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https://read.qxmd.com/read/30875294/a-rare-case-of-paratesticular-leiomyoma-in-a-child
#1
Aydan Arslan, Sila Ulus, Ümit İnce, Gonca Tekant, Ercan Karaarslan
Leiomyomas are benign, slow-growing, smooth muscle tumors, which can occur at many locations in the body. The male genitourinary tract is seldom affected and scrotal leiomyomas are extremely rare. Most of the scrotal leiomyomas are localized in the testis, epididymis, spermatic cord, subcutaneous tissue, tunica albuginea, and scrotal skin and only a few of them are reported in the origin of isolated tissue without paratesticular structures in the paratesticular region. We are presenting a case of solitary paratesticular leiomyoma in a child, which is very rare in terms of lesion location and patient age, and describing the imaging features of this lesion...
September 12, 2018: Turkish Journal of Urology
https://read.qxmd.com/read/30874375/transcriptome-wide-mapping-of-m-6-a-and-m-6-am-at-single-nucleotide-resolution-using-miclip
#2
Ben R Hawley, Samie R Jaffrey
The most prevalent modified base in mRNA, N6 -methyladenosine (m6 A), is found in several thousand transcripts, typically near the stop codon, although it can occur anywhere in the mRNA. In addition, the highly similar nucleotide N6 ,2'-O-dimethyladenosine (m6 Am), which is difficult to distinguish from m6 A, occurs as the first transcribed nucleotide of certain transcripts. Both the m6 A and m6 Am modifications have been implicated in numerous biological processes, and their precise mapping is crucial to understanding their functions...
March 15, 2019: Current Protocols in Molecular Biology
https://read.qxmd.com/read/30865383/genetically-encoded-fret-based-tension-sensors
#3
Anna-Lena Cost, Samira Khalaji, Carsten Grashoff
Genetically encoded Förster resonance energy transfer (FRET)-based tension sensors measure piconewton-scale forces across individual molecules in living cells or whole organisms. These biosensors show comparably high FRET efficiencies in the absence of tension, but FRET quickly decreases when forces are applied. In this article, we describe how such biosensors can be generated for a specific protein of interest, and we discuss controls to confirm that the observed differences in FRET efficiency reflect changes in molecular tension...
March 13, 2019: Current Protocols in Cell Biology
https://read.qxmd.com/read/30865281/safety-and-efficacy-of-the-selective-progesterone-receptor-modulator-asoprisnil-for-heavy-menstrual-bleeding-with-uterine-fibroids-pooled-analysis-of-two-12-month-placebo-controlled-randomized-trials
#4
E A Stewart, M P Diamond, A R W Williams, B R Carr, E R Myers, R A Feldman, W Elger, C Mattia-Goldberg, B M Schwefel, K Chwalisz
STUDY QUESTION: Can asoprisnil, a selective progesterone receptor modulator, provide clinically meaningful improvements in heavy menstrual bleeding (HMB) associated with uterine fibroids with an acceptable safety profile? SUMMARY ANSWER: Uninterrupted treatment with asoprisnil for 12 months effectively controlled HMB and reduced fibroid and uterine volume with few adverse events. WHAT IS KNOWN ALREADY: In a 3-month study, asoprisnil (5, 10 and 25 mg) suppressed uterine bleeding, reduced fibroid and uterine volume, and improved hematological parameters in a dose-dependent manner...
March 13, 2019: Human Reproduction
https://read.qxmd.com/read/30863988/verification-of-the-elekta-monaco-tps-monte-carlo-in-modelling-radiation-transmission-through-metals-in-a-water-equivalent-phantom
#5
Kurt Byrnes, Andriana Ford, Nick Bennie
Many studies have performed dosimetric studies using various metal implants however these are difficult to translate to other implants of a different geometry or material (Rijken and Colyer, J Appl Clin Med Phys 18:5:301-306, 2017; Ade and du Plessis, J Appl Clin Med Phys 18:5:162-173, 2017; Prabhakar et al. Rep Pract Oncol Radiother 18:209-213, 2013; Ng et al. Rep Pract Oncol Radiother 20:273-277, 2015; Reft et al. Med Phys 30:1162-1182, 2003; Sasaki et al., Nihon Hoshasen Gijutsu Gakkai Zasshi 72(9):735-745, 2016)...
