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JOURNAL ARTICLE
Bertrand Chauveau, Jean-Baptiste Gibier, Jérôme Olagne, Antoine Morel, Selda Aydin, Stephen P McAdoo, Nicolas Viallet, Hélène Perrochia, Emilie Pambrun, Virginie Royal, Nathalie Demoulin, Jean-Louis Kemeny, Carole Philipponnet, Alexandre Hertig, Jean-Jacques Boffa, Emmanuelle Plaisier, Camille Domenger, Isabelle Brochériou, Clément Deltombe, Jean-Paul Duong Van Huyen, David Buob, Candice Roufosse, Thomas Hellmark, Vincent Audard, Fabrice Mihout, Samih H Nasr, Karine Renaudin, Anissa Moktefi, Marion Rabant
RATIONALE & OBJECTIVE: Atypical anti-glomerular basement membrane (GBM) nephritis is characterized by a bright linear immunoglobulin staining along the GBM by immunofluorescence without a diffuse crescentic glomerulonephritis nor serum anti-GBM antibodies by conventional enzyme-linked immunosorbent assay (ELISA). We characterized a series of patients with atypical anti-GBM disease. STUDY DESIGN: Case series. SETTING & PARTICIPANTS: Patients identified by the French Nephropathology Group as having atypical anti-GBM nephritis between 2003 and 2022...
January 1, 2024: American Journal of Kidney Diseases
#22
JOURNAL ARTICLE
Sarah Vincent, Régis Marchiano, Jean-Louis Thomas
Acoustic tweezers offer a contactless, three-dimensional, and selective approach to trapping objects by harnessing the acoustic radiation force. Precise control of this technique requires accurate calibration of the force, which depends on the object's properties and the spherical harmonics expansion of the incident field through the beam shape coefficients. Previous studies showed that these coefficients can be determined using either the Lebedev quadrature or the angular spectrum methods. However, the former is highly susceptible to noise, while the latter demands extensive implementation time due to the number of required measurement points...
December 1, 2023: Journal of the Acoustical Society of America
#23
JOURNAL ARTICLE
Jean-Louis Merlin, Marie Husson, Nassim Sahki, Pauline Gilson, Vincent Massard, Alexandre Harlé, Agnès Leroux
Based on immunohistochemistry (IHC) and in situ hybridization (ISH), HER2-low breast cancers (BC) subtype-defined as IHC1+ or IHC2+/ISH- tumors-emerged and represent more than half of all BC. We evaluated the performance of NGS for integrated molecular characterization of HER2-low BC, including identification of actionable molecular targets, copy number variation (CNV), and microsatellite instability (MSI) analysis. Thirty-one BC specimens (11 HER2+, 10 HER2-, and 10 HER2-low) were routinely analyzed using IHC and ISH, and were selected and analyzed using NGS for gene mutations including ESR1 , PIK3CA , AKT1 , ERBB2 , TP53 , BRCA1 , and BRCA2 , CNV, and MSI...
November 28, 2023: Biomedicines
#24
JOURNAL ARTICLE
Nohad Gresh, Krystel El Hage, Louis Lagardère, Frédérique Brégier, Jérémy Godard, Jean-Philip Piquemal, Martine Perrée-Fauvet, Vincent Sol
Bisacridinyl-bisarginyl porphyrin (BABAP) is a trisintercalating derivative of a tricationic porphyrin, formerly designed and synthesized in order to selectively target and photosensitize the ten-base pair palindromic sequence d(CGGGCGCCCG)2 . We resorted to the previously derived (Far et al., 2004) lowest energy-minimized (EM) structure of the BABAP complex with this sequence as a starting point. We performed polarizable molecular dynamics (MD) on this complex. It showed, over a 150 ns duration, the persistent binding of the Arg side-chain on each BABAP arm to the two G bases upstream from the central porphyrin intercalation site...
December 13, 2023: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
#25
Zoe Schmilovich, Vincent-Raphaël Bourque, Elise Douard, Guillaume Huguet, Cécile Poulain, Jay P Ross, Paria Alipour, Charles-Étienne Castonguay, Nadine Younis, Martineau Jean-Louis, Zohra Saci, Zdenka Pausova, Tomas Paus, Gunter Schuman, David Porteous, Gail Davies, Paul Redmond, Sarah E Harris, Ian J Deary, Heather Whalley, Caroline Hayward, Patrick A Dion, Sébastien Jacquemont, Guy A Rouleau
Rare copy number variants (CNVs) and polygenic risk for intelligence (PRS-IQ) both confer risk for autism spectrum disorder (ASD) but have opposing effects on cognitive ability. The field has struggled to disentangle the effects of these two classes of genomic variants on cognitive ability from their effects on ASD risk, in part because previous studies did not include controls with cognitive measures. We aim to investigate the impact of these genomic variants on ASD risk while adjusting for their known effects on cognitive ability...
