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Glenn Hernández, Gustavo A Ospina-Tascón, Lucas Petri Damiani, Elisa Estenssoro, Arnaldo Dubin, Javier Hurtado, Gilberto Friedman, Ricardo Castro, Leyla Alegría, Jean-Louis Teboul, Maurizio Cecconi, Giorgio Ferri, Manuel Jibaja, Ronald Pairumani, Paula Fernández, Diego Barahona, Vladimir Granda-Luna, Alexandre Biasi Cavalcanti, Jan Bakker
Importance: Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established. Objective: To determine if a peripheral perfusion-targeted resuscitation during early septic shock in adults is more effective than a lactate level-targeted resuscitation for reducing mortality...
February 17, 2019: JAMA: the Journal of the American Medical Association
#2
Sophie J M Rijnen, Ikram Meskal, Marjan Bakker, Wouter De Baene, Geert-Jan M Rutten, Karin Gehring, Margriet M Sitskoorn
Background: Meningioma patients are known to face cognitive deficits before and after surgery. We examined individual changes in cognitive performance over time and identified preoperative predictors of cognitive functioning 12 months after surgery in a large sample of meningioma patients. Methods: Patients underwent neuropsychological assessment (NPA) using CNS Vital Signs 1 day before (T0), and 3 (T3) and 12 (T12) months after surgery. Patients' sociodemographically-corrected scores on 7 cognitive domains were compared to performance of a normative sample using one-sample z tests and Chi-square tests of independence...
February 7, 2019: Neuro-oncology
#3
Chantal M den Bakker, Frederieke G Schaafsma, Eva van der Meij, Wilhelmus Jhj Meijerink, Baukje van den Heuvel, Astrid H Baan, Paul Hp Davids, Petrus C Scholten, Suzan van der Meij, W Marchien van Baal, Annette D van Dalsen, Daniel J Lips, Jan Willem van der Steeg, Wouter Kg Leclercq, Peggy Maj Geomini, Esther Cj Consten, Steven E Schraffordt Koops, Steve Mm de Castro, Paul Jm van Kesteren, Huib A Cense, Hein Bac Stockmann, A Dorien Ten Cate, Hendrik J Bonjer, Judith Af Huirne, Johannes R Anema
BACKGROUND: Support for guiding and monitoring postoperative recovery and resumption of activities is usually not provided to patients after discharge from the hospital. Therefore, a perioperative electronic health (eHealth) intervention ("ikherstel" intervention or "I recover" intervention) was developed to empower gynecological patients during the perioperative period. This eHealth intervention requires a need for further development for patients who will undergo various types of general surgical and gynecological procedures...
February 6, 2019: Journal of Medical Internet Research
#4
Thomas W L Scheeren, Jan Bakker, Daniel De Backer, Djillali Annane, Pierre Asfar, E Christiaan Boerma, Maurizio Cecconi, Arnaldo Dubin, Martin W Dünser, Jacques Duranteau, Anthony C Gordon, Olfa Hamzaoui, Glenn Hernández, Marc Leone, Bruno Levy, Claude Martin, Alexandre Mebazaa, Xavier Monnet, Andrea Morelli, Didier Payen, Rupert Pearse, Michael R Pinsky, Peter Radermacher, Daniel Reuter, Bernd Saugel, Yasser Sakr, Mervyn Singer, Pierre Squara, Antoine Vieillard-Baron, Philippe Vignon, Simon T Vistisen, Iwan C C van der Horst, Jean-Louis Vincent, Jean-Louis Teboul
BACKGROUND: Vasopressors are commonly applied to restore and maintain blood pressure in patients with sepsis. We aimed to evaluate the current practice and therapeutic goals regarding vasopressor use in septic shock as a basis for future studies and to provide some recommendations on their use. METHODS: From November 2016 to April 2017, an anonymous web-based survey on the use of vasoactive drugs was accessible to members of the European Society of Intensive Care Medicine (ESICM)...
