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https://read.qxmd.com/read/30879162/negative-impact-of-proteinuria-on-circulating-myeloid-dendritic-cells
#1
Masato Ikeda, Risa Terashima, Taku Yamada, Masahiro Suyama, Shinya Yokote, Masatsugu Nakao, Izumi Yamamoto, Keita Hirano, Hideo Okonogi, Hiroyasu Yamamoto, Takashi Yokoo
BACKGROUND: A decrease in absolute numbers (abs.) of circulating dendritic cells (DCs) and recruitment into target organs has been reported, but whether the level of proteinuria associates with circulating DC abs. has not been clarified. METHODS: We conducted a cross-sectional study of 210 patients with kidney disease aged 21-96 years who were admitted to our hospital for kidney biopsy in 2007-2010. For accuracy, the level of proteinuria was thoroughly measured by 24-h urine collection from patients in their admitted condition...
March 16, 2019: Clinical and Experimental Nephrology
https://read.qxmd.com/read/30879101/urethral-diverticulum-in-pregnancy-a-case-report
#2
Frida M Carswell
INTRODUCTION AND HYPOTHESIS: Urethral diverticulum in pregnancy is a rare finding and difficult to diagnose. The classical triad of dysuria, dyspareunia and dribbling of urine is found in a minority of women. METHODS: A young woman presented during the first trimester of pregnancy with vaginal and suprapubic pain as well as voiding difficulty. Ultrasound demonstrated a 2-cm hypoechoic lesion to the left of the urethra. She went on to have a cystoscopy that demonstrated a diverticulum...
March 16, 2019: International Urogynecology Journal
https://read.qxmd.com/read/30878999/rationale-for-raising-current-clinical-practice-guideline-target-for-serum-25-hydroxyvitamin-d-in-chronic-kidney-disease
#3
Stephen A Strugnell, Stuart M Sprague, Akhtar Ashfaq, Martin Petkovich, Charles W Bishop
BACKGROUND: Vitamin D repletion is recommended for secondary hyperparathyroidism (SHPT) and associated vitamin D insufficiency (VDI) in chronic kidney disease (CKD), but optimal levels of serum total 25-hydroxyvitamin D remain undefined. Clinical practice guidelines target sufficiency, whereas recent data indicate that higher levels are required to control the elevation of intact parathyroid hormone (iPTH) as CKD advances. This secondary analysis of 2 randomized controlled trials seeks to identify the minimum level of mean serum 25-hydroxyvitamin D required to control SHPT arising from VDI in stage 3 or 4 CKD...
March 15, 2019: American Journal of Nephrology
https://read.qxmd.com/read/30878738/profiles-variability-and-predictors-of-concentrations-of-blood-trihalomethanes-and-urinary-haloacetic-acids-along-pregnancy-among-1760-chinese-women
#4
Yi-Xin Wang, Chong Liu, Ying-Jun Chen, Peng Duan, Qi Wang, Chao Chen, Yang Sun, Li-Li Huang, Liang Wang, Chen Chen, Jin Li, Song-Hua Ai, Zhen Huang, Li Sun, Zhen-Zhen Wan, An Pan, Tian-Qing Meng, Wen-Qing Lu
Blood trihalomethanes (THMs) and urinary haloacetic acids (HAAs) are the leading candidate biomarkers for disinfection byproduct (DBP) exposure. However, no studies have assessed the exposure profiles, temporal variability, and potential predictors of these biomarkers during pregnancy. Here we collected blood (n = 4304) and urine samples (n = 4165) from 1760 Chinese pregnant women during early, mid-, and late pregnancy, which were separately analyzed for 4 THMs and 2 HAAs. We calculated the intraclass correlation coefficients (ICCs) to assess the variability of these biomarkers and estimated their correlations with sociodemographic, water-use behavioral, dietary and sample collection factors using mixed models...
March 8, 2019: Environmental Research
https://read.qxmd.com/read/30878616/the-phase-of-the-estrous-cycle-modifies-the-endocrine-metabolic-and-behavior-rhythms-in-ewes
#5
Livia Pinto-Santini, Rodolfo Ungerfeld
The aim of this study was to compare circadian rhythms of serum cortisol and insulin concentrations, glycemia, glycemia:insulin ratio (GLY:INS), rectal, vaginal and surface (ST) temperatures as well behavioral patterns during the follicular (FOL) and luteal (LUT) phases in ewes. All the variables were measured during both phases of the estrous cycle in 8 West African ewes during a 24 h period. Cortisol concentrations were greater during FOL than LUT (30.9 ± 2.1 ng mL-1 vs 24.1 ± 2.1 ng mL-1 ; P < 0...
