keyword
https://read.qxmd.com/read/38522142/a-cluster-of-type-i-interferon-regulated-genes-associates-with-disease-activity-and-prognosis-in-patients-with-iga-nephropathy
#1
JOURNAL ARTICLE
Shu Qu, Ting Gan, Yan-Na Wang, Yuan-Yuan Qi, Yue-Miao Zhang, Celine C Berthier, Li-Jun Liu, Su-Fang Shi, Ji-Cheng Lv, Hong Zhang, Xu-Jie Zhou
The exact pathogenesis of IgA nephropathy (IgAN) is complex and so far, not well defined. Since it has been shown that microbial infections could induce high levels of type I interferon (IFN-I) and there is an evident link between mucosal infection and gross hematuria in IgAN, we hypothesized that IFN-I may play a role in the pathogenic process. In this study, we investigated the type I interferon status in IgAN based on the expression of 17 IFN-regulated genes (IRGs) in whole blood from 59 IgAN patients in a cross-sectional study, of which 34 patients followed longitudinally...
March 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38504538/protective-effect-of-modified-huangqi-chifeng-decoction-on-immunoglobulin-a-nephropathy-through-toll-like-receptor-4-myeloid-differentiation-factor-88-nuclear-factor-kappa-b-signaling-pathway
#2
JOURNAL ARTICLE
L I Liusheng, Zhao Mingming, Chang Meiying, S I Yuan, Zhao Jinning, Yang Bin, Zhang Yu
OBJECTIVE: To examine the nephroprotective mechanism of modified Huangqi Chifeng decoction (, MHCD) in immunoglobulin A nephropathy (IgAN) rats. METHODS: To establish the IgAN rat model, the bovine serum albumin, lipopolysaccharide, and carbon tetrachloride 4 method was employed. The rats were then randomly assigned to the control, model, telmisartan, and high-, medium-, and low-dose MHCD groups, and were administered the respective treatments via intragastric administration for 8 weeks...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38481921/post-renal-biopsy-retroperitoneal-haematoma-accompanied-by-decreased-coagulation-factor-xiii-levels-in-immunoglobulin-a-nephropathy
#3
Yoko Hirano, Shoichiro Kanda, Moe Hidaka, Motohiro Kato, Masako Nishikawa, Yutaka Yatomi, Hiroyuki Tanaka, Akiko Kinumaki, Yuko Kajiho, Yutaka Harita
Post-biopsy bleeding is the primary complication of renal biopsy. Retroperitoneal haematoma is a rare but severe bleeding complication; it commonly occurs among patients who have risk factors or vascular lesions. The bleeding risks in patients with immunoglobulin A (IgA) nephropathy (IgAN) have been discussed in the literature, but clinical data are lacking. Here, we report a case of a post-biopsy retroperitoneal haematoma accompanied by decreased coagulation factor XIII (FXIII) in a patient with IgAN. A 14-year-old male patient with haematuria and proteinuria but no bleeding or family history of bleeding underwent pre-renal biopsy evaluation that showed no coagulation abnormalities...
February 2024: Curēus
https://read.qxmd.com/read/38477957/a-case-of-insidious-onset-of-kimura-disease-associated-immunoglobulin-a-nephropathy-without-eosinophil-infiltration-in-the-renal-tissue
#4
JOURNAL ARTICLE
Linxin Liu, Haoxian Gou, Yongfa Liu, Shuai Hu, Xiaoli Yang, Bo Li
Kimura disease (KD), also known as eosinophilic lymphogranuloma, is a rare chronic inflammatory or allergic disease. It can present with immune-related diseases such as nephrotic syndrome, asthma, and ankylosing spondylitis. In this study, we report a case of KD combined with immunoglobulin A nephropathy that first presented as a mass in the inguinal region, followed by recurrent renal involvement. Previous reports suggested that renal involvement caused by KD was due to direct infiltration of eosinophils; however, in this case, no eosinophil infiltration was found in the renal tissue after renal biopsy...
December 28, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38453268/a-low-protein-plant-dominant-gluten-free-diet-for-immunoglobulin-a-nephropathy-and-focal-segmental-glomerulosclerosis
#5
REVIEW
Jason Patel, Kamyar Kalantar-Zadeh, Melanie Betz, Shivam Joshi
Immunoglobulin A nephropathy is the most common glomerulonephritis syndrome in the world, yet there is currently no cure. While blood pressure control, renin-angiotensin-aldosterone system inhibition, and immunosuppression may slow disease progression, low-protein diets, defined as a daily dietary protein intake of 0.6 to 0.8 g/kg body weight, may also decrease immune complex deposition and disease severity, as evidenced in animal models. The link between secondary immunoglobulin A nephropathy and celiac disease has also led to the rise of gluten-free diets and zinc supplementation as potential lifestyle modifications to help manage common immunoglobulin A nephropathy symptoms such as proteinuria and hematuria...
