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Jean-Louis Vincent

Sara Rezai Amin, Carole Gruszczynski, Bruno P Guiard, Jacques Callebert, Jean-Marie Launay, Franck Louis, Catalina Betancur, Vincent Vialou, Sophie Gautron
Cre/loxP recombination is a widely used approach to study gene function in vivo, using mice models expressing the Cre recombinase under the control of specific promoters or through viral delivery of Cre-expressing constructs. A profuse literature on transgenic mouse lines points out the deleterious effects of Cre expression in various cell types and tissues, presumably by acting on illegitimate loxP-like sites present in the genome. However, most studies reporting the consequences of Cre-lox gene invalidation often omit adequate controls to exclude the potential toxic effects of Cre, compromising the interpretation of data...
February 12, 2019: Journal of Neurochemistry
Jean-Louis Vincent, Wasineenart Mongkolpun
Sepsis, defined as infection plus some degree of organ dysfunction, is still associated with high mortality and morbidity rates. Management focuses on three key areas: infection control, hemodynamic stabilization and organ support, and modulation of the sepsis response. Areas covered: This review will not cover infection control. Hemodynamic stabilization essentially involves use of adequate fluid resuscitation and vasopressors. Fluid and vasopressor choices and targets are discussed, and the need to adapt these to the individual patient is stressed...
February 12, 2019: Expert Review of Anti-infective Therapy
Daniel De Backer, Maurizio Cecconi, Jeffrey Lipman, Flavia Machado, Sheila Nainan Myatra, Marlies Ostermann, Anders Perner, Jean-Louis Teboul, Jean-Louis Vincent, Keith R Walley
While guidelines provide important information on how to approach a patient in septic shock, "many challenges remain" for the management of these patients. In this narrative review, the panel discusses the challenges in identifying the right hemodynamic target, optimization of fluid therapy, selection of vasopressor agents, identification of patients who may benefit from inotropic agents or on the contrary beta-blockade, and use of steroids. The place for microcirculation-targeted therapy is debated as well as the use of alternative techniques (blood purification) and therapies (vitamin C)...
February 11, 2019: Intensive Care Medicine
Carine Bossenmeyer-Pourié, A David Smith, Sylvain Lehmann, Vincent Deramecourt, Bernard Sablonnière, Jean-Michel Camadro, Grégory Pourié, Racha Kerek, Deborah Helle, Remy Umoret, Rosa-Maria Guéant-Rodriguez, Valérie Rigau, Audrey Gabelle, Jeffrey M Sequeira, Edward V Quadros, Jean-Luc Daval, Jean-Louis Guéant
The pathomechanisms that associate a deficit in folate and/or vitamin B12 and the subsequent hyperhomocysteinemia with pathological brain ageing are unclear. We investigated the homocysteinylation of microtubule-associated proteins (MAPs) in brains of patients with Alzheimer's disease or vascular dementia, and in rats depleted in folate and vitamin B12, Cd320 KO mice with selective B12 brain deficiency and H19-7 neuroprogenitors lacking folate. Compared with controls, N-homocysteinylated tau and MAP1 were increased and accumulated in protein aggregates and tangles in the cortex, hippocampus and cerebellum of patients and animals...
February 8, 2019: Journal of Pathology
Thomas Besnard, Natacha Sloboda, Alice Goldenberg, Sébastien Küry, Benjamin Cogné, Flora Breheret, Eva Trochu, Solène Conrad, Marie Vincent, Wallid Deb, Xavier Balguerie, Sébastien Barbarot, Geneviève Baujat, Tawfeg Ben-Omran, Anne-Claire Bursztejn, Virginie Carmignac, Alexandre N Datta, Aline Delignières, Laurence Faivre, Betty Gardie, Jean-Louis Guéant, Paul Kuentz, Marion Lenglet, Marie-Cécile Nassogne, Vincent Ramaekers, Rhonda E Schnur, Yue Si, Erin Torti, Julien Thevenon, Pierre Vabres, Lionel Van Maldergem, Dorothea Wand, Arnaud Wiedemann, Bertrand Cariou, Richard Redon, Antonin Lamazière, Stéphane Bézieau, Francois Feillet, Bertrand Isidor
PURPOSE: Lanosterol synthase (LSS) gene was initially described in families with extensive congenital cataracts. Recently, a study has highlighted LSS associated with hypotrichosis simplex. We expanded the phenotypic spectrum of LSS to a recessive neuroectodermal syndrome formerly named alopecia with mental retardation (APMR) syndrome. It is a rare autosomal recessive condition characterized by hypotrichosis and intellectual disability (ID) or developmental delay (DD), frequently associated with early-onset epilepsy and other dermatological features...
