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Nanotechnology skin

Atefeh Pesaraklou, Nasser Mahdavi-Shahri, Halimeh Hassanzadeh, Masoud Ghasemi, Mahboubeh Kazemi, Nasser Sanjar Mousavi, Maryam M Matin
Today advancements in nanotechnology have made extensive progress in tissue engineering. Application of cerium oxide nanoparticles (CeO2) has improved regenerative medicine due to their antioxidant properties. In this study, nanoparticles were used to increase the efficacy of skin substitutes. Human skin samples were decellularized using four methods and studied via histological stainings and DNA content analyses. Then CeO2 dispersing and its stability were investigated. The prepared acellular dermal matrices (ADMs) were immersed in CeO2 suspension and their effects were evaluated on growth of cultured human adipose derived-mesenchymal stem cells (hAd-MSCs) using MTT assay and histological methods...
February 12, 2019: Biomedical Materials
Andrea A Greschner, Xavier Ropagnol, Mohamed Kort, Nabilah Zuberi, Jonathan Perreault, Luca Razzari, Tsuneyuki Ozaki, Marc A Gauthier
Recent observations have suggested that non-ionizing radiation in the microwave and terahertz (THz; far infrared) regimes could have an effect on double-stranded DNA (dsDNA). These observations are of significance owing to the omnipresence of microwave emitters in our daily lives (e.g., food preparation, telecommunication, wireless internet) and the increasing prevalence of THz emitters for imaging (e.g., concealed weapon detection in airports, screening skin cancer) and communication technologies. By examining multiple DNA nanostructures as well as two plasmid DNA, microwaves were shown to promote the repair and assembly of DNA nanostructures and single-stranded regions of plasmid DNA, while intense THz pulses had the opposite effect (in particular for short dsDNA)...
February 1, 2019: Journal of the American Chemical Society
Divya Thakur, Gurpreet Kaur
BACKGROUND: Over the past century, prevalence of skin diseases has substantially increased. These diseases present a significant physical, emotional and socio-economic burden to the society. Such conditions are also associated with multitude of psychological traumas to the suffering patients. The effective treatment strategy implicates targeting of drugs to skin. The field of drug targeting has been revolutionized with an advent of nanotechnology. The emergence of stimulus responsive nano platforms has provided remarkable control over fundamental polymer properties for external triggers...
January 23, 2019: Current Drug Delivery
Danny Meetoo, Louise Wong, Bertha Ochieng
New ways of measuring blood glucose bring hope of easing the burden of diabetes management for patients living with the conditions. The smart tattoo is an innovation that represents a nascent nanotechnology, which is designed to be implanted within the skin to provide continuous and reliable glucose detection for individuals diagnosed with diabetes. The potential benefits of the smart tattoo are compelling not only due to the potential of these nanodevices to prevent diabetic complications and decrease the related social costs, but also due to ease of use and relative user comfort...
January 24, 2019: British Journal of Nursing: BJN
Ahmed M Abdellah, Mahmoud A Sliem, Mona Bakr, Rehab M Amin
AIM: There is an urgent need to develop alternative antimicrobial agents and, one of which is via the use of nanotechnology. Green synthetic routes are recently being replaced for nanoparticles preparation. Methods results: Silver-curcumin nanoconjugates (Ag-CurNCs) were prepared in an eco-friendly method. The prepared nanomaterials were characterized and the photostability was studied under the influence of UV irradiation. Results showed that, the conjugation between curcumin and silver in the nanoform improve the photostability of curcumin...
November 2018: Future Medicinal Chemistry
Alessandra Nigro, Michele Pellegrino, Marianna Greco, Alessandra Comandè, Diego Sisci, Luigi Pasqua, Antonella Leggio, Catia Morelli
Advances in nanotechnology for drug delivery are fostering significant progress in medicine and diagnostics. The multidisciplinary nature of the nanotechnology field encouraged the development of innovative strategies and materials to treat a wide range of diseases in a highly specific way, which allows reducing the drug dosage and, consequently, improving the patient's compliance. Due to their good biocompatibility, easy synthesis, and high versatility, inorganic frameworks represent a valid tool to achieve this aim...
December 1, 2018: Pharmaceutics
Javed Ahmad, Anuj Gautam, Shahadali Komath, Mehdiya Bano, Anuj Garg, Keerti Jain
BACKGROUNDS: Acne vulgaris is a common chronic skin disease that affects approximately 650 million people or about 9.4% of the population globally. Growing research in the area of nanotechnology over the years has now been exploited in management of various human disorders by their application in drug delivery. These approaches have an enormous opportunity for the designing of a novel, low-dose and effective treatment systems to control acne disease. Topical nanoemulsion-based gel preparations are said to have various benefits over the conventional formulations...
