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Biomarker in plasma

Igor Kaidashev, Liudmyla G Savchenko, Nataliia I Digtiar, Liudmyla G Selikhova, Elvira I Kaidasheva, Oksana A Shlykova, Liudmyla E Vesnina
INTRODUCTION: Liraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify a level of inflammatory biomarkers. L can influence NF-kB inflammatory cascade, but the mechanisms of anti-inflammatory activities of L remain to be determined. In animal models L influenced an activity of Sirtuin 1(SIRT1). Moreover, recent evidences strongly suggest that SIRT1 up-regulation may serve as a potent therapeutic approach against development and progression of diabetic complications ...
January 1, 2019: Romanian Journal of Internal Medicine
Fabian Eichelmann, Matthias B Schulze, Clemens Wittenbecher, Juliane Menzel, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Andreas Fritsche, Heiner Boeing, Krasimira Aleksandrova
Importance: Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. Objective: To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. Design, Setting, and Participants: Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort who were followed for up to 16 years...
March 1, 2019: JAMA Network Open
Nynke Simons, François-Guillaume Debray, Nicolaas C Schaper, M Eline Kooi, Edith J M Feskens, Carla E M Hollak, Lucas Lindeboom, Ger H Koek, Judith A P Bons, Dirk J Lefeber, Leanne Hodson, Casper G Schalkwijk, Coen D A Stehouwer, David Cassiman, Martijn C G J Brouwers
CONTEXT: There is an ongoing debate on whether and how fructose is involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). A recent experimental study showed an increased intrahepatic triglycerides (IHTG) content in mice deficient for aldolase B (aldo B-/-), the enzyme that converts fructose-1-phosphate to triose phosphates. OBJECTIVE: To translate these experimental findings to the human situation. DESIGN: Case-control study...
March 22, 2019: Journal of Clinical Endocrinology and Metabolism
Prajokta Ray, Andrew J Steckl
We report a novel label-free quantitative detection of human performance "stress" biomarkers in different body fluids based on optical absorbance of the biomarkers in the ultraviolet (UV) region. Stress biomarker (hormones and neurotransmitters) concentrations in bodily fluids (blood, sweat, urine, saliva) predict the physical and mental state of the individual. Stress biomarkers primarily focused on in this manuscript are cortisol, serotonin, dopamine, norepinephrine, and neuropeptide Y. UV spectroscopy of stress biomarkers performed in the 190 - 400 nm range has revealed primary and secondary absorption peaks at near UV wavelengths depending on their molecular structure...
March 22, 2019: ACS Sensors
Rahul R Deshpande, Pranav Prakash Dungarwal, Komal K Bagde, Priyadarshini S Thakur, Pankti M Gajjar, Ananth P Kamath
Context: Autism prevalence is increasing, with current estimates at 1/68-1/50 individuals diagnosed with autism. Diagnosis is based on behavioral assessments. Early diagnosis and intervention are known to greatly improve functional outcomes in people with autism. Diagnosis, treatment monitoring, and prognosis of autistic children's symptoms could be facilitated with biomarkers to complement behavioral assessments. Aims: The aim of this study is to compare and evaluate salivary zinc concentration in saliva samples of autistic and healthy children in mixed dentition age group...
January 2019: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Reza Fardid, Parisa Ghahramani, Mohammad-Amin Mosleh-Shirazi, Tahereh Kalantari, Abbas Behzad-Behbahani, Elaheh Kazemi, Mohammad-Ali Okhovat
Context: There are plenty of evidence that suggest that the potential high doses of radiation result in severe health effects to exposed individuals, although there is no consensus about the health impact of low dose of ionizing radiation (IR). Aims: This study aimed to discuss the effect a range of IR doses on the changes of gene expression and serum protein levels of two immune factors transforming growth factor-β (TGF-β) and interferon gamma (IFN-γ) in rats...
March 2019: Journal of Cancer Research and Therapeutics
Tinashe Chikowore, Venesa Sahibdeen, Liesl M Hendry, Shane A Norris, Julia H Goedecke, Lisa K Micklesfield, Zané Lombard
Aim: To evaluate the association between loss-of-function (LOF) PCSK9 variants (A433T/rs28362263 and C679X/rs28362286) and biomarkers of cardiometabolic risk, specifically fasting glucose and low density lipoprotein cholesterol (LDL-C) concentrations. Methods: Our study comprised 757 male and female black South African adolescents (mean age 18.0 ± 0.5 years) who are part of the Birth to Twenty Plus Cohort and had been genotyped for the two above-mentioned variants...
June 2019: Journal of Clinical & Translational Endocrinology
Zofia M Szemraj-Rogucka, Janusz Szemraj, Konrad Masiarek, Agata Majos
Introduction: Despite the fact that cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) is a proven method for detecting myocardial fibrosis, there is a need for new and reliable serological biomarkers. Circulating miRNAs could be a practical and attractive alternative. The purpose of the study was to assess the miRNAs well established in myocardial fibrosis - miR-21, miR-29a, miR-30d and miR-133a - in the plasma of patients with left ventricular non-compaction (LVNC) that have areas of LGE assessed by CMR...