March 13, 2019: Physiology & Behavior
https://read.qxmd.com/read/30878540/results-of-the-first-national-human-biomonitoring-in-slovenia-trace-elements-in-men-and-lactating-women-predictors-of-exposure-and-reference-values
#6
Janja Snoj Tratnik, Ingrid Falnoga, Darja Mazej, David Kocman, Vesna Fajon, Marta Jagodic, Anja Stajnko, Ajda Trdin, Zdenka Šlejkovec, Zvonka Jeran, Joško Osredkar, Alenka Sešek-Briški, Mladen Krsnik, Alfred B Kobal, Lijana Kononenko, Milena Horvat
The first national human biomonitoring in Slovenia surveyed cadmium (Cd), lead (Pb), mercury (Hg), arsenic (As), manganese (Mn), selenium (Se), copper (Cu) and zinc (Zn) in a childbearing population (18-49 years) selected from lactating primiparous women and men (N = 1084). The overall aim was to estimate trace elements' levels and geographical variations in order to identify sources of possible exposures and set the national reference values. The study population was selected evenly from 12 study areas across Slovenia, including rural, urban and known or potentially contaminated environments...
March 14, 2019: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/30878204/electrochemical-sensing-of-nicotine-using-cuwo-4-decorated-reduced-graphene-oxide-immobilized-glassy-carbon-electrode
#7
REVIEW
A Karthika, P Karuppasamy, S Selvarajan, A Suganthi, M Rajarajan
A novel and selective electrochemical sensing of nicotine is studied using copper tungstate decorated reduced graphene oxide nanocomposite (CuWO4 /rGO) nafion (Nf) immobilized GC electrode (GCE). The CuWO4 /rGO nanocomposite is synthesized using sonication method and characterized by HR-TEM (High resolution transmission electron microscopy), SEM (Scanning electron microscopy), FT-IR (Fourier transform infrared spectroscopy), SAED (Selected area of electron diffraction pattern), XRD (X-ray diffraction), Raman spectroscopy, Thermo gravimetric analysis (TGA) and EDX (Energy dispersive X-ray diffraction) techniques...
January 29, 2019: Ultrasonics Sonochemistry
https://read.qxmd.com/read/30877981/simultaneous-determination-of-seven-effective-components-of-tripterygium-glycosides-in-human-biological-matrices-by-ultra-performance-liquid-chromatography-triple-quadrupole-mass-spectrometry
#8
Xi Du, Xin He, Yuhong Huang, Bin Fu, Bingnan Liang, Chunxiao Lv, Yan Li, Xue Gao, Yangyang Wang
This paper developed a novel, sensitive, and selective ultra-performance liquid chromatography-triple quad mass spectrometry method to simultaneously determine seven effective constituents (triptolide, triptophenolide, celastrol, wilforgine, wilforine, wilfordine and wilfortrine) of Tripterygium glycosides (GTW) in human serum and urine. The chromatographic separation was performed on the C18 column using an ammonium acetate buffer solution-acetonitrile (both containing 0.1% formic acid) in a gradient program with a flow rate of 0...
February 25, 2019: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/30877956/arsenic-exposure-of-child-populations-in-northern-argentina
#9
Marta Calatayud, Silvia Sara Farias, Gladys Soria de Paredes, Mónica Olivera, Natalia Ávila Carreras, Maria Cecilia Giménez, Vicenta Devesa, Dinoraz Vélez
Chronic exposure to inorganic arsenic (As) is associated with numerous adverse effects. Argentina is one of the countries affected by arsenicism; however, there are few studies that evaluate inorganic As exposure and its effects on child population. The aim of this study is to evaluate exposure to As through water and food in child populations living in the provinces of Santiago del Estero and Chaco (n = 101), and to determine the impact of this exposure analysing biomarkers of exposure (urine and hair As contents) and effect [8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG)]...
February 27, 2019: Science of the Total Environment
https://read.qxmd.com/read/30877916/distribution-of-the-parent-compound-and-its-metabolites-in-serum-urine-and-feces-of-mice-administered-2-2-4-4-tetrabromodiphenyl-ether
#10
Hao Xu, Chao Feng, Yiyi Cao, Ying Lu, Jing Xi, Jieyun Ji, Dasheng Lu, Xin-Yu Zhang, Yang Luan
2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is a predominant polybromodiphenyl ether congener in the environment. Its absorption, excretion, and metabolism in animals have been investigated; however, the distribution of BDE-47 and its metabolites in excreta and blood at steady-state conditions has been unclear. In the present study, we addressed the issue by determining the amounts of BDE-47, eight monohydroxylated metabolites (OH-BDEs), and 2,4-dibromophenol (2,4-DBP) in serum, urine, and feces of gpt delta transgenic mice orally administered BDE-47 at 1...
