrical slow-wave parameters during intestinal ischemia caused by total occlusion of the superior mesenteric artery. The purpose of this study was to use noninvasive biomagnetic techniques to assess functional physiological changes in intestinal slow waves in response to partial mesenteric ischemia...
February 20, 2019: Journal of Surgical Research
Premal A Patel, Kishore Minhas, Jestine Ang, Sam Stuart, Paolo De Coppi, Ralph Gnannt
Paediatric interventional radiology is an evolving speciality which is able to offer numerous minimally invasive treatments for gastrointestinal tract pathologies. Here we describe interventions performed by paediatric interventional radiologists on the alimentary tract from the mouth to the rectum. The interventions include sclerotherapy, stricture management by dilation, stenting and adjunctive therapies such as Mitomycin C administration and enteral access for feeding, motility assessment and administration of enemas...
March 2019: European Journal of Radiology
Elena Goleva, Evgeny Berdyshev, Donald Ym Leung
Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). This Review describes the formation of the skin barrier and analyzes the link between altered skin barrier formation and the pathogenesis of AD...
February 18, 2019: Journal of Clinical Investigation
Kashif Mukhtar, Hasham Nawaz, Shahab Abid
Despite their high prevalence, lack of understanding of the exact pathophysiology of the functional gastrointestinal disorders has restricted us to symptomatic diagnostic tools and therapies. Complex mechanisms underlying the disturbances in the bidirectional communication between the gastrointestinal tract and the brain have a vital role in the pathogenesis and are key to our understanding of the disease phenomenon. Although we have come a long way in our understanding of these complex disorders with the help of studies on animals especially rodents, there need to be more studies in humans, especially to identify the therapeutic targets...
February 7, 2019: World Journal of Gastroenterology: WJG
Wen-Yan Wang, Feng-Xia Liang, Ai-Qun Song, Qi Huang, Rui Chen
Large number of microflora is parasitized in the human intestinal tract, which maintains the stability of the microecological environment in the host's intestinal tract and the healthy state of the body. Once the steady state is out of balance, the intestinal microflora is dysfunctional and a variety of diseases will be induced. Acupuncture and moxibustion have a positive role in improving different types of clinical problems by regulating qi , harmonizing yin and yang , and strengthening the body's resistance...
January 25, 2019: Zhen Ci Yan Jiu, Acupuncture Research
Heather Cleveland, Sheena Pimpalwar, Daniel Ashton, Alex Chau, Aaditya Nagaraj, J Alberto Hernandez
PURPOSE: To evaluate technical and clinical success and report long-term outcomes of portal vein (PV) recanalization in pediatric orthotopic liver transplant (OLT) patients with chronic PV occlusion. MATERIALS AND METHODS: This is a retrospective review of 15 OLT patients (5 males) with chronic PV occlusion who underwent PV recanalization (33 procedures) between October 2011 and February 2018. Median age was 4.5 years (range, 1-16 years); median weight was 16.6 kg (range, 11...
February 14, 2019: Journal of Vascular and Interventional Radiology: JVIR
Li Ge, Rena C Moon, Ha Nguyen, Luiz Gustavo de Quadros, Andre F Teixeira, Muhammad A Jawad
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is the preferred surgical intervention to treat morbid obesity. Despite the rising popularity of LSG, little is known on the histopathologic findings of the resected partial stomach specimens. Our study aims to identify prevalent pathologic findings of the removed stomach and explore the association between patient characteristics and abnormal findings. METHODS: A retrospective analysis was conducted using a prospectively maintained database of 649 patients who underwent LSG between November 1, 2013 and December 31, 2015 at our institution...
February 15, 2019: Surgical Endoscopy
César Ramírez-Cáceres, Estrella Uzcátegui-Paz, Ricardo Lozano-Hernández
Introduction: Peroperative treatment has required multimodal protocols that stimulate patient evolution and shorten hospital stay. Objective: Identify the type of pathology, intervention performed and evaluate the effectiveness of the Rapid Postoperative Improvement Protocol (RAMPO) in patients undergoing elective gastrointestinal surgery. Method: A total of 122 patients were evaluated, a group of 61 patients received the RAMPO protocol and the other group of equal number of patients were treated with traditional protocols (Controls)...
2019: Cirugia y Cirujanos
Amey D Sonavane, Deepak N Amarapurkar, Krantikumar R Rathod, Sundeep J Punamiya
Background: There has been significant improvement in understanding the etiology and management of Budd-Chiari Syndrome (BCS). Patients with chronic or acute-on-chronic BCS need radiological interventions in the form of angioplasty, hepatic vein/inferior vena cava stenting or Transjugular Intrahepatic Portosystemic Shunt (TIPS). Data regarding the long term follow up of patients undergoing TIPS is limited. We thus prospectively followed-up BCS patients who underwent TIPS at our center...
