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Guiling Ma, Yidan Wang, Dongyan Hou, Jiamei Liu, Juan Zhang, Lin Xu, Hua Wang, Wenshu Zhao, Yuan Zhang, Lin Zhang
BACKGROUND: Peripartum cardiomyopathy (PPCM) is characterized by heart failure. Our previous study found that autoantibodies against the M2-muscarinic receptor (anti-M2-R) are increased in PPCM patients. We aimed to evaluate the association of anti-M2-R on prognosis of PPCM patients with standard treatment. METHODS: Synthetic peptides corresponding to the M2 receptor served as the target antigens in an enzyme-linked immunosorbent assay experiment. They were used to screen the sera of 80 PPCM patients, who were separated into anti-M2-R-negative and positive groups according to their anti-M2-R reactivity...
March 13, 2019: Journal of Cardiology
Michael C Honigberg, Uri Elkayam, Navin Rajagopalan, Kalgi Modi, Joan E Briller, Mark H Drazner, Gretchen L Wells, Dennis M McNamara, Michael M Givertz
BACKGROUND: There is limited data on electrocardiographic (ECG) abnormalities and their prognostic significance in women with peripartum cardiomyopathy (PPCM). We sought to characterize ECG findings in PPCM and explore the association of ECG findings with myocardial recovery and clinical outcomes. HYPOTHESIS: We hypothesized that ECG indicators of myocardial remodeling would portend worse systolic function and outcomes. METHODS: Standard 12-lead ECGs were obtained at enrollment in the Investigations of Pregnancy-Associated Cardiomyopathy study and analyzed for 88 women...
March 7, 2019: Clinical Cardiology
Ida Behrens, Saima Basit, Jacob A Lykke, Mattis F Ranthe, Jan Wohlfahrt, Henning Bundgaard, Mads Melbye, Heather A Boyd
BACKGROUND: Peripartum cardiomyopathy (PPCM) is a serious cardiac disorder occurring late in pregnancy or early in the postpartum period. We examined associations between hypertensive disorders of pregnancy (HDP: preeclampsia and gestational hypertension) and PPCM, accounting for other pregnancy-related risk factors for PPCM. METHODS: Using nationwide Danish register data, we constructed a cohort of all women with ≥1 live birth or stillbirth in Denmark between 1978 and 2012...
2019: PloS One
Saereh Khanamiri, June-Wha Rhee, David T Paik, Ian Y Chen, Chun Liu, Nazish Sayed
Peripartum cardiomyopathy (PPCM) is a rare form of congestive heart failure characterized by left ventricular dysfunction that develops towards the end of pregnancy or during the early postpartum phase. Even though the majority of PPCM patients show partial or complete recovery of their heart functions, the mortality rate of PPCM remains high. Previous research has suggested that vascular dysfunction triggered by late-gestational hormones and potent anti-angiogenic factors play key roles in the pathogenesis of PPCM; however, the exact mechanisms remain elusive due to limited patient tissues for characterization...
February 14, 2019: Journal of Vascular Research
Michael C Honigberg, Michael M Givertz
Peripartum cardiomyopathy (PPCM) is a rare, often dilated, cardiomyopathy with systolic dysfunction that presents in late pregnancy or, more commonly, the early postpartum period. Although the condition is prevalent worldwide, women with black ancestry seem to be at greatest risk, and the condition has a particularly high incidence in Nigeria and Haiti. Other risk factors include pre-eclampsia, advanced maternal age, and multiple gestation pregnancy. Although the complete pathophysiology of peripartum cardiomyopathy remains unclear, research over the past decade suggests the importance of vasculo-hormonal pathways in women with underlying susceptibility...
January 30, 2019: BMJ: British Medical Journal
Harshida Patel, Cecily Begley, Åsa Premberg, Maria Schaufelberger
BACKGROUND: Fathers' experience of childbirth has been described as both distressing and wonderful, but little has been described in the literature about fathers´ reactions when their partners get life threatening diagnoses such as peripartum cardiomyopathy (PPCM) during the peripartum period. AIM: To learn more about fathers' reactions over their partner's diagnosis of peripartum cardiomyopathy. METHODS: Fourteen fathers, whose partner was diagnosed with PPCM before or after giving birth, were interviewed...
January 2, 2019: Midwifery
Mechthild Westhoff-Bleck, Denise Hilfiker-Kleiner, Sabine Pankuweit, Bernhard Schieffer
Pregnancy-associated diseases of the cardiovascular system occur in up to 10% of all pregnancies and the incidence is increasing. Besides congenital heart disease or pre-existing cardiomyopathy in the mother, the clinical focus has moved especially to peripartum cardiomyopathy (PPCM) because of the condition's dramatic clinical course and the identification of the underlying mechanisms. This review article concentrates therefore on PPCM, which occurs either in the last month of pregnancy or in the first 6 months following delivery in women with previously healthy hearts...
