Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Sergi Clotet-Freixas, Olga Zaslaver, Max Kotlyar, Chiara Pastrello, Andrew T Quaile, Caitriona M McEvoy, Aninda D Saha, Sofia Farkona, Alex Boshart, Katarina Zorcic, Slaghaniya Neupane, Kieran Manion, Maya Allen, Michael Chan, Xuqi Chen, Arthur P Arnold, Peggy Sekula, Inga Steinbrenner, Anna Köttgen, Allison B Dart, Brandy Wicklow, Jon M McGavock, Tom D Blydt-Hansen, Clara Barrios, Marta Riera, María José Soler, Amandine Isenbrandt, Jérôme Lamontagne-Proulx, Solène Pradeloux, Katherine Coulombe, Denis Soulet, Shravanthi Rajasekar, Boyang Zhang, Rohan John, Aman Mehrotra, Adam Gehring, Maija Puhka, Igor Jurisica, Minna Woo, James W Scholey, Hannes Röst, Ana Konvalinka
Diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD) and progresses faster in males than in females. We identify sex-based differences in kidney metabolism and in the blood metabolome of male and female individuals with diabetes. Primary human proximal tubular epithelial cells (PTECs) from healthy males displayed increased mitochondrial respiration, oxidative stress, apoptosis, and greater injury when exposed to high glucose compared with PTECs from healthy females. Male human PTECs showed increased glucose and glutamine fluxes to the TCA cycle, whereas female human PTECs showed increased pyruvate content...
March 6, 2024: Science Translational Medicine
#2
JOURNAL ARTICLE
Martin L Schulman, Nicole K Hayes, Tracy A Wilson, John D Grewar
In North America, range constraints due to burgeoning development increasingly encroach on wild horse habitat and necessitate effective but humane reproductive management. The largest free-roaming wild horse fertility control program by population (>3500) and territory size (≈300,000 acres) is located within Nevada's Virginia Range. Data from a field study investigated porcine zona pellucida (pZP) immunocontraception via remote dart delivery to mares in this population. Analyses aimed to measure efficacy by treatment effects on annual birth rates and population demographics and to evaluate treatment frequency and season against these variables...
January 18, 2024: Vaccines
#3
JOURNAL ARTICLE
Nallely R Morales-Mancillas, Fabiola Velazquez-Valenzuela, Shigeru Kinoshita, Tomo Suzuki, Annegret H Dahlmann-Noor, John K G Dart, Melanie Hingorani, Asim Ali, Simon Fung, Yonca A Akova, Serge Doan, Noopur Gupta, Kristin M Hammersmith, Donald T H Tan, J Homar Paez-Garza, Alejandro Rodriguez-Garcia
IMPORTANCE: Pediatric blepharokeratoconjunctivitis (PBKC) is a chronic, sight-threatening inflammatory ocular surface disease. Due to the lack of unified terminology and diagnostic criteria, nonspecific symptoms and signs, and the challenge of differentiation from similar ocular surface disorders, PBKC may be frequently unrecognized or diagnosed late. OBJECTIVE: To establish a consensus on the nomenclature, definition, and diagnostic criteria of PBKC. DESIGN, SETTING, AND PARTICIPANTS: This quality improvement study used expert panel and agreement applying the non-RAND modified Delphi method and open discussions to identify unified nomenclature, definition, and definitive diagnostic criteria for PBKC...
January 1, 2024: JAMA Ophthalmology
#4
JOURNAL ARTICLE
Zhan Ye, John Mayer, Emili J Leary, Terrie Kitchner, Richard A Dart, Murray H Brilliant, Scott J Hebbring
It is well known that common variants in specific genes influence drug metabolism and response, but it is currently unknown what fraction of patients are given prescriptions over a lifetime that could be contraindicated by their pharmacogenomic profiles. To determine the clinical utility of pharmacogenomics over a lifetime in a general patient population, we sequenced the genomes of 300 deceased Marshfield Clinic patients linked to lifelong medical records. Genetic variants in 33 pharmacogenes were evaluated for their lifetime impact on drug prescribing using extensive electronic health records...