February 6, 2019: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Jiajie Wei, Rigel J Kishton, Matthew Angel, Crystal S Conn, Nicole Dalla-Venezia, Virginie Marcel, Anne Vincent, Frédéric Catez, Sabrina Ferré, Lilia Ayadi, Virginie Marchand, Devin Dersh, James S Gibbs, Ivaylo P Ivanov, Nathan Fridlyand, Yohann Couté, Jean-Jacques Diaz, Shu-Bing Qian, Louis M Staudt, Nicholas P Restifo, Jonathan W Yewdell
The MHC class I antigen presentation system enables T cell immunosurveillance of cancers and viruses. A substantial fraction of the immunopeptidome derives from rapidly degraded nascent polypeptides (DRiPs). By knocking down each of the 80 ribosomal proteins, we identified proteins that modulate peptide generation without altering source protein expression. We show that 60S ribosomal proteins L6 (RPL6) and RPL28, which are adjacent on the ribosome, play opposite roles in generating an influenza A virus-encoded peptide...
January 24, 2019: Molecular Cell
Thomas W L Scheeren, Jan Bakker, Daniel De Backer, Djillali Annane, Pierre Asfar, E Christiaan Boerma, Maurizio Cecconi, Arnaldo Dubin, Martin W Dünser, Jacques Duranteau, Anthony C Gordon, Olfa Hamzaoui, Glenn Hernández, Marc Leone, Bruno Levy, Claude Martin, Alexandre Mebazaa, Xavier Monnet, Andrea Morelli, Didier Payen, Rupert Pearse, Michael R Pinsky, Peter Radermacher, Daniel Reuter, Bernd Saugel, Yasser Sakr, Mervyn Singer, Pierre Squara, Antoine Vieillard-Baron, Philippe Vignon, Simon T Vistisen, Iwan C C van der Horst, Jean-Louis Vincent, Jean-Louis Teboul
BACKGROUND: Vasopressors are commonly applied to restore and maintain blood pressure in patients with sepsis. We aimed to evaluate the current practice and therapeutic goals regarding vasopressor use in septic shock as a basis for future studies and to provide some recommendations on their use. METHODS: From November 2016 to April 2017, an anonymous web-based survey on the use of vasoactive drugs was accessible to members of the European Society of Intensive Care Medicine (ESICM)...
January 30, 2019: Annals of Intensive Care
Alexandre Buffet, Laurène Ben Aim, Sophie Leboulleux, Delphine Drui, Delphine Vezzosi, Rossella Libé, Christiane Ajzenberg, Daniele Bernardeschi, Bertrand Cariou, Frédéric Chabolle, Olivier Chabre, Vincent Darrouzet, Brigitte Delemer, Rachel Desailloud, Bernard Goichot, Annabelle Esvant, Lucile Offredo, Philippe Herman, Sandrine Laboureau, Hervé Lefebvre, Peggy Pierre, Isabelle Raingeard, Yves Reznik, Jean-Louis Sadoul, Julien Hadoux, Antoine Tabarin, Igor Tauveron, Delphine Zenaty, Judith Favier, Jérôme Bertherat, Eric Baudin, Laurence Amar, Anne-Paule Gimenez-Roqueplo
Context: Paragangliomas and pheochromocytomas (PPGL) are characterized by a strong genetic component with up to 40 % of patients carrying a germline mutation in a PPGL susceptibility gene, and international guidelines recommend that genetic screening should be proposed to all patients with PPGL. Objective: Our objective was to evaluate how a positive genetic test impacts the management and outcome of patients with SDHx or VHL-related PPGL. Design: We performed a multicentric retrospective study on 221 propositus carrying a SDHB, SDHD, SDHC or VHL germline mutation...
January 29, 2019: Journal of Clinical Endocrinology and Metabolism
Daniel Patricio, Lorenzo Peluso, Alexandre Brasseur, Olivier Lheureux, Mirko Belliato, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
BACKGROUND: The potential benefit of extracorporeal cardiopulmonary resuscitation (ECPR) compared to conventional CPR (CCPR) for patients with refractory cardiac arrest (CA) remains unclear. METHODS: This study is a retrospective analysis of a prospective database of CA patients, which includes all consecutive adult patients admitted to the Department of Intensive Care after CA between January 2012 and December 2017. The decision to initiate ECPR was made by the attending physician and ECPR performed by the ECPR team, which is composed of ICU physicians...
