Ebe D'Adamo, Gabriella Levantini, Michela Librandi, Valentina Botondi, Laura Di Ricco, Sara De Sanctis, Cynzia Spagnuolo, Francesca Gazzolo, Danilo Aw Gavilanes, Patrizia Di Gregorio, Jessica Di Monte, Maria Chiara Strozzi, Antonio Maconi, Maurizio Cassinari, Roberta Libener, Diego Gazzolo
OBJECTIVES: Early sepsis detection and diagnosis still constitutes an open issue since the accuracy of standard-of care parameters is biased by a series of perinatal factors including hypoxia. Therefore, we aimed at investigating the effect of fetal chronic hypoxia insult on urine levels of a promising new marker of sepsis, namely presepsin (P-SEP). METHODS: We conducted a prospective case-control study in 22 cases of early-intrauterine growth restriction (E-IUGR) compared with 22 small-for-gestational-age (SGA) newborns and 66 healthy controls...
February 2, 2024: Clinical Chemistry and Laboratory Medicine: CCLM