November 2023: Adv Kidney Dis Health
https://read.qxmd.com/read/38452919/urinary-plasminogen-as-a-marker-of-disease-progression-in-human-glomerular-disease
#6
JOURNAL ARTICLE
Marina de Cos, Gohar Mosoyan, Kinsuk Chauhan, Jonathan P Troost, Jenny S Wong, Sean Lefferts, Paul Morgan, Kristin Meliambro, Marc Egerman, Justina Ray, Tom Parker, Daniel Levine, Surya Seshan, Yoni Bardash, Benjamin Horowitz, Candice A Kent, Melissa M Shaw, Alan Perlman, Dennis G Moledina, Steven G Coca, Kirk N Campbell
RATIONALE & OBJECTIVE: Glomerular disorders have a highly variable clinical course and biomarkers that reflect molecular mechanisms underlying progression are needed. Based on our previous work identifying plasminogen as a direct cause of podocyte injury, we designed this study to test the association between urine plasmin(ogen) (i.e., plasmin and its precursor plasminogen) and end-stage kidney disease (ESKD). STUDY DESIGN: Multicenter cohort study. SETTING & PARTICIPANTS: 1010 patients enrolled in the CureGN Cohort with biopsy-proven glomerular disease (focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A nephropathy)...
March 5, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38450299/advances-in-the-treatment-of-iga-nephropathy-with-biological-agents
#7
REVIEW
Yongze Zhuang, Hailing Lu, Junxia Li
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease, and the "four-hit" theory represents its currently accepted pathogenic mechanism. Mucosal immunity triggered by infections in the respiratory tract, intestines, or other areas leads to antigen presentation, T cell stimulation, B cell maturation, and the production of IgA-producing plasma cells. The proteins B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are involved in this process, and alternative complement and lectin pathway activation are also part of the pathogenic mechanism...
March 2024: Chronic Diseases and Translational Medicine
https://read.qxmd.com/read/38421587/a-case-of-non-lupus-full-house-nephropathy-diagnosed-by-kidney-biopsy-but-observed-iga-nephropathy-on-second-biopsy
#8
JOURNAL ARTICLE
Yoichi Iwafuchi, Tetsuo Morioka, Yuko Oyama, Ichiei Narita
We describe a case of full-house nephropathy without any underlying disease, including systemic lupus erythematosus. A 40-year-old woman was referred to our hospital with mild proteinuria and microscopic hematuria. The patient was diagnosed with immune complex-mediated glomerulonephritis with a predominant mesangioproliferative pattern based on renal histopathological results using full-house immunofluorescence staining. She showed no clinical criteria for the diagnosis of systemic lupus erythematosus, except for kidney disorders, and tested negative for antinuclear antibodies throughout her clinical course...
February 29, 2024: CEN Case Reports
https://read.qxmd.com/read/38411173/new-therapies-for-immunoglobulin-a-nephropathy-what-s-the-standard-of-care-in-2023
#9
REVIEW
Bryce Barr, Sean Barbour
PURPOSE OF REVIEW: As the most common primary glomerulonephritis, immunoglobulin A (IgA) nephropathy (IgAN) is an important cause of kidney failure and mortality. Until recently, therapeutic options were limited. Fortunately, there have been numerous recent clinical trials demonstrating efficacy of new therapies in slowing chronic kidney disease (CKD) progression at varying stages of disease. RECENT FINDINGS: The TESTING trial has provided high-quality evidence for slowing estimated glomerular filtration rate (eGFR) decline with a reduced-dose glucocorticoid regimen, while demonstrating an improved safety profile...
May 1, 2024: Current Opinion in Nephrology and Hypertension
https://read.qxmd.com/read/38406008/a-case-of-combination-of-iga-nephropathy-and-interstitial-nephritis-after-covid-19-vaccination
#10
Yuki Yoshida, Kenta Torigoe, Ryosuke Sakamoto, Shinichi Abe, Kumiko Muta, Hiroshi Mukae, Tomoya Nishino
A 66-year-old male presented with renal dysfunction. At the time of presentation, his serum creatinine (sCr) was 2.55 mg/dL, estimated glomerular filtration rate (eGFR) was 20.93 ml/min/1.73 m2 , urinary red blood cell (RBC) was 30-49/high power field, and urine protein-creatinine ratio was 0.43 g/gCr. The patient had no urinalysis abnormalities or renal dysfunction within the year prior to presentation but had gross hematuria after the third and fourth coronavirus disease 2019 (COVID-19) vaccinations...