November 29, 2023: medRxiv
#26
MULTICENTER STUDY
Benjamin de Valence, Marion Delaune, Yann Nguyen, Vincent Jachiet, Mael Heiblig, Alexis Jean, Stanislas Riescher Tuczkiewicz, Pierrick Henneton, Philippe Guilpain, Nicolas Schleinitz, Guillaume Le Guenno, Hervé Lobbes, Valentin Lacombe, Samuel Ardois, Estibaliz Lazaro, Vincent Langlois, Roderau Outh, Julien Vinit, Jean-Philippe Martellosio, Paul Decker, Thomas Moulinet, Yannick Dieudonné, Adrien Bigot, Louis Terriou, Alexandre Vlakos, Baptiste de Maleprade, Guillaume Denis, Jonathan Broner, Marie Kostine, Sebastien Humbert, Francois Lifermann, Maxime Samson, Susann Pechuzal, Achille Aouba, Olivier Kosmider, Jeremie Dion, Sylvie Grosleron, Rim Bourguiba, Benjamin Terrier, Sophie Georgin-Lavialle, Olivier Fain, Arsène Mekinian, Marjolaine Morgand, Thibault Comont, Jerome Hadjadj
INTRODUCTION: Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is an acquired autoinflammatory monogenic disease with a poor prognosis whose determinants are not well understood. We aimed to describe serious infectious complications and their potential risk factors. METHODS: Retrospective multicentre study including patients with VEXAS syndrome from the French VEXAS Registry. Episodes of serious infections were described, and their risk factors were analysed using multivariable Cox proportional hazards models...
February 15, 2024: Annals of the Rheumatic Diseases
#27
RANDOMIZED CONTROLLED TRIAL
Bruno Garcia, Fuhong Su, Laurence Dewachter, Yong Wang, Ning Li, Myriam Remmelink, Marie Van Eycken, Amina Khaldi, Raphaël Favory, Antoine Herpain, Anthony Moreau, Alexander Moiroux-Sahraoui, Francesca Manicone, Filippo Annoni, Lin Shi, Jean-Louis Vincent, Jacques Creteur, Fabio S Taccone
BACKGROUND: Extracellular histones have been associated with severity and outcome in sepsis. The aim of the present study was to assess the effects of sodium-β-O-Methyl cellobioside sulfate (mCBS), a histone-neutralizing polyanion, on the severity and outcome of sepsis in an experimental model. METHODS: This randomized placebo-controlled experimental study was performed in 24 mechanically ventilated female sheep. Sepsis was induced by fecal peritonitis. Animals were randomized to three groups: control, early treatment, and late treatment (n = 8 each)...
November 24, 2023: Critical Care: the Official Journal of the Critical Care Forum
#28
REVIEW
Margaux Betz, Vincent Massard, Pauline Gilson, Andréa Witz, Julie Dardare, Alexandre Harlé, Jean-Louis Merlin
The predominant forms of breast cancer (BC) are hormone receptor-positive (HR+) tumors characterized by the expression of estrogen receptors (ERs) and/or progesterone receptors (PRs). Patients with HR+ tumors can benefit from endocrine therapy (ET). Three types of ET are approved for the treatment of HR+ BCs and include selective ER modulators, aromatase inhibitors, and selective ER downregulators. ET is the mainstay of adjuvant treatment in the early setting and the backbone of the first-line treatment in an advanced setting; however, the emergence of acquired resistance can lead to cancer recurrence or progression...
October 27, 2023: Cancers
#29
JOURNAL ARTICLE
Mervyn Singer, Antoni Torres, Corina C Heinz, Sabrina Weißmüller, Alexander Staus, Steffen Kistner, Ksenia Jakubczyk, Thomas Häder, Patrick Langohr, Andrea Wartenberg-Demand, Jörg Schüttrumpf, Jean-Louis Vincent, Tobias Welte
BACKGROUND: The phase II CIGMA trial performed in 160 patients with severe community-acquired pneumonia (sCAP) found treatment with trimodulin (human polyvalent immunoglobulin [Ig]: ~ 23% IgM, ~ 21% IgA, ~ 56% IgG) was associated with a lower mortality in those patients with elevated baseline serum levels of C-reactive protein (CRP) and/or subnormal IgM. METHODS: In this post hoc analysis, the pharmacodynamic effects of trimodulin treatment (182...