December 2018: Geburtshilfe und Frauenheilkunde
Firdevs Aysenur Ekizler, Serkan Cay, Habibe Kafes, Ozcan Ozeke, Firat Ozcan, Serkan Topaloglu, Ahmet Temizhan, Dursun Aras
BACKGROUND: Peripartum cardiomyopathy (PPCM) is an uncommon complication of pregnancy. Clinical courses of PPCM are markedly heterogeneous. Positive T waves in lead aVR (TaVR) are shown to be associated with adverse cardiac events in several cardiovascular diseases. We aimed to investigate the prevalence and prognostic role of positive TaVR in patients with PPCM. METHODS: A total of 82 patients (mean age 29.1 ± 6.3 years) with the diagnosis of PPCM were enrolled...
January 17, 2019: Annals of Noninvasive Electrocardiology
Kate Kerpen, Paraskevi Koutrolou-Sotiropoulou, Chencan Zhu, Jie Yang, Jennifer-A Lyon, Fabio V Lima, Kathleen Stergiopoulos
There is limited information about differences in maternal deaths from peripartum cardiomyopathy (PPCM) between advanced and developing countries. To review the literature to define the global prevalence of death from PPCM, and to determine the differences in PPCM mortality rates and risk factors between advanced and developing countries. Studies in the English language reporting mortality data on patients with PPCM were included from searches of MEDLINE, Embase, CINAHL, the Cochrane Library, the Web of Science Core Collection and Scopus from 01 January 2000 to 11 May 2016...
December 26, 2018: Archives of Cardiovascular Diseases
Yusuf Saidu, Maimuna Jumai Usman, Suleiman Ahmed Isa, Simeon Alabi Isezuo, Lawal Suleiman Bilbis, Saddiku Malam Sahabi, Ahmad Bello, Suleiman Alhaji Muhammad
BACKGROUND: The customary puerperal practice of Natron consumption has been identified as one of the predisposing factors in the etiology of peripartum cardiomyopathy (PPCM). This study was designed to investigate the effect of Natron in postpartum Wistar albino rats. METHODS: A total of 30 postpartum Wistar rats were exposed to different doses (50mg/kg, 100mg/kg, 200mg/kg and 300mg/kg) of Natron for 28days. After the treatment, we carried out biochemical analyses and histological evaluations of kidney, liver and heart...
November 2018: Indian Heart Journal
Nagisa Morikawa, Takaharu Nakayoshi, Hanae Yoshimura, Megumi Watanabe, Jun Kumanomido, Aya Furusho, Daisuke Fukui, Kazuko Eto, Norifumi Nishida, Michihide Nishihara, Chizuko A Kamiya, Yoshihiro Fukumoto
Peripartum cardiomyopathy (PPCM) is rare but life-threatening. We herein report the case of a 48-year-old woman with PPCM after oocyte donation and delivery of twins. Two weeks after delivery, she suffered from severe symptoms of heart failure [orthopnea, New York Heart Association (NYHA) class IV, pulmonary edema and a reduced left ventricular ejection fraction of 18%]. Although standard heart failure therapy was effective for diminishing the congestion, it was not sufficient to improve her symptoms or left ventricular systolic dysfunction...
December 18, 2018: Internal Medicine
Maxime Tremblay-Gravel, Guillaume Marquis-Gravel, Robert Avram, Olivier Desplantie, Anique Ducharme, Lior Bibas, Christine Pacheco, Etienne Couture, François Simard, Anthony Poulin, Isabelle Malhamé, Dan Tran, Evelyne Rey, François Tournoux, Luc Harvey, Mario Sénéchal, Pierre Bélisle, Laurence Descarries, Paul Farand, Nicolas Pranno, Ariel Diaz, Jonathan Afilalo, Hung Q Ly, Annik Fortier, Etienne Marc Jolicoeur
AIMS: Bromocriptine is thought to facilitate left ventricular (LV) recovery in peripartum cardiomyopathy (PPCM) through inhibition of prolactin secretion. However, this potential therapeutic effect remains controversial and was incompletely studied in diverse populations. METHODS AND RESULTS: Consecutive women with new-onset PPCM (n = 76) between 1994 and 2015 in Quebec, Canada, were classified according to treatment (n = 8, 11%) vs. no treatment (n = 68, 89%) with bromocriptine...
February 2019: ESC Heart Failure
J Hoevelmann, C A Viljoen, K Manning, J Baard, L Hahnle, M Ntsekhe, J Bauersachs, K Sliwa
BACKGROUND: Peripartum cardiomyopathy (PPCM) is an important cause of pregnancy-associated heart failure, which appears in previously healthy women towards the end of pregnancy or within five months following delivery. Although the ECG is widely used in clinical practice, its prognostic value has not been established in PPCM. METHODS: We analysed 12-lead ECGs of patients with PPCM, taken at index presentation and follow-up visits at 6 and 12 months. Poor outcome was determined by the composite endpoint of death, readmission, NYHA functional class III/IV or left ventricular ejection fraction (LVEF) of ≤35% at follow-up...