January 2024: Curēus
https://read.qxmd.com/read/38403757/is-podocytopathy-associated-with-gross-hematuria-after-covid-19-vaccination-in-patients-with-immunoglobulin-a-nephropathy
#11
JOURNAL ARTICLE
Atsuhiko Suenaga, Naoki Sawa, Yuki Oba, Daisuke Ikuma, Akinari Sekine, Masayuki Yamanouchi, Eiko Hasegawa, Hiroki Mizuno, Tatsuya Suwabe, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Motoaki Miyazono, Yutaka Yamaguchi, Noriko Uesugi, Yoshifumi Ubara
We experienced three cases of a fever and subsequent severe, prolonged gross hematuria after COVID-19 vaccination. A kidney biopsy revealed immunoglobulin A (IgA) nephropathy, and electron microscopy showed two types of podocytopathy (podocyte damage): loss of foot processes from the glomerular basement membrane and foot process effacement. Mesangial interposition was also present in cases 1 and 3 but not in case 2. Podocytopathy is known to be a cause of proteinuria; however, the reactions to COVID-19 vaccination described here suggest that it may also be related to hematuria in IgA nephropathy...
February 26, 2024: Internal Medicine
https://read.qxmd.com/read/38402501/a-multi-center-randomized-controlled-trial-to-investigate-potential-effects-of-exercise-therapy-on-renal-function-stratified-by-renal-disorders-and-renal-pathology-beneficial-or-harmful-effect-in-immunoglobulin-a-nephropathy
#12
JOURNAL ARTICLE
Takahide Kimura, Naoki Washida, Shigeaki Ohtsuki, Kazuya Sugita, Kozi Hosoya, Kiyotaka Uchiyama
BACKGROUND: The effects of exercise therapy (ET) on renal function in chronic kidney disease (CKD) remain unclear. METHODS: In a randomized controlled trial (UMIN-CTR number: UMIN000038415), we investigated whether ET affects renal function in CKD; eligible patients had undergone renal biopsy in the past 3 months. We stratified patients by disease (immunoglobulin A [IgA] nephropathy, n = 16; diabetic nephropathy, n = 4; benign nephrosclerosis, n = 13; and other CKD types, n = 13) and randomized them to 12 weeks' observation and 24 weeks' ET comprising home-based aerobic exercise 3×/week and resistance training 2×/week (intervention group) or usual care (non-intervention group)...
February 25, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38399535/mortality-in-iga-nephropathy-a-long-term-follow-up-of-an-eastern-european-cohort
#13
JOURNAL ARTICLE
Gabriel Ștefan, Adrian Zugravu, Simona Stancu
Background and Objectives : IgA nephropathy (IgAN), the most common primary glomerulonephritis, has been extensively studied for renal outcomes, with limited data on patient survival, particularly in Eastern Europe. We aimed to investigate the long-term survival rate of patients with IgAN and the associated risk factors in an Eastern European cohort. Materials and Methods : We conducted a retrospective analysis of 215 IgAN patients (median age 44, 71% male) diagnosed at a Romanian tertiary center between 2010 and 2017...
January 31, 2024: Medicina
https://read.qxmd.com/read/38398259/an-update-on-current-therapeutic-options-in-iga-nephropathy
#14
REVIEW
Regina Shaoying Lim, See Cheng Yeo, Jonathan Barratt, Dana V Rizk
Immunoglobulin A nephropathy (IgAN) remains the leading cause of primary glomerular disease worldwide. Outcomes are poor with high rates of progressive chronic kidney disease and kidney failure, which contributes to global healthcare costs. Although this disease entity has been described, there were no disease-specific treatments until recently, with the current standard of care focusing on optimal supportive measures including lifestyle modifications and optimization of the renin-angiotensin-aldosterone blockade...
February 7, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38390575/the-causal-effect-of-triglyceride-and-high-blood-pressure-on-iga-nephropathy-a-mendelian-randomization-study
#15
JOURNAL ARTICLE
Yijun Yang, Yang Li, Xinshun Feng, Chenguang Ding, Jing Zhang, Zunwei Liu
BACKGROUND: It has been reported that high blood pressure (HBP) and triglyceride (TG) are considered risk factors in immunoglobulin A nephropathy (IgAN). This study aimed to explore the causalities between HBP and TG, and IgAN on the basis of Mendelian randomization (MR) analysis. METHODS: Firstly, the genome-wide association study (GWAS) summary data of IgAN (GCST90018866) and two exposure factors, TG (ukb-d-30870_raw) and HBP (ukb-a-437), were sourced from the GWAS Catalog and Integrative Epidemiology Unit (IEU) OpenGWAS databases, respectively...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38389153/comparison-between-characteristics-of-immunoglobulin-m-nephropathy-and-other-glomerular-diseases
#16
JOURNAL ARTICLE
Giae Yun, Eun Jeong Kwon, Seokwoo Park, Jong Cheol Jeong, Sejoong Kim, Ki Young Na, Ho Jun Chin
BACKGROUND: Immunoglobulin M (IgM) nephropathy (IgMN) is characterized by the IgM deposition in the kidney's mesangium. We assessed the impact of electron-dense deposits (EDDs) on IgMN and compared it to other kidney diseases. METHODS: We enrolled 63 adult patients with IgMN who underwent renal biopsy from May 2003 to June 2017. We compared clinicopathological features of IgMN based on EDD presence; compared characteristics to 91 minimal change disease (MCD), 103 focal segmental glomerulosclerosis (FSGS), and 469 immunoglobulin A nephropathy (IgAN) patients...
