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"Immunoglobulin A nephropathy"

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https://read.qxmd.com/read/30895344/-immunoglobulin-a-nephropathy
#1
REVIEW
C Seikrit, T Rauen, J Floege
Immunoglobulin A nephropathy (IgAN) is the most prevalent primary form of glomerulopathy in the western world. The pathogenetic relevance of autoimmune mechanisms, genetics and environmental or nutritional factors is not fully established. The majority of IgAN patients present with mild symptoms; however, the exact prognosis of the individual IgAN course is often difficult to predict. In approximately one third of the patients the disease remains on a stable benign course, whereas approximately 30% may develop end-stage renal disease...
March 20, 2019: Der Internist
https://read.qxmd.com/read/30868039/uremic-pancolitis-in-an-adult-patient-with-newly-diagnosed-rapidly-progressive-crescentic-immunoglobulin-a-nephropathy
#2
Hector H Gonzalez, Meaghan McMahon, Angel E Sanchez, Jennifer G Foster, Ira Lazar
Uremic gastroenteropathy is a well-accepted but less often described sequelae of an underlying renal disease. With the advent of modern dialysis treatments, rarer manifestations, such as pancolitis, may go overlooked in the evaluation, pursuing more common diagnoses. The underlying pathophysiology of uremic gastroenteropathy is not completely understood; however, several underlying mechanisms have been identified to play a role. Here, we present an exceptionally rare case of uremic pancolitis in a Hispanic male who presented with clinical, imaging, and pathological findings consistent with newly diagnosed, rapidly progressive crescentic IgA nephropathy (IgAN)...
January 4, 2019: Curēus
https://read.qxmd.com/read/30855344/a-non-invasive-diagnostic-model-of-immunoglobulin-a-nephropathy-and-serological-markers-for-evaluating-disease-severity
#3
Qiu-Xia Han, Yong Wang, Han-Yu Zhu, Dong Zhang, Jing Gao, Zhang-Suo Liu, Guang-Yan Cai, Xiang-Mei Chen
BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most common pathological type of glomerular disease. Kidney biopsy, the gold standard for IgAN diagnosis, has not been routinely applied in hospitals worldwide due to its invasion nature. Thus, we aim to establish a non-invasive diagnostic model and determine markers to evaluate disease severity by analyzing the serological parameters and pathological stages of patients with IgAN. METHODS: A total of 272 biopsy-diagnosed IgAN inpatients and 518 non-IgA nephropathy inpatients from the Department of Nephrology of Chinese People's Liberation Army General Hospital were recruited for this study...
March 20, 2019: Chinese Medical Journal
https://read.qxmd.com/read/30852287/immunosuppressive-effect-of-artemisinin-and-hydroxychloroquine-combination-therapy-on-iga-nephropathy-via-regulating-the-differentiation-of-cd4-t-cell-subsets-in-rats
#4
REVIEW
Lixia Bai, Honglian Li, Jicheng Li, Jianping Song, Yuan Zhou, Bihao Liu, Ruirui Lu, Peichun Zhang, Junqi Chen, Dandan Chen, Yu Pang, Xusheng Liu, Junbiao Wu, Chunling Liang, Jiuyao Zhou
Immunoglobulin A nephropathy (IgAN) is an autoimmune kidney disease with complex pathogenesis leading to end-stage renal damage. The crucial pathological characteristic in IgAN is IgA immune complexes deposition accompany with mesangial cell proliferation and mesangial matrix expansion. Artemisinin (ART) is isolated from traditional Chinese medicine Artemisia annua L. Hydroxychloroquine (HCQ) is a classical antimalarial drug used to treat autoimmune diseases. Both of them possess immunosuppressive, immunomodulatory and anti-inflammatory features...
March 7, 2019: International Immunopharmacology
https://read.qxmd.com/read/30808840/clinical-significance-of-crescent-formation-in-iga-nephropathy-a-multicenter-validation-study
#5
Sehoon Park, Chung Hee Baek, Su-Kil Park, Hee Gyung Kang, Hye Sun Hyun, Eujin Park, Seung Hyeok Han, Dong-Ryeol Ryu, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Kyung Chul Moon, Ho Jun Chin, Hajeong Lee
BACKGROUND/AIMS: Additional validation study was warranted to confirm the clinical significance of C score, which was recently added to the Oxford classification for immunoglobulin A nephropathy (IgAN). METHODS: We performed a multicenter retrospective cohort study in four hospitals in Korea. Patients who had biopsied glomeruli less than eight or inadequate follow-up information were excluded. Clinicopathologic parameters, including the degree of cellular or fibrocellular crescents, were collected and included in multivariable models for Cox regression analysis...
