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Keith Poole

Ángel Chamorro, Scott Brown, Sergio Amaro, Michael D Hill, Keith W Muir, Diederik W J Dippel, Wim van Zwam, Ken Butcher, Gary A Ford, Heleen M den Hertog, Peter J Mitchell, Andrew M Demchuk, Charles B L M Majoie, Serge Bracard, Igor Sibon, Ashutosh P Jadhav, Blanca Lara-Rodriguez, Aad van der Lugt, Elizabeth Osei, Arturo Renú, Sébastien Richard, David Rodriguez-Luna, Geoffrey A Donnan, Anand Dixit, Mohammed Almekhlafi, Sandrine Deltour, Jonathan Epstein, Benoit Guillon, Serge Bakchine, Meritxell Gomis, Richard du Mesnil de Rochemont, Demetrius Lopes, Vivek Reddy, Gernot Rudel, Yvo B W E M Roos, Alain Bonafe, Hans-Christoph Diener, Olvert A Berkhemer, Geoffrey C Cloud, Stephen M Davis, Robert van Oostenbrugge, Francis Guillemin, Mayank Goyal, Bruce C V Campbell, Bijoy K Menon
Background and Purpose- Hyperglycemia is a negative prognostic factor after acute ischemic stroke but is not known whether glucose is associated with the effects of endovascular thrombectomy (EVT) in patients with large-vessel stroke. In a pooled-data meta-analysis, we analyzed whether serum glucose is a treatment modifier of the efficacy of EVT in acute stroke. Methods- Seven randomized trials compared EVT with standard care between 2010 and 2017 (HERMES Collaboration [highly effective reperfusion using multiple endovascular devices])...
February 19, 2019: Stroke; a Journal of Cerebral Circulation
Shengzhi Sun, Kate R Weinberger, Keith R Spangler, Melissa N Eliot, Joseph M Braun, Gregory A Wellenius
BACKGROUND: Days of extreme temperature may be associated with transiently higher risk of preterm birth, but prior studies have been limited and results have been heterogeneous. OBJECTIVES: To evaluate the association between days of extreme heat and cold and risk of preterm birth among ~32 million live singleton births between 1989 and 2002 across 403 counties in the contiguous United States (US). METHODS: We used a distributed lag nonlinear model to estimate the association between population-weighted daily mean temperature and risk of preterm birth in each county and then pooled results across geographic regions and climate zones...
February 15, 2019: Environment International
Mayank Goyal, Mohammed Almekhlafi, Diederik W Dippel, Bruce C V Campbell, Keith Muir, Andrew M Demchuk, Serge Bracard, Antoni Davalos, Francis Guillemin, Tudor G Jovin, Bijoy K Menon, Peter J Mitchell, Scott Brown, Philip White, Charles B L M Majoie, Jeffrey L Saver, Michael D Hill
Background and Purpose- We report the relation of onset-to-treatment time and door-to-needle time with functional outcomes and mortality among patients with ischemic stroke with imaging-proven large vessel occlusion treated with intravenous alteplase. Methods- Individual patient-level data from the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) collaboration were pooled from 7 trials that randomized patients to mechanical thrombectomy added to best medical therapy versus best medical therapy alone...
February 14, 2019: Stroke; a Journal of Cerebral Circulation
Jennifer A Villwock, Chelsea S Hamill, Keith A Sale, Kevin J Sykes
BACKGROUND: Efficient, nonbiased methods for screening residency candidates are lacking. The purpose of this study is to highlight the design, implementation, and impact of the Selection Tool for Applicants to Residency (STAR), an objective approach to selecting candidates to interview for residency selection purposes. MATERIALS AND METHODS: Single-institution retrospective cohort study of medical student applicants and current residents of a single otolaryngology residency program from 2008 to 2015 was performed...
March 2019: Journal of Surgical Research
Iliana Tenvooren, Mónica Z Jenks, Hamza Rashid, Katherine L Cook, Joëlle K Muhlemann, Christopher Sistrunk, Julia Holmes, Kevin Wang, Keith Bonin, Kurt Hodges, Hui-Wen Lo, Ayaz Shaikh, Ignacio G Camarillo, Sophie A Lelièvre, Victoria Seewaldt, Pierre-Alexandre Vidi
Obesity is a highly prevalent and modifiable breast cancer risk factor. While the role of obesity in fueling breast cancer progression is well established, the mechanisms linking obesity to breast cancer initiation are poorly understood. A hallmark of breast cancer initiation is the disruption of apical polarity in mammary glands. Here we show that mice with diet-induced obesity display mislocalization of Par3, a regulator of cellular junctional complexes defining mammary epithelial polarity. We found that epithelial polarity loss also occurs in a 3D coculture system that combines acini with human mammary adipose tissue, and establish that a paracrine effect of the tissue adipokine leptin causes loss of polarity by overactivation of the PI3K/Akt pathway...
