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Systolic dysfunction

Jignesh K Patel, Andrew Figueroa, Rian Shah, Haasitha Korlipara, Puja B Parikh
OBJECTIVE: We sought to identify the impact of echocardiographic right ventricular (RV) systolic dysfunction on mortality in adults with cardiac arrest (CA). METHODS: The study population included 147 adults hospitalized with CA who underwent both echocardiogram and coronary angiogram at an academic tertiary medical center. The primary outcome of interest was all-cause in-hospital mortality. RESULTS: Of the 147 patients studied, 20 (13.6%) had evidence of RV systolic dysfunction while 127 (86...
February 12, 2019: Resuscitation
David Houghton, Paweł Zalewski, Kate Hallsworth, Sophie Cassidy, Christian Thoma, Leah Avery, Joanna Slomko, Timothy Hardy, Alastair D Burt, Dina Tiniakos, Kieren G Hollingsworth, Roy Taylor, Christopher P Day, Steven Masson, Stuart McPherson, Quentin M Anstee, Julia L Newton, Michael I Trenell
BACKGROUND: Cardiovascular disease is the principle cause of death in patients with elevated liver fat unrelated to alcohol consumption, more so than liver related morbidity and mortality. OBJECTIVES: The aim of this study was to evaluate the relationship between liver fat and cardiac and autonomic function. Secondly, how impairment in cardiac and autonomic function is influenced by metabolic risk factors. METHODS: Cardiovascular and autonomic function were assessed in 96 sedentary individuals: 1) NAFLD (n = 46, hepatic steatosis >5% by magnetic resonance spectroscopy), 2) Hepatic steatosis and alcohol (DAFLD) (n = 16, >5%, consuming >20g/day of alcohol) and 3) CONTROLS (n = 34, no cardiac, liver or metabolic disorders, <20g/day of alcohol)...
February 12, 2019: Journal of Hepatology
Eric J Chow, Kasey J Leger, Neel S Bhatt, Daniel A Mulrooney, Colin J Ross, Sanjeev Aggarwal, Neha Bansal, Matthew J Ehrhardt, Saro H Armenian, Jessica M Scott, Borah Hong
With five-year survival of children with cancer exceeding 80% in developed countries, premature cardiovascular disease is now a major cause of early morbidity and mortality. In addition to the acute and chronic cardiotoxic effects of anthracyclines, related chemotherapeutics, and radiation, a growing number of new molecular targeted agents may also have detrimental effects on the cardiovascular system. Survivors of childhood cancer also may have earlier development of conventional cardiovascular risk factors such as hypertension, dyslipidemia, and diabetes, which further increase their risk of serious cardiovascular disease...
February 15, 2019: Cardiovascular Research
Baojing Guo, Chencheng Dai, Qiangqiang Li, Wenxiu Li, Ling Han
AimThe aim was to attach importance to the hazards of ventricular pre-excitation on left ventricular systolic function and size. METHOD: We analysed the clinical, electrophysiological, and echocardiographic characteristics of the 25 cases with abnormal ventricular wall motion, left ventricular systolic dysfunction, or dilation with co-existing right-sided overt accessary pathways before and after ablation or medication during March 2011 and June 2017. Moreover, we compared the therapy effect between patients with ventricular pre-excitation-induced dilated cardiomyopathy and idiopathic dilated cardiomyopathy without ventricular pre-excitation...
February 15, 2019: Cardiology in the Young
Jennifer L Philip, Thomas M Murphy, David A Schreier, Sydney Stevens, Diana Marcela Tabima, Marjorie E Albrecht, Andrea L Frump, Timothy A Hacker, Tim Lahm, Naomi Chesler
MOTIVATION: Left heart failure (LHF) is the most common cause of pulmonary hypertension, which confers an increase in morbidity and mortality in this context. Pulmonary vascular resistance has prognostic value in LHF but otherwise the mechanical consequences of LHF for the pulmonary vasculature and right ventricle remain unknown. We sought to investigate mechanical mechanisms of pulmonary vascular and right ventricular dysfunction in a rodent model of LHF to address the knowledge gaps in understanding disease pathophysiology...
February 15, 2019: American Journal of Physiology. Heart and Circulatory Physiology
Lukas Chmielewski, Michael Bietenbeck, Alexandru Patrascu, Sabine Rösch, Udo Sechtem, Ali Yilmaz, Anca-Rezeda Florian
BACKGROUND: Cardiac involvement in myotonic dystrophy type 1 (MD1) includes conduction disease, arrhythmias, and left-ventricular (LV) systolic dysfunction leading to an increased sudden cardiac death risk. An understanding of the interplay between electrical and structural myocardial changes could improve the prediction of adverse cardiac events. We aimed to explore the relationship between signs of cardiomyopathy by conventional and advanced cardiovascular magnetic resonance (CMR), and electrical abnormalities in MD1...