November 28, 2018: Recent Patents on Anti-infective Drug Discovery
Erzsebet Csanyi, Mónika Bakonyi, Anita Kovács, Mária Budai-Szűcs, Ildikó Csóka, Szilvia Berkó
BACKGROUND: One of the most compelling medical challenges of this century is the treatment of cancer and among them, skin cancer is the most common type. Thus, current treatments need to be renewed continuously to handle this challenge. OBJECTIVE: This review presents considerations which can be employed during the development of nanosized formulations dedicated to the topical treatment of skin cancer. We aimed to collect and organize literature data on the treatment options for skin cancer in order to determine the required quality attributes of an effective dermal anticancer formulation...
November 16, 2018: Current Medicinal Chemistry
Elidamar Nunes de Carvalho Lima, José Roberto Castilho Piqueira, Durvanei Augusto Maria
Malignant melanoma is an aggressive skin cancer with limited therapeutic options. Cancer is the second largest cause of death in society and one of the most difficult diseases to treat. Advances in biotechnology have enabled the current use of nanotechnology via the application of nanomaterials, especially as drug delivery systems for the transportation of very small particles. In this context, carbon nanotubes, with a potential role in the diagnosis and treatment of melanoma, are still an emerging research field...
December 2018: Molecular Diagnosis & Therapy
Carlos Zgheib, Sarah A Hilton, Lindel C Dewberry, Maggie M Hodges, Subhadip Ghatak, Junwang Xu, Sushant Singh, Sashwati Roy, Chandan K Sen, Sudipta Seal, Kenneth W Liechty
BACKGROUND: Diabetic wounds have become one of the most challenging public health issues of the 21st century and yet there's no effective treatment available. We have previously shown that the diabetic wound healing impairment is associated with increased inflammation and decreased expression of the regulatory microRNA miR-146a. We have conjugated miR-146a to cerium oxide nanoparticles (CNP-miR146a) to target reactive oxygen species (ROS) and inflammation. This study aims to evaluate the consequences of CNP-miR146a treatment of diabetic wounds...
September 27, 2018: Journal of the American College of Surgeons
Jian Yang, Zhuojun Meng, Qing Liu, Yasuhito Shimada, René C L Olsthoorn, Herman P Spaink, Andreas Herrmann, Alexander Kros
Nanoscale engineering of surfaces is becoming an indispensable technique to modify membranes and, thus cellular behaviour. Here, such membrane engineering related was explored on the surface of a living animal using DNA nanotechnology. We demonstrate the immobilization of oligonucleotides functionalized with a membrane anchor on 2 day old zebrafish. The protruding single-stranded DNA on the skin of zebrafish served as a handle for complementary DNAs, which allowed the attachment of small molecule cargo, liposomes and dynamic relabeling by DNA hybridization protocols...
September 28, 2018: Chemical Science
Solmaz Ghaffari, Faezeh Alihosseini, Seyed Mahdi Rezayat Sorkhabadi, Sepideh Arbabi Bidgoli, Seyyedeh Elaheh Mousavi, Setareh Haghighat, Ahoo Afshar Nasab, Nooshin Kianvash
Purpose: Wound healing is a natural biologic process, but the duration of it may take too long. Trying to shorten this process is one of the challenges for scientists. Many technologies were applied to achieve this goal as well as nanotechnology. In this study semi solid formulations containing curcumin and ampicillin solid lipid nanoparticles (SLNs) were prepared to evaluate as burn wound healing agent. Methods: Curcumin as an anti-inflammatory and anti-bacterial agent and ampicillin as an antibiotic were applied...
August 2018: Advanced Pharmaceutical Bulletin
Shivani Verma, Puneet Utreja, Lalit Kumar
BACKGROUND: Acne is a multifactorial skin disease associated with pilosebaceous unit and caused by bacteria Propionibacterium acnes and Acne vulgaris. Near about 95% people throughout the world suffer from acne at some point in their life span. This disease is more prominent in adults compared to neonates and prepubescent children. Conventionally it is treated with either creams or gels having large number of side effects on patients. METHODS: We searched about recent advancements in the use of nanotechnological carriers for effective treatment of acne...
