Use the keywords feature with a free QxMD account.

Use Read by QxMD to access full text via your institution or open access sources.

Read also provides personalized recommendations to keep you up to date in your field.

Existing User

New to Read

Get Started

Keywords P2Y4 and hyperglycemia

P2Y4 and hyperglycemia

Follow Keyword ＋

JOURNAL ARTICLE

Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters.

Cleide Gonçalves da Silva, Robert Jarzyna, Anke Specht, Elzbieta Kaczmarek

AMP-activated protein kinase (AMPK) plays a key role in the regulation of energy homeostasis and is activated in response to cellular stress, including hypoxia/ischemia and hyperglycemia. The stress events are accompanied by rapid release of extracellular nucleotides from damaged tissues or activated endothelial cells (EC) and platelets. We demonstrate that extracellular nucleotides (ATP, ADP, and UTP, but not UDP) and adenosine independently induce phosphorylation and activation of AMPK in human umbilical vein EC (HUVEC) by the mechanism that is not linked to changes in AMP:ATP ratio...

16497986

March 17, 2006: Circulation Research

Make the most of Read.
Download the mobile app.

Use the keywords feature with a free QxMD account.

P2Y4 and hyperglycemia

Save your favorite articles in one place with a free QxMD account.

Read

Search Tips