February 22, 2019: Kidney & Blood Pressure Research
https://read.qxmd.com/read/30808834/renal-outcomes-of-pregnant-patients-with-immunoglobulin-a-nephropathy-a-systematic-review-and-meta-analysis
#6
Fan Wang, Jian-Da Lu, Ying Zhu, Ting-Ting Wang, Jun Xue
BACKGROUND: Is the prognosis of immunoglobulin A nephropathy (IgAN) influenced by pregnancy and delivery? The answer to this question still remains to be a controversial topic. Here, we undertook a systematic review and meta-analysis to obtain the overall estimate of potential effect of IgAN and pregnancy on each other. METHODS: We systematically searched MEDLINE, EMBASE, Chinese Biological Medicine and Cochrane for cohort and case-control studies; a total of 1,378 articles were reviewed and 9 studies were included in the end...
February 26, 2019: American Journal of Nephrology
https://read.qxmd.com/read/30778541/the-oxford-classification-for-immunoglobulin-a-nephropathy-a-common-language-blurred-by-dissonant-voices
#7
Nicolas Maillard, Christophe Mariat
No abstract text is available yet for this article.
February 18, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30704417/the-association-of-tumor-necrosis-factor-superfamily-13-with-recurrence-of-immunoglobulin-a-nephropathy-in-living-related-kidney-transplantation
#8
Hyung Ah Jo, Seung Seok Han, Sunhwa Lee, Joo Young Kim, Seung Hee Yang, Hajeong Lee, Jae Seok Yang, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Curie Ahn, Jin Suk Han, Dong Ki Kim
BACKGROUND: An increasing amount of evidence has demonstrated an association between an increase in the level of tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) progression. We aimed to evaluate if the level of pre-transplant serum TNFSF13 is predictive of IgAN recurrence after kidney transplantation. METHODS: This analysis was based on the clinical and laboratory data of 69 patients with IgAN who underwent first kidney transplantation with no evidence of mesangial IgA deposits in zero-time transplantation biopsy...
January 31, 2019: BMC Nephrology
https://read.qxmd.com/read/30698804/podocytopathy-in-the-mesangial-proliferative-immunoglobulin-a-nephropathy-new-insights-into-the-mechanisms-of-damage-and-progression
#9
Hernán Trimarchi, Rosanna Coppo
Immunoglobulin A nephropathy (IgAN) was defined as a mesangiopathic disease, since the primary site of deposition of IgA immune material is the mesangium, and proliferation of mesangial cells and matrix excess deposition are the first histopathologic lesions. However, the relentless silent progression of IgAN is mostly due to the development of persistent proteinuria, and recent studies indicate that a major role is played by previous damage of function and anatomy of podocytes. In IgAN, the podocytopathic changes are the consequence of initial alterations in the mesangial area with accumulation of IgA containing immune material...
January 29, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30665673/tonsillectomy-plus-steroid-pulse-therapy-is-the-most-effective-treatment-in-adult-patients-with-c-grade-i-iga-nephropathy-and-the-weight-of-the-extracted-palatine-tonsils-and-yamamoto-scale-have-no-significant-correlation-with-the-effects-of-this-treatment
#10
Norio Kondo, Takahito Moriyama, Mayako Tachikawa, Erika Tomita, Ai Hattori, Yukie Yamamura, Manabu Nonaka
OBJECTIVE: We studied patients who underwent tonsillectomy plus steroid pulse therapy (TSP) for immunoglobulin A nephropathy (IgAN), in order to investigate the clinical factors associated with a positive response to this treatment. METHODS: We analyzed 118 IgAN patients who underwent TSP. We collected patients' data retrospectively, including age, sex, blood pressure, onset of IgAN, pathological findings of a renal biopsy, serum concentration of creatinine, estimated glomerular filtration rate, serum concentration of protein, urinary protein, hematuria, past history of tonsillitis, the Yamamoto scale, the weight and pathological findings of the extracted palatine tonsils, and the presence or absence of anti-platelet drugs and renin-angiotensin system inhibitors (RAS-I) usage...
