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Yicun Yao, Dongping Ye, Weiguo Liang, Haixiong Miao, Jinfeng Wu, Ziqiang Zhou
Objective: To evaluate the effectiveness of Coflex interspinous dynamic internal fixation combined with spinal fusion for lumbar disc degeneration. Methods: The clinical data of 39 patients with two-level lumbar disc degeneration who met the selection criteria between June 2010 and December 2011 was retrospectively analyzed. They were divided into group A (20 cases, simple lumbar decompression and fusion) and group B (19 cases, Coflex interspinous dynamic internal fixation combined with spinal fusion) according to different surgical methods...
March 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
Mauro Santos, Margarida Matos, Sheng Pei Wang, David M Althoff
Wang and Althoff (2019) explored the capacity of Drosophila melanogaster to exhibit adaptive plasticity in a novel environment. In a full-sib, half-sib design, they scored the activity of the enzyme alcohol dehydrogenase (ADH) and plastic responses, measured as changes in ADH activity across ethanol concentrations in the range of 0-10% (natural variation) and 16% (the novel environment). ADH activity increased with alcohol concentration, and there was a positive association between larval viability and ADH activity in the novel environment...
March 15, 2019: Evolution; International Journal of Organic Evolution
Kun Han, Yanting Zhang, Zhenwei Yang
Alcohol abuse and chronic alcohol consumption are major causes of alcoholic liver disease worldwide, particularly alcohol-induced hepatic fibrosis (AHF). Liver fibrosis is an important public health concern because of its high morbidity and mortality. The present study examined the mechanisms and effects of the phosphodiesterase III inhibitor cilostazol on AHF. Rats received alcohol infusions via gavage to induce liver fibrosis and were treated with colchicine (positive control) or cilostazol. The serum alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities and the albumin/globulin (A/G), enzymes and hyaluronic acid (HA), type III precollagen (PC III), laminin (LA), and type IV collagen (IV-C) levels were measured using commercially available kits...
March 2019: Experimental and Therapeutic Medicine
(no author information available yet)
No abstract text is available yet for this article.
March 2019: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
Liem T Bui, Giacomo Novi, Lara Lombardi, Cristina Iannuzzi, Jacopo Rossi, Antonietta Santaniello, Anna Mensuali, Françoise Corbineau, Beatrice Giuntoli, Pierdomenico Perata, Mirko Zaffagnini, Francesco Licausi
Ethanol fermentation is considered as one of the main metabolic adaptations to ensure energy production in higher plants under anaerobic conditions. Following this pathway, pyruvate is decarboxylated and reduced to ethanol with the concomitant oxidation of NADH to NAD+. Despite its acknowledgement as an essential metabolic strategy, the conservation of this pathway and its regulation throughout plant evolution have not been assessed so far. To address this question, we compared ethanol fermentation in species representing subsequent steps in plant evolution and related it to the structural features and transcriptional regulation of the two enzymes involved: pyruvate decarboxylase (PDC) and alcohol dehydrogenase (ADH)...
February 28, 2019: Journal of Experimental Botany
Richard Ha, Simukayi Mutasa, Eduardo Pascual Van Sant, Jenika Karcich, Christine Chin, Michael Z Liu, Sachin Jambawalikar
OBJECTIVE: The purpose of this study was to test the hypothesis that convolutional neural networks can be used to predict which patients with pure atypical ductal hyperplasia (ADH) may be safely monitored rather than undergo surgery. MATERIALS AND METHODS: A total of 298 unique images from 149 patients were used for our convolutional neural network algorithm. A total of 134 images from 67 patients with ADH that had been diagnosed by stereotactic-guided biopsy of calcifications but had not been upgraded to ductal carcinoma in situ or invasive cancer at the time of surgical excision...
March 12, 2019: AJR. American Journal of Roentgenology
Jiajia Dai, Ao Chen, Meilin Zhu, Xin Qi, Wei Tang, Ming Liu, Dehai Li, Qianqun Gu, Jing Li
The goal of this study is to explore the mechanism of a heat shock protein 90 (Hsp90) C-terminal inhibitor, Penicisulfuranol A (PEN-A), for cancer therapy. Penicisulfuranol A (PEN-A) was produced by a mangrove endophytic fungus Penicillium janthinellum and had a new structure with a rare 3H-spiro [benzofuran-2, 2'-piperazine] ring system. PEN-A caused depletion of multiple Hsp90 client proteins without induction of heat shock protein 70 (Hsp70). Subsequently, it induced apoptosis and inhibited xerograph tumor growth of HCT116 cells in vitro and in vivo...
