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Mucin 1

Aditi Bhatt, Praveen Kammar, Sanket Mehta, Dileep Damodaran, Shabber Zaveri, Mahesh D Patel, Snita Sinukumar, Mukurdipi Ray, Ramakrishnan Seshadri
Cytoreductive surgery (CRS) and HIPEC results in a median disease-free survival (DFS) of 12-15 months, overall survival (OS) of 23-63 months, and cure in around 15% of patients with colorectal peritoneal metastases (CPM). The wide variation in OS may largely be attributed to different criteria for patient selection employed by different investigators. To evaluate outcomes of CRS and HIPEC for CPM in patients enrolled in the Indian HIPEC registry. A retrospective analysis of patients enrolled in the registry since its inception in March 2016 was performed...
February 2019: Indian Journal of Surgical Oncology
Kang Soo Lee, Márton Palatinszky, Fátima C Pereira, Jen Nguyen, Vicente I Fernandez, Anna J Mueller, Filippo Menolascina, Holger Daims, David Berry, Michael Wagner, Roman Stocker
Stable-isotope probing is widely used to study the function of microbial taxa in their natural environment, but sorting of isotopically labelled microbial cells from complex samples for subsequent genomic analysis or cultivation is still in its early infancy. Here, we introduce an optofluidic platform for automated sorting of stable-isotope-probing-labelled microbial cells, combining microfluidics, optical tweezing and Raman microspectroscopy, which yields live cells suitable for subsequent single-cell genomics, mini-metagenomics or cultivation...
March 18, 2019: Nature Microbiology
Yasuhiko Koga, Hiroaki Tsurumaki, Haruka Aoki-Saito, Makiko Sato, Masakiyo Yatomi, Kazutaka Takehara, Takeshi Hisada
There are many downstream targets of mitogen-activated protein kinase (MAPK) signalling that are involved in neuronal development, cellular differentiation, cell migration, cancer, cardiovascular dysfunction and inflammation via their functions in promoting apoptosis and cell motility and regulating various cytokines. It has been reported that cyclic AMP response element-binding protein (CREB) is phosphorylated and activated by cyclic AMP signalling and calcium/calmodulin kinase. Recent evidence also points to CREB phosphorylation by the MAPK signalling pathway...
March 17, 2019: International Journal of Molecular Sciences
X P Wu, Y F Zhu, K Y Zhang, X M Ding, S P Bai, J P Wang, H W Peng, Q F Zeng
This study investigated the effect of different specific surface area micronized zinc oxide (ZnO) on growth performance, zinc (Zn) tissue content, jejunal morphology, jejunal antioxidative status, and intestinal mucosa barrier-related gene expression in meat ducks. A total of 480 one-day-old Cherry Valley ducks were randomly divided into 4 dietary treatments, which each had 12 replicates; therefore, each replicate consisted of 10 ducks. Experimental diets included the basal diet supplemented with ZnSO4 (control group) and 3 different treatments of specific surface area micronized ZnO, in which the specific surface area was either 11...
March 16, 2019: Poultry Science
C Zheng, F Jiang, H Lin, S Li
PURPOSE: Emerging data have shown that patients with left-sided cancers have better survival than patients with right-sided cancers in terms of metastatic colorectal cancer. However, the available information and findings remain limited and contradictory in localized colorectal cancer. This study aimed to evaluate the clinical characteristics and prognosis of primary tumor location (PTL) in colorectal cancer. METHODS: Patients' diagnoses were identified using the Surveillance, Epidemiology, and End Result database between 2006 and 2015...
March 14, 2019: Clinical & Translational Oncology
Evanna Huynh, Jenna Penney, Jeff Caswell, Julang Li
Cathelicidins, a class of antimicrobial peptides, have been widely studied for their antimicrobial role in innate immune responses during infection and inflammation. At sub-antimicrobial concentrations, various cathelicidins from different species have been reported to exert chemotactic activity on neutrophils, monocytes, dendritic cells and T-cells, and also enhance angiogenesis and wound healing. To date, the role of the pig cathelicidin, protegrin-1 (PG-1), in immune modulation and tissue repair in the intestinal tract has not been investigated...
2019: Frontiers in Pharmacology
Kazuhiro Mochizuki, Satoshi Kawana, Shoki Yamada, Moe Muramatsu, Hideki Sano, Shogo Kobayashi, Yoshihiro Ohara, Nobuhisa Takahashi, Michiyuki Hakozaki, Hitoshi Yamada, Yuko Hashimoto, Atsushi Kikuta
Long-term survival rates for pediatric patients with cancer have significantly improved, but novel approaches are desired for those with refractory/relapsed solid tumors. Recently, programed cell death-1/programed cell death-ligand-1 blockade has emerged as an effective option for many intractable cancers. However, not all patients show objective response to such therapy. On the other hand, several other checkpoint pathways, including Herpes virus entry mediator (HVEM)/B- and T-lymphocyte attenuator (BTLA), galectin-9 (GAL9)/T-cell immunoglobulin and mucin domain-3 (TIM3), and major histocompatibility complex class II (MHC-II)/lymphocyte activation gene-3 (LAG3), also regulate immune responses in the tumor microenvironment and may be alternative targets for novel immune therapies...