January 2019: Journal of Clinical and Experimental Hepatology
Xianping Li, Liqiong Song, Siyi Zhu, Yuchun Xiao, Yuanming Huang, Yuting Hua, Qiongfang Chu, Zhihong Ren
Vancomycin-resistant Enterococcus (VRE) infection is a serious challenge for clinical management and there is no effective treatment at present. Fecal microbiota transplantation (FMT) and probiotic intervention have been shown to be promising approaches for reducing the colonization of certain pathogenic bacteria in the gastrointestinal tract, however, no such studies have been done on VRE. In this study, we evaluated the effect of FMT and two Lactobacillus strains (Y74 and HT121) on the colonization of VRE in a VRE-infection mouse model...
2019: Frontiers in Cellular and Infection Microbiology
Caroline J K Wallace, Jane A Foster, Claudio N Soares, Roumen V Milev
BACKGROUND: A growing body of evidence has linked mental health outcomes to the gut microbiome. This has led to the investigation of the GI tract as a target for novel treatments and interventions for depression, including probiotic supplementation. Our recent pilot study provided the first evidence of probiotics improving symptoms of depression in treatment-naive depressed patients. To further support and expand upon this evidence, data from the pilot study were used to plan a 16-week, double-blind, randomized, placebo-controlled trial to assess the effects of probiotics on depression...
February 13, 2019: Neuropsychobiology
Chih-Jen Huang, Ming-Yii Huang, Pen-Tzu Fang, Frank Chen, Yu-Tsang Wang, Chung-Ho Chen, Shyng-Shiou Yuan, Chun-Ming Huang, Kuei-Hau Luo, Hung-Yi Chuang, Yen-Yun Wang, Hsin-Hua Lee
Background: Glutamine is the primary fuel for the gastrointestinal epithelium and maintains the mucosal structure. Oncologists frequently encounter oral mucositis, which can cause unplanned breaks in radiotherapy (RT). Objectives: The aim of this study was to explore the association between oral glutamine and acute toxicities in patients with head and neck cancer undergoing RT. Methods: This was a parallel, double-blind, randomized, placebo-controlled Phase III trial conducted in a university hospital...
February 9, 2019: American Journal of Clinical Nutrition
Ali Hasanpour-Dehkordi, Kamal Solati, Shahriar Salehi Tali, Mohamad Ali Dayani
INTRODUCTION: surgery is a stressful experience for patients and most surgical patients have some degree of anxiety. The purpose of this study was to investigate the effect of a relaxation technique in addition to narcotic analgesic on health promotion in surgical patients. METHODS: in this clinical trial, 70 patients who were candidates for elective upper and lower gastrointestinal system surgery were selected. They were randomly divided into two groups: case (morphine 0...
February 14, 2019: British Journal of Nursing: BJN
Chien-Ho Lee, Tzu-Hsien Tsai, Cheng-Jui Lin, Shu-Kai Hsueh, Wen-Jung Chung, Cheng-I Cheng
OBJECTIVE: This study investigated the efficacy and safety of ticagrelor compared with clopidogrel in patients with end-stage renal disease (ESRD) and acute myocardial infarction (AMI). METHODS: We retrospectively enrolled patients who had received regular dialysis and had undergone percutaneous coronary intervention (PCI) for AMI at our hospital between January 2013 and December 2016. Outcomes analyzed included cardiovascular death, death from any cause, MI, stroke, and bleeding events...
February 12, 2019: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
Cátia Reis, Sara Dias, Ana Maria Rodrigues, Rute Dinis Sousa, Maria João Gregório, Jaime Branco, Helena Canhão, Teresa Paiva
Background: Adequate sleep is essential for health. Both, short and long sleep durations are associated to worse quality of life and poor health outcomes. Portugal represents a specific population model, since according to European statistics it has high rates of chronic diseases like depression, hypertension, diabetes and stroke; and low quality of life as well as low index of physical activity, while in parallel it has some other good health indicators such as: low age-standardized mortality for both genders, nutrition in terms of energy and fruit consumption, smoking and alcohol, obesity and overweight prevalence...
July 2018: Sleep Science
Kelsey Carter Stoker
PURPOSE: No national policies or clinical practice guidelines have been identified regarding best practices in addressing postoperative pain after abdominal surgery with adjunctive nonpharmacologic therapies, such as abdominal binders. DESIGN: Integrative review. METHODS: An integrative review was conducted using Cochrane, PubMed, Medline, and Cumulative Index to Nursing and Allied Health Literature databases, collecting articles published within the last 5 years regarding abdominal binder use after adult gastrointestinal surgeries...
February 7, 2019: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
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