keyword
https://read.qxmd.com/read/38333627/microangiopathy-associated-with-poor-outcome-of-immunoglobulin-a-nephropathy-a-cohort-study-and-meta-analysis
#21
JOURNAL ARTICLE
Lei Dong, Yuncan Hu, Dan Yang, Liu Liu, Yueqiang Li, Shuwang Ge, Ying Yao
BACKGROUND: Microangiopathy (MA) lesions are not rare in immunoglobulin A nephropathy (IgAN) and have been suggested to have a potential role in increasing risk in renal function decline. However, this suggestion has not been universally accepted. We aimed to investigate its role in our cohort and in multiple studies through a systematic meta-analysis. METHODS: This cohort study included 450 IgAN patients, confirmed by renal biopsy, at Tongji Hospital, China, from January 2012 to December 2016...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38323871/kidney-failure-events-cardiovascular-disease-events-and-all-cause-mortality-in-immunoglobulin-a-nephropathy-patients-in-a-real-world-database
#22
JOURNAL ARTICLE
Edgar V Lerma, Kamlesh M Thakker, Mark E Bensink, Richard Lieblich, C Martin Bunke, Wu Gong, Andrew R Rava, Kaijun Wang, Diana T Amari, David Oliveri, Michael V Murphy, David M W Cork, Juan Carlos Q Velez
BACKGROUND: IgA nephropathy (IgAN) associated glomerular injury leads to proteinuria, hematuria, and progressive loss of glomerular filtration rate, with progression to kidney failure (KF). This retrospective study evaluated the prognostic effects of proteinuria and progression to KF on cardiovascular disease (CVD)/mortality events and KF/mortality events in the United States. METHODS: We conducted a non-interventional, retrospective cohort study in adult IgAN patients using Optum's de-identified Market Clarity Data (01/01/2007 to 03/31/2021)...
February 7, 2024: Kidney360
https://read.qxmd.com/read/38322631/thickened-perirenal-fat-predicts-poor-renal-outcome-in-patients-with-immunoglobulin-a-nephropathy-a-population-based-retrospective-cohort-study
#23
JOURNAL ARTICLE
Hongtu Hu, Zongwei Zhang, Zikang Liu, Fan Chu, Jialu Ran, Wei Liang
INTRODUCTION: Perirenal fat is a pad that fills the retroperitoneal space outside the kidney, which affects kidney function in various ways. However, the association between perirenal fat and IgA nephropathy (IgAN) has not yet been elucidated. This study aimed to investigate the role of perirenal fat in predicting IgAN progression. METHODS: A total of 473 patients with biopsy-proven IgAN and follow-up information were recruited, and perirenal fat thickness (PFT) was measured using color Doppler ultrasonography at renal biopsy...
February 2024: Kidney Diseases
https://read.qxmd.com/read/38294502/-immunoglobulin%C3%A2-a-nephropathy-new-treatment-possibilities
#24
REVIEW
Matthias Girndt
Immunoglobulin A (IgA) nephropathy is the most frequent glomerulonephritis in adults in Central Europe. It is characterized by microhematuria and occasionally macrohematuria, proteinuria and a chronic loss of kidney function. The diagnosis is made based on a kidney biopsy. The progressive kidney damage must always be slowed down by normalizing blood pressure, using angiotensin inhibitors and consistently avoiding additional toxic substances. In many cases this is not sufficient and then sodium-glucose transporter 2 (SGLT-2) inhibitors and immunomodulators are used...
January 31, 2024: Inn Med (Heidelb)
https://read.qxmd.com/read/38291238/identification-of-inflammatory-biomarkers-in-iga-nephropathy-using-the-nanostring-technology-a-validation-study-in-caucasians
#25
JOURNAL ARTICLE
Laurence Gaumond, Caroline Lamarche, Stéphanie Beauchemin, Nathalie Henley, Naoual Elftouh, Casimiro Gerarduzzi, Louis-Philippe Laurin
OBJECTIVE AND DESIGN: Immunoglobulin A nephropathy (IgAN) is a kidney disease characterized by the accumulation of IgA deposits in the glomeruli of the kidney, leading to inflammation and damage to the kidney. The inflammatory markers involved in IgAN remain to be defined. Gene expression analysis platforms, such as the NanoString nCounter system, are promising screening and diagnostic tools, especially in oncology. Still, their role as a diagnostic and prognostic tool in IgAN remains scarce...