March 12, 2019: Australasian Physical & Engineering Sciences in Medicine
https://read.qxmd.com/read/30862592/glue-embolization-with-guide-catheter-dextrose-push-of-a-recurrent-dural-arteriovenous-fistula-previously-embolized-with-onyx-neuroendovascular-surgical-video
#6
Sophia F Shakur, Denise Brunozzi, Ali Alaraj
Onyx (ethylene vinyl alcohol, ev3, Irvine, California) is commonly used to treat dural arteriovenous fistulas (DAVF) and presents several advantages over n-butyl cyanoacrylate glue (Codman Neurovascular Inc, Raynham, Massachusetts), including slower more controlled injections and better penetration via radial casting. However, Onyx is non-thrombogenic and may result in incomplete casting, recanalization, and DAVF recurrence. Here, we demonstrate glue embolization with guide catheter dextrose push of a recurrent DAVF previously embolized with Onyx...
March 9, 2019: World Neurosurgery
https://read.qxmd.com/read/30861637/predicting-cell-populations-in-single-cell-mass-cytometry-data
#7
Tamim Abdelaal, Vincent van Unen, Thomas Höllt, Frits Koning, Marcel J T Reinders, Ahmed Mahfouz
Mass cytometry by time-of-flight (CyTOF) is a valuable technology for high-dimensional analysis at the single cell level. Identification of different cell populations is an important task during the data analysis. Many clustering tools can perform this task, which is essential to identify "new" cell populations in explorative experiments. However, relying on clustering is laborious since it often involves manual annotation, which significantly limits the reproducibility of identifying cell-populations across different samples...
March 12, 2019: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://read.qxmd.com/read/30861320/in-vivo-electroporation-and-time-lapse-imaging-of-the-rostral-migratory-stream-in-developing-rodent-brain
#8
Zhihui Huang, Ying Wang
Interneurons in the olfactory bulb are generated from neuronal precursor cells migrating from the anterior subventricular zone (SVZa) throughout the embryonic and postnatal life of mammals. This article describes basic methods for in vivo electroporation to label SVZa cells of both embryonic and postnatal rats. In addition, it describes three methods for tracing SVZa progenitors and following their migration pathway and differentiation, including immunohistochemistry, time-lapse live imaging in slice culture, and time-lapse imaging following transplantation in slice culture...
March 12, 2019: Current Protocols in Neuroscience
https://read.qxmd.com/read/30860666/impact-of-trivalent-ions-on-the-stability-and-cohesion-of-calcium-polyphosphate-coacervates-for-embolization-applications
#9
Esther Mae Valliant, Mark Joseph Filiaggi
Polyphosphates (PPs) are of interest as temporary in situ setting embolic agents for which cohesive characteristics are vital. Trivalent ions Al3+ and Ga3+ were substituted into calcium PP up to 10 mol % for two PP chain lengths (degree of polymerization, Dp 200 and 9000) and the effect on the dissolution rate of the resulting coacervate was examined. High levels of trivalent ions were found to increase the dissolution rate, especially with aluminum (Al) where the coacervate with the greatest Al content (10 mol %) and larger Dp completely dissolved within the first few hours in tris(hydroxymethyl)aminomethane buffered saline...
March 12, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30860656/synthesis-of-rna-crosslinking-oligonucleotides-modified-with-2-amino-7-deaza-7-propynyl-6-vinylpurine
#10
Ken Yamada, Yusuke Abe, Fumi Nagatsugi
This article describes procedures to synthesize 2'-OMe-RNA modified with cross-linkable 2-amino-7-deaza-7-propynyl-6-vinylpurine (ADpVP) and preparation of the RNA-crosslinking experiment in vitro. All synthesis steps yield the desired compound in moderate or high yield without expensive chemical reagents or specific devices. The crosslink-active form of modified RNA can also be purified by commonly used reversed-phase HPLC, can be stored at -80°C after lyophilization for a few days, and is ready to use for crosslinking experiments...
