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https://read.qxmd.com/read/30763745/pneumatosis-intestinalis-after-molecular-targeted-therapy
#1
Nauman S Chaudhry, Wenya Linda Bi, Saksham Gupta, Abhishek Keraliya, Naomi Shimizu, E Antonio Chiocca
BACKGROUND: Pneumoperitoneum after surgical manipulation of the abdomen implies a perforation. Rare cases of non-operated cancer patients, largely with gastrointestinal or genitourinary cancers, have been noted to have radiological findings of pneumatosis intestinalis and/or pneumoperitoneum as a complication of molecular-targeted therapy (MTT) without confounding factors for perforation. We present a patient with a cranial malignancy treated with bevacizumab who subsequently manifested with pneumatosis intestinalis...
February 11, 2019: World Neurosurgery
https://read.qxmd.com/read/30761297/application-of-3-d-microfluidic-models-for-studying-mass-transport-properties-of-the-tumor-interstitial-matrix
#2
Alex Avendano, Marcos Cortes-Medina, Jonathan W Song
The physical remodeling associated with cancer progression results in barriers to mass transport in the tumor interstitial space. This hindrance ultimately affects the distribution of macromolecules that govern cell fate and potency of cancer therapies. Therefore, knowing how specific extracellular matrix (ECM) and cellular components regulate transport in the tumor interstitium could lead to matrix normalizing strategies that improve patient outcome. Studies over the past decades have provided quantitative insights into interstitial transport in tumors by characterizing two governing parameters: (1) molecular diffusivity and (2) hydraulic conductivity...
2019: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/30758247/smartphone-application-versus-pedometer-to-promote-physical-activity-in-prostate-cancer-patients
#3
Byung Joo Lee, Yong Hyun Park, Ji Youl Lee, Soo Jin Kim, Yongjun Jang, Jong In Lee
BACKGROUND: Recently, the application of smartphone in medical field has received great attention. INTRODUCTION: The objective of this study was to compare the effectiveness of smartphone-based and conventional pedometer-based exercise monitoring systems in promoting home exercise among prostate cancer patients. METHODS: Prostate cancer patients who have undergone surgery or androgen deprivation therapy were recruited. All participants were provided with physical activity goals based on their activities and were advised to achieve these goals during their home exercise period...
February 13, 2019: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://read.qxmd.com/read/30754679/hydroxyethyl-starch-based-nanoparticles-featured-with-redox-sensitivity-and-chemo-photothermal-therapy-for-synergized-tumor-eradication
#4
Chan Yu, Chuqi Liu, Shaocong Wang, Zheng Li, Hang Hu, Ying Wan, Xiangliang Yang
Chemo-photothermal combination therapy could achieve synergistically enhanced efficiency against tumors. Nanocarriers with good safety and high efficiency for chemo- photothermal therapy are pressingly needed. A new type of hydroxyethyl starch (HES) based on nanoparticles (NPs) loaded with doxorubicin (DOX) and indocyanine green (ICG) was, thus, developed in this study. DOX-loaded HES conjugates with redox-sensitivity (HES-SS-DOX) were first synthesized and they were then combined with ICG to self-assemble into HES-SS-DOX@ICG NPs with controlled compositions and sizes via collaborative interactions...
February 11, 2019: Cancers
https://read.qxmd.com/read/30745579/haematopoietic-stem-cell-activity-and-interactions-with-the-niche
#5
REVIEW
Sandra Pinho, Paul S Frenette
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal, differentiation and migration of HSCs and progenitor cells at steady state and in response to emergencies and injury. Improved methods for HSC isolation, driven by advances in single-cell and molecular technologies, have led to a better understanding of their behaviour, heterogeneity and lineage fate and of the niche cells and signals that regulate their function...
February 11, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30745202/how-are-patients-with-prostate-cancer-managing-androgen-deprivation-therapy-side-effects
#6
Erik Wibowo, Richard J Wassersug, John W Robinson, Andrew Matthew, Deborah McLeod, Lauren M Walker
BACKGROUND: Androgen deprivation therapy (ADT) for prostate cancer has numerous side effects. Clinical guidelines for side effect management exist; however, these are not always integrated into routine practice. What remains undocumented and therefore the objective of this study, is to describe patients' willingness to employ established strategies. PATIENTS AND METHODS: Study participants were 91 men who had attended an educational program (ie, attend a class plus read a book), designed to prepare patients for managing ADT side effects...