January 31, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38287343/use-of-corticosteroids-in-norwegian-patients-with-immunoglobulin-a-nephropathy-progressing-to-end-stage-kidney-disease-a-retrospective-cohort-study
#26
JOURNAL ARTICLE
Mariell Rivedal, Yngvar Lunde Haaskjold, Øystein Eikrem, Rune Bjørneklett, Hans Peter Marti, Thomas Knoop
BACKGROUND: Despite several clinical trials, the use of corticosteroid therapy for treating immunoglobulin A nephropathy (IgAN) remains controversial. We aimed to describe the use of corticosteroid therapy combined with supportive therapy in Norwegian patients with IgAN who had progressed to end-stage kidney disease. METHODS: We conducted a retrospective cohort study using data from the Norwegian Renal Registry. Overall, 143 patients with primary IgAN who progressed to end-stage kidney disease were divided into two groups: the corticosteroid group, who had been treated with corticosteroids and supportive therapy, and the non-corticosteroid group, which had underwent only supportive therapy...
January 29, 2024: BMC Nephrology
https://read.qxmd.com/read/38285068/network-pharmacology-and-molecular-docking-to-elucidate-the-common-mechanism-of-hydroxychloroquine-treatment-in-lupus-nephritis-and-iga-nephropathy
#27
JOURNAL ARTICLE
Yixuan Chen, Meiqi Lu, Mengshu Lin, Qing Gao
OBJECTIVE: Hydroxychloroquine (HCQ), characterized by a broad effect on immune regulation, has been widely used in the treatment of autoimmune glomerulonephritis such as lupus nephritis (LN) and immunoglobulin A nephropathy (IgAN). The current research investigates whether HCQ plays a role in the treatment of LN and IgAN through common mechanisms since the pathogenesis of both LN and IgAN is closely related to immune complex deposition, complement activation, and ultimately inflammation...
January 29, 2024: Lupus
https://read.qxmd.com/read/38282694/kidney-failure-attributed-to-immunoglobulin-a-nephropathy-a-usrds-retrospective-cohort-study-of-epidemiology-treatment-modalities-and-economic-burden
#28
JOURNAL ARTICLE
Mark E Bensink, Deborah Goldschmidt, Zheng-Yi Zhou, Kaijun Wang, Richard Lieblich, Martin C Bunke
RATIONALE & OBJECTIVE: This study describes the epidemiology, characteristics, and outcomes of patients with immunoglobulin A nephropathy (IgAN)-attributed kidney failure in the US Renal Data System (USRDS) from 2008 to 2018, including health care resource utilization and costs among patients with Medicare-linked data. STUDY DESIGN: Retrospective cohort study. SETTING & POPULATION: Patients with IgAN-attributed kidney failure in the USRDS...
February 2024: Kidney medicine
https://read.qxmd.com/read/38278877/glomerular-spatial-transcriptomics-of-iga-nephropathy-according-to-the-presence-of-mesangial-proliferation
#29
JOURNAL ARTICLE
Sehoon Park, Minji Kang, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Hyun Je Kim, Kyung Chul Moon, Hajeong Lee
Mesangial proliferation is a diagnostic feature and a prognostic predictor of immunoglobulin A nephropathy (IgAN). We aimed to investigate the gene expression profiles of IgAN glomerulus according to the presence of mesangial proliferation. We performed spatial-specific transcriptomic profiling on kidney biopsy tissues using the GeoMx Digital Spatial Profiler. Twelve cases with three glomeruli for each case were profiled using direct pathologic classification (4 M1-IgAN, 4 M0-IgAN, and 4 donor controls). The results of enriched glom-specific genes demonstrated that M1-IgAN could be distinguished from controls (77 upregulated and 55 downregulated DEGs), while some DEGs were identified between M1-IgAN and M0-IgAN cases (24 upregulated and 8 downregulated DEGs) or between M0 and controls (1 upregulated and 16 downregulated DEGs)...
January 26, 2024: Scientific Reports
https://read.qxmd.com/read/38254967/liquid-biopsy-a-new-avenue-for-the-diagnosis-of-kidney-disease-diabetic-kidney-disease-renal-cancer-and-iga-nephropathy
#30
REVIEW
Jill Dybiec, Weronika Frąk, Joanna Kućmierz, Julita Tokarek, Armanda Wojtasińska, Ewelina Młynarska, Jacek Rysz, Beata Franczyk
Kidney diseases are some of the most common healthcare problems. As the population of elderly individuals with concurrent health conditions continues to rise, there will be a heightened occurrence of these diseases. Due to the renal condition being one of the longevity predictors, early diagnosis of kidney dysfunction plays a crucial role. Currently, prevalent diagnostic tools include laboratory tests and kidney tissue biopsies. New technologies, particularly liquid biopsy and new detection biomarkers, hold promise for diagnosing kidney disorders...
