Yang Zheng, Cenglin Xu, Jinyi Sun, Wenjie Ming, Sijie Dai, Yuying Shao, Xiaoyun Qiu, Menghan Li, Chunhong Shen, Jinghong Xu, Fan Fei, Jiajia Fang, Xuhong Jiang, Guoqing Zheng, Weiwei Hu, Yi Wang, Shuang Wang, Meiping Ding, Zhong Chen
Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery, likely due to the widespread seizure network. Previous studies have primarily focused on the disruption of dysplastic lesions, rather than remote regions such as the hippocampus. Here, we first quantified the epileptogenicity of the hippocampus in patients with late-stage cortical dysplasia. We further investigated the cellular substrates leading to the epileptic hippocampus, using multiscale tools including calcium imaging, optogenetics, immunohistochemistry and electrophysiology...
May 17, 2023: Signal Transduction and Targeted Therapy