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SEP or micropeptides

Tuyet-Trinh N Truong, Andrew S Dunn, Ken McCardle, Allison Glasser, Shirish Huprikar, Hooman Poor, Beth Raucher, Jashvant Poeran
OBJECTIVE: The Surviving Sepsis Campaign and Centers for Medicare and Medicaid Services (CMS) Severe Sepsis and Septic Shock Management Bundle (SEP-1) recommend rapid crystalloid infusion (≥30 mL/kg) for patients with sepsis-induced hypoperfusion or septic shock. We aimed to assess compliance with this recommendation, factors associated with non-compliance, and how compliance relates to mortality. DESIGN: Retrospective, observational study. SETTING: 1136-bed academic and 235-bed community hospital (January 2015-June 2016)...
February 5, 2019: Journal of Critical Care
So Jeong Lee, Allen F Brooks, Naoko Ichiishi, Katarina J Makaravage, Andrew V Mossine, Melanie S Sanford, Peter J H Scott
This report describes a Pd-mediated C-H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C-H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.
February 19, 2019: Chemical Communications: Chem Comm
Renhui Zhan, Xiaofeng Li, Wenfei Guo, Xiaojun Liu, Zhi-Xian Liu, Kehua Xu, Bo Tang
A growing body of evidence indicates that micropeptides encoded by long noncoding RNAs (lncRNAs) act independently or as regulators of larger proteins in fundamental biological processes, especially in the maintenance of cellular homeostasis. However, due to their small size and low intracellular expression, visual monitoring of micropeptides in living cells is still a challenge. In this work, we have designed and synthesized an aptamer-based near-infrared fluorescence nanoprobe for fluorescence imaging of phospholamban (PLN), which is an intracellular micropeptide that affects calcium homeostasis, and is closely associated with human heart failure in clinic...
February 19, 2019: ACS Sensors
Hengqiang Zhao, Hehe Li
PURPOSE: To evaluate the performance of preoperative ultrasound in the diagnosis of cervical lymph nodes metastases (CLNM) of papillary thyroid cancer (PTC) and its value in assisting cervical lymph node dissection (CLND). METHODS: PubMed, EMBASE and Cochrane Library databases were searched to identify relevant studies up to Sep. 2017. Overall sensitivity, specificity, and diagnostic odds ratio (DOR) were used to assess the diagnostic efficacy of ultrasound in detecting central and lateral CLNM of PTC...
March 2019: European Journal of Radiology
Niccolò Parri, Giulia Trippella, Catiuscia Lisi, Maurizio de Martino, Luisa Galli, Elena Chiappini
Neonatal sepsis represents a major cause of morbidity and mortality in neonates. No diagnostic test has been demonstrated to be sufficiently accurate to confirm or exclude neonatal sepsis. This study aimed to evaluate the diagnostic accuracy of presepsin (P-SEP) for neonatal sepsis. Areas covered: A systematic review of literature was performed on Medline and EMBASE. A meta-analysis was performed to calculate pooled sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver operating characteristic of P-SEP for neonatal sepsis...
February 18, 2019: Expert Review of Anti-infective Therapy
Bailin Liu, Ce-Hui Mo, Yingmei Zhang
Single extraction procedures (SEPs) have been extensively conducted to determine Cd bioavailability (Cd-Bav) in soils. However, whether SEPs can simultaneously predict Cd accumulation in crop grains and bioaccessibility (Cd-Bac) in soils remains unclear. To assess their suitability, the Cd-Bav in 20 contaminated soils (containing 0.27-56.59 mg/kg Cd) determined by four SEPs (including DTPA, EDTA, HOAc and HCl) was compared with Cd concentrations in crop grains (wheat and rice) and Cd-Bac in soils (based on SBET and PBET assays)...
February 1, 2019: Science of the Total Environment
Eloïse Berger, Raphaële Castagné, Marc Chadeau-Hyam, Murielle Bochud, Angelo d'Errico, Martina Gandini, Maryam Karimi, Mika Kivimäki, Vittorio Krogh, Michael Marmot, Salvatore Panico, Martin Preisig, Fulvio Ricceri, Carlotta Sacerdote, Andrew Steptoe, Silvia Stringhini, Rosario Tumino, Paolo Vineis, Cyrille Delpierre, Michelle Kelly-Irving
Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013...