January 22, 2019: Oncogene
Romain Bourcier, Mayank Goyal, David S Liebeskind, Keith W Muir, Hubert Desal, Adnan H Siddiqui, Diederik W J Dippel, Charles B Majoie, Wim H van Zwam, Tudor G Jovin, Elad I Levy, Peter J Mitchell, Olvert A Berkhemer, Stephen M Davis, Imad Derraz, Geoffrey A Donnan, Andrew M Demchuk, Robert J van Oostenbrugge, Michael Kelly, Yvo B Roos, Reza Jahan, Aad van der Lugt, Marieke Sprengers, Stephane Velasco, Geert J Lycklama À Nijeholt, Wagih Ben Hassen, Paul Burns, Scott Brown, Emmanuel Chabert, Timo Krings, Hana Chloe, Christian Weimar, Bruce C V Campbell, Gary A Ford, Marc Ribo, Phil White, Geoffrey C Cloud, Luis San Roman, Antoni Davalos, Olivier Naggara, Michael D Hill, Serge Bracard
Importance: Reperfusion is a key factor for clinical outcome in patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy (EVT) for large-vessel intracranial occlusion. However, data are scarce on the association between the time from onset and reperfusion results. Objective: To analyze the rate of reperfusion after EVT started at different intervals after symptom onset in patients with AIS. Design, Setting, and Participants: We conducted a meta-analysis of individual patient data from 7 randomized trials of the Highly Effective Reperfusion Using Multiple Endovascular Devices (HERMES) group...
January 22, 2019: JAMA Neurology
Bobby V M Dasari, James Hodson, Robert P Sutcliffe, Ravi Marudanayagam, Keith J Roberts, Manuel Abradelo, Paolo Muiesan, Darius F Mirza, John Isaac
BACKGROUND: Hepatobiliary surgeons continue to expand the pool of patients undergoing liver resection using combinations of surgical and interventional procedures with chemotherapy. Improved perioperative care allows for operation on higher risk surgical patients. Postoperative outcomes, including 90-day mortality that improved over the past decade but still varies across cohorts. This study developed a preoperative risk score, on the basis significant clinical and laboratory variables, to predict 90-day mortality after hepatectomy...
January 13, 2019: Journal of Surgical Oncology
Anna M M Boers, Ivo G H Jansen, Scott Brown, Hester F Lingsma, Ludo F M Beenen, Thomas G Devlin, Luis San Román, Ji-Hoe Heo, Marc Ribó, Mohammed A Almekhlafi, David S Liebeskind, Jeanne Teitelbaum, Patricia Cuadras, Richard du Mesnil de Rochemont, Marine Beaumont, Martin M Brown, Albert J Yoo, Geoffrey A Donnan, Jean Louis Mas, Catherine Oppenheim, Richard J Dowling, Thierry Moulin, Nelly Agrinier, Demetrius K Lopes, Lucía Aja Rodríguez, Kars C J Compagne, Fahad S Al-Ajlan, Jeremy Madigan, Gregory W Albers, Sebastien Soize, Jordi Blasco, Stephen M Davis, Raul G Nogueira, Antoni Dávalos, Bijoy K Menon, Aad van der Lugt, Keith W Muir, Yvo B W E M Roos, Phil White, Peter J Mitchell, Andrew M Demchuk, Wim H van Zwam, Tudor G Jovin, Robert J van Oostenbrugge, Diederik W J Dippel, Bruce C V Campbell, Francis Guillemin, Serge Bracard, Michael D Hill, Mayank Goyal, Henk A Marquering, Charles B L M Majoie
Importance: The positive treatment effect of endovascular therapy (EVT) is assumed to be caused by the preservation of brain tissue. It remains unclear to what extent the treatment-related reduction in follow-up infarct volume (FIV) explains the improved functional outcome after EVT in patients with acute ischemic stroke. Objective: To study whether FIV mediates the relationship between EVT and functional outcome in patients with acute ischemic stroke. Design, Setting, and Participants: Patient data from 7 randomized multicenter trials were pooled...
January 7, 2019: JAMA Neurology
Louis A Cannon, Carey D Kimmelstiel, Anthony White, Roger Hill, Timothy P Grady, Paul R Myers, Paul Underwood, Keith D Dawkins
BACKGROUND: The ION Study assessed clinical outcomes for the thin-strut, ION™ (TAXUS Element) Paclitaxel-Eluting Platinum Chromium Coronary Stent System (Boston Scientific, Marlborough, MA) in unselected patients. METHODS: This prospective, open-label registry enrolled the first 1,120 consenting patients treated with the ION stent without clinical or angiographic inclusion criteria at 40 clinical sites. Follow-up was at discharge, 30 days, 180 days, 1 and 2 years...
