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scfa AND ICU

Tomoki Yamada, Kentaro Shimizu, Hiroshi Ogura, Takashi Asahara, Koji Nomoto, Kazuma Yamakawa, Toshimitsu Hamasaki, Yasutaka Nakahori, Mitsuo Ohnishi, Yasuyuki Kuwagata, Takeshi Shimazu
BACKGROUND: The gut is an important target organ for injury after severe insult. Short-chain fatty acids (SCFAs) are end-products of fermentation of dietary fibers by anaerobic microbiota. They are related to intestinal energy, motility, and transport and to protective effects against infection and inflammation. However, there are few clinical data on SCFAs in critically ill patients. We evaluated serial change in fecal SCFAs in patients with severe systemic inflammatory response syndrome (SIRS)...
July 2015: JPEN. Journal of Parenteral and Enteral Nutrition
Hazreen A Majid, Jayne Cole, Peter W Emery, Kevin Whelan
BACKGROUND & AIMS: Patients with diarrhoea during enteral nutrition (EN) have been shown to have low faecal bifidobacteria concentrations. Oligofructose/inulin selectively stimulate the growth of bifidobacteria in healthy humans. This study investigates the effect of additional oligofructose/inulin on the gastrointestinal microbiota, short-chain fatty acids (SCFA) and faecal output in patients receiving EN. METHODS: Adult patients in the intensive care unit (ICU) who were starting EN with a formula containing fibre were randomised to receive 7 g/d of additional oligofructose/inulin or an identically packaged placebo (maltodextrin)...
December 2014: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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