Haowei Li, Risako Tamura, Daiki Hayashi, Hirotaka Asai, Junya Koga, Shota Ando, Sayumi Yokota, Jun Kaneko, Keisuke Sakurai, Akira Sumiyoshi, Tadashi Yamamoto, Keigo Hikishima, Kazumasa Z Tanaka, Thomas J McHugh, Tatsuhiro Hisatsune
Adult neurogenesis confers the hippocampus with unparalleled neural plasticity, essential for intricate cognitive functions. The specific influence of sparse newborn neurons (NBNs) in modulating neural activities and subsequently steering behavior, however, remains obscure. Using an engineered NBN-tetanus toxin mouse model (NBN-TeTX), we noninvasively silenced NBNs, elucidating their crucial role in impulse inhibition and cognitive flexibility as evidenced through Morris water maze reversal learning and Go/Nogo task in operant learning...
January 12, 2024: Science Advances