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internal medicine researches

Xiao Li, Juntao Li, Xianrui Li, Jisheng Wang, Hengheng Dai, Jingshang Wang
BACKGROUND: Premature ejaculation (PE) is one of the most common male sexual dysfunctions, which can directly harm men's self-esteem and affect the stability of the relationship between husband and wife. To some extent, PE even affects the harmony and stability of society. So, men's health has gained more and more attention. As one of the long-acting selective serotonin reuptake inhibitors (SSRIs), fluoxetine has been proven to be effective in the treatment of PE by many trails. In this study, we aim to evaluate the effectiveness and safety of fluoxetine for PE to provide the newest evidence for clinical use...
February 2019: Medicine (Baltimore)
Abolfazl Khoshi, Hossein Shams Gooshki, Norouz Mahmoudi
In this data article, hybrid fuzzy Analytic Hierarchy Process (AHP) and fuzzy Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) were used to prioritize the effective qualifications of teachers of medical courses at university from the viewpoint of students of allied medicine school in Tehran University of Medical Sciences in 2013-2014. To obtain data, 200 students of allied medicine school of Tehran University of Medical Sciences were selected using random sampling method, and surveyed according to Cochran׳s formula...
December 2018: Data in Brief
Ben Goldacre, Henry Drysdale, Aaron Dale, Ioan Milosevic, Eirion Slade, Philip Hartley, Cicely Marston, Anna Powell-Smith, Carl Heneghan, Kamal R Mahtani
BACKGROUND: Discrepancies between pre-specified and reported outcomes are an important source of bias in trials. Despite legislation, guidelines and public commitments on correct reporting from journals, outcome misreporting continues to be prevalent. We aimed to document the extent of misreporting, establish whether it was possible to publish correction letters on all misreported trials as they were published, and monitor responses from editors and trialists to understand why outcome misreporting persists despite public commitments to address it...
February 14, 2019: Trials
Jing Zhang, Jia Liu, Dan Li, Canfei Zhang, Ming Liu
BACKGROUND: The sudden loss of blood supply in ischemic stroke is associated with an increase of calcium ions within neurons. Inhibiting this increase could protect neurons and might reduce neurological impairment, disability, and handicap after stroke. OBJECTIVES: To assess the effects of calcium antagonists for reducing the risk of death or dependency after acute ischemic stroke. We investigated the influence of different drugs, dosages, routes of administration, time intervals after stroke, and trial design on the outcomes...
February 13, 2019: Cochrane Database of Systematic Reviews
Anastasia A Nikitina, Alexey A Orlov, Liubov I Kozlovskaya, Vladimir A Palyulin, Dmitry I Osolodkin
The discovery of antiviral drugs is a rapidly developing area of medicinal chemistry research. The emergence of resistant variants and outbreaks of poorly studied viral diseases make this area constantly developing. The amount of antiviral activity data available in ChEMBL consistently grows, but virus taxonomy annotation of these data is not sufficient for thorough studies of antiviral chemical space. We developed a procedure for semi-automatic extraction of antiviral activity data from ChEMBL and mapped them to the virus taxonomy developed by the International Committee for Taxonomy of Viruses (ICTV)...
January 1, 2019: Database: the Journal of Biological Databases and Curation
S G Attar, V J Poustie, S W Smye, J M Beety, D B Hawcutt, S Littlewood, L Oni, M Pirmohamed, M W Beresford
Introduction or background: Stratified medicine is an important area of research across all clinical specialties, with far reaching impact in many spheres. Despite recently formulated global policy and research programmes, major challenges for delivering stratified medicine studies persist. Across the globe, clinical research infrastructures have been setup to facilitate high quality clinical research. Sources of data: This article reviews the literature and summarizes views collated from a workshop held by the UK Pharmacogenetics and Stratified Medicine Network and the NIHR Clinical Research Network in November 2016...
February 7, 2019: British Medical Bulletin
Sid Ahmed Dahdi, Asma Ben Abdelaziz, Tarek Baroumi, Ousmane Ba, Mohamadou Diagana, Lebchir Dada, Ahmed Ben Abdelaziz
BACKGROUND: As part of the preparatory work for the elaboration of a strategic plan for the development of scientific research in Mauritania, an overview of national biomedical research was recommended by the supervisory authorities. AIM: Describe the bibliometric profile of biomedical scientific publications in Mauritania, indexed in Medline database, over the past 25 years. METHODS: A bibliometric study was carried out on Medline Database covering the period from 1 January 1992 to 31 December 2016...