January 18, 2019: Auris, Nasus, Larynx
https://read.qxmd.com/read/30573994/kartagener-syndrome-complicated-by-immunoglobulin-a-nephropathy
#11
Kentaro Oka, Taro Sugase, Tetsu Akimoto, Takuya Murakami, Izumi Nagayama, Miwa Kaneko, Maki Asakura, Ken Ohara, Osamu Saito, Daisuke Nagata
We herein report the case of a 36-year-old woman with Kartagener syndrome (KS), which is an autosomal recessive disorder defined by a triad of bronchiectasis, sinusitis, and situs inversus, with complications of asymptomatic microhematuria and proteinuria. She was finally diagnosed with biopsy-proven immunoglobulin (Ig) A nephropathy. KS constitutes a subgroup of primary ciliary dyskinesia (PCD) characterized by structural and/or functional ciliary abnormalities resulting in sinopulmonary involvement with varying severity...
2018: International Medical Case Reports Journal
https://read.qxmd.com/read/30561721/reproducibility-of-the-oxford-classification-of-immunoglobulin-a-nephropathy-impact-of-biopsy-scoring-on-treatment-allocation-and-clinical-relevance-of-disagreements-evidence-from-the-validation-of-iga-study-cohort
#12
Shubha S Bellur, Ian S D Roberts, Stéphan Troyanov, Virginie Royal, Rosanna Coppo, H Terence Cook, Daniel Cattran, Yolanda Arce Terroba, Anna Maria Asunis, Ingeborg Bajema, Elisabetta Bertoni, Jan A Bruijn, Pablo Cannata-Ortiz, Donatella Casartelli, Anna Maria Di Palma, Franco Ferrario, Mirella Fortunato, Luciana Furci, Hariklia Gakiopoulou, Danica Galesic Ljubanovic, Konstantinos Giannakakis, Montserrat Gomà, Hermann-Josef Gröne, Eduardo M Gutiérrez, S Asma Haider, Eva Honsova, Elli Ioachim, Henryk Karkoszka, David Kipgen, Jagoda Maldyk, Gianna Mazzucco, Diclehan Orhan, Yasemin Ozluk, Afroditi Pantzaki, Agnieszka Perkowska-Ptasinska, Zivili Riispere, Magnus P Soderberg, Eric Steenbergen, Antonella Stoppacciaro, Birgitta Sundelin Von Feilitzen, Regina Tardanico
Background: The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were associated with the decision to give corticosteroid/immunosuppressive (CS/IS) treatments, and to determine the impact of differences in MEST-C scoring between central and local pathologists on the clinical value of the Oxford Classification...
December 15, 2018: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30543739/-urinary-retention-caused-by-necrotic-tissues-in-the-bladder-of-a-female-recipient-of-a-living-donor-kidney-transplant-a-case-report
#13
Yuki Muranishi, Nobuyuki Fukuzawa, Yoshiki Wada, Takashige Abe, Nobuo Shinohara, Hiroshi Harada
We report a patient who developed urinary retention due to the presence of necrotic tissues in the bladder 5 months after kidney transplantation. The patient was a 47-year-old female who had been diagnosed with immunoglobulin A nephropathy. She requested to receive a living-donor kidney transplant from her husband, and was referred to our hospital. Given that the patient had anuria preoperatively, her bladder capacity was presumed to have decreased following the transplantation. There were no events regarding vascular anastomosis during the surgery...
October 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://read.qxmd.com/read/30537719/prediction-of-esrd-in-iga-nephropathy-patients-from-an-asian-cohort-a-random-forest-model
#14
Yexin Liu, Yan Zhang, Di Liu, Xia Tan, Xiaofang Tang, Fan Zhang, Ming Xia, Guochun Chen, Liyu He, Letian Zhou, Xuejing Zhu, Hong Liu
BACKGROUND/AIMS: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied. METHODS: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Demographic and clinicopathological data were obtained within 1 month of renal biopsy...