December 20, 2018: Clinical Genitourinary Cancer
https://read.qxmd.com/read/30744585/encapsulated-mir-200c-and-nkx2-1-in-a-nuclear-mitochondria-transcriptional-regulatory-network-of-non-metastatic-and-metastatic-lung-cancer-cells
#7
Olga D'Almeida, Omar Mothar, Esther Apraku Bondzie, Yolande Lieumo, Laure Tagne, Sumeet Gupta, Thomas Volkert, Stuart Levine, Jean-Bosco Tagne
BACKGROUND: MicroRNAs are noncoding RNA molecules of ~ 22 nucleotides with diagnostic and therapeutic action [Curr Drug Targets, 2015. 16(12): p. 1381-403], affecting the expression of mRNAs involved in invasion, migration, and development [Oncotarget, 2015. 6(9): p. 6472-98, Cancer Manag Res, 2014. 6: p. 205-16]. miR-200c is part of the miR-200c/141 cluster on chromosome 12p13. Its mechanism of action when encapsulated is critical in lung cancer when patients express changes in miRNAs...
February 11, 2019: BMC Cancer
https://read.qxmd.com/read/30739635/actigraphy-as-an-assessment-of-performance-status-in-patients-with-advanced-lung-cancer
#8
Daisuke Fujisawa, Jennifer S Temel, Joseph A Greer, Areej El-Jawahri, Lara Traeger, Jamie M Jacobs, Stacy Cutrono, William F Pirl
OBJECTIVE: Wearable devices such as a wrist actigraph may have a potential to objectively estimate patients' functioning and may supplement performance status (PS). This proof-of-concept study aimed to evaluate whether actigraphy data are significantly associated with patients' functioning and are predictive of their survival in patients with metastatic non-small cell lung cancer. METHOD: We collected actigraphy data for a three-day period in ambulatory patients with stage IV non-small cell lung cancer...
February 11, 2019: Palliative & Supportive Care
https://read.qxmd.com/read/30739558/quality-of-life-and-cost-of-strategies-of-two-chemotherapy-lines-in-metastatic-colorectal-cancer-results-of-the-ffcd-2000-05-trial
#9
Benjamin Lacas, Olivier Bouché, Pierre-Luc Etienne, Mohamed Gasmi, Patrick Texereau, Dany Gargot, Catherine Lombard-Bohas, Ahmed Azzedine, Bernard Denis, Patrick Geoffroy, Dominique Auby, Pierre Michel, Jean-Pierre Pignon, Côme Lepage, Michel Ducreux, Isabelle Borget
OBJECTIVES: This study compared the cost and quality of life (QoL) of 407 advanced colorectal cancer patients, randomly assigned to receive LV5FU2 followed by FOLFOX6 (sequential strategy) or FOLFOX6 followed by FOLFIRI (combination strategy). METHODS: Costs were compared from the French health insurance perspective, until the end of 2nd line of treatment. Consumed resources, collected during the trial, included medicines, hospitalisations, examinations and transportation...
February 9, 2019: Expert Review of Pharmacoeconomics & Outcomes Research
https://read.qxmd.com/read/30739214/guidelines-for-treatment-and-monitoring-of-adult-survivors-of-pediatric-brain-tumors
#10
REVIEW
Anna J Janss, Claire Mazewski, Briana Patterson
Pathologies of pediatric brain tumors are more varied than those diagnosed in adults and survival outcomes more optimistic. Therapies for pediatric brain tumors are also diverse and treatment options are expanding. The growing number of adult survivors of childhood brain tumors is quite diverse. Medical management of these adults requires understanding the tumor diagnosis and location, the modalities used to treat the tumor, the age of the survivor at the time of diagnosis and treatment, any complications of treatment, and, most importantly, the baseline medical condition and neurological function of each adult survivor...
February 9, 2019: Current Treatment Options in Oncology
https://read.qxmd.com/read/30738097/reflections-on-depletion-of-tumor-stroma-in-pancreatic-cancer
#11
REVIEW
Wen-Quan Wang, Liang Liu, Jin-Zhi Xu, Xian-Jun Yu
Pancreatic cancer characteristically has an extremely dense stroma, which facilitates chemoresistance by creating physical and biological barriers to therapeutic agents. Thus, stroma-depleting agents may enhance the delivery and efficacy of chemotherapy drugs. However, stroma-targeting therapy for pancreatic cancer is a double-edged sword, as the stroma can also inhibit tumor metastasis and malignancy. In-depth understanding of the critical role of the stroma in cancer metastasis may improve therapeutic approaches by allowing them to harness specific features of the stroma to treat pancreatic cancer...