February 14, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Hasanain Ali Hameed Bshiebish, Ali Hussein Al-Musawi, Safaa Ali Khudeir
Objectives: To detect systolic dysfunction in heart failure with preserved ejection fraction (HFpEF) patients by using global longitudinal strain (GLS). Methods: This study included 46 heart failure patients: 24 with heart failure with reduced ejection fraction (HFrEF) and 22 with heart failure with preserved ejection fraction (HFpEF), and 20 patients with similar risk factor but no symptoms or signs of heart failure, matched for age and sex, as controls. All patients were screened by echocardiography...
April 2019: Journal of the Saudi Heart Association
Salisu M Abubakar, Moses T Ukeyima, Jeremy P E Spencer, Julie A Lovegrove
BACKGROUND/OBJECTIVES: The acute impact of Hibiscus sabdariffa calyces (HSC) extract on postprandial vascular function and other cardiometabolic risk factors have not been studied previously. This study investigated the acute impact of HSC extract consumption on blood pressure (BP), vascular function and other cardiometabolic risk markers. SUBJECTS/METHODS: Twenty-five men with 1% to 10% cardiovascular disease (CVD) risk (determined by QRISK® 2) were randomised to consume either 250 mL of the aqueous extract of HSC or water with breakfast in a randomised, controlled, single-blinded, 2-meal cross-over study (ClinicalTrials...
February 5, 2019: Nutrients
Veerle A B van den Bogaard, Peter van Luijk, Yoran M Hummel, Peter van der Meer, E Schuit, Liselotte M Boerman, Saskia W M C Maass, Jan F Nauta, Lars C Steggink, Jourik A Gietema, Geertruida H de Bock, Annette J Berendsen, Wilma G J M Smit, Nanna M Sijtsema, Roel G J Kierkels, Johannes A Langendijk, Anne P G Crijns, John H Maduro
PURPOSE: The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiotherapy (RT). METHODS AND MATERIALS: We conducted a cross-sectional study consisting of 109 BC survivors treated with RT between 2005 and 2011. The endpoint was cardiac function, assessed by echocardiography. Systolic function was assessed with the left ventricle ejection fraction (LVEF) (n=107) and the global longitudinal strain (GLS) of the left ventricle (LV) (n=52)...
February 11, 2019: International Journal of Radiation Oncology, Biology, Physics
Noha I Hussien, Hend S El-Wakeel, Safwa M Souror, Inas A Ahmed
Chronic stress is associated with oxidative stress and mitochondrial dysfunction. These mechanisms promote adverse cardiovascular events. Though many experimental studies have reported a protective effect of vitamin D (VitD) on cardiovascular system, its effect on cardiovascular system in case of chronic stress is not studied yet. The present study aimed to detect the effects of VitD treatment against chronic immobilization stress (CIS)-induced cardiac dysfunction, focusing mainly on mitochondrial function and oxidative stress in rats...
January 2019: General Physiology and Biophysics
June-Sung Kim, Muyeol Kim, Youn-Jung Kim, Seung Mok Ryoo, Chang Hwan Sohn, Shin Ahn, Won Young Kim
(1) Background: Myocardial dysfunction in patients with sepsis is not an uncommon phenomenon, yet reported results are conflicting and there is no objective definition. Measurement of troponin may reflect the state of the heart and may correlate with echocardiographically derived data. This study aimed to evaluate the role of admission and peak troponin-I testing for the identification of sepsis-induced myocardial dysfunction (SIMD) by transthoracic echocardiography (TTE). (2) Methods: This was a retrospective cohort study using a prospective registry of septic shock at an Emergency Department from January 2011 and April 2017...
February 12, 2019: Journal of Clinical Medicine
Riobaldo Cintra, Filipe A Moura, Luis Sergio F de Carvalho, Joaquim Barreto, Marcos Tambascia, Roberto Pecoits-Filho, Andrei C Sposito
The prevalence of type 2 diabetes mellitus (T2DM) in the elderly grew sharply over the last decade. Reduced insulin sensitivity and secretory capacity, weight gain, sarcopenia, and elevated adiposity are all common metabolic and body changes in the aging population that favor an increased risk of hypoglycemia, frailty syndrome, falls, and cognitive dysfunction. First line antidiabetic therapy is frequently not safe in older individuals because of its high risk of hypoglycemia and prevalent co-morbid diseases, such as chronic kidney disease, osteoporosis, cardiovascular disease, and obesity...
January 2019: Revista da Associação Médica Brasileira
U H Ferdaushi, M A Ali, N Islam, S Nabi, M Islam, M S Alom, G K Paul
Cardiac resynchronization therapy (CRT) reduces symptoms and improves left ventricular function in patients with heart failure due to left ventricular systolic dysfunction and cardiac dyssynchrony. We analyzed the clinical and echocardiographic outcome of CRT in heart failure patients. Thirty five (35) heart failure patients were included in this prospective observational study, conducted from February 2015 to February 2016 in the Department of cardiology, National Institute of Cardiology & Vascular Disease (NICVD) hospital, Dhaka, Bangladesh...