January 7, 2024: Genes
https://read.qxmd.com/read/38244220/clinical-application-value-of-ultrafast-pulse-wave-velocity-in-early-cardiovascular-injury-of-immunoglobulin-a-nephropathy
#31
JOURNAL ARTICLE
Bili Liu, Xing Si, Yue Shan, Wenxia Xia, Min Li, Dan Ge, Pingping Zhang
AIM: To investigate the application and the related influencing factors of ultrafast pulse wave velocity (ufPWV) in the evaluation of carotid artery elasticity in patients with Immunoglobulin A nephropathy (IgAN). MATERIAL AND METHODS: A total of 156 IgAN patients and 50 healthy individuals were selected as the control group. The ufPWV technique was employed to measure carotid arterial elasticity parameters, including carotid intima-media thickness (cIMT), pulse wave velocity at the beginning of systole (BS-PWV) and pulse wave velocity at the end of systole (ES-PWV)...
January 11, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38241588/successful-management-of-proteinuria-in-recurrent-immunoglobulin-a-nephropathy-after-deceased-donor-kidney-transplantation-a-case-report
#32
JOURNAL ARTICLE
Sehyun Jung, Seunghye Lee, Hyejin Jeon, Min Hye Kim, Jong Sil Lee, Se-Ho Chang, Hyun-Jung Kim, Hani Jang
BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most common type of primary glomerulonephritis, and recurrent IgAN is common after kidney transplantation (KT). Owing to the differences in various biopsy protocols and follow-ups in each study, the recurrence rate varies from 9.7% to 46%. Although the relapse rates are high, there is no definitive treatment for IgAN recurrence. METHODS: We present a case of successful management of proteinuria in recurrent IgAN after deceased donor KT...
January 19, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38239236/-not-available
#33
REVIEW
Pu Jiang, Changliang Yao, De-An Guo
Immune-related nephropathy (IRN) refers to immune-response-mediated glomerulonephritis and is the main cause of end-stage renal failure. The pathogenesis of IRN is not fully understood; therefore, treatment is challenging. Traditional Chinese medicines (TCMs) have potent clinical effects in the treatment of the IRN conditions immunoglobulin A nephropathy, lupus nephropathy, and diabetic nephropathy. The underlying mechanisms mainly include its inhibition of inflammation; improvements to renal interstitial fibrosis, oxidative stress, autophagy, apoptosis; and regulation of immunity...
January 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38234117/haematuria-in-immunoglobulin-a-nephropathy-to-be-or-not-to-be
#34
EDITORIAL
Jessica Sun, Muh Geot Wong
No abstract text is available yet for this article.
February 2024: Nephrology
https://read.qxmd.com/read/38213485/clinicopathological-prognostic-stratification-for-proteinuria-and-kidney-survival-in-iga-nephropathy-a-japanese-prospective-cohort-study
#35
JOURNAL ARTICLE
Kentaro Koike, Tetsuya Kawamura, Keita Hirano, Masako Nishikawa, Akira Shimizu, Kensuke Joh, Ritsuko Katafuchi, Akinori Hashiguchi, Yuichiro Yano, Keiichi Matsuzaki, Masato Matsushima, Nobuo Tsuboi, Shoichi Maruyama, Ichiei Narita, Takashi Yokoo, Yusuke Suzuki
BACKGROUND: We require a clinicopathological risk stratification method for immunoglobulin A nephropathy (IgAN) to predict kidney outcomes. We examined a renal failure risk group (RF-RG) classification system created following a prior multicentre, retrospective study to determine if RF-RG could predict kidney outcomes. METHODS: We collected data from Japanese patients with IgAN registered between 1 April 2005 and 31 August 2015. The primary outcome was a composite 50% increase in serum creatinine from baseline or dialysis induction...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38187325/prognostic-factors-affecting-long-term-outcomes-in-patients-with-concurrent-iga-nephropathy-and-membranous-nephropathy
#36
JOURNAL ARTICLE
Yunlong Qin, Zixian Yu, Hao Wu, Anjing Wang, Fang Wang, Di Wang, Qing Jia, Jinguo Yuan, Yan Xing, Yumeng Zhang, Jin Zhao, Shiren Sun