March 8, 2019: Chemosphere
https://read.qxmd.com/read/30877861/artificial-intelligence-based-discovery-of-the-association-between-depression-and-chronic-fatigue-syndrome
#11
Feilong Zhang, Chuanhong Wu, Caixia Jia, Kuo Gao, Jinping Wang, Huihui Zhao, Wei Wang, Jianxin Chen
BACKGROUND: Both of the modern medicine and the traditional Chinese medicine classify depressive disorder (DD) and chronic fatigue syndrome (CFS) to one type of disease. Unveiling the association between depressive and the fatigue diseases provides a great opportunity to bridge the modern medicine with the traditional Chinese medicine. METHODS: In this work, 295 general participants were recruited to complete Zung Self-Rating Depression Scales and Chalder Fatigue Scales, and meanwhile, to donate plasma and urine samples for 1 H NMR-metabolic profiling...
March 8, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30877805/validation-of-the-neogen-elisa-benzodiazepine-kit-using-clonazepam-as-the-target-molecule-for-blood-and-urine
#12
Grayce Behnke, Nicholas B Tiscione, John Rakus, Lauren Richards-Waugh
This study demonstrates the validation of a semi-quantitative method for the rapid screening of whole blood and urine specimens using clonazepam as the target molecule for the Neogen® Benzodiazepine kit. Decision points were validated at 10.0 ng/mL for whole blood and 25.0 ng/mL for urine. The validation design was based on the Scientific Working Group for Forensic Toxicology (SWGTOX) Standard Practices for Method Validation and included the evaluation of sensitivity, precision, specificity, carryover, hook effect, drift, ruggedness/robustness and a case sample evaluation...
March 16, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/30877800/is-capillary-electrophoresis-a-new-tool-to-monitor-acute-lithium-poisoning-in-human-%C3%A2
#13
Tsandni Jamal, Carole Hennequin, Rabah Gahoual, Annie Leyris, Jean-Louis Beaudeux, Frédéric J Baud, Pascal Houzé
A 38-year-old man was admitted in the intensive care unit (ICU) after supposed ingestion of 504 sustained-release tablets of Theralithe™ corresponding ~200 g of lithium carbonate. At the admission, ~19.5 h after ingestion, the patient was conscious with trembling limbs, intense thirst, profuse sweats and vomiting and lithium serum concentration was 14.2 mmol/L. Toxicological screenings performed in urine and serum, were negative. Patient was treated with continuous extrarenal epuration by continue veno-venous hemodiafiltration starting (CCVHDF) 24 h post-admission and was carried on until 64 h...
March 16, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/30877795/testing-for-sgt-151-cumyl-pegaclone-and-its-metabolites-in-blood-and-urine-after-surreptitious-administration
#14
Frédéric Aknouche, Alice Ameline, Camille Richeval, Anne-Julie Schapira, Audrey Coulon, Christophe Maruejouls, Jean-Michel Gaulier, Pascal Kintz
The authors aim to report a case of surreptitious administration of a synthetic cannabinoid (SC) and the subsequent toxicological investigations to be able to document accurately the case for submission at a hearing. A dealer gave surreptitiously a substance to two juvenile migrants who experienced shakings and faintness. The laboratory received a blood sample from each of the two victims, who, according to the investigators, were probably exposed to SGT-151, a SC, also known as CUMYL-PEGACLONE. Blood and urine specimens from the dealer, who claimed being a user of SGT-151 were received at the same time...
March 16, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/30877569/pharmacokinetics-and-safety-of-olaparib-in-patients-with-advanced-solid-tumours-and-renal-impairment
#15
Christian Rolfo, Judith de Vos-Geelen, Nicolas Isambert, L Rhoda Molife, Jan H M Schellens, Jacques De Grève, Luc Dirix, Peter Grundtvig-Sørensen, Guy Jerusalem, Karin Leunen, Morten Mau-Sørensen, Ruth Plummer, Maria Learoyd, Wendy Bannister, Anitra Fielding, Alain Ravaud
BACKGROUND: Olaparib, a potent oral poly(ADP-ribose) polymerase inhibitor, is partially renally cleared. We investigated the pharmacokinetics and safety of olaparib in patients with mild or moderate renal impairment to provide dosing recommendations. METHODS: This phase I open-label study assessed the pharmacokinetics, safety and tolerability of single-dose, oral 300-mg olaparib tablets in adults (aged 18-75 years) with solid tumours. Patients had normal renal function, or mild or moderate renal impairment (estimated creatinine clearance ≥ 81, 51-80 or 31-50 mL/min, respectively)...