January 28, 2019: Critical Care: the Official Journal of the Critical Care Forum
François Tubez, Cédric Schwartz, Jean-Louis Croisier, Olivier Brüls, Vincent Denoël, Julien Paulus, Bénédicte Forthomme
The trophy position is a coaching cue for the tennis serve that usually corresponds to the racquet high point (RHP) during the preparatory action for the stroke. Mastering this position and its time of occurrence seems essential in overarm movements like in the tennis serve. Clinicians and coaches have a real interest in understanding the trophy position and its evolution during the development of the elite players at different ages. A 3D motion system was used to measure the kinematics of the serve. A group of high-level tennis players were selected for three different age groups: 8 adults (ITN 1), 8 teenagers (ITN 3) and 8 children (ITN 5-6)...
January 28, 2019: Sports Biomechanics
Mathurin Fumery, Marion Tilmant, Clara Yzet, Franck Brazier, Julien Loreau, Justine Turpin, Jean Philippe Le Mouel, Vincent Goeb, Eric Nguyen-Khac, Siddarth Singh, Jean-Louis Dupas, Momar Diouf
INTRODUCTION: Up to 25% of patients treated with infliximab experience hypersensitivity reactions. Prophylactic premedication prior to infliximab infusion, comprising corticosteroids and/or antihistamines, is widely used in clinical practice but its efficacy has recently been called into question due to the lack of pathophysiological rationale and validation by controlled trials. MATERIALS AND METHODS: We conducted a comprehensive literature search of multiple electronic databases from inception to June 2017 to identify studies reporting the impact of corticosteroid and/or antihistamine premedication on the risk of acute (<24 h) hypersensitivity reaction to infliximab in immune-mediated inflammatory diseases (IMIDs)...
December 13, 2018: Digestive and Liver Disease
Patrick J Gleeson, Ilaria Alice Crippa, Wasineenart Mongkolpun, Federica Zama Cavicchi, Tess Van Meerhaeghe, Serge Brimioulle, Fabio Silvio Taccone, Jean-Louis Vincent, Jacques Creteur
OBJECTIVES: To characterize renin in critically ill patients. Renin is fundamental to circulatory homeostasis and could be a useful marker of tissue-perfusion. However, diurnal variation, continuous renal replacement therapy and drug-interference could confound its use in critical care practice. DESIGN: Prospective observational study. SETTING: Single-center, mixed medical-surgical ICU in Europe. PATIENTS: Patients over 18 years old with a baseline estimated glomerular filtration rate greater than 30 mL/min/1...
February 2019: Critical Care Medicine
Julien Meilhac, Jean-Louis Durand, Vincent Beguier, Isabelle Litrico
Background and Aims: The positive effects of species diversity on the functioning and production of ecosystems have been discussed widely in the literature. In agriculture, these effects are increasingly being applied to mixed-species crops and particularly to temporary grasslands. However, the effects of increases in genetic diversity (i.e. within-species diversity) on productivity in multispecies crops have not been much studied. Nevertheless, genetic diversity may have strong positive effects on agricultural ecosystems and positively influence production and species abundances in multispecies covers...
January 5, 2019: Annals of Botany
Vincent Looten, Liliane Kong Win Chang, Antoine Neuraz, Marie-Anne Landau-Loriot, Benoit Vedie, Jean-Louis Paul, Laëtitia Mauge, Nadia Rivet, Angela Bonifati, Gilles Chatellier, Anita Burgun, Bastien Rance
OBJECTIVE: To identify common temporal evolution profiles in biological data and propose a semi-automated method to these patterns in a clinical data warehouse (CDW). MATERIALS AND METHODS: We leveraged the CDW of the European Hospital Georges Pompidou and tracked the evolution of 192 biological parameters over a period of 17 years (for 445,000 + patients, and 131 million laboratory test results). RESULTS: We identified three common profiles of evolution: discretization, breakpoints, and trends...