November 9, 2023: Critical Care: the Official Journal of the Critical Care Forum
#30
JOURNAL ARTICLE
Sabrina Sidali, Raphaël Borie, Flore Sicre de Fontbrune, Kinan El Husseini, Pierre-Emmanuel Rautou, Elodie Lainey, Odile Goria, Bruno Crestani, Jacques Cadrane, Vincent Cottin, Vincent Bune, Jérôme Dumortier, Emmanuel Jacquemin, Noémi Reboux, Sandrine Hirschi, Arnaud Bourdin, Magdalena Meszaros, Sebastien Dharancy, Sophie Hilaire, Vincent Mallet, Martine Reynaud-Gaubert, Louis Terriou, Frédéric Gottrand, Wadih Abou Chahla, Jean-Emmanuel Khan, Paul Carrier, Faouzi Saliba, Laura Rubbia-Brandt, John-David Aubert, Laure Elkrief, Victor de Lédinghen, Armand Abergel, Tournilhac Olivier, Pauline Houssel, Stephane Jouneau, Lidwine Wemeau, Anne Bergeron, Thierry Leblanc, Isabelle Ollivier-Hourmand, Eric Nguyen Khac, Hélène Morisse-Pradier, Ibrahima Ba, Catherine Boileau, Françoise Roudot-Thoraval, Valérie Vilgrain, Christophe Bureau, Hilario Nunes, Jean-Marc Naccache, François Durand, Claire Francoz, Dominique Roulot, Dominique Valla, Valérie Paradis, Caroline Kannengiesser, Aurélie Plessier
BACKGROUND AND AIM: Germline mutations of telomere-related genes (TRG) induce multiorgan dysfunction, and liver-specific manifestations have not been clearly outlined. We aimed to describe TRG mutations-associated liver diseases. APPROACH AND RESULTS: Retrospective multicentre analysis of liver disease (transaminases>30 IU/L and/or abnormal liver imaging) in patients with TRG mutations. Main measurements were characteristics, outcomes, and risk factors of liver disease in a TRG mutations cohort...
November 6, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#31
JOURNAL ARTICLE
Guilhem Royer, Emmanuel Lecorche, Céline Sakr, Florence Cizeau, David Ducellier, Vincent Fihman, Keyvan Razazi, Paul-Louis Woerther, Jean-Winoc Decousser
No abstract text is available yet for this article.
November 3, 2023: Infection Control and Hospital Epidemiology
#32
JOURNAL ARTICLE
Florence Delestre, Pierre Charles, Alexandre Karras, Christian Pagnoux, Antoine Néel, Pascal Cohen, Olivier Aumaître, Stanislas Faguer, Pierre Gobert, François Maurier, Maxime Samson, Pascal Godmer, Bernard Bonnotte, Vincent Cottin, Catherine Hanrotel-Saliou, Thomas Le Gallou, Pierre-Louis Carron, Hélène Desmurs-Clavel, Guillaume Direz, Noémie Jourde-Chiche, Francois Lifermann, Nicolas Martin-Silva, Grégory Pugnet, Thomas Quéméneur, Marie Matignon, Ygal Benhamou, Eric Daugas, Estibaliz Lazaro, Nicolas Limal, Maïzé Ducret, Antoine Huart, Jean-François Viallard, Eric Hachulla, Elodie Perrodeau, Xavier Puechal, Loïc Guillevin, Raphaël Porcher, Benjamin Terrier
OBJECTIVE: To compare the long-term efficacy and safety of azathioprine (AZA), 18-month fixed-schedule rituximab (RTX), 18-month tailored RTX and 36-month RTX in preventing relapses in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis who achieved a complete remission after induction therapy. Patients treated with 36-month RTX received either a fixed or a tailored regimen for the first 18 months and a fixed regimen for the last 18 months (36-month fixed/fixed RTX and 36-month tailored/fixed RTX, respectively)...
January 11, 2024: Annals of the Rheumatic Diseases
#33
EDITORIAL
Marc Leone, Ines Lakbar, Jean-Louis Vincent
No abstract text is available yet for this article.
October 31, 2023: Revue D'épidémiologie et de Santé Publique
#34
JOURNAL ARTICLE
Victoria Madeleine Garnfeldt, Jean-Louis Vincent, Damien Gruson, Osvaldo Ulises Garay, Stefaan Vansieleghem, Leonardo Iniguez, Alexander Lefevre
In Belgium, antibiotic resistance leads to approximately 530 deaths with a €24 million financial burden annually. This study estimated the impact of procalcitonin-guided antibiotic stewardship programs to reduce antibiotic consumption versus standard of care in patients with suspected sepsis. A decision analytic tree modelled health and budget outcomes of procalcitonin-guided antibiotic stewardship programs for patients admitted to the intensive care unit (ICU). A literature search, a survey with local clinical experts, and national database searches were conducted to obtain model input parameters...