March 12, 2019: Current Protocols in Nucleic Acid Chemistry
https://read.qxmd.com/read/30860496/cd19-car-t-cell-product-and-disease-attributes-predict-leukemia-remission-durability
#11
Olivia C Finney, Hannah M Brakke, Stephanie Rawlings-Rhea, Roxana Hicks, Danielle Doolittle, Marisa Lopez, Robert B Futrell, Rimas J Orentas, Daniel Li, Rebecca A Gardner, Michael C Jensen
BACKGROUND: Chimeric antigen receptor (CAR) T cells can induce remission in highly refractory leukemia and lymphoma subjects, yet the parameters for achieving sustained relapse-free survival are not fully delineated. METHODS: We analyzed 43 pediatric and young adult subjects participating in a Phase I trial of defined composition CD19CAR T cells (NCT02028455). CAR T cell phenotype, function and expansion, as well as starting material T cell repertoire, were analyzed in relation to therapeutic outcome (defined as achieving complete remission within 63 days) and duration of leukemia free survival and B cell aplasia...
March 12, 2019: Journal of Clinical Investigation
https://read.qxmd.com/read/30860297/enhanced-laser-surface-ablation-with-an-integrated-photoacoustic-imaging-and-high-intensity-focused-ultrasound-system
#12
David Hazlewood, Xinmai Yang
BACKGROUND AND OBJECTIVE: Combined laser and ultrasound treatments have been found to have synergistic effects, which may be of particular note in dermatology. We aim to investigate the potential of this technology for dermatology through in vitro and ex vivo experiments. METHODS: In vitro tissue phantoms made of agar and tattoo ink and tattooed ex vivo chicken breast tissue were used. An integrated photoacoustic imaging and high intensity focused ultrasound (HIFU) system, using a 5-ns tunable OPO laser system and a 5 MHz HIFU transducer, was used to perform photoacoustic analysis to identify the optical contrast, and perform combined laser and ultrasound ablation...
March 12, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30860002/89-a-novel-modified-release-drug-delivery-technology-containing-amphetamine-ion-exchange-complexes
#13
Barry K Herman, Thomas R King, Judith C Kando, Antonio Pardo
The proprietary immediate and extended drug delivery technology LiquiXR™ utilizes an ion-exchange resin that complexes with amphetamine or any other active moiety that can be protonated and is water-soluble. The active drug product forms a complex with ion-exchange polymers contained in the resin, which is then formed into micron-sized particles. Some of these particles are coated with an aqueous, pH-independent polymer designed to provide immediate or sustained release of active drug product. The polymer coating applied to the ion-exchange resin particles is of varying thickness, allowing for programmed, extended release of active drug product...
February 2019: CNS Spectrums
https://read.qxmd.com/read/30859984/63-long-term-outcomes-with-aripiprazole-lauroxil-for-the-treatment-of-schizophrenia-a-2-year-phase-3-multicenter-extension-study
#14
Peter J Weiden, Amy Claxton, Yangchun Du, John Lauriello
BACKGROUND: One of the challenges in schizophrenia long-term trials is that clinical outcomes are often confounded by covert nonadherence to prescribed oral antipsychotics. This is a post hoc analysis (>2 years) of the symptoms and illness trajectory of patients treated with the long-acting injectable (LAI) antipsychotic aripiprazole lauroxil (AL). As adherence to LAIs can be monitored, these data could assess outcome trajectories unaffected by medication discontinuations that may occur with oral antipsychotics...
February 2019: CNS Spectrums
https://read.qxmd.com/read/30859960/31-a-modified-release-drug-delivery-technology-containing-amphetamine-ion-exchange-complexes
#15
Barry K Herman, Thomas R King, Judith C Kando, Antonio Pardo
The proprietary, immediate and extended drug delivery technologyLiquiXR® utilizes an ion-exchange resin that complexes with amphetamine or any active moiety that can be protonated and is water-soluble. The active ingredient of the drug product forms a complex with an ion exchange polymer of the resin resulting in micron-sized particles. A portion of these particles is then coated with an aqueous, pH-independent polymer designed to provide sustained release of drug product. The polymer coating applied to the ion-exchange resin particles is of varying thickness, allowing for extended release of active drug while uncoated particles provide for immediate release of drug...