March 14, 2019: Pediatric Hematology and Oncology
Kaiyuan Jiang, Hongmei Liu, Dongyi Xie, Qiang Xiao
Gastric cancer (GC) is one of the most common malignancies worldwide. To the best of our knowledge, no biomarkers have been widely accepted for the early diagnosis and prognostic prediction of GC. This study aimed to identify potential novel prognostic biomarkers for GC. The dataset GSE29272, which originates from the public database Gene Expression Omnibus, was employed in the present study. The online tool GEO2R was used to calculate the differentially expressed genes (DEGs) in GSE29272 between tumour tissues and adjacent tissues...
March 2019: Oncology Letters
Isabel Alvarado-Cabrero, W Glenn McCluggage, Rafael Estevez-Castro, Delia Pérez-Montiel, Simona Stolnicu, Raji Ganesan, Josefa Vella, Rosario Castro, Javier Canedo-Matute, Jessica Gomez-Cifuentes, Vilma M Rivas-Lemus, Kay J Park, Robert A Soslow, Esther Oliva, Raquel Valencia-Cedillo
Micropapillary adenocarcinoma has been reported as an aggressive variant of adenocarcinoma in several organs, where it is associated with poor clinical outcome. This study reports the clinicopathologic features and outcomes of cervical adenocarcinomas with a micropapillary component (micropapillary cervical adenocarcinomas); this represents the largest reported study of these neoplasms. The study comprised 44 cervical adenocarcinomas of usual (human papillomavirus-related)-type (84%), mucinous, not otherwise specified (4...
March 8, 2019: American Journal of Surgical Pathology
Huimin Yang, Tingting Xie, Dengren Li, Xianhong Du, Tixiao Wang, Chunyang Li, Xiaojia Song, Leiqi Xu, Fan Yi, Xiaohong Liang, Lifen Gao, Xiangdong Yang, Chunhong Ma
OBJECTIVE: Macrophage-mediated inflammation plays a significant role in the development and progression of diabetic nephropathy (DN). However, the underlying mechanisms remain unclear. Studies suggest that T cell immunoglobulin domain and mucin domain-3 (Tim-3) has complicated roles in regulating macrophage activation, but its roles in the progression of DN are still completely unknown. METHODS: We downregulated Tim-3 expression in kidney (intrarenal injection of Tim-3 shRNA expressing lentivirus or global Tim-3 knockout mice) and induced DN by streptozotocin (STZ)...
February 26, 2019: Molecular Metabolism
Elisa Conde Moreno, Alejandro Pascual, Daniel Prieto-Cuadra, Val F Laza, Javier Molina-Cerrillo, Miren Edurne Ramos-Muñoz, Esperanza Macarena Rodríguez-Serrano, José Luis Soto, Alfredo Carrato, María Laura García-Bermejo, Carmen Guillén-Ponce
microRNAs (miRNA) expression in colorectal (CR) primary tumours can facilitate a more precise molecular characterization. We identified and validated a miRNA profile associated with clinical and histopathological features that might be useful for patient stratification. In situ hybridization array using paraffin-embedded biopsies of CR primary tumours were used to screen 1436 miRNAs. 17 miRNAs were selected for validation by quantitative reverse transcription polymerase chain reaction (qRT-PCR) ( n = 192) and were further correlated with clinical and histopathological data...
March 11, 2019: Cancers
J A Li, X Han, Y Fang, L Zhang, W H Lou, X F Xu, W C Wu, T T Kuang, D S Wang, Y F Rong
Objective: To explore preoperative predictive markers for invasive malignancy in intraductal papillary mucinous neoplasm(IPMN). Methods: The retrospective case-controlled study was adopted.Seventy-nine patients who underwent surgery and with pathologically confirmed IPMN from January 2005 to December 2014 at Department of Pancreatic Surgery, Zhongshan Hospital Fudan University were enrolled.Forty-six patients were male and 33 were female,with an average age of (62.9±8.9)years (range:37-82 years).Tumor sites:56 tumors were located at the head of the pancreas,22 were located at the body and tail of the pancreas,and 1 was located across the whole pancreas...
March 1, 2019: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Ágatha Nagli de Mello Gomes, Maria Aparecida Nagai, Silvia Vanessa Lourenço, Cláudia Malheiros Coutinho-Camillo
Human salivary gland (SG) branching morphogenesis is an intricate mechanism divided into stages, prebud, initial bud, pseudoglandular, canalicular, and terminal bud, to form the final lobular structure of the organ. The coordination of molecular cascades, including cell proliferation and apoptosis, are fundamental to this process. The intrinsic apoptosis pathway appears to be important in the early phases of ductal cavitation and luminisation; however, the role of the extrinsic apoptosis pathway has still to be determined...