2023: Frontiers in Medicine
#5
JOURNAL ARTICLE
Samuel A Theuerkauf, Elena Herrera-Carrillo, Fabian John, Luca J Zinser, Mariano A Molina, Vanessa Riechert, Frederic B Thalheimer, Kathleen Börner, Dirk Grimm, Petr Chlanda, Ben Berkhout, Christian J Buchholz
Precise delivery of genes to therapy-relevant cells is crucial for in vivo gene therapy. Receptor-targeting as prime strategy for this purpose is limited to cell types defined by a single cell-surface marker. Many target cells are characterized by combinations of more than one marker, such as the HIV reservoir cells. Here, we explored the tropism of adeno-associated viral vectors (AAV2) displaying designed ankyrin repeat proteins (DARPins) mono- and bispecific for CD4 and CD32a. Cryo-electron tomography revealed an unaltered capsid structure in the presence of DARPins...
November 16, 2023: Biomaterials
#6
JOURNAL ARTICLE
John K G Dart, Vincenzo Papa, Paolo Rama, Karl Anders Knutsson, Saj Ahmad, Scott Hau, Sara Sanchez, Antonella Franch, Federica Birattari, Pia Leon, Adriano Fasolo, Ewa Mrukwa Kominek, Katarzyna Jadczyk-Sorek, Fiona Carley, Parwez Hossain, Darwin C Minassian
OBJECTIVES: To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml) + propamidine 0.1% (1 mg/ml) [PHMB 0.02%+propamidine] to PHMB 0.08% (0.8 mg/ml) with placebo [PHMB 0.08%] for Acanthamoeba keratitis (AK) treatment. DESIGN: Prospective randomized, double-masked, active-controlled, multicentre, Phase3 study (ClinicalTrials.gov NCT03274895). PARTICIPANTS: 135 at six European centres between 08/17/2017 to 06/18/2021. METHODS: Principal inclusion criteria: ≥12 years old; in vivo confocal microscopy (IVCM) with clinical findings consistent with AK...
October 4, 2023: Ophthalmology
#7
JOURNAL ARTICLE
Robin J Dart, Iva Zlatareva, Pierre Vantourout, Efstathios Theodoridis, Ariella Amar, Shichina Kannambath, Philip East, Timothy Recaldin, John C Mansfield, Christopher A Lamb, Miles Parkes, Peter M Irving, Natalie J Prescott, Adrian C Hayday
Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in humans, we characterized the colonic γδ T cell compartment, identifying a diverse repertoire that includes a phenotypically distinct subset coexpressing T cell receptor Vγ4 and the epithelium-binding integrin CD103. This subset was disproportionately diminished and dysregulated in inflammatory bowel disease, whereas on-treatment CD103+ γδ T cell restoration was associated with sustained inflammatory bowel disease remission...
September 15, 2023: Science
#8
Natalie Pawlak, Christine Dart, Hernan Sacoto Aguilar, Emmanuel Ameh, Abebe Bekele, Maria F Jimenez, Kokila Lakhoo, Doruk Ozgediz, Nobhojit Roy, Girma Terfera, Adesoji O Ademuyiwa, Barnabas Tobi Alayande, Nivaldo Alonso, Geoffrey A Anderson, Stanley N C Anyanwu, Alazar Berhe Aregawi, Soham Bandyopadhyay, Tahmina Banu, Alemayehu Ginbo Bedada, Anteneh Gadisa Belachew, Fabio Botelho, Emmanuel Bua, Leticia Nunes Campos, Chris Dodgion, Michalina Drejza, Marcel E Durieux, Rohini Dutta, Sarnai Erdene, Rodrigo Vaz Ferreira, Zipporah Gathuya, Dhruva Ghosh, Randeep Singh Jawa, Walter D Johnson, Fauzia Anis Khan, Fanny Jamileth Navas Leon, Kristin L Long, Jana B A Macleod, Anshul Mahajan, Rebecca G Maine, Grace Zurielle C Malolos, Craig D McClain, Mary T Nabukenya, Peter M Nthumba, Benedict C Nwomeh, Daniel Kinyuru Ojuka, Norgrove Penny, Martha A Quiodettis, Jennifer Rickard, Lina Roa, Lucas Sousa Salgado, Lubna Samad, Justina Onyioza Seyi-Olajide, Martin Smith, Nichole Starr, Richard J Stewart, John L Tarpley, Julio L Trostchansky, Ivan Trostchansky, Thomas G Weiser, Adili Wobenjo, Elliot Wollner, Sudha Jayaraman
[This corrects the article DOI: 10.1371/journal.pgph.0002102.].