September 18, 2018: Recent Patents on Anti-infective Drug Discovery
Marziyeh Hajialyani, Devesh Tewari, Eduardo Sobarzo-Sánchez, Seyed Mohammad Nabavi, Mohammad Hosein Farzaei, Mohammad Abdollahi
Wound healing process is an intricate sequence of well-orchestrated biochemical and cellular phenomena to restore the integrity of the skin and subcutaneous tissue. Several plant extracts and their phytoconstituents are known as a promising alternative for wound healing agents due to the presence of diverse active components, ease of access, and their limited side effects. The development of nanotechnological methods can help to improve the efficacy of different therapeutics as well as herbal-based products...
2018: International Journal of Nanomedicine
Rikhav P Gala, Rokon Uz Zaman, Martin J D'Souza, Susu M Zughaier
Neisseria gonorrhoeae is a strict human pathogen responsible for more than 100 million new sexually transmitted infections worldwide each year. Due to the global emergence of antibiotic resistance, the Center for Disease control (CDC) recently listed N. gonorrhoeae as an urgent threat to public health. No vaccine is available in spite of the huge disease burden and the possibility of untreatable gonorrhea. The aim of this study is to investigate the immunogenicity of a novel whole-cell-based inactivated gonococcal microparticle vaccine formulation loaded in dissolvable microneedles for transdermal administration...
September 4, 2018: Vaccines
Menglei Wang, Xuan Lai, Longquan Shao, Li Li
Nanotechnology is an interdisciplinary science that has developed rapidly in recent years. Metallic nanoparticles (NPs) are increasingly utilized in dermatology and cosmetology, because of their unique properties. However, skin exposure to NPs raises concerns regarding their transdermal toxicity. The tight junctions of epithelial cells form the skin barrier, which protects the host against external substances. Recent studies have found that NPs can pass through the skin barrier into deeper layers, indicating that skin exposure is a means for NPs to enter the body...
2018: International Journal of Nanomedicine
Khadijeh Khezri, Majid Saeedi, Solmaz Maleki Dizaj
Developments in nanotechnology have expanded novel nanoparticles for several applications, including cosmetic topical preparation. The aim of this article was to review recent literature on percutaneous delivery of cosmetics active ingredient by nanoparticles. The main focus here, is on lipid based nanoparticles since they are of great importance in skin cargo delivery and have vast application in current cosmetic formulations. Data were collected via electronic databases using MeSH keywords, including nanoparticles, lipid particles, cosmetic, dermal delivery and combinations of these words...
October 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Harshita Mishra, Pawan K Mishra, Adam Ekielski, Manu Jaggi, Zeenat Iqbal, Sushama Talegaonkar
INTRODUCTION: Melanoma is the most serious form of skin cancer causing most of the skin cancer-related deaths. The incidence of melanoma has risen so dramatically over past few years that no other solid or blood malignancy comes close to it in terms of increased incidence. The main problem associated with the treatment of melanoma is low response rate to the existing treatment modalities, which in turn is due to the incomplete response by chemotherapeutic agents and inherent resistance of melanoma cells...
December 2018: Journal of Cancer Research and Clinical Oncology
T G Sahana, P D Rekha
Wound is a growing healthcare challenge affecting several million worldwide. Lifestyle disorders such as diabetes increases the risk of wound complications. Effective management of wound is often difficult due to the complexity in the healing process. Addition to the conventional wound care practices, the bioactive polymers are gaining increased importance in wound care. Biopolymers are naturally occurring biomolecules synthesized by microbes, plants and animals with highest degree of biocompatibility. The bioactive properties such as antimicrobial, immune-modulatory, cell proliferative and angiogenic of the polymers create a microenvironment favorable for the healing process...
August 9, 2018: Molecular Biology Reports
Maira N Pereira, Camila Y Ushirobira, Marcilio Ss Cunha-Filho, Guilherme M Gelfuso, Tais Gratieri
Alopecia is the partial or total reduction of hair in a specific area of the skin that affects millions of men and women worldwide. Most common approved treatments present inconvenient therapeutic regimes and serious adverse effects. In this scenario, nanoencapsulation has emerged as a relatively simple technology for improving the therapeutic outcome of this pathology, promoting a targeted drug delivery with enhanced local bioavailability, which could reduce the adverse effects. Herein, we present some recent studies involving the nanosystems developed for the pharmacological treatment of alopecia, highlighting how each system represents an improvement in relation to conventional drug products and the future perspectives of these new technologies in reaching the market...
August 2018: Therapeutic Delivery
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