January 2019: Mymensingh Medical Journal: MMJ
Marilucy Lopez-Sublet, Nicolas Girerd, Erwan Bozec, Jean-Loup Machu, João Pedro Ferreira, Faiez Zannad, Jean-Jacques Mourad, Patrick Rossignol
Objective: The attenuation of physiological nocturnal decline of blood pressure (BP) - called nondipper pattern - has previously been reported to be associated with target organ damage in hypertensive subjects. However, this association remains debated and poorly studied in normotensive patients. The present study aimed to investigate the association between nondipper pattern and subclinical cardiovascular and renal damage in an initially healthy population-based cohort study. Methods: The STANISLAS Cohort is a single-center, familial longitudinal cohort comprised of 1006 families (4295 subjects) recruited in 1993-1995 for a 5-year periodic health examination...
February 7, 2019: American Journal of Hypertension
Benjamin J Lerman, Rita A Popat, Themistocles L Assimes, Paul A Heidenreich, Sherry M Wren
Importance: Heart failure is an established risk factor for postoperative mortality, but how left ventricular ejection fraction and heart failure symptoms affect surgical outcomes is not fully described. Objectives: To determine the risk of postoperative mortality among patients with heart failure at various levels of echocardiographic (left ventricular systolic dysfunction) and clinical (symptoms) severity compared with those without heart failure and to evaluate how risk varies across levels of surgical complexity...
February 12, 2019: JAMA: the Journal of the American Medical Association
Stefano Toldo, Adolfo Gabriele Mauro, Zachary Cutter, Benjamin W Van Tassell, Eleonora Mezzaroma, Marco Giuseppe Del Buono, Andrea Prestamburgo, Nicola Potere, Antonio Abbate
BACKGROUND: Activation of the NLRP3 inflammasome is a primary driver of sterile inflammation in response to myocardial ischemia reperfusion. Pharmacologic inhibitors of the NLRP3 inflammasome are being developed. We proposed that OLT1177 (dapansutrile), a novel NLRP3 inflammasome inhibitor, could preserve myocardial function after ischemia reperfusion injury in the mouse. METHODS: We used an experimental murine model of myocardial ischemia reperfusion injury through transient ligation of the left coronary artery, and measured the effects of OLT1177 (6, 60 or 600 mg/kg intraperitoneal dose) on infarct size at pathology and on systolic cardiac function at echocardiography...
February 8, 2019: Journal of Cardiovascular Pharmacology
Jacentha Buggs, Madison Shramek, Ebonie Rogers, Ambuj Kumar, Nyingi Kemmer
No abstract text is available yet for this article.
November 1, 2018: American Surgeon
Martino Deidda, Christian Cadeddu Dessalvi, Selina Campus, Francesco Ortu, Paolo Piano, Pier Paolo Bassareo, Giuseppe Mercuro
Objective: Human immunodeficiency virus (HIV) infection may also be associated with cardiac dysfunction, thus negatively affecting patients' morbidity and mortality. This preliminary study aimed at evaluating whether bi-and three-dimensional (3D) strain echocardiographic facilities were able to identify alterations in the right ventricular (RV) function in highly selected - because free from cardiovascular risk factors and other comorbidities - HIV patients. Materials and Methods: Eight of these specific HIV patients (age: 32...
October 2018: Journal of Cardiovascular Echography
Néstor Báez-Ferrer, María Manuela Izquierdo-Gómez, Belén Marí-López, Javier Montoto-López, Amelia Duque-Gómez, Javier García-Niebla, Julio Miranda-Bacallado, Alejandro de la Rosa Hernández, Ignacio Laynez-Cerdeña, Juan Lacalzada-Almeida
Ischemic mitral regurgitation (IMR) is a frequent complication after acute myocardial infarction (AMI) associated with a worse prognosis. The pathophysiological mechanisms of IMR are not fully understood, but it is known to be a complex process in which ventricular remodelling is the main causal factor. The various imaging techniques in cardiology and echocardiography fundamentally have contributed significantly to clarify the mechanisms that cause and progressively aggravate IMR. At present, different therapeutic options, the most important of which are cardio-surgical, address this problem...
December 2018: Journal of Thoracic Disease
Takehito Sasaki, Kohki Nakamura, Shigeto Naito
A 28-year-old female presented with fulminant lymphocytic myocarditis. She developed cardiogenic shock, frequent sustained ventricular tachycardia, and fibrillation (VT and VF). The left ventricular ejection fraction improved from 5% to 40% after medical therapy, but the right ventricular systolic dysfunction and enlargement persisted. In addition, sustained VTs, requiring direct current cardioversion, occurred during oral administration of amiodarone following intravenous amiodarone, even after percutaneous stellate ganglion block...
February 8, 2019: International Heart Journal
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