2023: PLOS Glob Public Health
#9
REVIEW
Laurie Geffen, Nick J Spencer
Australian neuroscientists at the turn of the twentieth century and in the succeeding decades faced formidable obstacles to communication and supply due to their geographical isolation from centers of learning in Europe and North America. Consequently, they had to spend significant periods of their lives overseas for training and experience. The careers of six pioneers-Laura Forster, James Wilson, Grafton Elliot Smith, Alfred Campbell, Raymond Dart, and John Eccles-are presented in the form of vignettes that address their lives and most enduring scientific contributions...
July 21, 2023: Journal of the History of the Neurosciences
#10
JOURNAL ARTICLE
Natalie Pawlak, Christine Dart, Hernan Sacoto Aguilar, Emmanuel Ameh, Abebe Bekele, Maria F Jimenez, Kokila Lakhoo, Doruk Ozgediz, Nobhojit Roy, Girma Terfera, Adesoji O Ademuyiwa, Barnabas Tobi Alayande, Nivaldo Alonso, Geoffrey A Anderson, Stanley N C Anyanwu, Alazar Berhe Aregawi, Soham Bandyopadhyay, Tahmina Banu, Alemayehu Ginbo Bedada, Anteneh Gadisa Belachew, Fabio Botelho, Emmanuel Bua, Leticia Nunes Campos, Chris Dodgion, Michalina Drejza, Marcel E Durieux, Rohini Dutta, Sarnai Erdene, Rodrigo Vaz Ferreira, Zipporah Gathuya, Dhruva Ghosh, Randeep Singh Jawa, Walter D Johnson, Fauzia Anis Khan, Fanny Jamileth Navas Leon, Kristin L Long, Anshul Mahajan, Rebecca G Maine, Grace Zurielle C Malolos, Craig D McClain, Mary T Nabukenya, Peter M Nthumba, Benedict C Nwomeh, Daniel Kinyuru Ojuka, Norgrove Penny, Martha A Quiodettis, Jennifer Rickard, Lina Roa, Lucas Sousa Salgado, Lubna Samad, Justina Onyioza Seyi-Olajide, Martin Smith, Nichole Starr, Richard J Stewart, John L Tarpley, Julio L Trostchansky, Ivan Trostchansky, Thomas G Weiser, Adili Wobenjo, Elliot Wollner, Sudha Jayaraman
Academic global surgery is a rapidly growing field that aims to improve access to safe surgical care worldwide. However, no universally accepted competencies exist to inform this developing field. A consensus-based approach, with input from a diverse group of experts, is needed to identify essential competencies that will lead to standardization in this field. A task force was set up using snowball sampling to recruit a broad group of content and context experts in global surgical and perioperative care. A draft set of competencies was revised through the modified Delphi process with two rounds of anonymous input...