January 30, 2019: Annals of Intensive Care
#5
Anne-Grete Märtson, Daan Touw, Kevin Damman, Martijn Bakker, Annemieke Oude Lansink-Hartgring, Tjip van der Werf, Marjolein Knoester, Jan-Willem C Alffenaar
This paper presents three cases of immunocompromised patients for whom therapeutic drug monitoring (TDM) of ganciclovir in combination with cytomegalovirus (CMV) viral load measurement was used to guide treatment. The first patient is diagnosed with Thymoma A, the second is a heart transplant recipient and the third is an HIV positive patient. These patients were all diagnosed with CMV and treated with ganciclovir. Our case studies illustrate how TDM guided dosing can be helpful in the management of these complex cases...
January 25, 2019: Therapeutic Drug Monitoring
#6
Pierre C M Herpers, Mireille J Bakker-Huvenaars, Corina U Greven, Evita C Wiegers, Karin S Nijhof, Arianne N Baanders, Jan K Buitelaar, Nanda N J Rommelse
Oppositional defiant disorder, conduct disorder (ODD/CD), and autism spectrum disorder (ASD) share poor empathic functioning and have been associated with impaired emotional processing. However, no previous studies directly compared similarities and differences in these processes for the two disorders. A two-choice emotional valence detection task requiring differentiation between positive, negative, and neutral IAPS pictures was administered to 52 adolescents (12-19 years) with ODD/CD, 52 with ASD and 24 typically developing individuals (TDI)...
January 24, 2019: European Child & Adolescent Psychiatry
#7
Jessica van Setten, Niek Verweij, Hamdi Mbarek, Maartje N Niemeijer, Stella Trompet, Dan E Arking, Jennifer A Brody, Ilaria Gandin, Niels Grarup, Leanne M Hall, Daiane Hemerich, Leo-Pekka Lyytikäinen, Hao Mei, Martina Müller-Nurasyid, Bram P Prins, Antonietta Robino, Albert V Smith, Helen R Warren, Folkert W Asselbergs, Dorret I Boomsma, Mark J Caulfield, Mark Eijgelsheim, Ian Ford, Torben Hansen, Tamara B Harris, Susan R Heckbert, Jouke-Jan Hottenga, Anita Iorio, Jan A Kors, Allan Linneberg, Peter W MacFarlane, Thomas Meitinger, Christopher P Nelson, Olli T Raitakari, Claudia T Silva Aldana, Gianfranco Sinagra, Moritz Sinner, Elsayed Z Soliman, Monika Stoll, Andre Uitterlinden, Cornelia M van Duijn, Melanie Waldenberger, Alvaro Alonso, Paolo Gasparini, Vilmundur Gudnason, Yalda Jamshidi, Stefan Kääb, Jørgen K Kanters, Terho Lehtimäki, Patricia B Munroe, Annette Peters, Nilesh J Samani, Nona Sotoodehnia, Sheila Ulivi, James G Wilson, Eco J C de Geus, J Wouter Jukema, Bruno Stricker, Pim van der Harst, Paul I W de Bakker, Aaron Isaacs
Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR interval). In the current study, we meta-analyzed genome-wide association results from 30,000 mostly Dutch samples on four ECG traits: PR interval, QRS duration, QT interval, and RR interval. SNP genotype data was imputed using the Genome of the Netherlands reference panel encompassing 19 million SNPs, including millions of rare SNPs (minor allele frequency < 5%)...
January 24, 2019: European Journal of Human Genetics: EJHG
#8
Ruben J G Hulswit, Yifei Lang, Mark J G Bakkers, Wentao Li, Zeshi Li, Arie Schouten, Bram Ophorst, Frank J M van Kuppeveld, Geert-Jan Boons, Berend-Jan Bosch, Eric G Huizinga, Raoul J de Groot
Human betacoronaviruses OC43 and HKU1 are endemic respiratory pathogens and, while related, originated from independent zoonotic introductions. OC43 is in fact a host-range variant of the species Betacoronavirus-1 , and more closely related to bovine coronavirus (BCoV)-its presumptive ancestor-and porcine hemagglutinating encephalomyelitis virus (PHEV). The β1-coronaviruses (β1CoVs) and HKU1 employ glycan-based receptors carrying 9- O -acetylated sialic acid (9- O -Ac-Sia). Receptor binding is mediated by spike protein S, the main determinant of coronavirus host specificity...
