keyword
https://read.qxmd.com/read/37958452/a-pictorial-exploration-of-mammary-paget-disease-insights-and-perspectives
#21
REVIEW
Luciano Mariano, Luca Nicosia, Davide Pupo, Antonia Maria Olivieri, Sofia Scolari, Filippo Pesapane, Antuono Latronico, Anna Carla Bozzini, Nicola Fusco, Marta Cruz Blanco, Giovanni Mazzarol, Giovanni Corso, Viviana Enrica Galimberti, Massimo Venturini, Maria Pizzamiglio, Enrico Cassano
Mammary Paget disease (MPD) is a rare condition primarily affecting adult women, characterized by unilateral skin changes in the nipple-areolar complex (NAC) and frequently associated with underlying breast carcinoma. Histologically, MPD is identified by large intraepidermal epithelial cells (Paget cells) with distinct characteristics. Immunohistochemical profiles aid in distinguishing MPD from other skin conditions. Clinical evaluation and imaging techniques, including magnetic resonance imaging (MRI), are recommended if MPD is suspected, although definitive diagnosis always requires histological examination...
November 3, 2023: Cancers
https://read.qxmd.com/read/37889547/time-for-detailed-clinical-management-of-paget-s-disease-of-the-breast-a-commentary-on-treatment-of-mammary-paget-disease-a-systematic-review-and-meta-analysis-of-real-world-data
#22
JOURNAL ARTICLE
Chaofan Li, Yusheng Wang, Mengjie Liu, Jingkun Qu, Shuqun Zhang
No abstract text is available yet for this article.
October 27, 2023: International Journal of Surgery
https://read.qxmd.com/read/37829736/the-effects-of-clinicopathological-and-imaging-findings-on-recurrence-and-survival-in-mammary-paget-s-disease
#23
JOURNAL ARTICLE
Hakan Baysal, Cem Ilgin Erol, Begumhan Baysal, Ibrahim Ali Ozemir, Mehmet Sait Ozsoy, Fatih Buyuker, Gozde Kir, Orhan Alimoglu
OBJECTIVE: Mammary Paget's disease (MPD) is a rare presentation type of breast cancer. The aim of this study was to evaluate the clinicopathological and imaging features affecting the invasive component, loco-regional recurrence, prognosis, and survival of MPD. METHODS: Patients who had undergone surgery due to MPD in a 10-year period were included. Parameters including mammography and magnetic resonance imaging (MRI) findings, tumor stage, molecular subtype, axillary involvement, presence of invasive carcinoma, loco-regional recurrence, overall survival (OS), and disease-free survival (DFS) were recorded and statistically analyzed...
2023: Northern Clinics of Istanbul
https://read.qxmd.com/read/37750594/nipple-lesions-of-the-breast-an-update-on-morphologic-features-immunohistochemical-findings-and-differential-diagnosis
#24
JOURNAL ARTICLE
Edi Brogi, Cristian Scatena
Because of the unique anatomic structure of the nipple, a few specific breast lesions occur only at this site. Large lactiferous sinuses may be involved by inflammatory conditions such as squamous metaplasia of lactiferous ducts and ductal ectasia or be the site of uncommon superficial epithelial neoplasms such as nipple adenoma or syringomatous tumor of the nipple. Paget disease of the nipple may be secondary to intraepidermal extension of ductal carcinoma in situ in the underlying lactiferous ducts or develop from malignant transformation of Toker cells...
November 1, 2023: Advances in Anatomic Pathology
https://read.qxmd.com/read/37682691/oncologic-outcomes-after-breast-conserving-surgery-with-radiotherapy-versus-mastectomy-in-patients-with-paget-s-disease-of-the-breast-systematic-review-and-meta-analysis
#25
JOURNAL ARTICLE
Serene S N Goh, Nicholas L X Syn, Cheryl J E Lim, Rui En Lee, Miny Samuel, Celene W Q Ng
BACKGROUND: The conventional approach to treatment for Paget's disease of the breast has been mastectomy, but there is an increasing trend to consider breast-conserving surgery (BCS) followed by radiotherapy (RT) in these patients. This study aimed to provide an updated systematic review and meta-analysis comparing outcomes after BCS with RT versus mastectomy in the treatment of Paget's disease of the breast. METHODS: Studies before May 2021 were included. Primary outcomes were overall survival and local recurrence...