December 29, 2018: Computer Methods and Programs in Biomedicine
Alexandre Joosten, Amélie Delaporte, Brenton Alexander, Fuhong Su, Jacques Creteur, Jean-Louis Vincent, Maxime Cannesson, Joseph Rinehart
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Intraoperative hypotension has been associated with adverse postoperative outcomes.A randomized controlled trial of individualized blood pressure management in patients undergoing major abdominal surgery found reduced postoperative adverse events in patients in the blood pressure management intervention group versus the standard of care group. WHAT THIS ARTICLE TELLS US THAT IS NEW: In this study of pigs with normovolemic hypotension induced by administration of sodium nitroprusside, an automated closed-loop vasopressor administration device was able to maintain mean arterial pressure within 5 mmHg of 80 mmHg for 98% of the intraoperative period...
December 31, 2018: Anesthesiology
Alexandre Joosten, Alexandra Jacobs, Olivier Desebbe, Jean-Louis Vincent, Saxena Sarah, Joseph Rinehart, Luc Van Obbergh, Alexander Hapfelmeier, Bernd Saugel
Pulse pressure variation (PPV) and stroke volume variation (SVV) can be used to assess fluid status in the operating room but usually require dedicated advanced hemodynamic monitors. Recently, a smartphone application (Capstesia™), which automatically calculates PPV from a picture of the invasive arterial pressure waveform from any monitor screen (PPVCAP ), has been developed. The purpose of this study was to compare PPVCAP with SVV from an uncalibrated pulse wave analysis monitor (SVVPC ). In 40 patients undergoing major abdominal surgery, we compared PPVCAP with SVVPC at post-induction, pre-incision, post-incision, end of surgery, and during every hypotensive episode (mean arterial pressure < 65 mmHg)...
January 3, 2019: Journal of Clinical Monitoring and Computing
Yasser Sakr, Ulrich Jaschinski, Xavier Wittebole, Tamas Szakmany, Jeffrey Lipman, Silvio A Ñamendys-Silva, Ignacio Martin-Loeches, Marc Leone, Mary-Nicoleta Lupu, Jean-Louis Vincent
Background: There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe. Methods: The Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted to the ICU between May 8 and May 18, 2012, except those admitted for less than 24 hours for routine postoperative surveillance. Data were collected daily for a maximum of 28 days in the ICU, and patients were followed up for outcome data until death, hospital discharge, or for 60 days...
December 2018: Open Forum Infectious Diseases
Maurizio Cecconi, Glenn Hernandez, Martin Dunser, Massimo Antonelli, Tim Baker, Jan Bakker, Jacques Duranteau, Sharon Einav, A B Johan Groeneveld, Tim Harris, Sameer Jog, Flavia R Machado, Mervyn Mer, M Ignacio Monge García, Sheila Nainan Myatra, Anders Perner, Jean-Louis Teboul, Jean-Louis Vincent, Daniel De Backer
The original article can be found online.
December 13, 2018: Intensive Care Medicine
Dan Longrois, Marc Maegele, Hugues Bersini, George Crooks, Ives Hubloue, Ann Nowé, Peter C Rimensberger, Marc Sabbe, Jonathan Tilsed, Jef Vandemeulebroucke, Werner Verhelst, Jean-Louis Vincent
PURPOSE: Major trauma remains a significant cause of morbidity and mortality in the developed and developing world. In 2013, nearly 5 million people worldwide died from their injuries, and almost 1 billion individuals sustained injuries that warranted some type of healthcare, accounting for around 10% of the global burden of disease in general. Behind the statistics, severe trauma takes a major toll on individuals, their families and healthcare systems. Management of the patient with severe trauma requires multiple interventions in a highly time-sensitive context and fragmentation of care, characterised by loss of information and time among disciplines, departments and individuals, both outside the hospital and within it, is frequent...
December 12, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Philippe Ariès, Kahina Bensafia, Ali Mansour, Benoît Clément, Jean-Louis Vincent, Ba Vinh Nguyen
BACKGROUND: Wired electrocardiogram monitors are an important component of current perioperative monitoring. Wireless monitoring units could help reduce the number of cables attached to patients and thus improve anesthesia ergonomics and patient management. However, there is concern that electromagnetic interference generated by electrosurgical units may prevent effective wireless signals in the operating room. To evaluate the extent of this problem, we developed a Bluetooth electrocardiogram prototype monitor and compared its electrocardiogram traces to those captured with a standard wired electrocardiogram monitor in our operating room...
December 11, 2018: Anesthesia and Analgesia
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