October 2018: La Tunisie Médicale
Davorina Petek, Ambrož Pušnik, Polona Selič, Eva Cedilnik-Gorup, Žan Trontelj, Marine Riou, Jean Yves Le Reste
Introduction: Therapeutic alliance is a term most commonly associated with psychotherapeutic treatment, but recently its use has become increasingly significant in the other fields of medicine. An increasing amount of evidence implies that the quality of the therapeutic alliance between the doctor and patient substantially affects treatment outcomes. A European consensus chose the Working Alliance Inventory - Short Revised (WAI-SR) scale as the most efficient for European primary care...
March 2019: Zdravstveno Varstvo
Laura Leticia Salazar-Sepúlveda, Jesús Zacarías Villarreal-Pérez
BACKGROUND: Obesity is a growing epidemic associated with a 30% increase in general mortality. Despite this, diagnosis and treatment is still deficient. A large number of patients with overweight and obesity enter hospitals daily; therefore, the hospital setting could be used as a scenario for intervention in this population. OBJECTIVES: To determine the frequency of diagnosis and treatment of overweight/obesity in hospitalized patients and to identify the factors involved in the probability of offering a diagnosis and treatment...
February 8, 2019: Obesity Research & Clinical Practice
Waleed M Sweileh
BACKGROUND: Worldwide, natural disasters have caused a large number of deaths and considerable morbidity. Nevertheless, limited information is available on how the health-related literature on natural disasters has evolved. The current study aims to assess the growth and pattern of health-related literature on natural disasters. METHOD: A bibliometric method was implemented using Scopus database for the period from 1900 to 2017. Keywords used in the search strategy were obtained from the classifications of natural disasters presented by the Centre for Research on the Epidemiology of Disasters...
February 11, 2019: Health Research Policy and Systems
Umit Gokhan Sendur, Mine Adas
INTRODUCTION: Diabetes mellitus is a chronic disease that requires continuous medical care. Raising awareness and determining the factors affecting awareness about diabetes and its complications have an important role in achieving glycemic control and preventing complications. OBJECTIVE: In this study, we aimed to determine the sociodemographic properties of participants, the status of patients' awareness, and the factors affecting awareness. We also aimed to determine the relationships between these factors and diabetes regulation...
February 11, 2019: Experimental and Clinical Endocrinology & Diabetes
Emma Day, Tina Broder, Julie Bruneau, Sally Cruse, Melisa Dickie, Suzanne Fish, Celine Grillon, Niklas Luhmann, Kate Mason, Elizabeth McLean, Stacey Trooskin, Carla Treloar, Jason Grebely
It is estimated that 6.1 million people with recent injecting drug use (PWID) are living with hepatitis C virus (HCV). Although HCV-related morbidity and mortality among PWID continues to increase, the advent of direct acting antiviral (DAA) HCV regimens with cure rates >95% provides an opportunity to reverse the rising burden of disease. Additionally, given evidence that opioid substitution therapy and high-coverage needle and syringe programs can reduce HCV incidence by up to 80%, there is an opportunity to reduce HCV transmission with increased coverage of harm reduction services...
February 8, 2019: International Journal on Drug Policy
Aaron C Elkins, Myrna A Deseo, Simone Rochfort, Vilnis Ezernieks, German Spangenberg
The social push for the therapeutic use of cannabis extracts has increased significantly over recent years. Cannabis is being used for treatment for conditions such as epilepsy, cancer and pain management. There are a range of medicinal cannabis products available, but the use of cannabis resin obtained by super critical fluid extraction, often diluted in oil, is becoming increasingly more prominent. Much of the research on cannabis has focused on plant biomass or the final therapeutic product with a concerning lack of information on the intermediate resin...