October 10, 2023: British Journal of Surgery
https://read.qxmd.com/read/37649299/transcriptional-repressor-gata-binding-1-trps1-immunoexpression-in-normal-skin-tissues-and-various-cutaneous-tumors
#26
JOURNAL ARTICLE
Kohei Taniguchi, Keisuke Goto, Hiroki Yabushita, Rie Yamasaki, Koichi Ichimura
BACKGROUND: Transcriptional repressor GATA binding 1 (TRPS1) is a transcription factor recently shown to play a role in the development of breast and liver cancer. Here, we evaluate TRPS1 immunoexpression in normal skin tissues and various cutaneous tumors. METHODS: TRPS1 immunohistochemistry was performed in 109 cases of primary cutaneous tumors and 19 cases of metastatic carcinomas. TRPS1 expression was also evaluated in the normal skin tissues. RESULTS: The normal epidermis was TRPS1-...
August 30, 2023: Journal of Cutaneous Pathology
https://read.qxmd.com/read/37554941/a-clinicopathological-analysis-of-forkhead-box-a1-foxa1-and-estrogen-receptor-alpha-expression-in-extramammary-paget-s-disease
#27
JOURNAL ARTICLE
Chiho Sumitomo, Yohei Iwata, Masaru Arima, Kazumitsu Sugiura
OBJECTIVES: Extramammary Paget's disease (EMPD) is a neoplastic skin disease of unknown etiology. EMPD is frequently associated with forkhead box A1 (FOXA1) expression, which correlates with the expression of estrogen receptor alpha (ER). FOXA1 regulates the transcriptional activity of ER and may function cooperatively in the tumorigenesis of breast cancer. METHODS: We performed immunohistochemical staining for FOXA1 and ER using tissue samples from 16 patients with EMPD...
August 2023: Fujita medical journal
https://read.qxmd.com/read/37531879/extensive-paget-s-disease-of-the-nipple-case-report
#28
Bencherifi Younes, Bousada Zakaria, Nouri Meriem, Mustapha Benhessou, Simohamed Ennachit, Mohammed El Karroumi
INTRODUCTION AND IMPORTANCE: Paget's disease of the nipple is a rare form of ductal carcinoma in situ. It is often associated with an underlying breast cancer or, more rarely, may be isolated with no associated breast neoplasm. PRESENTATION OF CASE: We report the case of a patient with extensive Paget's disease of the nipple without associated breast lesions, treated by mastectomy with coverage by a dorsalis major flap. CLINICAL DISCUSSION: The association of Paget's disease of the nipple with breast cancer is the most frequent situation, requiring a complete radiological work-up of the breast...
August 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37527989/-expression-of-msi1-and-her2-in-mammary-paget-s-disease-and-their-correlation-with-clinicopathological-features-and-prognosis
#29
JOURNAL ARTICLE
X W Hu, H Liu, D S Ma, C X Xiang, H Chen, H T Pi
Objective: To investigate the expression of MSI1 and HER2 in mammary Paget's disease, and the correlation between the expression levels of MSI1 and HER2 and the clinicopathologic characteristics and prognosis of the patients. Methods: Clinical data and paraffin-embedded specimens of 34 pairs of mammary Paget's disease and underlying breast cancer were collected at the Department of Pathology, Affiliated Lianyungang Oriental Hospital of Xuzhou Medical University from March 2011 to December 2019. Immunohistochemistry was used to detect the expression of MSI1 and HER2 in mammary Paget's disease and the accompanying breast cancer, and to analyze the correlation between the expression levels of MSI1 and HER2 and their clinicopathologic features, as well as their influence on prognosis...
August 8, 2023: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://read.qxmd.com/read/37519599/studying-the-presentation-of-paget-disease-of-the-breast
#30
Iqbal S Grewal, Thiru Rajagopal
Paget disease of the breast is a rare breast cancer that accounts for 1-3% of all new presentations of breast cancer. It is characterized by an eczematous and ulcerative lesion of the nipple that may extend to the areola. Nearly 90% of cases are associated with underlying breast cancer. We report the presentation of Paget disease of the breast in a 41-year-old female, who presented due to a one-year history of an eczematous lesion of the left nipple area with no palpable mass, who was later found to have high-grade invasive ductal carcinoma treated with unilateral mastectomy and sentinel node biopsy...