2023: PloS One
#35
JOURNAL ARTICLE
Elaine Cavalcante Dos Santos, Péter Bakos, Diego Orbegozo, Jacques Creteur, Jean-Louis Vincent, Fabio Silvio Taccone
BACKGROUND: Alterations in skin blood flow is a marker of inadequate tissue perfusion in critically ill patients after initial resuscitation. The effects of red blood cell transfusions (RBCT) on skin perfusion are not described in this setting. We evaluated the effects of red blood cell transfusions on skin tissue perfusion in critically ill patients without acute bleeding after initial resuscitation. METHODS: A prospective observational study included 175 non-bleeding adult patients after fluid resuscitation requiring red blood cell transfusions...
2023: Frontiers in Medicine
#36
JOURNAL ARTICLE
Natalie Vankka, Vivian H Y Ip
No abstract text is available yet for this article.
October 5, 2023: Canadian Journal of Anaesthesia
#37
RANDOMIZED CONTROLLED TRIAL
Josée Savard, Hanane Moussa, Jean-François Pelletier, Pierre Julien, Louis Lacombe, Rabi Tiguert, Yves Caumartin, Thierry Dujardin, Paul Toren, Frédéric Pouliot, Michele Lodde, Yves Fradet, Karine Robitaille, Vincent Fradet
BACKGROUND: In the general population, a higher omega-3 polyunsaturated fatty acids intake is associated with lower levels of several psychological symptoms, especially depression. However, the existing evidence in cancer is equivocal. METHODS: This phase IIB double-blind, placebo-controlled trial was aimed at comparing the effects of eicosapentaenoic acid monoacylglyceride (MAG-EPA) supplementation and high oleic acid sunflower oil (HOSO; placebo) on depression levels (primary outcome) and other symptoms (anxiety, fear of cancer recurrence, fatigue, insomnia, perceived cognitive impairments; secondary outcomes)...
October 2023: Cancer Medicine
#38
JOURNAL ARTICLE
Patrick James Gleeson, Ilaria Alice Crippa, Aurélie Sannier, Caroline Koopmansch, Lucie Bienfait, Justine Allard, Donal J Sexton, Vito Fontana, Sandrine Rorive, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
BACKGROUND: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) portends a poor prognosis. We aimed to better characterize predictors of survival and the mechanism of kidney failure in these patients. METHODS: This was a retrospective observational study using clinical and radiological electronic health records, analysed by univariable and multivariable binary logistic regression. Histopathological examination of post-mortem renal tissue was performed...
October 2023: Clinical Kidney Journal
#39
JOURNAL ARTICLE
Alejandro Orrico-Sanchez, Bruno P Guiard, Stella Manta, Jacques Callebert, Jean-Marie Launay, Franck Louis, Antoine Paccard, Carole Gruszczynski, Catalina Betancur, Vincent Vialou, Sophie Gautron
Selective serotonin reuptake inhibitors (SSRI) are common first-line treatments for major depression. However, a significant number of depressed patients do not respond adequately to these pharmacological treatments. In the present preclinical study, we demonstrate that organic cation transporter 2 (OCT2), an atypical monoamine transporter, contributes to the effects of SSRI by regulating the routing of the essential amino acid tryptophan to the brain. Contrarily to wild-type mice, OCT2-invalidated mice failed to respond to prolonged fluoxetine treatment in a chronic depression model induced by corticosterone exposure recapitulating core symptoms of depression, i...
September 29, 2023: Translational Psychiatry
#40
JOURNAL ARTICLE
Aziz Zaanan, Julie Henriques, Anthony Turpin, Sylvain Manfredi, Romain Coriat, Eric Terrebonne, Jean-Louis Legoux, Thomas Walter, Christophe Locher, Olivier Dubreuil, Simon Pernot, Chloé Vernet, Olivier Bouché, Vincent Hautefeuille, Johan Gagniere, Thierry Lecomte, David Tougeron, Thomas Grainville, Dewi Vernerey, Pauline Afchain, Thomas Aparicio
BACKGROUND: Small bowel adenocarcinoma (SBA) is a rare cancer and the role of adjuvant chemotherapy (AC) for localized disease is still debated. METHODS: This retrospective multicenter study included all consecutive patients who underwent curative surgical resection for localized SBA between 1996 and 2019 from 3 French cohorts' study. Prognostic and predictive factors of AC efficacy were analyzed for disease-free survival (DFS) and overall survival (OS). The inverse probability of treatment weighting method (IPTW) was applied in the Cox regression model using the propensity score derived from multivariable logistic regression...
September 29, 2023: JNCI Cancer Spectrum
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