March 2019: Archives of Medical Science: AMS
Mohamed Romdhani, Omar Hammouda, Yassine Chaabouni, Kacem Mahdouani, Tarak Driss, Karim Chamari, Nizar Souissi
To compare the effects of two types of partial sleep deprivation (PSD) at the beginning (PSDBN) and the end (PSDEN) of the night on mood, cognitive performances, biomarkers of muscle damage, haematological status and antioxidant responses before and after repeated-sprint exercise in the post-lunch dip. Fourteen male athletes performed the Running-based Anaerobic Sprint Test following: (i) baseline normal sleep night, (ii) PSDBN, or (iii) PSDEN in a randomized and counter-balanced order. During each condition, participants performed simple and choice reaction time tests, the Profile of Mood States, subjective sleepiness, and the Running-based Anaerobic Sprint Test...
March 2019: Biology of Sport
Suchita Nadkarni, Hazem Lashin, Jane Hollywood, Bhaskar Dasgupta, Justin C Mason, Mauro Perretti
We have reported the existence of a distinct neutrophil phenotype in giant cell arteritis (GCA) patients arising at week 24 of steroid treatment. In the present study, we investigated whether longitudinal analysis of neutrophil phenotype in patients with polymyalgia rheumatica (PMR) could reveal a novel association with disease status and immune cell cross-talk. Thus, we monitored PMR patient neutrophil phenotype and plasma microvesicle profiles in blood aliquots collected pre-steroid, and then at weeks 1, 4, 12 and 24 post-steroid treatment...
March 21, 2019: Clinical Science (1979-)
Ron T Gansevoort, Maatje D A van Gastel, Arlene B Chapman, Jaime D Blais, Frank S Czerwiec, Eiji Higashihara, Jennifer Lee, John Ouyang, Ronald D Perrone, Katrin Stade, Vicente E Torres, Olivier Devuyst
In the TEMPO 3:4 Trial, treatment with tolvaptan, a vasopressin V2 receptor antagonist, slowed the increase in total kidney volume and decline in estimated glomerular filtration rate (eGFR) in autosomal dominant polycystic kidney disease (ADPKD). We investigated whether plasma copeptin levels, a marker of plasma vasopressin, are associated with disease progression, and whether pre-treatment copeptin and treatment-induced change in copeptin are associated with tolvaptan treatment efficacy. This post hoc analysis included 1,280 TEMPO 3:4 participants (aged 18-50 years, estimated creatinine clearance ≥60 ml/min and total kidney volume ≥750 mL) who had plasma samples available at baseline for measurement of copeptin using an automated immunofluorescence assay...
March 9, 2019: Kidney International
S Y Yao, J Liu, Y Li, M Wang, C Wang, H Xue
Objective: Previous studies have shown that plasma microRNA-29a (miRNA-29a) is associated with myocardial fibrosis and the degree of cardiac hypertrophy in patients with hypertrophic cardiomyopathy. However, the relationship between plasma miRNA-29a and hypertensive left ventricular hypertrophy (LVH) has not yet been reported. So the purpose of this study is to investigate the relationship between the plasma miRNA-29a and hypertensive LVH. Method: Enrolled 168 hypertensive patients and classified the patients into 2 groups: those with LVH (LVH group, n= 41) and those without LVH (NLVH group, n= 127)...
March 24, 2019: Zhonghua Xin Xue Guan Bing za Zhi
Oscar Mancera-Páez, Kelly Estrada-Orozco, María Fernanda Mahecha, Francy Cruz, Kely Bonilla-Vargas, Nicolás Sandoval, Esneyder Guerrero, David Salcedo-Tacuma, Jesús D Melgarejo, Edwin Vega, Jenny Ortega-Rojas, Gustavo C Román, Rodrigo Pardo-Turriago, Humberto Arboleda
BACKGROUND: Biomarkers are essential for identification of individuals at high risk of mild cognitive impairment (MCI) for potential prevention of dementia. We investigated DNA methylation in the APOE gene and apolipoprotein E (ApoE) plasma levels as MCI biomarkers in Colombian subjects with MCI and controls. METHODS: In total, 100 participants were included (71% women; average age, 70 years; range, 43⁻91 years). MCI was diagnosed by neuropsychological testing, medical and social history, activities of daily living, cognitive symptoms and neuroimaging...
March 20, 2019: International Journal of Molecular Sciences
Naglaa K Idriss, Michel Fakhry, Hala M Imam, Fatema A Abd-Elmoez, Hossam Abdelewahab, Lobna Abdel-Wahid, Wael A Abbas, Mohamed A A Abozaid, Zain Sayed, Ahmed M Ashmawy
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is the fifth most common malignancy and most frequently develops in patients with cirrhosis. Surveillance strategies are recommended in high-risk groups because early detection of small lesions improves the likelihood of curative treatment. This study investigated the prospective clinical significance of serum levels of anti-Ku86 and plasma levels of lamin B1and vimentin as early markers of HCC. METHODS: We recruited 74 patients at Assiut University Hospital-37 with HCC and 37 with chronic liver disease (liver cirrhosis patients)-and 36 age- and sex-matched healthy controls...