June 2023: Curēus
https://read.qxmd.com/read/37421583/extramammary-paget-disease-a-therapeutic-challenge-for-a-rare-entity
#31
REVIEW
Chamorro Pérez Jesús, Cortes Salgado Alfonso, Pérez-Mies Belén, Domínguez Rullán Jose Antonio, Ajuria-Illarramendi Odile, Guerra Alia Eva María, Juan José Serrano Domingo
PURPOSE OF REVIEW: Extramammary Paget disease (EMPD) is a rare entity which is more frequently localized at the vulva, though it only accounts for 1-2% of vulvar neoplasms. It is a primary cutaneous adenocarcinoma whose cell of origin is still a matter of controversy: it can either arise from apocrine/eccrine glands or from stem cells. The diagnosis demands a biopsy and entails a histopathological analysis by which cells show similar characteristics as breast Paget disease. RECENT FINDINGS: Treatment approach can entail surgery, radiotherapy, photodynamic therapy, systemic chemotherapy, and topical chemotherapy...
July 8, 2023: Current Oncology Reports
https://read.qxmd.com/read/37373062/dendritic-cell-subpopulations-are-associated-with-morphological-features-of-breast-ductal-carcinoma-in-situ
#32
JOURNAL ARTICLE
Joanna Szpor, Joanna Streb, Anna Glajcar, Anna Streb-Smoleń, Agnieszka Łazarczyk, Paulina Korta, Karolina Brzuszkiewicz, Robert Jach, Diana Hodorowicz-Zaniewska
Ductal carcinoma in situ (DCIS) is the preinvasive form of breast cancer (BC). It is disputed whether all cases of DCIS require extensive treatment as the overall risk of progression to BC is estimated at 40%. Therefore, the crucial objective for researchers is to identify DCIS with significant risk of transformation into BC. Dendritic cells (DC) are professional antigen presenting cells and as such play a pivotal role in the formation of immune cells that infiltrate in breast tumors. The aim of this study was to investigate the relationship between the density of DCs with different superficial antigens (CD1a, CD123, DC-LAMP, DC-SIGN) and various histopathological characteristics of DCIS...
June 8, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37322374/zoledronic-acid-induced-severe-lymphopenia
#33
JOURNAL ARTICLE
Savaş Karpuz
Although anemia, thrombocytopenia, and mild lymphopenia have been reported in the acute phase response after zoledronic acid, severe lymphopenia has not been reported. This article describes a case of severe lymphopenia following a 5 mg zoledronic acid infusion administered to treat osteoporosis. Zoledronic acid is used to treat osteoporosis, hypercalcemia, Paget's disease, and solid malignancies, including multiple myeloma, breast cancer, and prostate cancer. An acute phase response can be seen in 42% of patients after zoledronic acid treatment...
June 15, 2023: Osteoporosis International
https://read.qxmd.com/read/37272622/nipple-adenoma-clinicopathologic-characterization-of-50-cases
#34
JOURNAL ARTICLE
Maximillian A Weigelt, Andrew P Sciallis, Patrick J McIntire, Jennifer S Ko, Steven D Billings, Shira Ronen
Nipple adenoma (NA) is a rare, benign proliferation of the nipple ducts. It may be clinically mistaken for Paget disease or squamous cell carcinoma; thus, microscopic evaluation is paramount. A large case series of NA has not been undertaken since the 1980s. Therefore, we undertook this study to evaluate the clinicopathologic characteristics of NA, emphasizing differential diagnoses and follow-up data. We retrieved 50 cases from our in-house archives or consultation files between 2003 and 2022. Available slides were reviewed, and clinical data and follow-up information were obtained...