February 2019: CNS Spectrums
https://read.qxmd.com/read/30859957/28-how-is-postpartum-depression-currently-diagnosed-and-managed-insights-from-a-virtual-patient-simulation
#16
Jovana Lubarda, Martin Warters, Piyali Chatterjee, Marlene P Freeman, Roger S McIntyre
OBJECTIVES: The goal of this study was to determine physician performance in diagnosis and management of postpartum depression (PPD) and to provide needed education in the consequence free environment of a virtual patient simulation (VPS). METHODS: ∙ A continuing medical education activity was delivered via an online VPS learning platform that offers a lifelike clinical care experience with complete freedom of choice in clinical decision-making and expert personalized feedback to address learner's practice gaps∙ Physicians including psychiatrists, primary care physicians (PCPs), and obstetricians/gynecologists (ob/gyns) were presented with two cases of PPD designed to model the experience of actual practice by including use of electronic health records∙ Following virtual interactions with patients, physicians were asked to make decisions regarding assessments, diagnoses, and pharmacologic therapies...
February 2019: CNS Spectrums
https://read.qxmd.com/read/30859956/27-a-new-method-for-initiating-treatment-with-the-long-acting-antipsychotic-aripiprazole-lauroxil
#17
Jonathan Meyer, Rakesh Jain, Angela Wehr, Bhaskar Rege, Lisa von Moltke, Peter J Weiden
STUDY OBJECTIVESlow release is a fundamental feature of long-acting injectable (LAI) antipsychotics. This property allows continuous drug exposure between dosing intervals. However, there can be a significant delay between giving the first LAI dose and achievement of efficacious plasma concentrations. This time period requires additional pharmacologic intervention. Until now, this delay was addressed with one of two strategies: 1) continuing with supplemental oral antipsychotic, or 2) giving more LAI up front (e...
February 2019: CNS Spectrums
https://read.qxmd.com/read/30859950/21-patient-preferences-concerning-the-efficacy-and-side-effect-profile-of-schizophrenia-medication-a-survey-of-patients-living-with-schizophrenia
#18
Eric D Achtyes, Adam Simmons, Anna Skabeev, Ying Jiang, Patricia Marcy, Nikki Levy, Peter J Weiden
Study objectivePatient-reported outcomes and preferences rely on reports of the status of a patient's health condition that comes directly from the patient, without interpretation or qualification by clinicians or investigators. Patient-reported outcomes and preferences have become an accepted approach in drug development. As part of this effort, we assessed the relative importance to patients with schizophrenia of trying a new antipsychotic that might improve symptoms in the context of common antipsychotic side effects, especially weight gain...
February 2019: CNS Spectrums
https://read.qxmd.com/read/30856105/sublingual-microcirculation-in-pancreatico-biliary-surgery-an-observational-study
#19
Mustafa Suker, M Sherezade Tovar Doncel, Alexandre A Pinto Lima, Can Ince, Casper H J van Eijck
BACKGROUND: An observational cohort study was conducted to identify potential sublingual microcirculation parameters as a target for goal-directed fluid therapy. METHODS: Patients that were scheduled for an open elective pancreatico-biliary surgery in Erasmus Medical Center were included. All patients underwent sublingual microcirculatory measurement at three time points: one day before surgery (T0), within the first 24 hours after surgery (T1) and on the fourth day after surgery (T2)...
March 2, 2019: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/30852023/assessing-bioavailability-of-ruminally-protected-methionine-and-lysine-prototypes
#20
A J Fleming, K A Estes, H Choi, B A Barton, C A Zimmerman, M D Hanigan
Met and Lys are essential AA that can limit lactational performance in dairy cattle fed protein-sufficient diets. Thus, there is industry demand for ruminally protected (RP) sources of Met and Lys. One method of providing ruminal protection for Met and Lys is lipid encapsulation. The objective of this work was to assess 3 lipid-encapsulated Met prototypes (P1, P2, and P3) and 1 Lys prototype (P4) to determine ruminal protection, small intestine absorption (experiment 1), and animal production responses (experiment 2)...
March 6, 2019: Journal of Dairy Science
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