February 15, 2024: Kidney Research and Clinical Practice
https://read.qxmd.com/read/38387189/renin-angiotensin-aldosterone-system-inhibitors-increase-the-serum-level-of-complement-component-4-in-patients-with-immunoglobulin-a-nephropathy
#17
JOURNAL ARTICLE
Min Mao, Yun Zhou, Xu Zhang, Xiao-Yu Zhao, Chen-Dan Wang, Ping Chen
OBJECTIVE: To investigate the impact of renin-angiotensin-aldosterone-system (RAAS) inhibitors on complement component 4 (C4) serum levels in patients with immunoglobulin A nephropathy (IgAN). METHODS: A total of 423 patients diagnosed with IgAN at Shanxi Provincial People's Hospital, China, between 1 January 2017 and 31 December 2021 were divided into two groups, a RAAS inhibitor group and a non-RAAS inhibitor group, for comparative analysis. RESULTS: The RAAS inhibitor group exhibited significantly increased C4 and eGFR levels and had a higher proportion of patients with hypertension compared with the non-RAAS inhibitor group...
February 21, 2024: International Immunopharmacology
https://read.qxmd.com/read/38363464/development-of-a-conceptual-model-for-the-patient-experience-of-immunoglobulin%C3%A2-a-nephropathy-igan-a-qualitative-literature-review
#18
REVIEW
Natalie V J Aldhouse, Helen Kitchen, Tamara Al-Zubeidi, Madeleine Thursfield, Randall Winnette, Sandi See Tai, Linda Zhu, Cecilia Freitas, Nicolas Garnier, Christine L Baker
INTRODUCTION: Immunoglobulin A nephropathy (IgAN) is a kidney disorder that can lead to progressive kidney disease. Currently, there lacks a comprehensive overview of the symptoms and impacts experienced by those living with IgAN that would help inform the selection or development of fit-for-purpose clinical outcome assessments (COA) to be used in clinical trials. The aim of this study was to develop a conceptual model of the adult and pediatric patient experience of IgAN, including disease signs and symptoms, treatment side effects, and impact on functioning and well-being...
February 16, 2024: Advances in Therapy
https://read.qxmd.com/read/38348104/causal-associations-between-prostate-diseases-renal-diseases-renal-function-and-erectile-dysfunction-risk-a-2-sample-mendelian-randomization-study
#19
JOURNAL ARTICLE
Diliyaer Dilixiati, Kaisaierjiang Kadier, Jian-De Lu, Shiping Xie, Baihetiya Azhati, Reyihan Xilifu, Mulati Rexiati
BACKGROUND: Previous observational studies have found a potential link between prostate disease, particularly prostate cancer (PCa), and kidney disease, specifically chronic renal disease (CKD), in relation to erectile dysfunction (ED), yet the causal relationship between these factors remains uncertain. AIM: The study sought to explore the potential causal association between prostate diseases, renal diseases, renal function, and risk of ED. METHODS: In this study, 5 analytical approaches were employed to explore the causal relationships between various prostate diseases (PCa and benign prostatic hyperplasia), renal diseases (CKD, immunoglobulin A nephropathy, membranous nephropathy, nephrotic syndrome, and kidney ureter calculi), as well as 8 renal function parameters, with regard to ED...
February 2024: Sexual Medicine
https://read.qxmd.com/read/38345589/clinicopathological-profile-of-immunoglobulin-a-nephropathy-a-study-from-northeast-india
#20
JOURNAL ARTICLE
Pranjal Kalita, Jaya Mishra, Biswajit Dey, Vandana Raphael, Monaliza Lyngdoh, Himesh Barman, Animesh Mishra
Immunoglobulin A (IgA) nephropathy is the most common primary glomerulopathy, with wide variation in its prevalence as well as clinical symptoms. Among the laboratory parameters, increased serum creatinine (SCr) levels, mean arterial pressure (MAP), and a decreased estimated glomerular filtration rate (eGFR) point toward poorer renal function. The Oxford 2016 scoring system for IgA nephropathy identified various histopathological variables, which serve as indicators of renal outcomes. There is a paucity of studies on the prevalence as well as the various clinical laboratory parameters correlating with the 2016 Oxford scoring system in northeastern India...
July 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
keyword
keyword
171419
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.