August 1, 2023: American Journal of Surgical Pathology
https://read.qxmd.com/read/37265790/oncoplastic-surgery-for-paget-s-disease-of-the-breast
#35
JOURNAL ARTICLE
Rafael José Fábio Pelorca, Idam de Oliveira-Junior, René Aloisio da Costa Vieira
INTRODUCTION: Paget's disease of the breast (PDB) is a rare nipple entity associated with multifocality. Due to its location, resection of the entire nipple-areolar complex is necessary. Historically central quadrantectomy and mastectomy have the surgical treatments of choice. The feasibility of oncoplastic breast surgery (OBS) for PDB is unknown. METHODS: This was a retrospective study performed in a Brazilian oncological hospital. We evaluated the factors related to the performance of OBS in PDB...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37260825/her2-negative-mammary-paget-s-disease-or-in-situ-melanoma-a-case-report-and-review-of-the-literature
#36
Luana-Andreea Boșoteanu, Mariana Așchie, Cristian Ionuţ Orǎșanu, Mădălina Boșoteanu
Mammary Paget's disease (MPD) is a rare histological condition, accounting for 1-4% of female breast cancers, which may appear either independently (1.4-13% of the cases), or in association with an in situ or invasive ductal carcinoma (approximately 90% of the cases). The purpose of this article is to highlight the histopathological challenges related to the microscopical polymorphism of this disease and the utmost importance of immunohistochemistry in the thorough process of Paget's disease differential diagnosis...
2023: Case Reports in Pathology
https://read.qxmd.com/read/37252610/rare-paget-s-disease-associated-with-breast-cancer-in-a-70-year-old-male
#37
Megan Bradley, Brittany Miles, Peter Young, Jing He, Quan D Nguyen
Male breast cancer is far less common compared to female breast cancer. Paget's disease of the breast (PDB) is a rare disease, making it even rarer in men. It often presents with eczematous patches over the nipple and areola region, mimics benign dermatological conditions, and can result in a greatly delayed diagnosis. This report presents a rare case of PDB in a 70-year-old male and includes a review of its clinical presentation, radiographic findings, histology, carcinogenic potential, and management.
April 2023: Curēus
https://read.qxmd.com/read/37203381/the-utility-of-p63-ck7-and-cam5-2-staining-in-differentiating-pagetoid-intraepidermal-carcinomas
#38
JOURNAL ARTICLE
Rebekah Wieland, Prajesh Adhikari, Jeffrey North
BACKGROUND: Extramammary Paget disease (EMPD), pagetoid squamous cell carcinoma in situ (PSCCIS), and Paget disease of the breast (PD) are intraepidermal carcinomas with overlapping histopathologic features. CK7 and CAM5.2 stains are frequently utilized to distinguish PSCCIS from EMPD and PD. However, some cases of PSCCIS can stain positively for CAM5.2 and CK7, indicating a potential pitfall with these stains. p63 has been shown to distinguish PSCCIS from EMPD. We assessed p63 staining in PD and compared it to p63 staining of PSCCIS and EMPD...
May 19, 2023: Journal of Cutaneous Pathology
https://read.qxmd.com/read/37170681/using-immunohistochemistry-to-classify-the-molecular-subtypes-of-paget-s-disease-of-the-breast
#39
JOURNAL ARTICLE
Yujiao Cai, Zhongquan Cheng, Jiarui Nangong, Xiaodan Zheng, Zhu Yuan
PURPOSE: To classify the molecular subtypes of Paget's disease of the breast, and then compare them with general breast cancer to get deeper understanding of this disease and offer better management of associate patients in clinical decisions. METHODS: We used immunohistochemistry to examine 42 cases of this disease by antibodies against estrogen and progesterone receptors, Ki-67, as well as human epidermal growth factor receptor 2 (HER-2). Due to damage and loss of specimens, etc...
May 11, 2023: Cancer Medicine
https://read.qxmd.com/read/37097071/extra-mammary-paget-s-disease-of-the-penis
#40
JOURNAL ARTICLE
Sorcha O'Meara, Ivor M Cullen
Paget's disease was first described in 1874 as an eczematoid changes of the nipple associated with underlying breast carcinoma. Extra-mammary Paget's disease (EMPD) is rare with involvement of the male genitalia described in small case series and management options varying according to location and extent. The diagnosis of EMPD requires a high index of clinical suspicion and close liaison with the multidisciplinary team, particularly histopathology. We present two cases of EMPD affecting the male external genitalia that highlight important learnings in the presentation, diagnosis, and management of EMPD...
April 25, 2023: International Journal of STD & AIDS
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