2018: Kidney & Blood Pressure Research
https://read.qxmd.com/read/30476257/towards-a-personalized-treatment-for-iga-nephropathy-considering-pathology-and-pathogenesis
#15
Rosanna Coppo
The search of personalized treatment for a subject with immunoglobulin A nephropathy (IgAN) is appealing since the individual long-term outcome is highly variable in spite of common mild clinical signs such as microscopic haematuria, moderate proteinuria and slightly reduced glomerular filtration rate (GFR). The only risk factor considered by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines to target corticosteroid/immunosuppressive treatment in IgAN is proteinuria persistently >1 g/day despite 3-6 months of optimized supportive care...
November 26, 2018: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30462346/modulation-of-the-microbiota-by-oral-antibiotics-treats-immunoglobulin-a-nephropathy-in-humanized-mice
#16
Jonathan M Chemouny, Patrick J Gleeson, Lilia Abbad, Gabriella Lauriero, Erwan Boedec, Karine Le Roux, Céline Monot, Maxime Bredel, Julie Bex-Coudrat, Aurélie Sannier, Eric Daugas, Francois Vrtovsnik, Loreto Gesualdo, Marion Leclerc, Laureline Berthelot, Sanae Ben Mkaddem, Patricia Lepage, Renato C Monteiro
Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. IgA is mainly produced by the gut-associated lymphoid tissue (GALT). Both experimental and clinical data suggest a role of the gut microbiota in this disease. We aimed to determine if an intervention targeting the gut microbiota could impact the development of disease in a humanized mouse model of IgAN, the α1KI-CD89Tg mice. Methods: Four- and 12-week old mice were divided into two groups to receive either antibiotics or vehicle control...
November 20, 2018: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30454740/approach-to-the-child-with-hematuria
#17
REVIEW
Denver D Brown, Kimberly J Reidy
The causes of macroscopic and microscopic hematuria overlap; both are often caused by urinary tract infections or urethral/bladder irritation. Coexistent hypertension and proteinuria should prompt investigation for glomerular disease. The most common glomerulonephritis in children is postinfectious glomerulonephritis. In most patients, and especially with isolated microscopic hematuria, the diagnostic workup reveals no clear underlying cause. In those cases whereby a diagnosis is made, the most common causes of persistent microscopic hematuria are thin basement membrane nephropathy, immunoglobulin A nephropathy, or idiopathic hypercalciuria...
February 2019: Pediatric Clinics of North America
https://read.qxmd.com/read/30454736/immunoglobulin-a-nephropathy-and-immunoglobulin-a-vasculitis
#18
REVIEW
Oana Nicoara, Katherine Twombley
Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are common glomerulopathies in the pediatric population that deserve special attention. In some cases the primary care provider can follow the patient but others need more intensive management. Delaying this treatment can lead to worse morbidity. This article provides information on the pathogenesis, outcomes, and follow-up strategies that will aid in the diagnosis and referral of patients at risk for kidney disease.
February 2019: Pediatric Clinics of North America
https://read.qxmd.com/read/30445530/repeat-renal-biopsy-improves-the-oxford-classification-based-prediction-of-immunoglobulin-a-nephropathy-outcome
#19
Perrine Jullien, Blandine Laurent, François Berthoux, Ingrid Masson, Miriana Dinic, Guillaume Claisse, Damien Thibaudin, Christophe Mariat, Eric Alamartine, Nicolas Maillard
Background: The prognosis of IgA nephropathy (IgAN) is very heterogeneous. Predicting the nature and the rate of the disease progression is crucial for refining patient treatment. The aim of this study was to evaluate the prognostic impact of an Oxford classification-based repeat kidney tissue evaluation to predict end-stage renal disease (ESRD). Methods: Patients with biopsy-proven primary IgAN who underwent two renal biopsies at our centre were analyzed retrospectively...
November 15, 2018: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30430129/successful-treatment-of-pyoderma-gangrenosum-with-concomitant-immunoglobulin-a-nephropathy-a-case-report-and-review-of-literature
#20
Xiao-Li Li, Zhi-Gang Ma, Wen-Hui Huang, Er-Qing Chai, Yun-Fei Hao
Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition of an unknown etiology and is often associated with immune diseases. However, PG rarely shows visceral involvement, especially in the kidney. A 20-year-old female presented with pedal edema and skin ulceration of both lower limbs. The skin lesion began as an erythematous plaque and then became a blister. She also complained of abdominal distension and a decreasing urine volume. Laboratory data showed high proteinuria, hypoalbuminemia and hyperlipidemia...
November 6, 2018: World Journal of Clinical Cases
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