February 6, 2019: Biochimica et biophysica acta. Reviews on cancer
https://read.qxmd.com/read/30734018/safety-and-feasibility-of-preoperative-exercise-training-during-neoadjuvant-treatment-before-surgery-for-adenocarcinoma-of-the-gastro-oesophageal-junction
#12
J F Christensen, C Simonsen, A Banck-Petersen, S Thorsen-Streit, A Herrstedt, S S Djurhuus, C Egeland, C E Mortensen, S C Kofoed, T S Kristensen, R S Garbyal, B K Pedersen, L B Svendsen, P Højman, P de Heer
Background: Neoadjuvant chemotherapy or chemoradiotherapy is used widely before tumour resection in cancer of the gastro-oesophageal junction (GOJ). Strategies to improve treatment tolerability are warranted. This study examined the safety and feasibility of preoperative exercise training during neoadjuvant treatment in these patients. Methods: Patients were allocated to a standard-care control group or an exercise group, who were prescribed standard care plus twice-weekly high-intensity aerobic exercise and resistance training sessions...
February 2019: BJS open
https://read.qxmd.com/read/30733293/therapeutic-targeting-of-her2-cb-2-r-heteromers-in-her2-positive-breast-cancer
#13
Sandra Blasco-Benito, Estefanía Moreno, Marta Seijo-Vila, Isabel Tundidor, Clara Andradas, María M Caffarel, Miriam Caro-Villalobos, Leyre Urigüen, Rebeca Diez-Alarcia, Gema Moreno-Bueno, Lucía Hernández, Luis Manso, Patricia Homar-Ruano, Peter J McCormick, Lucka Bibic, Cristina Bernadó-Morales, Joaquín Arribas, Meritxell Canals, Vicent Casadó, Enric I Canela, Manuel Guzmán, Eduardo Pérez-Gómez, Cristina Sánchez
Although human epidermal growth factor receptor 2 (HER2)-targeted therapies have dramatically improved the clinical outcome of HER2-positive breast cancer patients, innate and acquired resistance remains an important clinical challenge. New therapeutic approaches and diagnostic tools for identification, stratification, and treatment of patients at higher risk of resistance and recurrence are therefore warranted. Here, we unveil a mechanism controlling the oncogenic activity of HER2: heteromerization with the cannabinoid receptor CB2 R...
February 7, 2019: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/30724657/physical-activity-levels-of-women-with-breast-cancer-during-and-after-treatment-a-comparison-with-the-dutch-female-population
#14
R Gal, E M Monninkhof, P H M Peeters, C H van Gils, D H J G van den Bongard, G C W Wendel-Vos, N P A Zuithoff, H M Verkooijen, A M May
BACKGROUND: Physical activity has been shown to reduce side-effects of breast cancer and its treatment. As physical activity levels of patients with breast cancer are largely unknown, we investigated these levels and compared them to women from the general population. METHODS: In this prospective cohort study, physical activity levels of women with breast cancer participating in the UMBRELLA cohort were assessed at radiotherapy intake and thereafter every 6 months up to 3 years with the SQUASH questionnaire, which was also used in a random sample of the Dutch population...
February 6, 2019: Acta Oncologica
https://read.qxmd.com/read/30722683/psychological-resilience-of-women-after-breast-cancer-surgery-a-cross-sectional-study-of-associated-influencing-factors
#15
Yuanni Huang, Yanhong Huang, Mian Bao, Shukai Zheng, Taifeng Du, Kusheng Wu
The psychological resilience (PR) of postoperative patients is found relatively low in clinical work. We recruited 220 postoperative women with breast cancer to survey PR of them and the influencing factors. General demographic data and physical exercise status were collected by questionnaire, clinical characteristics data were obtained from medical records. Measures comprised the Chinese version of the Connor and Davidson Resilience Scale (CD-RISC), General Self-Efficacy Scale (GSES), Family Hardiness Index (FHI) and Social Support Rate Scale (SSRS)...