March 8, 2019: Biochemical Pharmacology
De-Lin Pan, Gang Wang, Tao Wang, Zhan-Hui Jia, Zhong-Ren Guo, Ji-Yu Zhang
APETALA2/ethylene-responsive factor superfamily (AP2/ERF) is a transcription factor involved in abiotic stresses, for instance, cold, drought, and low oxygen. In this study, a novel ethylene-responsive transcription factor named AdRAP2.3 was isolated from Actinidia deliciosa 'Jinkui'. AdRAP2.3 transcription levels in other reproductive organs except for the pistil were higher than those in the vegetative organs (root, stem, and leaf) in kiwi fruit. Plant hormones (Salicylic acid (SA), Methyl-jasmonate acid (MeJA), 1-Aminocyclopropanecarboxylic Acid (ACC), Abscisic acid (ABA)), abiotic stresses (waterlogging, heat, 4 °C and NaCl) and biotic stress ( Pseudomonas Syringae pv...
March 8, 2019: International Journal of Molecular Sciences
Jennifer D Robison, Yuji Yamasaki, Stephen K Randall
During cold stress, soybean CBF/DREB1 transcript levels increase rapidly; however, expected downstream targets appear unresponsive. Here, we asked whether the ethylene signaling pathway, which is enhanced in the cold can negatively regulate the soybean CBF/DREB1 cold responsive pathway; thus contributing to the relatively poor cold tolerance of soybean. Inhibition of the ethylene signaling pathway resulted in a significant increase in GmDREB1A;1 and GmDREB1A;2 transcripts, while stimulation led to decreased GmDREB1A;1 and GmDREB1B;1 transcripts...
2019: Frontiers in Plant Science
Wei Wenguang, Zhang Huifang, Wu Guiwen, Yang Zhentie, Han Rui
.This study was designed to investigate the curative effect of traditional Chinese medicine Zhiyi decoction combined with acupuncture in the treatment of enuresis and its influence on serum ADH and inflammatory factors. A total of 84 enuresis patients treated were selected as cases from September 2014 to January 2017, randomly divided into study and control group with 42 cases each. The control group was treated with traditional Chinese medicine Zhiyi decoction while the study group was treated with traditional Chinese medicine Zhiyi decoction combined with acupuncture...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Qian Ren, Zhenguo Liang, Xin Jiang, Ping Gong, Lihua Zhou, Zhihong Sun, Jingjing Xiang, Zhen Xu, Xinghua Peng, Sanpeng Li, Wenjun Li, Lintao Cai, Jiaoning Tang
Hyaluronic acid (HA) is a natural biopolymer that can target to tumor cells due to CD44 receptors overexpressed in tumor cells. Here, a theranostic nanoparticle HA-Ce6 (DOX) with enzyme and pH dual-responsive is presented, which combined HA and a highly promised photosensitizer chlorin e6 (Ce6) using adipic dihydrazide (ADH) as a linker. The hydrazide group on its surface can efficiently conjugate doxorubicin to form HA-Ce6 (DOX) nanoparticles through the pH-sensitive hydrazone bond. In this study, the dual-response of HA-Ce6 (DOX) nanoparticles in the tumor cell are discussed...
March 4, 2019: International Journal of Biological Macromolecules
Tanjina Kader, Prue Hill, Magnus Zethoven, David L Goode, Kenneth Elder, Niko Thio, Maria Doyle, Timothy Semple, Wajiha Sufyan, David J Byrne, Jia-Min B Pang, Anand Murugasu, Islam M Miligy, Andrew R Green, Emad A Rakha, Stephen B Fox, G Bruce Mann, Ian G Campbell, Kylie L Gorringe
The current model for breast cancer progression proposes independent "low-grade (LG) like" and "high-grade (HG) like" pathways but lacks a known precursor to HG cancer. We applied low coverage whole genome sequencing to atypical ductal hyperplasia (ADH) with and without carcinoma to shed light on breast cancer progression. 14/20 isolated ADH cases harboured at least one copy number alteration (CNA), but had fewer aberrations than LG or HG ductal carcinoma in situ (DCIS). ADH carried more HG-like CNA than LG DCIS (eg...
March 6, 2019: Journal of Pathology
Masato Tamura, Tsubasa Sekiguchi, Shun-Ichi Ishiuchi, Anne Zehnacker-Rentien, Masaaki Fujii
Chirality plays an essential role in biological molecular recognition such as neurotransmission. Here, we apply electrospray - cold ion trap spectroscopy to complexes of a partial binding motif SIVSF of β2 -adrenergic receptor pocket with L- and D-epinephrine AdH+ . The UV spectrum of the SIVSF-AdH+ complex is changed drastically when L-AdH+ is replaced by its enantiomer. The isomer-selected IR spectra reveal that D-AdH+ is bound to SIVSF by its protonated amino-group or a single catechol OH, and induces non-helical secondary structures of SIVSF...
March 6, 2019: Journal of Physical Chemistry Letters
Ihsan Ullah, Bassam Oudh Al-Johny, Khalid M S Al-Ghamdi, Hind A A Al-Zahrani, Yasir Anwar, Ahmad Firoz, Naser Al-Kenani, Mohammed Ali Ahmed Almatry
Cadmium (Cd) is a toxic heavy metal and an abiotic stressor to plants; however, inoculation of endophytic bacteria can raise resistance in plants against Cd, as well as improve plant growth. In the present study, two endophytic bacterial strains were isolated from Solanum nigrum, identified as Serratia sp. IU01 and Enterobacter sp. IU02 by 16S DNA sequencing. Both IU01 and IU02 were tolerant up to 9.0 mM of Cd in culture broth and successive increase in Cd concentration from 0 mM to 9.0 mM, led to an increase in the SOD enzyme activity of the isolates...