March 16, 2019: Clinical Pharmacokinetics
https://read.qxmd.com/read/30877560/preliminary-results-of-biodistribution-and-dosimetric-analysis-of-68-ga-ga-dota-zol-a-new-zoledronate-based-bisphosphonate-for-pet-ct-diagnosis-of-bone-diseases
#16
Ambreen Khawar, Elisabeth Eppard, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian C Gaertner, Markus Essler, Ralph A Bundschuh
OBJECTIVE: Pre-clinical studies with gallium-68 zoledronate ([68 Ga]Ga-DOTAZOL ) have proposed it to be a potent bisphosphonate for PET/CT diagnosis of bone diseases and diagnostic counterpart to [177 Lu]Lu-DOTAZOL and [225 Ac]Ac-DOTAZOL . This study aims to be the first human biodistribution and dosimetric analysis of [68 Ga]Ga-DOTAZOL . METHODS: Five metastatic skeletal disease patients (mean age: 72 years, M: F; 4:1) were injected with 150-190 MBq (4.05-5.14 mCi) of [68 Ga]Ga-DOTAZOL i...
March 15, 2019: Annals of Nuclear Medicine
https://read.qxmd.com/read/30877352/reconstruction-of-the-urethra-with-an-anterior-vaginal-mucosal-flap-in-female-urethral-stricture
#17
Sakineh Hajebrahimi, Hamed Maroufi, Hadi Mostafaei, Hanieh Salehi-Pourmehr
INTRODUCTION AND HYPOTHESIS: We present our single institution experience with urethral reconstruction by using anterior U-shaped vaginal flap in female patients with urethral stricture. METHODS: Retrospective analysis was performed from March 2014 to April 2018. Fourteen patients with retention or severe voiding dysfunction and failed conservative management were enrolled. The demographic characteristics, vaginal examination, urodynamic parameters, and post-void residual urine (PVR) were reviewed...
March 15, 2019: International Urogynecology Journal
https://read.qxmd.com/read/30876856/diagnostic-performance-evaluation-of-sulfate-conjugated-cholesterol-metabolites-as-urinary-biomarkers-of-niemann-pick-disease-type-c
#18
Masamitsu Maekawa, Aya Narita, Isamu Jinnoh, Takashi Iida, Thorsten Marquardt, Eugen Mengel, Yoshikatsu Eto, Peter T Clayton, Hiroaki Yamaguchi, Nariyasu Mano
BACKGROUND: Niemann-Pick disease type C (NPC) is an autosomal recessive inherited disorder with progressive neuronal degeneration. Because conventional diagnostic methods are complicated and invasive, biomarker tests have drawn attention. We aimed to evaluate three urinary conjugated cholesterol metabolites as diagnostic biomarkers for NPC. METHODS: Urine samples from 23 patients with NPC, 28 healthy controls, and 7 patients with inherited metabolic disorders were analyzed...
March 12, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/30876603/rapid-liquid-phase-microextraction-of-analytes-from-complex-samples-on-superwetting-porous-silicon-for-onsite-saldi-ms-analysis
#19
Xueyun Wang, Fei Teng, Yalei Wang, Nan Lu
To simplify the pretreatment process of complex samples is a key step for rapid detection. Herein, we report a single-step method to rapidly extract analytes with liquid-phase microextraction (LPME) from complex samples on a superwetting porous silicon (PSi) for onsite detection with surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). The operation time is less than 3 min with this simple method. The limit of detection (LOD) of malachite green in lake water is lowered to 10-13 M, that of verapamil and methadone in whole blood is down to 10-11 M and 10-13 M, in urine is 10-13 M and 10-14 M, respectively; and the ranges of quantification is up to 8 or 9 orders of magnitude with high precision (coefficients of determination (R2 ) > 0...
June 1, 2019: Talanta
https://read.qxmd.com/read/30876585/electrochemical-determination-of-antihypertensive-drugs-by-employing-costless-and-portable-unmodified-screen-printed-electrodes
#20
Ahmed A Khorshed, Mohamed Khairy, Craig E Banks
Hypertension increases the risk of heart disease and stroke, is commonly known as a silent killer disease and considered as one of the key risk factor for premature death and disability over the world. Herein, we report for the first time a sensitive, costless and reproducible voltammetric method for individual determination of five antihypertensive drugs namely, propranolol (PRO), timolol (TIM), amlodipine (AML), amiloride (AMI) and triamterene (TRI) using differential pulse voltammetry at bare/unmodified screen-printed carbon electrodes (SPEs) in presence of sodium dodecyl sulfate (SDS)...
June 1, 2019: Talanta
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