February 5, 2019: Psychology, Health & Medicine
https://read.qxmd.com/read/30720441/comprehensive-lifestyle-improvement-program-for-prostate-cancer-clipp-protocol-for-a-feasibility-and-exploratory-efficacy-study-in-men-on-androgen-deprivation-therapy
#16
Amit Algotar, Chiu-Hsieh Hsu, H H Sherry Chow, Shona Dougherty, Hani M Babiker, David Marrero, Ivo Abraham, Rachit Kumar, Jennifer Ligibel, Kerry S Courneya, Cynthia Thomson
BACKGROUND: Androgen deprivation therapy (ADT) for prostate cancer is associated with adverse cardiometabolic effects such as reduced libido, hot flashes, metabolic syndrome, diabetes, myocardial infarction, and stroke. This reduces quality of life and potentially increases mortality. Several large clinical trials have demonstrated improvements in cardiometabolic risk with comprehensive multimodality lifestyle modification. However, there is a lack of data for such interventions in men on ADT for prostate cancer, and existing studies have used non-standardized interventions or lacked data on metabolic risk factors...
February 5, 2019: JMIR Research Protocols
https://read.qxmd.com/read/30719488/rural-primary-care-offices-and-cancer-survivorship-care-part-of-the-care-trajectory-for-cancer-survivors
#17
Maresi Berry-Stoelzle, Kim Parang, Jeanette Daly
Background: A cancer diagnosis is a monumental event in a patient's life and with the number of cancer survivors increasing; most of these patients will be taken care of by a primary care provider at some point after their cancer therapy. The purpose of this study is to identify primary care physician's needs to care for a patient who has had cancer. Methods: A cross-sectional survey of the physician members of the Iowa Research Network was conducted. The survey was designed to measure physician confidence in cancer survivor's care, office strategies regarding cancer survivorship care, and resources available for patients with cancer...
January 2019: Health Services Research and Managerial Epidemiology
https://read.qxmd.com/read/30715425/problems-goals-and-solutions-reported-by-cancer-patients-participating-in-group-problem-solving-therapy
#18
Tomoko Matsui, Kei Hirai, Masako Shokoji, Naoko Kanai, Arika Yoshizaki, Naoko Wada, Naoshi Ito, Madoka Tokuyama
Background: The purpose of the present study was to categorize and develop lists of contents of problems, goals, solution plans generated through the brainstorming work in therapy, and selected solutions for execution, that treated in problem-solving therapy (PST) for cancer patients in clinical settings, and to describe their characteristics. Additionally, examining the associations of problem domains with characteristics of participants, was also aimed. Methods: We conducted content analysis using records of thirty-one cancer patients (M = 62...
January 31, 2019: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/30713591/lifestyle-interventions-for-breast-cancer-prevention
#19
Justin C Brown, Jennifer A Ligibel
One-in-eight women in the United States will develop breast cancer in her lifetime. Despite the established efficacy of selective estrogen receptor modulators and aromatase inhibitors in reducing the risk of developing hormone receptor positive breast cancer, use of these therapies in clinical practice is often limited by concerns over toxicities that may negatively influence quality of life. There is emerging interest in the oncology community to understand how modifiable risk factors related to energy balance-such as obesity, physical inactivity, and poor dietary patterns-may relate to breast cancer risk...
September 2018: Current Breast Cancer Reports
https://read.qxmd.com/read/30712964/-epithelial-ovarian-cancer-and-elderly-patients-article-drafted-from-the-french-guidelines-in-oncology-entitled-initial-management-of-patients-with-epithelial-ovarian-cancer-developed-by-francogyn-cngof-sfog-gineco-arcagy-under-the-aegis-of-cngof-and-endorsed
#20
C Falandry, S Gouy
In ovarian, tubal and primary peritoneal cancers, older adults have an over-mortality due to more aggressive disease (NP4), surgical and chemotherapy under treatment (NP4) and co-morbidities (NP4). Older age is at higher risk for postoperative morbidity and mortality (NP4). Surgery is more often incomplete in this elderly population (NP4). Older age is a risk factor for lower dose intensity in adjuvant chemotherapy (NP4) and incomplete chemotherapy (NP4). Nevertheless, the benefit of a complete surgery remains identical to that of the younger population (NP2)...
January 31, 2019: Gynecologie, Obstetrique, Fertilite & Senologie
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