February 28, 2019: Ecotoxicology and Environmental Safety
Jeong-Hoon Park, Do-Hyung Kim, Han-Shin Kim, George F Wells, Hee-Deung Park
In this work, the effects of granular activated carbon (GAC) supplementation on hydrogen fermentation were investigated in Clostridium butyricum. Maximum hydrogen production rate and ultimate hydrogen volume increased up to 1.7 and 1.9 fold, respectively, with 1 g/L GAC supplementation. Indicators of stable hydrogen production, such as acetate and butyrate formation increased with increasing GAC concentration. To identify the factors for hydrogen production enhancement, transcriptome analysis was conducted...
February 25, 2019: Bioresource Technology
Debabrata Maity, Sunil Kumar, Francesca Curreli, Asim Debnath, Andrew Hamilton
An oligopyridylamide-based foldamer approach has been employed to target HIV TAR RNA-TAT assembly as a model system to study RNA-protein interactions. The oligopyridylamide scaffold adopts a constrained conformation which presents surface functionalities at distinct spatial locations and mimic the chemical features of the secondary structure of proteins. We have designed a library of oligopyridylamides containing diverse surface functionalities which mimic the side chain residues of the TAT protein domain. The interaction of TAR RNA and TAT plays a pivotal role in facilitating HIV replication...
March 1, 2019: Chemistry: a European Journal
Adnan Ali Thabit, Tawfik Al-Khatib, Wagdi Hazaea Mohammed Hail, Ahmed Al-Soofi, Najib Abdulaziz Abdullah Thabit, Jamal Boather, Abdulkgabbar Abdullah, Rebecca Mann Flueckiger, Alexandre L Pavluck, Rebecca Willis, Paul Courtright, Colin K Macleod, Anthony W Solomon
PURPOSE: In suspected trachoma-endemic areas of Yemen, we sought to determine the prevalence of the sign trachomatous inflammation-follicular (TF) in children aged 1-9 years, and the potential individual and household risk factors for TF in that age group. We also sought to determine the prevalence of trichiasis in adults aged ≥15 years. METHODS: We conducted a cluster-sampled survey in each of 42 evaluation units (EUs) comprising 166 rural districts of nine Governorates (Adh Dhale'a, Al Hodeihah, Al Jawf, Hadramoot, Hajjah, Ibb, Lahj, Ma'rib, Taiz) using the Global Trachoma Mapping Project systems and methodologies...
December 2018: Ophthalmic Epidemiology
Yong-Soo Park, Jisu Kang, Won-Hyong Chung, Mi Young Lim, Myung-Ji Seo, Young-Do Nam, Jung-Hoon Yoon, Dong-Ho Seo
Acetate is an important metabolite in infants as it can affect metabolism as well as immune and inflammatory responses. However, there have been no studies on acetate production by Klebsiella pneumoniae isolated from infant feces. In this study, we isolated a K. pneumoniae strain, L5-2, from infant feces, and we found it produces acetate. The genome of L5-2 consisted of a 5,237,123-bp single chromosome and a 139,211-bp single plasmid. The G + C content was 57.27%. By whole-genome analysis of K. pneumoniae L5-2, we identified seven genes related to acetate production ( poxA, pta, eutD, ackA, eutP, eutQ , and adhE )...
March 2019: 3 Biotech
Heike Römermann, Diethelm Johannsmann
A suitable balance of convective and diffusive transport of small molecules contained in the liquid phase of a drying latex film leads to auto-stratification and to functionally graded films. Differing from blends of latex particles, which may also experience drying-induced segregation, small molecules retain their mobility after the particles have touched and have formed an elastically coupled network. The use of a thickener, which turns the dispersion into a weak gel and prevents the free flow of particles, is compatible with this approach (and even advantageous)...
February 21, 2019: European Physical Journal. E, Soft Matter
Mohamed Ismail, Lea Schroeder, Marcel Frese, Tilman Kottke, Frank Hollmann, Caroline E Paul, Norbert Sewald
Flavin-dependent halogenases are known to regioselectively introduce halide substituents into aromatic moieties, for example, the indole ring of tryptophan. The process requires halide salts and oxygen instead of molecular halogen in the chemical halogenation. However, the reduced cofactor flavin adenine dinucleotide (FADH2 ) has to be regenerated using a flavin reductase. Consequently, coupled biocatalytic steps are usually applied for cofactor regeneration. Nicotinamide adenine dinucleotide (NADH) mimics can be employed stoichiometrically to replace enzymatic cofactor regeneration in biocatalytic halogenation...
February 1, 2019: ACS Catalysis
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