December 30, 2018: Catheterization and Cardiovascular Interventions
Mariam L Alam, Ronit Katz, Keith A Bellovich, Zeenat Y Bhat, Frank C Brosius, Ian H de Boer, Crystal A Gadegbeku, Debbie S Gipson, Jennifer J Hawkins, Jonathan Himmelfarb, Bryan R Kestenbaum, Matthias Kretzler, Cassianne Robinson-Cohen, Susan P Steigerwalt, Courtney Tuegel, Nisha Bansal
Introduction: Cardiac biomarkers soluble ST2 (sST2) and galectin-3 may reflect cardiac inflammation and fibrosis. It is plausible that these mechanisms may also contribute to the progression of kidney disease. We examined associations of sST2 and galectin-3 with kidney function decline in participants with chronic kidney disease (CKD). Methods: This was a pooled analysis of 2 longitudinal cohorts of participants with CKD: the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS)...
January 2019: KI Reports
Keith Luckett, Tiffany Kaiser, Khurram Bari, Kamran Safdar, Michael R Schoech, Senu Apewokin, Tayyab Diwan, Madison C Cuffy, Nadeem Anwar, Shimul A Shah
INTRO: Given the shortage of available liver grafts, transplantation (LTx) of Hepatitis C antibody positive, nucleic acid test negative (HCV Ab+/NAT-) livers into non-viremic HCV recipients may expand the donor pool. Having previously described the sentinel experience of HCV Ab+/NAT- allografts in non-viremic recipients, we report the growth and extended follow-up of this program for 55 patients compared to recipients of PHS increased risk donor (IRD) HCV Ab-/NAT- allografts. STUDY DESIGN: A prospective review of all HCV non-viremic LTx recipients transplanted with an HCV Ab+/NAT- organs between 3/2016 and 8/2018 was performed...
December 23, 2018: Journal of the American College of Surgeons
Julie Lajoie, Annelie Tjernlund, Kenneth Omollo, Gabriella Edfeldt, Maria Rohl, Geneviève Boily-Larouche, Juliana Cheruiyot, Makobu Kimani, Joshua Kimani, Julius Oyugi, Kristina Broliden, Keith Raymond Fowke
INTRODUCTION: Depot medroxyprogesterone acetate (DMPA) is the most common hormonal contraceptive used by women in sub-Saharan Africa, however, it has been epidemiologically associated with HIV infections. To assess if DMPA has an effect on the number and activation of HIV target cells, this study assessed the levels and phenotype of blood-and mucosal derived HIV target cells among women using DMPA. METHODS: Thirty-five HIV uninfected women from the Pumwani Sex Worker cohort from Nairobi, Kenya were enrolled in the study (15 using DMPA and 20 not using hormonal contraception)...
December 26, 2018: AIDS Research and Human Retroviruses
Gregory Y H Lip, Allison Keshishian, Xiaoyan Li, Melissa Hamilton, Cristina Masseria, Kiran Gupta, Xuemei Luo, Jack Mardekian, Keith Friend, Anagha Nadkarni, Xianying Pan, Onur Baser, Steven Deitelzweig
Background and Purpose- This ARISTOPHANES study (Anticoagulants for Reduction in Stroke: Observational Pooled Analysis on Health Outcomes and Experience of Patients) used multiple data sources to compare stroke/systemic embolism (SE) and major bleeding (MB) among a large number of nonvalvular atrial fibrillation patients on non-vitamin K antagonist oral anticoagulants (NOACs) or warfarin. Methods- A retrospective observational study of nonvalvular atrial fibrillation patients initiating apixaban, dabigatran, rivaroxaban, or warfarin from January 1, 2013, to September 30, 2015, was conducted pooling Centers for Medicare and Medicaid Services Medicare data and 4 US commercial claims databases...
December 2018: Stroke; a Journal of Cerebral Circulation
Magdalen G Schluter, Hyoun S Kim, Julia C Poole, David C Hodgins, Daniel S McGrath, Keith S Dobson, Hermano Taveres
BACKGROUND AND OBJECTIVES: Symptoms of depression are highly prevalent among individuals with gambling disorder, and severity of depression is associated with severity of gambling problem. Yet, little is known about the psychological mechanisms by which symptoms of depression lead to greater gambling severity. In this study, we tested whether cognitive distortions represent one such mechanism, as cognitive distortions are key characteristics in both depression and gambling disorder and have been shown to be associated with gambling severity...