February 15, 2019: Nature Communications
Angelo Insola, Vincenzo Di Lazzaro, Giovanni Assenza
OBJECTIVE: The pathophysiology of epilepsia partialis continua (EPC) is still unclear, a thalamo-cortical circuit dysfunction has been hypothesized. The aim of present study is the functional evaluation of the thalamo-cortical network in EPC by means of the study of low- and high-frequency somatosensory evoked potentials (LF-SEP and HF-SEP). METHODS: Median LF-SEP and HF-SEP were recorded in 3 patients with EPC and in 2 patients with rolandic lesions without EPC (non-EPC)...
January 25, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Karen M Oude Hengel, Pieter Coenen, Suzan J W Robroek, Cecile R L Boot, Allard J van der Beek, Frank J Van Lenthe, Alex Burdorf
INTRODUCTION: Obesity and unhealthy behaviour are more prevalent among workers with a low compared with a high socioeconomic position (SEP), and thus contribute to socioeconomic health inequalities. The occupational setting is considered an important setting to address unhealthy behaviours due to the possibility to efficiently reach a large group of adults through worksite health promotion. This paper describes the rationale and design for an individual participant data (IPD) meta-analysis and a socioeconomic equity-specific reanalysis aiming to: (1) investigate socioeconomic differences in the effectiveness of interventions aimed at promoting healthy behaviour and preventing obesity, (2) examine socioeconomic differences in reach and compliance and (3) to investigate underlying factors affecting possible socioeconomic differences...
February 13, 2019: BMJ Open
Peng Hu, Hong-Qi Zhang, Xiao-Yu Li, Xian-Zeng Tong
BACKGROUND: The STA connected to proximal MCA has been reported before. However, the flow supply capacity of the double-barrel STA to proximal MCA bypass in treating complex intracranial aneurysms has not been well documented. METHODS: Consecutive cases using this technique to treat complex intracranial aneurysms during the past five years have been collected. SEP and MEP monitoring were applied for each patient to determine any ischaemic events during the surgery...
February 8, 2019: World Neurosurgery
William C Newman, Johnathan A Engh
OBJECTIVE: Deep-seated brain tumors are often best treated with primary surgical excision. Traditional microsurgical techniques may cause retraction injury and extensive brain dissection. To mitigate this risk, stereotactic-guided tubular retractors were developed, but the risk of shear injury remains. We created a stereotactic-guided dilatable port system to create a corridor for deep brain tumor surgery along the trajectory of a brain needle in order to minimize iatrogenic brain injury...
February 7, 2019: World Neurosurgery
C R A Silveira, J MacKinley, K Coleman, Z Li, E Finger, R Bartha, S A Morrow, J Wells, M Borrie, R G Tirona, C A Rupar, G Zou, R A Hegele, D Mahuran, P MacDonald, M E Jenkins, M Jog, S H Pasternak
BACKGROUND: Currently there are no disease-modifying treatments for Parkinson's disease dementia (PDD), a condition linked to aggregation of the protein α-synuclein in subcortical and cortical brain areas. One of the leading genetic risk factors for Parkinson's disease is being a carrier in the gene for β-Glucocerebrosidase (GCase; gene name GBA1). Studies in cell culture and animal models have shown that raising the levels of GCase can decrease levels of α-synuclein. Ambroxol is a pharmacological chaperone for GCase and is able to raise the levels of GCase and could therefore be a disease-modifying treatment for PDD...
February 9, 2019: BMC Neurology
Haochen Dong, Liu Feng, Yu Qin, Muxinjian Luo
Three sequential extraction procedures (SEPs), modified Tessier, modified BCR, and CIEMAT, were compared for mercury fractionation in polluted soils. With satisfactory total mercury recovery, the modified Tessier and modified BCR SEPs were comparable with each other in terms of extraction efficiency in equivalent mercury fractions, whereas both SEPs were not as efficient as the CIEMAT SEP. However, the CIEMAT SEP might underestimate the oxidizable mercury fractions due to the humic and fulvic complexes instead of the organic matter of the other two SEPs...
February 9, 2019: Environmental Science and Pollution Research International
Jing Tian, Seana Gall, Kira Patterson, Petr Otahal, Leigh Blizzard, George Patton, Terry Dwyer, Alison Venn
BACKGROUND: It remains unclear how life course socioeconomic position (SEP) variations impact later smoking status. We aimed to investigate the associations using a novel methodology - a structured regression framework and to explore the potential underlying mechanisms. METHODS: Data were from an Australian national cohort (n = 1489). SEP was measured in childhood (aged 7-15 years), young- (aged 26-36 years) and mid-adulthood (aged 31-41 years), including highest parental occupation in childhood and self-occupation in young- and mid-adulthood...
