Marina de Cos, Gohar Mosoyan, Kinsuk Chauhan, Jonathan P Troost, Jenny S Wong, Sean Lefferts, Paul Morgan, Kristin Meliambro, Marc Egerman, Justina Ray, Tom Parker, Daniel Levine, Surya Seshan, Yoni Bardash, Benjamin Horowitz, Candice A Kent, Melissa M Shaw, Alan Perlman, Dennis G Moledina, Steven G Coca, Kirk N Campbell
RATIONALE & OBJECTIVE: Glomerular disorders have a highly variable clinical course and biomarkers that reflect molecular mechanisms underlying progression are needed. Based on our previous work identifying plasminogen as a direct cause of podocyte injury, we designed this study to test the association between urine plasmin(ogen) (i.e., plasmin and its precursor plasminogen) and end-stage kidney disease (ESKD). STUDY DESIGN: Multicenter cohort study. SETTING & PARTICIPANTS: 1010 patients enrolled in the CureGN Cohort with biopsy-proven glomerular disease (focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A nephropathy)...
March 5, 2024: American Journal of Kidney Diseases