2023: PLOS Glob Public Health
#11
JOURNAL ARTICLE
Kenneth A Michelson, Richard G Bachur, Joseph A Grubenhoff, Andrea T Cruz, Pradip P Chaudhari, Scott D Reeves, John J Porter, Michael C Monuteaux, Arianna H Dart, Jonathan A Finkelstein
BACKGROUND: Missed diagnosis can predispose to worse condition-specific outcomes. OBJECTIVE: To determine 90-day complication rates and hospital utilization after a missed diagnosis of pediatric appendicitis, new-onset diabetic ketoacidosis (DKA), and sepsis. METHODS: We evaluated patients under 21 years of age visiting five pediatric emergency departments (EDs) with a study condition. Case patients had a preceding ED visit within 7 days of diagnosis and underwent case review to confirm a missed diagnosis...
April 18, 2023: Journal of Emergency Medicine
#12
JOURNAL ARTICLE
Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Maria Teresa Landi, Dongxin Lin, Wei Zheng, Zhihua Yin, Baosen Zhou, Bao Song, Jiucun Wang, Wei Jie Seow, Lei Song, I-Shou Chang, Wei Hu, Li-Hsin Chien, Qiuyin Cai, Yun-Chul Hong, Hee Nam Kim, Yi-Long Wu, Maria Pik Wong, Brian Douglas Richardson, Karen M Funderburk, Shilan Li, Tongwu Zhang, Charles Breeze, Zhaoming Wang, Batel Blechter, Bryan A Bassig, Jin Hee Kim, Demetrius Albanes, Jason Y Y Wong, Min-Ho Shin, Lap Ping Chung, Yang Yang, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young-Chul Kim, Neil E Caporaso, Jiang Chang, James Chung Man Ho, Michiaki Kubo, Yataro Daigo, Minsun Song, Yukihide Momozawa, Yoichiro Kamatani, Masashi Kobayashi, Kenichi Okubo, Takayuki Honda, Dean H Hosgood, Hideo Kunitoh, Harsh Patel, Shun-Ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Hidehito Horinouchi, Masahiro Tsuboi, Ryuji Hamamoto, Koichi Goto, Yuichiro Ohe, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Megumi Hara, Yuichiro Nishida, Kenji Takeuchi, Kenji Wakai, Koichi Matsuda, Yoshinori Murakami, Kimihiro Shimizu, Hiroyuki Suzuki, Motonobu Saito, Yoichi Ohtaki, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Hongji Dai, Mitchell J Machiela, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Kun-Chieh Chen, Yu-Tang Gao, Biyun Qian, Chen Wu, Daru Lu, Jianjun Liu, Ann G Schwartz, Richard Houlston, Margaret R Spitz, Ivan P Gorlov, Xifeng Wu, Ping Yang, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, Bu-Tian Ji, H-Erich Wichmann, David C Christiani, Gadi Rennert, Susanne Arnold, Paul Brennan, James McKay, John K Field, Sanjay S Shete, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Lambertus A Kiemeney, Shan Zienolddiny-Narui, Kjell Grankvist, Mikael Johansson, Angela Cox, Fiona Taylor, Jian-Min Yuan, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Hyo-Sung Jeon, Shih Sheng Jiang, Jae Sook Sung, Chung-Hsing Chen, Chin-Fu Hsiao, Yoo Jin Jung, Huan Guo, Zhibin Hu, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Belynda Hicks, Jia Liu, Bin Zhu, Sonja I Berndt, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Wen-Chang Wang, Jun Xu, Peng Guan, Wen Tan, Chong-Jen Yu, Gong Yang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, In Kyu Park, Ping Xu, Qincheng He, Chih-Liang Wang, Hsiao-Han Hung, Roel C H Vermeulen, Iona Cheng, Junjie Wu, Wei-Yen Lim, Fang-Yu Tsai, John K C Chan, Jihua Li, Hongyan Chen, Hsien-Chih Lin, Li Jin, Jie Liu, Norie Sawada, Taiki Yamaji, Kathleen Wyatt, Shengchao A Li, Hongxia Ma, Meng Zhu, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ann Chao, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Chih-Yi Chen, Chien-Jen Chen, Pan-Chyr Yang, Jinming Yu, Victoria L Stevens, Joseph F Fraumeni, Nilanjan Chatterjee, Olga Y Gorlova, Chao Agnes Hsiung, Christopher I Amos, Hongbing Shen, Stephen J Chanock, Nathaniel Rothman, Takashi Kohno, Qing Lan
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13...