March 12, 2019: Journal of Anatomy
Hyung Gyun Na, Yong-Dae Kim, Yoon Seok Choi, Chang Hoon Bae, Si-Youn Song
Exposure to diesel exhaust particles (DEPs) is known to cause serious health problems, owing to a steady increase in the number of diesel vehicles worldwide. DEPs comprise approximately 90% particle mass existing in the fine size range (≤2.5 μm) and are mainly absorbed in the respiratory tract. However, limited information is available on the effects of DEP exposure on the respiratory tract in humans. Here, we investigated the effect and signaling pathways of DEPs on the expression of mucin, especially MUC5AC and MUC5B, in human airway epithelial cells by reverse-transcriptase polymerase chain reaction (PCR), real-time PCR, enzyme-linked immunosorbent assay, western blotting, and immunofluorescence staining...
March 8, 2019: Biochemical and Biophysical Research Communications
Tsung-Wei Huang, Sheng-Tien Li, Tai-Horng Young
Developing a biomaterial that promotes regeneration of both respiratory epithelium (RE) and olfactory neuroepithelium (ON) improves the surgical outcome of endoscopic sinus surgery. Although chitosan (CS) inhibits mucociliary differentiation of RE, it has been reported to regenerate ON. In addition, hyaluronic acid (HA) has been demonstrated to promote regeneration of RE. Whether the composite CS + HA would simultaneously benefit RE and ON remains unexplored. Human nasal respiratory epithelial cells (RECs) and olfactory neuroepithelial cells (ONCs) are respectively obtained from the RE and the ON...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Ji Li, Yan Liu, Bin Wang, Xun Sun, Xiangwei Meng
RATIONALE: Primary malignant melanoma of the esophagus (PMME) is a rare malignancy that only accounts for <2% of all primary esophageal tumors. Here, we report the even rarer occurrence of PMME in combination with poorly differentiated mucinous adenocarcinoma of the stomach. PATIENT CONCERNS: A 64-year-old man was presented to the hospital with >1 month of eating dysphagia. Enhanced computed tomography (CT) scan only found a space-occupying lesion in the lower esophagus with moderate enhancement...
March 2019: Medicine (Baltimore)
Yanyan Zhang, Jinyao Dong, Ruyi Shi, Liguo Feng, Yike Li, Caixia Cheng, Ling Zhang, Bin Song, Yanghui Bi, He Huang, Pengzhou Kong, Jiansheng Guo, Jing Liu
Colorectal cancer (CRC) with the V600E mutation of B-Raf proto-oncogene serine/threonine kinase (BRAFV600E ) mutation is insensitive to chemotherapy and is indicative of a poor patient prognosis. Although BRAF inhibitors have a marked effect on malignant melanoma harboring the BRAFV600E mutation, they have a limited effect on patients with CRC with the same BRAF mutation. A previous study identified a novel gene, monopolar spindle protein kinase 1 (Mps1), a downstream target of BRAFV600E only, rather than of wild-type BRAF as well, which contributes to tumorigenesis in melanoma...
March 2019: Oncology Letters
Zheng Li, Guobin Mao, Mingyuan Du, Songbai Tian, Longqing Niu, Xinghu Ji, Zhike He
A fluorometric method is described for the determination of the tumor biomarker mucin 1 (MUC1). It is based on signal amplification of the hybridization chain reaction (HCR), and the interaction between a luminescent ruthenium(II) complex and CdZnTeS quantum dots (QDs). If MUC1 bind to the biotin-labeled aptamer, it will initiate HCR with hairpins H1 and H2 to form a long-range dsDNA. The long nucleic acid chains are then linked on the surface of streptavidin-modified magnetic microparticles (MMPs) through streptavidin-biotin interaction...
March 9, 2019: Mikrochimica Acta
Masashi Mikubo, Raito Maruyama, Hirokuni Kakinuma, Tsutomu Yoshida, Yukitoshi Satoh
Ciliated muconodular papillary tumors (CMPTs) of the lung are rare, likely benign neoplastic lesions. Here we describe a case of a CMPT, focusing on its cytologic features, which to our knowledge have not been reported previously. Owing to dull back pain, a 69-year-old male non-smoker underwent CT, which revealed a 1.3 × 1.3-cm solid nodule in the peripheral field of the left lower lung lobe. A wedge resection of the nodule was performed, with the provisional diagnosis being primary lung cancer. Macroscopic examination of a resected specimen showed a 1...
March 8, 2019: Diagnostic Cytopathology
Francesca Negri, Annamaria De Giorgi, Annalisa Gilli, Cinzia Azzoni, Lorena Bottarelli, Letizia Gnetti, Matteo Goldoni, Laura Manotti, Paolo Sgargi, Maria Michiara, Francesco Leonardi, Guido Rindi, Stefano Cascinu, Enrico Maria Silini
Recent data suggest that tumor laterality and mucinous histology may be clinically relevant. We investigated how both variables impact on the prognosis and the response to therapies in a large population-based cohort of cancer patients. Incidence data, clinical and pathological features, and outcome were systematically collected from the Tumor Registry of Parma over the years 2004-2009. Survival data were modeled by multivariable analysis. 1358 patients affected by stage I-IV colon cancer were considered; 661 (49%) had right-sided and 697 (51%) left-sided tumors...
March 6, 2019: Scientific Reports
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