February 12, 2019: Proceedings of the National Academy of Sciences of the United States of America
#9
Glenn Hernández, Jean-Louis Teboul, Jan Bakker
The original version of this article unfortunately contained a mistake.
January 23, 2019: Intensive Care Medicine
#10
Jolianne M Rijks, Margriet G E Montizaan, Nine Bakker, Ankje de Vries, Steven Van Gucht, Corien Swaan, Jan van den Broek, Andrea Gröne, Hein Sprong
To increase knowledge of tick-borne encephalitis virus (TBEV) circulation in the Netherlands, we conducted serosurveillance in roe deer (Capreolus capreolus) during 2017 and compared results with those obtained during 2010. Results corroborate a more widespread occurrence of the virus in 2017. Additional precautionary public health measures have been taken.
February 2019: Emerging Infectious Diseases
#11
Ellen Strijbos, Martijn R Tannemaat, Iris Alleman, Robert H P de Meel, Jaap A Bakker, Ruud van Beek, Frank P Kroon, Guus F Rimmelzwaan, Jan J G M Verschuuren
OBJECTIVE: To investigate the efficacy and safety of an influenza vaccination in patients with myasthenia gravis with acetylcholine receptor antibodies (AChR MG). METHODS: An influenza vaccination or placebo was administered to 47 AChR MG patients. Before and 4 weeks after administration blood samples and clinical outcome scores were obtained. Antibodies to the vaccine strains A/California/7/2009 (H1N1)pdm09, A/Hong Kong/4801/14 (H3N2) and B/Brisbane/060/08 were measured using the hemagglutination-inhibition (HI) assay and disease-specific AChR antibody titers were measured with a radio-immunoprecipitation assay...
January 16, 2019: Vaccine
#12
Anne-Grete Märtson, Anette Veringa, Martijn Bakker, Edwin R van den Heuvel, Daan J Touw, Tjip S van der Werf, Lambert F R Span, Jan-Willem C Alffenaar
During inflammation, several cytochrome P450 enzymes are downregulated. Recently it was shown that voriconazole metabolism is reduced during inflammation. Posaconazole, another triazole with broad-spectrum antifungal activity, is metabolised only to a limited extent by cytochrome P450 enzymes and to a wider extent by phase 2 enzyme systems. The aim of this study was to investigate posaconazole concentrations during inflammation. Patients aged ≥18 years receiving posaconazole prophylaxis or treatment for fungal infections were enrolled in a prospective observational study...
January 11, 2019: International Journal of Antimicrobial Agents
#13
Glenn Hernández, Jean-Louis Teboul, Jan Bakker
No abstract text is available yet for this article.
January 10, 2019: Intensive Care Medicine
#14
Zoran Trogrlić, Mathieu van der Jagt, Hester Lingsma, Diederik Gommers, Huibert H Ponssen, Jeannette F J Schoonderbeek, Frodo Schreiner, Serge J Verbrugge, Servet Duran, Jan Bakker, Erwin Ista
OBJECTIVES: Implementation of delirium guidelines at ICUs is suboptimal. The aim was to evaluate the impact of a tailored multifaceted implementation program of ICU delirium guidelines on processes of care and clinical outcomes and draw lessons regarding guideline implementation. DESIGN: A prospective multicenter, pre-post, intervention study. SETTING: ICUs in one university hospital and five community hospitals. PATIENTS: Consecutive medical and surgical critically ill patients were enrolled between April 1, 2012, and February 1, 2015...
