Eike Burandt, Felix Lübbersmeyer, Natalia Gorbokon, Franziska Büscheck, Andreas M Luebke, Anne Menz, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Sören Weidemann, Christoph Fraune, Katharina Möller, Frank Jacobsen, Patrick Lebok, Till Sebastian Clauditz, Guido Sauter, Ronald Simon, Ria Uhlig, Waldemar Wilczak, Stefan Steurer, Sarah Minner, Rainer Krech, David Dum, Till Krech, Andreas Holger Marx, Christian Bernreuther
BACKGROUND: The E-Cadherin gene (CDH1, Cadherin 1), located at 16q22.1 encodes for a calcium-dependent membranous glycoprotein with an important role in cellular adhesion and polarity maintenance. METHODS: To systematically determine E-Cadherin protein expression in normal and cancerous tissues, 14,637 tumor samples from 112 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types were analyzed by immunohistochemistry in a tissue microarray format...
June 5, 2021: Biomarker Research