BACKGROUND: The incidence of concurrent immunoglobulin A nephropathy and membranous nephropathy (cIgAN/MN) is low and rarely reported, and the prognosis of patients with cIgAN/MN remains unclear. This study was designed to compare the clinical and prognostic characteristics of cIgAN/MN with IgAN and MN and to identify crucial factors influencing the outcomes of patients with cIgAN/MN. METHODS: We included biopsy-proven cIgAN/MN patients between December 2012 and December 2020 at Xijing Hospital...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38186900/kidney-and-urine-cell-transcriptomics-in-iga-nephropathy-and-lupus-nephritis-a-narrative-review
#37
REVIEW
Francesco P Schena, Samantha Chiurlia, Daniela I Abbrescia, Sharon N Cox
This narrative review sheds light on the use of transcriptomics in the analysis of kidney biopsies and urinary cell samples from patients with immunoglobulin A nephropathy or lupus nephritis. The conventional methods of examining kidney biopsy through light microscopy, immunofluorescence and electron microscopy provide valuable clinical information for diagnosis and prognosis but have some limitations that transcriptomics can address. Some recent studies have reported that kidney transcriptomics has uncovered new molecular biomarkers implicated in the inflammatory process induced by the deposition of circulating immune complexes in the investigated kidney diseases...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38186896/early-growth-response-1-as-a-podocyte-injury-marker-in-human-glomerular-diseases
#38
JOURNAL ARTICLE
Masahiro Okabe, Kentaro Koike, Izumi Yamamoto, Nobuo Tsuboi, Taiji Matsusaka, Takashi Yokoo
BACKGROUND: In human glomerular diseases, visualizing podocyte injury is desirable since podocytes do not regenerate and podocyte injury leads to podocyte loss. Herein, we investigated the utility of immunostaining for early growth response 1 (EGR1), which is expressed in injured podocytes from the early stages of injury in animal experiments, as a podocyte injury marker in human glomerular diseases. METHODS: This study included 102 patients with biopsy-proven glomerular diseases between 2018 and 2021...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38186867/tubulo-interstitial-inflammation-increases-the-risk-of-graft-loss-after-the-recurrence-of-iga-nephropathy
#39
JOURNAL ARTICLE
Emilio Rodrigo, Luis F Quintana, Teresa Vázquez-Sánchez, Ana Sánchez-Fructuoso, Anna Buxeda, Eva Gavela, Juan M Cazorla, Sheila Cabello, Isabel Beneyto, María O López-Oliva, Fritz Diekmann, José M Gómez-Ortega, Natividad Calvo Romero, María J Pérez-Sáez, Asunción Sancho, Auxiliadora Mazuecos, Jordi Espí-Reig, Carlos Jiménez, Domingo Hernández
BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most frequent recurrent disease in kidney transplant recipients and its recurrence contributes to reducing graft survival. Several variables at the time of recurrence have been associated with a higher risk of graft loss. The presence of clinical or subclinical inflammation has been associated with a higher risk of kidney graft loss, but it is not precisely known how it influences the outcome of patients with recurrent IgAN. METHODS: We performed a multicentre retrospective study including kidney transplant recipients with biopsy-proven recurrence of IgAN in which Banff and Oxford classification scores were available...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38175721/deciphering-roles-of-protein-post-translational-modifications-in-iga-nephropathy-progression-and-potential-therapy
#40
JOURNAL ARTICLE
Mengying Sun, Guojuan Shi, Xiaohan Zhang, Chao Kan, Shimin Xie, Weixiang Peng, Wenjun Liu, Peter Wang, Rui Zhang
Immunoglobulin A nephropathy (IgAN), one type of glomerulonephritis, displays the accumulation of glycosylated IgA in the mesangium. Studies have demonstrated that both genetics and epigenetics play a pivotal role in the occurrence and progression of IgAN. Post-translational modification (PTM) has been revealed to critically participate in IgAN development and progression because PTM dysregulation results in impaired degradation of proteins that regulate IgAN pathogenesis. A growing number of studies identify that PTMs, including sialylation, o-glycosylation, galactosylation, phosphorylation, ubiquitination and deubiquitination, modulate the initiation and progression of IgAN...
January 3, 2024: Aging
keyword
keyword
171419
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.