2019: Cellular Physiology and Biochemistry
Geeta N Eick, Maureen J Devlin, Tara J Cepon-Robins, Paul Kowal, Lawrence S Sugiyama, J Josh Snodgrass
OBJECTIVES: A number of basic questions about bone biology have not been answered, including population differences in bone turnover. In part, this stems from the lack of validated minimally invasive biomarker techniques to measure bone formation and resorption in field-based population-level research. The present study addresses this gap by validating a fingerprick dried blood spot (fDBS) assay for tartrate-resistant acid phosphatase 5b (TRACP-5b), a well-defined biomarker of bone resorption and osteoclast number...
March 21, 2019: American Journal of Human Biology: the Official Journal of the Human Biology Council
Fengfeng Cai, Lu Cai, Zhuchao Zhou, Xin Pan, Minghong Wang, Su Chen, Manuel Antonio Falar Luis, Chunmei Cen, Ewelina Biskup
Transcription intermediary factor 1γ (Tif1γ), a ubiquitous nuclear protein, is a regulator of transforming growth factor‑β (TGF‑β)/Smad signaling. Tif1γ can function as an oncogene and as a tumor suppressor. In the present study, Tif1γ levels were measured in the plasma of patients with breast cancer in order to investigate the association of Tif1γ with overall survival (OS). The results indicated that Tif1γ is an independent prognostic and predictive factor in breast cancer, and thus, a promising target protein for use in diagnostics and patient follow‑up...
March 14, 2019: Molecular Medicine Reports
Niharika B Mettu, Donna Niedzwiecki, Christel Rushing, Andrew B Nixon, Jingquan Jia, Sherri Haley, Wanda Honeycutt, Herbert Hurwitz, Johanna C Bendell, Hope Uronis
PURPOSE: This study was conducted to define the maximum tolerated dose (MTD), recommended phase two dose (RPTD), and toxicities of gemcitabine + dasatinib (GD) and gemcitabine + dasatinib + cetuximab (GDC) in advanced solid tumor patients. METHODS: This study was a standard phase I 3 + 3 dose escalation study evaluating two combination regimens, GD and GDC. Patients with advanced solid tumors were enrolled in cohorts of 3-6 to either GD or GDC. Gemcitabine was dosed at 1000 mg/m2 weekly for 3 of 4 weeks, dasatinib was dosed in mg PO BID, and cetuximab was dosed at 250 mg/m2 weekly after a loading dose of cetuximab of 400 mg/m2 ...
March 20, 2019: Cancer Chemotherapy and Pharmacology
Sun-Jung Cho, Hyun Joung Lim, Chulman Jo, Moon Ho Park, Changsu Han, Young Ho Koh
Alzheimer's disease (AD) is a major cause of dementia. Growing evidence suggests that dysregulation of autophagy, a cellular mechanism essential for self-digestion of damaged proteins and organelles, is involved in neurological degenerative diseases including AD. Previously, we reported that autophagosomes are increased in the brains of AD mouse model. However, the plasma levels of autophagic markers have not yet been investigated in patients with AD. In this study, we investigated the expression of autophagy-related genes 5 and 12 (ATG5 and ATG12, respectively) in cells in vitro upon amyloid-beta (Aβ) treatment and in the plasma of AD patients...
March 18, 2019: Scientific Reports
Cynthia Arbeeny, Hong Ling, Mandy M Smith, Stephen O'Brien, Stefan Wawersik, Steven R Ledbetter, M Allen McAlexander, Robert Willette, Diane Jorkasky
Underlying pathogenic mechanisms in chronic kidney disease (CKD) include chronic inflammation, oxidant stress, and matrix remodeling associated with dysregulated NF-ĸB, NRF2 and SMAD signaling pathways, respectively. Important cytoprotective mechanisms activated by oxidative inflammatory conditions are mediated by nitrated fatty acids (NO2-FA) that covalently modify proteins to limit inflammation and oxidant stress. In the present study we evaluated the effects of chronic treatment with CXA-10 (10-nitro-9(E)-octadec-9-enoic acid) in the uni-nephrectomized deoxycorticosterone acetate (DOCA)-high salt mouse model of CKD...
March 20, 2019: Journal of Pharmacology and Experimental Therapeutics
Marianne Lauwers, Siegrid De Baere, Ben Letor, Michael Rychlik, Siska Croubels, Mathias Devreese
A reliable and practical multi-method was developed for the quantification of mycotoxins in plasma, urine, and feces of pigs, and plasma and excreta of broiler chickens using liquid chromatography⁻tandem mass spectrometry. The targeted mycotoxins belong to the regulated groups, i.e., aflatoxins, ochratoxin A and Fusarium mycotoxins, and to two groups of emerging mycotoxins, i.e., Alternaria mycotoxins and enniatins. In addition, the developed method was transferred to a LC-high resolution mass spectrometry instrument to qualitatively determine phase I and II metabolites, for which analytical standards are not always commercially available...
March 19, 2019: Toxins
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