Jie Jia, Lianhui Zhu, Xihua Yue, Shuocheng Tang, Shuaiyang Jing, Chuanting Tan, Yulei Du, Jingkai Gao, Intaek Lee, Yi Qian
Hostile microenvironment of cancer cells provoke a stressful condition for endoplasmic reticulum (ER) and stimulate the expression and secretion of ER chaperones, leading to tumorigenic effects. However, the molecular mechanism underlying these effects is largely unknown. In this study, we reveal that the last four residues of ER chaperones, which are recognized by KDEL receptor (KDELR), is required for cell proliferation and migration induced by secreted chaperones. By combining proximity-based mass spectrometry analysis, split venus imaging and membrane yeast two hybrid assay, we present that EGF receptor (EGFR) may be a co-receptor for KDELR on the surface...
February 20, 2024: Cell Communication and Signaling: CCS