January 2, 2019: Critical Care Medicine
#15
Maurizio Cecconi, Glenn Hernandez, Martin Dunser, Massimo Antonelli, Tim Baker, Jan Bakker, Jacques Duranteau, Sharon Einav, A B Johan Groeneveld, Tim Harris, Sameer Jog, Flavia R Machado, Mervyn Mer, M Ignacio Monge García, Sheila Nainan Myatra, Anders Perner, Jean-Louis Teboul, Jean-Louis Vincent, Daniel De Backer
The original article can be found online.
December 13, 2018: Intensive Care Medicine
#16
Steven M A C van Heuven, Alice E Webb, Didier M de Bakker, Erik Meesters, Fleur C van Duyl, Gert-Jan Reichart, Lennart J de Nooijer
Anthropogenic pressures threaten the health of coral reefs globally. Some of these pressures directly affect coral functioning, while others are indirect, for example by promoting the capacity of bioeroders to dissolve coral aragonite. To assess the coral reef status, it is necessary to validate community-scale measurements of metabolic and geochemical processes in the field, by determining fluxes from enclosed coral reef patches. Here, we investigate diurnal trends of carbonate chemistry, dissolved organic carbon, oxygen, and nutrients on a 20 m deep coral reef patch offshore from the island of Saba, Dutch Caribbean by means of tent incubations...
2018: PeerJ
#17
EDITORIAL
Jan Bakker
No abstract text is available yet for this article.
February 2019: Journal of Critical Care
#18
Maryna Masyuk, Bernhard Wernly, Michael Lichtenauer, Marcus Franz, Bjoern Kabisch, Johanna M Muessig, Georg Zimmermann, Alexander Lauten, P Christian Schulze, Uta C Hoppe, Malte Kelm, Jan Bakker, Christian Jung
PURPOSE: Changes of lactate concentration over time were reported to be associated with survival in septic patients. We aimed to evaluate delta-lactate (ΔLac) 24 h after admission (Δ24Lac) to an intensive care unit (ICU) in critically ill patients for short- and long-term prognostic relevance. METHODS: In total, 26,285 lactate measurements of 2191 patients admitted to a German ICU were analyzed. Inclusion criterion was a lactate concentration at admission above 2...
November 26, 2018: Intensive Care Medicine
#19
Johannes P C van den Akker, Jan Bakker, A B J Groeneveld, C A den Uil
PURPOSE: In critical illness, the relation between the macrocirculation, microcirculation and organ dysfunction, such as acute kidney injury (AKI), is complex. This study aimed at identifying predictors for AKI in patients with cardiogenic shock. MATERIALS AND METHODS: Thirty-nine adult cardiogenic shock patients, with an admission creatinine <200 μmol l-1 , and whose microcirculation was measured within 48 h were enrolled. Patient data were analyzed if AKI stage ≥1 developed according to the Kidney Disease/Improving Outcomes classification within 48 h after admission...
November 10, 2018: Journal of Critical Care
#20
Maurizio Cecconi, Glenn Hernandez, Martin Dunser, Massimo Antonelli, Tim Baker, Jan Bakker, Jacques Duranteaum, Sharon Einav, A B Johan Groeneveld, Tim Harris, Sameer Jog, Flavia R Machado, Mervyn Mer, M Ignacio Monge Garcia, Sheila Nainan Myatra, Anders Perner, Jean-Louis Teboul, Jean-Louis Vincent, Daniel De Backer
An international team of experts in the field of fluid resuscitation was invited by the ESICM to form a task force to systematically review the evidence concerning fluid administration using basic monitoring. The work included a particular emphasis on pre-ICU hospital settings and resource-limited settings. The work focused on four main questions: (1) What is the role of clinical assessment to guide fluid resuscitation in shock? (2) What basic monitoring is required to perform and interpret a fluid challenge? (3) What defines a fluid challenge in terms of fluid type, ranges of volume, and rate of administration? (4) What are the safety endpoints during a fluid challenge? The expert panel found insufficient evidence to provide recommendations according to the GRADE system, and was only able to make recommendations for basic interventions, based on the available evidence and expert opinion...
November 19, 2018: Intensive Care Medicine
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