January 30, 2019: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Wouter Froyman, Chiara Landolfo, Bavo De Cock, Laure Wynants, Povilas Sladkevicius, Antonia Carla Testa, Caroline Van Holsbeke, Ekaterini Domali, Robert Fruscio, Elisabeth Epstein, Maria José Dos Santos Bernardo, Dorella Franchi, Marek Jerzy Kudla, Valentina Chiappa, Juan Luis Alcazar, Francesco Paolo Giuseppe Leone, Francesca Buonomo, Lauri Hochberg, Maria Elisabetta Coccia, Stefano Guerriero, Nandita Deo, Ligita Jokubkiene, Jeroen Kaijser, An Coosemans, Ignace Vergote, Jan Yvan Verbakel, Tom Bourne, Ben Van Calster, Lil Valentin, Dirk Timmerman
BACKGROUND: Ovarian tumours are usually surgically removed because of the presumed risk of complications. Few large prospective studies on long-term follow-up of adnexal masses exist. We aimed to estimate the cumulative incidence of cyst complications and malignancy during the first 2 years of follow-up after adnexal masses have been classified as benign by use of ultrasonography. METHODS: In the international, prospective, cohort International Ovarian Tumor Analysis Phase 5 (IOTA5) study, patients aged 18 years or older with at least one adnexal mass who had been selected for surgery or conservative management after ultrasound assessment were recruited consecutively from 36 cancer and non-cancer centres in 14 countries...
February 5, 2019: Lancet Oncology
Amanda Weidner, Lars E Peterson, Arch G Mainous, Avisek Datta, Bernard Ewigman
BACKGROUND AND OBJECTIVES: Capacity for conducting family medicine research has grown significantly since the specialty was founded. Many calls to increase this capacity have been published, but there has been no consistent, systematic, and longitudinal assessment. This survey was designed to gather baseline data with an easily replicable set of measures associated with research productivity that can guide and monitor the impact of efforts to build research capacity in US departments of family medicine (DFMs)...
February 2019: Family Medicine
Rodrigo A Olarte, Jon Menke, Ying Zhang, Shawn Sullivan, Jason C Slot, Yinyin Huang, Jonathan P Badalamenti, Alisha C Quandt, Joseph W Spatafora, Kathryn E Bushley
BACKGROUND: Genes involved in production of secondary metabolites (SMs) in fungi are exceptionally diverse. Even strains of the same species may exhibit differences in metabolite production, a finding that has important implications for drug discovery. Unlike in other eukaryotes, genes producing SMs are often clustered and co-expressed in fungal genomes, but the genetic mechanisms involved in the creation and maintenance of these secondary metabolite biosynthetic gene clusters (SMBGCs) remains poorly understood...
February 7, 2019: BMC Genomics
J J Díez, J C Galofré, A Oleaga, E Grande, M Mitjavila, P Moreno
AIM: There is an important lack of knowledge as to the functioning of multidisciplinary teams on thyroid cancer in current clinical practice. We aimed to retrieve data on the composition, structure, and procedures developed by the multidisciplinary units of thyroid cancer in Spain. METHODS: A nationwide survey consisting of questions about composition, structure, and functioning of multidisciplinary teams was designed. It was available online from November 15, 2017 to February 15, 2018...
February 5, 2019: Clinical & Translational Oncology
Vivek T Kulkarni, Sanjay M Salgado, Stephen R Pelletier, Helen M Shields
Background: The specific teaching methods used by internal medicine residents on walk rounds are unknown. Objectives: 1) To characterize in real time the specific teaching methods used by internal medicine residents on rounds and 2) to identify attributes of successful resident teaching on rounds. Materials and methods: We conducted a prospective mixed-methods study on inpatient medical services at a single academic medical center from September 2016 to January 2017...
2019: Advances in Medical Education and Practice
Mohit Butaney, Nannan Thirumavalavan, Dayron Rodriguez, Martin S Gross, Ricardo Munarriz
Penile shunting is the standard of care in management of ischemic priapism refractory (IPR) to non-surgical interventions. Due to high rates of impotence, corporal fibrosis, and loss of penile length, recent literature suggests these patients benefit from immediate penile prosthesis (PP) placement. An IRB-exempt anonymous electronic survey of the 2168 members of the International Society for Sexual Medicine (ISSM) was conducted. The survey included demographic information, confidence, and experience-related management of IPR...
February 4, 2019: International Journal of Impotence Research
Sai-Nan Fang, Xue Bai, Si-Hong Yang, Xue Feng, Xing Liao, Jian-Ping Liu, Wei Chen
Due to its own characteristics and research status, traditional Chinese medicine research often faces the reality of "insufficient evidence" or "very low quality" when making clinical practice guidelines. Therefore, in many cases, clinical decision-making of traditional Chinese medicine should rely mainly on expert consensus to achieve. A clear and detailed list of expert consensus report specifications will provide a good reporting tool for Chinese clinical expert consensus makers, which is very important for promoting the quality of consensus production and the promotion and application of consensus results...
December 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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