May 26, 2023: Nature Communications
#13
RANDOMIZED CONTROLLED TRIAL
John K Amory, Diana L Blithe, Regine Sitruk-Ware, Ronald S Swerdloff, William J Bremner, Clint Dart, Peter Y Liu, Arthi Thirumalai, Brian T Nguyen, Bradley D Anawalt, Min S Lee, Stephanie T Page, Christina Wang
Injectable male hormonal contraceptives are effective for preventing pregnancy in clinical trials; however, users may prefer to avoid medical appointments and injections. A self-administered transdermal contraceptive gel may be more acceptable for long-term contraception. Transdermal testosterone gels are widely used to treat hypogonadism and transdermal administration may have utility for male contraception; however, no efficacy data from transdermal male hormonal contraceptive gel are available. We designed and are currently conducting an international, multicenter, open-label study of self-administration of a daily combined testosterone and segesterone acetate (Nestorone) gel for male contraception...
August 2023: Contraception
#14
JOURNAL ARTICLE
Karen E Harman, Jag Barha, Jo R Chalmers, John K G Dart, Isobel Davies, Patricia Ellis, Douglas Grindlay, Philip J Hampton, Sharleen Hill, Sharon Hockey, Antonia Lloyd-Lavery, Maggie McPhee, Ruth Murphy, Saaeha Rauz, Jane F Setterfield, Ingrid Thompson, Melanie Westmoreland, Christina Waistell
No abstract text is available yet for this article.
May 18, 2023: British Journal of Dermatology
#15
JOURNAL ARTICLE
George Luo, Kristin Aldridge, Toby Chen, Vivek Aslot, Byung-Gyu Kim, Eun Hyang Han, Neelima Singh, Sai Li, Tsan Sam Xiao, Michael B Sporn, John J Letterio
Synthetic oleanane triterpenoids (SOTs) are small molecules with broad anti-cancer properties. A recently developed SOT, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-2-yl)-1H-imidazole (CDDO-2P-Im or '2P-Im'), exhibits enhanced activity and improved pharmacokinetics over CDDO-Im, a previous generation SOT. However, the mechanisms leading to these properties are not defined. Here we show synergy of 2P-Im and the proteasome inhibitor ixazomib in human multiple myeloma (MM) cells, and 2P-Im activity in a murine model of plasmacytoma...
May 7, 2023: Molecular Oncology
#16
JOURNAL ARTICLE
John T Randolph, Matthew J O'Connor, Fei Han, Charles W Hutchins, Y Amy Siu, Min Cho, Yunan Zheng, Jonathan A Hickson, Jana L Markley, Vlasios Manaves, Mikkel Algire, Kenton A Baker, Alex M Chapman, Sujatha M Gopalakrishnan, Sanjay C Panchal, Kelly Foster-Duke, DeAnne F Stolarik, Anita Kempf-Grote, Darby Dammeier, Stacey Fossey, Qi Sun, Chaohong Sun, Yu Shen, Michael J Dart, Warren M Kati, Albert Lai, Ari J Firestone, Michael E Kort
Compounds that inhibit glutathione peroxidase 4 (GPX4) hold promise as cancer therapeutics in their ability to induce a form of nonapoptotic cell death called ferroptosis. Our research identified 24 , a structural analog of the potent GPX4 inhibitor RSL3, that has much better plasma stability ( t 1/2 > 5 h in mouse plasma). The bioavailability of 24 provided efficacious plasma drug concentrations with IP dosing, thus enabling in vivo studies to assess tolerability and efficacy. An efficacy study in mouse using a GPX4-sensitive tumor model found that doses of 24 up to 50 mg/kg were tolerated for 20 days but had no effect on tumor growth, although partial target engagement was observed in tumor homogenate...