February 8, 2019: BMC Public Health
Jonathan B Ajo-Franklin, Shan Dou, Nathaniel J Lindsey, Inder Monga, Chris Tracy, Michelle Robertson, Veronica Rodriguez Tribaldos, Craig Ulrich, Barry Freifeld, Thomas Daley, Xiaoye Li
We present one of the first case studies demonstrating the use of distributed acoustic sensing deployed on regional unlit fiber-optic telecommunication infrastructure (dark fiber) for broadband seismic monitoring of both near-surface soil properties and earthquake seismology. We recorded 7 months of passive seismic data on a 27 km section of dark fiber stretching from West Sacramento, CA to Woodland, CA, densely sampled at 2 m spacing. This dataset was processed to extract surface wave velocity information using ambient noise interferometry techniques; the resulting VS profiles were used to map both shallow structural profiles and groundwater depth, thus demonstrating that basin-scale variations in hydrological state could be resolved using this technique...
February 4, 2019: Scientific Reports
Gloria L Beckles, Kai McKeever Bullard, Sharon Saydah, Giuseppina Imperatore, Fleetwood Loustalot, Adolfo Correa
Objective: We examined whether life course socioeconomic position (SEP) was associated with incidence of type 2 diabetes (t2DM) among African Americans. Design: Secondary analysis of data from the Jackson Heart Study, 2000-04 to 2012, using Cox proportional hazard regression to estimate hazard ratios (HR) with 95% CI for t2DM incidence by measures of life course SEP. Participants: Sample of 4,012 nondiabetic adults aged 25-84 years at baseline...
2019: Ethnicity & Disease
Marta Gaweł, Tomasz Kiljanek, Alicja Niewiadowska, Stanisław Semeniuk, Milena Goliszek, Olga Burek, Andrzej Posyniak
Current work presents a modified QuEChERS method for the determination of 207 pesticide residues in honey by LC-MS/MS and GC-MS/MS. Acetate buffered acetonitrile extraction with Z-Sep+ and PSA dispersive-SPE clean-up were used for sample preparation. Optimised conditions allows determination of neonicotinoids as well as other insecticides, fungicides, herbicides, acaricides, growth regulators and veterinary drugs in honey samples. Validated method enable sensitive analysis at least at concentrations from 0...
June 1, 2019: Food Chemistry
J Wu, A D Lu, L P Zhang, Y X Zuo, Y P Jia
Objective: To analyze the clinical outcome and the prognostic factor in pediatric patients with core binding factor-acute myeloid leukemia (CBF-AML). Methods: A total of 121 newly diagnosed pediatric CBF-AML patients enrolled from Aug. 2005 to Sep. 2017 were retrospectively reviewed. Cumulative incidence of relapse (CIR), event-free survival (EFS) and overall survival (OS) rates were estimated by Kaplan-Meier method and prognostic factors were evaluated by Cox regression with SPSS. Results: Of the 121 patients, 120 patients were assessed for bone marrow remission after induction chemotherapy...
January 14, 2019: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
L Y Zhang, J Chen, Y Zhang, Y H Gu, X M Rao, Y Ouyang
Objective: To explore the role of lung dendritic cells (DCs) and Th17/regulatory T cells (Treg) pathway in the pathogenesis of chronic obstructive pulmonary disease(COPD). Methods: COPD patients who received lobectomy from Sep. 2015 to Mar. 2016 in our hospital were enrolled and classified into non-smoking non-COPD group, smoking without COPD group and COPD group. The expression of CD(80), chemokine recepter-6 (CCR6), interleukin-17A (IL-17A) and fork-head transcription factor P3 (FoxP3) were detected by immunohistochemistry (IHC) in lung tissue...
February 1, 2019: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Shervin Assari
Background: Although depression and financial distress are correlated, this association may differ for demographic groups, particularly based on race. Aim: Using a national sample of American adults, this study tested whether the association between Major Depressive Episode (MDE) and financial distress differs between African Americans and Whites. Methods: The National Survey of American Life (NSAL), 2003, enrolled 3570 African American and 891 Non-Hispanic White American adults. Demographic data (age and gender), socioeconomic position (SEP; i...
January 30, 2019: Brain Sciences
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