November 26, 2018: Addictive Behaviors
Yunhee Kang, Víctor M Aguayo, Rebecca K Campbell, Keith P West
Stunting (length-for-age z score < -2) before 2 years of age has shown associations with poor child developmental indicators, but information at the population level is scarce in South Asia, the region with the highest burden of stunting. We examined associations between z scores (i.e., height for age [HAZ], weight for age [WAZ], and weight for height [WHZ]) and undernutrition (i.e., stunting [HAZ < -2], wasting [WHZ < -2], and underweight [WAZ < -2]) with learning/cognition and social-emotional development among children 36-59 months of age...
November 2018: Maternal & Child Nutrition
Keith P West, Lee S-F Wu, Hasmot Ali, Rolf D W Klemm, Karen Margaret Edmond, Lisa Hurt, Betty Kirkwood, Sam Newton, Caitlin Shannon, Sunita Taneja, Sarmila Mazumder, Kiran Bhatia, Nita Bhandari, Joanne Katz, James M Tielsch, Jean Humphrey, Tina Agoestina, Sajid Bashir Soofi, Shabina Ariff, Zaid Bhatti, Simon Cousens, Zulfiqar A Bhutta, Robert Ntozini, Honorati Masanja, Emily R Smith, Alfa Muhihi, Wafaie Fawzi, Rajiv Bahl, Jose Martines, Sachiyo Yoshida
BACKGROUND: Biannual vitamin A supplementation is a well-established survival tool for preschool children 6 months and older in vitamin A deficient populations but this schedule misses the opportunity to intervene on most young infant deaths. Randomised trials of neonatal vitamin A supplementation (NVAS) in the first few days of life to assess its impact on under 6-month mortality in low/middle-income countries have had varying results. METHODS: Investigators of 11 published randomised placebo-controlled NVAS trials (n=163 567 children) reanalysed their data according to an agreed plan and pooled the primary outcomes of mortality from supplementation through 6 and 12 months of age using random effects models and meta-regression...
November 13, 2018: Archives of Disease in Childhood
Keith C Meyer
Lung transplantation can improve quality of life and prolong survival for individuals with end-stage lung disease, and many advances in the realms of both basic science and clinical research aspects of lung transplantation have emerged over the past few decades. However, many challenges must yet be overcome to increase post-transplant survival. These include successfully bridging patients to transplant, expanding the lung donor pool, inducing tolerance, and preventing a myriad of post-transplant complications that include primary graft dysfunction, forms of cellular and antibody-mediated rejection, chronic lung allograft dysfunction, and infections...
2018: F1000Research
Simon P Stevens, Caroline Main, Simon Bailey, Barry Pizer, Martin English, Bob Phillips, Andrew Peet, Shivaram Avula, Sophie Wilne, Keith Wheatley, Pamela R Kearns, Jayne S Wilson
BACKGROUND: Surveillance magnetic resonance imaging (MRI) is routinely used to detect recurrence in children with high-grade central nervous system (CNS) tumors, although no consensus has been reached regarding its effectiveness and whether earlier detection is associated with improved patient outcomes. This review aimed to evaluate this practice and any associated benefits and harms. METHODS: Systematic searches for relevant studies were undertaken in a number of databases, including MEDLINE and EMBASE, from 1985 to August 2018...
November 8, 2018: Pediatric Blood & Cancer
Joyce Yeung, Keith Couper, Elizabeth G Ryan, Simon Gates, Nick Hart, Gavin D Perkins
PURPOSE: A systematic review and meta-analysis was conducted to answer the question 'In adults with respiratory failure requiring invasive ventilation for more than 24 h, does a weaning strategy with early extubation to non-invasive ventilation (NIV) compared to invasive ventilation weaning reduce all-cause hospital mortality?' METHODS: We included randomised and quasi-randomised controlled trials that evaluated the use of non-invasive ventilation, compared to invasive ventilation, as a weaning strategy in adults mechanically ventilated for at least 24 h...
October 31, 2018: Intensive Care Medicine
Yichen Zhang, Frédérick Faucher, Wenwen Zhang, Shu Wang, Nolan Neville, Keith Poole, Jun Zheng, Zongchao Jia
Pseudomonas aeruginosa utilizes the Type II secretion system (T2SS) to translocate a wide range of large, structured protein virulence factors through the periplasm to the extracellular environment for infection. In the T2SS, five pseudopilins assemble into the pseudopilus that acts as a piston to extrude exoproteins out of cells. Through structure determination of the pseudopilin complexes of XcpVWX and XcpVW and function analysis, we have confirmed that two minor pseudopilins, XcpV and XcpW, constitute a core complex indispensable to the pseudopilus tip...
October 2018: PLoS Pathogens
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