March 23, 2023: Journal of Medicinal Chemistry
#17
JOURNAL ARTICLE
Ariel Graykowski, Ryan A Lambert, Franck Marchis, Dorian Cazeneuve, Paul A Dalba, Thomas M Esposito, Daniel O'Conner Peluso, Lauren A Sgro, Guillaume Blaclard, Antonin Borot, Arnaud Malvache, Laurent Marfisi, Tyler M Powell, Patrice Huet, Matthieu Limagne, Bruno Payet, Colin Clarke, Susan Murabana, Daniel Chu Owen, Ronald Wasilwa, Keiichi Fukui, Tateki Goto, Bruno Guillet, Patrick Huth, Satoshi Ishiyama, Ryuichi Kukita, Mike Mitchell, Michael Primm, Justus Randolph, Darren A Rivett, Matthew Ryno, Masao Shimizu, Jean-Pierre Toullec, Stefan Will, Wai-Chun Yue, Michael Camilleri, Kathy Graykowski, Ron Janetzke, Des Janke, Scott Kardel, Margaret Loose, John W Pickering, Barton A Smith, Ian M Transom
On 26 September 2022 the Double Asteroid Redirection Test (DART) spacecraft impacted Dimorphos, a satellite of the asteroid 65803 Didymos1 . Because it is a binary system, it is possible to determine how much the orbit of the satellite changed, as part of a test of what is necessary to deflect an asteroid that might threaten Earth with an impact. In nominal cases, pre-impact predictions of the orbital period reduction ranged from ~ 8.8 - 17.2 minutes2,3 . Here we report optical observations of Dimorphos before, during and after the impact, from a network of citizen science telescopes across the world...
March 1, 2023: Nature
#18
JOURNAL ARTICLE
Andrew F Cheng, Harrison F Agrusa, Brent W Barbee, Alex J Meyer, Tony L Farnham, Sabina D Raducan, Derek C Richardson, Elisabetta Dotto, Angelo Zinzi, Vincenzo Della Corte, Thomas S Statler, Steven Chesley, Shantanu P Naidu, Masatoshi Hirabayashi, Jian-Yang Li, Siegfried Eggl, Olivier S Barnouin, Nancy L Chabot, Sidney Chocron, Gareth S Collins, R Terik Daly, Thomas M Davison, Mallory E DeCoster, Carolyn M Ernst, Fabio Ferrari, Dawn M Graninger, Seth A Jacobson, Martin Jutzi, Kathryn M Kumamoto, Robert Luther, Joshua R Lyzhoft, Patrick Michel, Naomi Murdoch, Ryota Nakano, Eric Palmer, Andrew S Rivkin, Daniel J Scheeres, Angela M Stickle, Jessica M Sunshine, Josep M Trigo-Rodriguez, Jean-Baptiste Vincent, James D Walker, Kai Wünnemann, Yun Zhang, Marilena Amoroso, Ivano Bertini, John R Brucato, Andrea Capannolo, Gabriele Cremonese, Massimo Dall'Ora, Prasanna J D Deshapriya, Igor Gai, Pedro H Hasselmann, Simone Ieva, Gabriele Impresario, Stavro L Ivanovski, Michèle Lavagna, Alice Lucchetti, Elena M Epifani, Dario Modenini, Maurizio Pajola, Pasquale Palumbo, Davide Perna, Simone Pirrotta, Giovanni Poggiali, Alessandro Rossi, Paolo Tortora, Marco Zannoni, Giovanni Zanotti
The NASA Double Asteroid Redirection Test (DART) mission performed a kinetic impact on asteroid Dimorphos, the satellite of the binary asteroid (65803) Didymos, at 23:14 UTC on September 26, 2022 as a planetary defense test1 . DART was the first hypervelocity impact experiment on an asteroid at size and velocity scales relevant to planetary defense, intended to validate kinetic impact as a means of asteroid deflection. Here we report the first determination of the momentum transferred to an asteroid by kinetic impact...