November 7, 2018: International Journal of Cardiology
Rebecca Simon, Sophia Yang, Afshan B Hameed
Objective  This study is to review published cases of peripartum cardiomyopathy (PPCM) treated with bromocriptine and outline pros and cons of the treatment strategy. Data Sources  Data were collected from PubMed/MedLine,; the years 2007 to 2018 were searched for English-language articles. Search terms: "bromocriptine and peripartum cardiomyopathy", "bromocriptine and cardiomyopathy." Methods of Study Selection  This search strategy yielded 171 articles. After excluding duplicates, 86 studies were reviewed...
October 2018: American Journal of Perinatology Reports
Kathryn J Lindley, Amanda K Verma, Lori A Blauwet
Occurring in approximately 1 in 1000 live births in the United States, peripartum cardiomyopathy (PPCM) is characterized by left ventricular ejection fraction reduced to less than 45% near the end of pregnancy or within the first 5 months after delivery. Although the cause of PPCM remains unclear, increasing evidence supports a complex interaction of genetic and environmental factors contributing to angiogenic imbalance, which may lead to myocardial dysfunction in a susceptible woman. This article reviews the progress that has been made regarding understanding of the cause, management, and natural history of PPCM...
January 2019: Heart Failure Clinics
Jasmine Peterson, April Hinds, Aida Garza, Jamie Barner, Lucas Hill, Michelle Nguyen, Phillip Lai, Tyler Gums
PURPOSE: A popular method for enhancing medication management within a patient-centered medical home (PCMH) is the physician-pharmacist collaborative management (PPCM) model. To improve efficiency of health-care delivery within 4 federally qualified health centers (FQHCs), the PPCM model was implemented through coordinated physician-pharmacist covisits. OBJECTIVE: To evaluate the impact of physician-pharmacist covisits on clinical outcomes among patients with uncontrolled diabetes...
November 14, 2018: Journal of Pharmacy Practice
Anne S Ersbøll, Annemie S Bojer, Maria G Hauge, Marianne Johansen, Peter Damm, Finn Gustafsson, Niels G Vejlstrup
Background Long-term clinical studies of peripartum cardiomyopathy ( PPCM ) are few. We aimed to measure the long-term effect of PPCM on cardiac function in comparison with the long-term effects of severe preeclampsia and uncomplicated pregnancy. Methods and Results A nationwide Danish cohort of women diagnosed with PPCM from 2005 to 2014 ( PPCM group) were invited to participate in a clinical follow-up study including maximal cardiopulmonary exercise testing and cardiac magnetic resonance imaging. Matched women with previous severe preeclampsia (preeclampsia group) and previous uncomplicated pregnancies (uncomplicated pregnancies group) served as comparison groups...
October 16, 2018: Journal of the American Heart Association
Giuseppe Limongelli, Marta Rubino, Augusto Esposito, Mariagiovanna Russo, Giuseppe Pacileo
PURPOSE OF REVIEW: To discuss the risk preexisting or new onset cardiomyopathy/heart failure (CMP/heart failure) in pregnant woman, and recent insights regarding their management and therapy. RECENT FINDINGS: Recent data from the European Registry on Pregnancy and Heart disease of the European Society of Cardiology (ROPAC) suggest that, after an adequate prepregnancy evaluation in specialized centres, the vast majority of pregnancies are safe for both mother and foetus...
December 2018: Current Opinion in Obstetrics & Gynecology
Takeshi Mikami, Hitoshi Kamiunten
Peripartum cardiomyopathy (PPCM) is an idiopathic left ventricular dysfunction in women who are in late pregnancy or the postpartum period. PPCM is a rare but sometimes fatal disease, and mechanical circulatory support is required if heart failure is refractory to conventional therapy. A 28-year-old woman in late pregnancy was admitted to our hospital due to congestive heart failure with cardiogenic shock. Her heart rate was 200 beats per minute (sinus tachycardia), and left ventricular ejection fraction (LVEF) was 10%...
June 2018: Journal of Cardiology Cases
Lindsey Rosman, Elena Salmoirago-Blotcher, John Cahill, Samuel F Sears
BACKGROUND: Psychological distress can adversely affect heart failure prognosis, yet the immediate and ongoing challenges faced by women diagnosed with peripartum cardiomyopathy (PPCM) are not well studied. OBJECTIVE: We examined psychological distress and quality of life in a large, national sample of patients with PPCM and evaluated whether these characteristics differ among newly diagnosed (0-1 year), short-term (2-4 years), and long-term (5-10 years) survivors...
September 28, 2018: Journal of Cardiovascular Nursing
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