March 1, 2023: Nature
#19
JOURNAL ARTICLE
R Terik Daly, Carolyn M Ernst, Olivier S Barnouin, Nancy L Chabot, Andrew S Rivkin, Andrew F Cheng, Elena Y Adams, Harrison F Agrusa, Elisabeth D Abel, Amy L Alford, Erik I Asphaug, Justin A Atchison, Andrew R Badger, Paul Baki, Ronald-L Ballouz, Dmitriy L Bekker, Julie Bellerose, Shyam Bhaskaran, Bonnie J Buratti, Saverio Cambioni, Michelle H Chen, Steven R Chesley, George Chiu, Gareth S Collins, Matthew W Cox, Mallory E DeCoster, Peter S Ericksen, Raymond C Espiritu, Alan S Faber, Tony L Farnham, Fabio Ferrari, Zachary J Fletcher, Robert W Gaskell, Dawn M Graninger, Musad A Haque, Patricia A Harrington-Duff, Sarah Hefter, Isabel Herreros, Masatoshi Hirabayashi, Philip M Huang, Syau-Yun W Hsieh, Seth A Jacobson, Stephen N Jenkins, Mark A Jensenius, Jeremy W John, Martin Jutzi, Tomas Kohout, Timothy O Krueger, Frank E Laipert, Norberto R Lopez, Robert Luther, Alice Lucchetti, Declan M Mages, Simone Marchi, Anna C Martin, Maria E McQuaide, Patrick Michel, Nicholas A Moskovitz, Ian W Murphy, Naomi Murdoch, Shantanu P Naidu, Hari Nair, Michael C Nolan, Jens Ormö, Maurizio Pajola, Eric E Palmer, James M Peachey, Petr Pravec, Sabina D Raducan, K T Ramesh, Joshua R Ramirez, Edward L Reynolds, Joshua E Richman, Colas Q Robin, Luis M Rodriguez, Lew M Roufberg, Brian P Rush, Carolyn A Sawyer, Daniel J Scheeres, Petr Scheirich, Stephen R Schwartz, Matthew P Shannon, Brett N Shapiro, Caitlin E Shearer, Evan J Smith, R Joshua Steele, Jordan K Steckloff, Angela M Stickle, Jessica M Sunshine, Emil A Superfin, Zahi B Tarzi, Cristina A Thomas, Justin R Thomas, Josep M Trigo-Rodríguez, B Teresa Tropf, Andrew T Vaughan, Dianna Velez, C Dany Waller, Daniel S Wilson, Kristin A Wortman, Yun Zhang
While no known asteroid poses a threat to Earth for at least the next century, the catalog of near-Earth asteroids is incomplete for objects whose impacts would produce regional devastation1,2 . Several approaches have been proposed to potentially prevent an asteroid impact with Earth by deflecting or disrupting an asteroid1-3 . A test of kinetic impact technology was identified as the highest priority space mission related to asteroid mitigation1 . NASA's Double Asteroid Redirection Test (DART) mission is the first full-scale test of kinetic impact technology...
March 1, 2023: Nature
#20
JOURNAL ARTICLE
Joseph Cataquiz Rimando, Ezhilarasi Chendamarai, Michael P Rettig, Reyka G Jayasinghe, Matthew Christopher, Julie K Ritchey, Stephanie Christ, Miriam Kim, Ezio Bonvini, John F DiPersio
Acute myeloid leukemia (AML) relapse is one of the most common and significant adverse events following allogeneic hematopoietic cell transplantation (allo-HCT). Downregulation of major histocompatibility class II (MHC-II) surface expression on AML blasts may represent a mechanism of escape from the graft-versus-malignancy effect and facilitate relapse. We hypothesized that T-cell immunotherapies targeting AML antigens would upregulate MHC-II surface expression via localized release of interferon gamma (IFN-γ), a protein known to upregulate MHC-II expression via JAK-STAT signaling...
December 23, 2022: Blood
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
