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Teresa DeMarco

Dalin Rifat, Brendan Prideaux, Radojka M Savic, Michael E Urbanowski, Teresa L Parsons, Brian Luna, Mark A Marzinke, Alvaro A Ordonez, Vincent P DeMarco, Sanjay K Jain, Veronique Dartois, William R Bishai, Kelly E Dooley
In clinical trials of two rifamycin antibiotics (rifampin and rifapentine) for treating tuberculosis (TB), patients with cavitary lung lesions did not appear to derive benefit from rifapentine. Rifapentine was found not to outperform rifampin, despite a lower minimum inhibitory concentration against Mycobacterium tuberculosis in mouse models of TB. To understand these findings, we have developed a rabbit model of TB that reliably develops lung cavities with features similar to those of patients with pulmonary cavitary TB...
April 4, 2018: Science Translational Medicine
Max N Brondfield, Michael J A Reid, Rachel L Rutishauser, Jennifer R Cope, Jevon Tang, Jana M Ritter, Almea Matanock, Ibne Ali, Sarah B Doernberg, Alexandra Hilts-Horeczko, Teresa DeMarco, Liviu Klein, Jennifer M Babik
Disseminated acanthamoebiasis is a rare, often fatal, infection most commonly affecting immunocompromised patients. We report a case involving sinuses, skin, and bone in a 60-year-old woman 5 months after heart transplantation. She improved with a combination of flucytosine, fluconazole, miltefosine, and decreased immunosuppression. To our knowledge, this is the first case of successfully treated disseminated acanthamoebiasis in a heart transplant recipient and only the second successful use of miltefosine for this infection among solid organ transplant recipients...
April 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Sarah E Martin, Jeffrey I Hunt, Lauren R Mernick, Mia DeMarco, Heather L Hunter, Maria Teresa Coutinho, John R Boekamp
Disruptive Mood Dysregulation Disorder (DMDD) is a new and controversial child psychiatric disorder characterized by persistent irritability and frequent temper loss. Among the controversies surrounding DMDD is whether the age of onset criterion-that DMDD may not be diagnosed before age 6 years-is justified. This study examined DMDD symptoms and associated patterns of psychiatric comorbidity, behavioral, and family functioning in a sample of 139 preschoolers (ages 4-0 to 5-11 years) admitted to an early childhood psychiatric day treatment program...
June 2017: Child Psychiatry and Human Development
Raymond L Benza, Mardi Gomberg-Maitland, Teresa Demarco, Adaani E Frost, Adam Torbicki, David Langleben, Tomas Pulido, Priscilla Correa-Jaque, Michael J Passineau, Howard W Wiener, Mayumi Tamari, Tomomitsu Hirota, Michiaki Kubo, Hemant K Tiwari
RATIONALE: Pulmonary arterial hypertension (PAH) is a progressive fatal disease. Variable response and tolerability to PAH therapeutics suggests that genetic differences may influence outcomes. The endothelin pathway is central to pulmonary vascular function, and several polymorphisms and/or mutations in the genes coding for endothelin (ET)-1 and its receptors correlate with the clinical manifestations of other diseases. OBJECTIVES: To examine the interaction of ET-1 pathway polymorphisms and treatment responses of patients with PAH treated with ET receptor antagonists (ERAs)...
December 1, 2015: American Journal of Respiratory and Critical Care Medicine
Edgar Turner Overton, Tej D Azad, Neva Parker, Debra Demarco Shaw, Judy Frain, Teresa Spitz, Elizabeth Westerhaus, Robert Paul, David B Clifford, Beau M Ances
The diagnosis of human immunodeficiency virus (HIV)-associated neurocognitive impairment is time-intensive and often omitted in busy outpatient settings. Brief screening tools are needed. The Montreal Cognitive Assessment (MoCA) and the Alzheimer's disease (AD)-8 have been used in neurodegenerative disorders. We evaluated the sensitivity and specificity of these brief screening tools in HIV-infected persons. The AD-8, MoCA, and formal neuropsychological testing were administered to 200 HIV-infected patients who were followed at a single institution...
February 2013: Journal of Neurovirology
William T Abraham, Inder Anand, Juan M Aranda, John Boehmer, Maria Rosa Costanzo, Teresa DeMarco, Richard Holcomb, Russell Ivanhoe, Michael Kolber, Barry Rayburn
BACKGROUND: Despite the current drug and device therapies, heart failure remains associated with high rates of disability, morbidity, and mortality. There is a need for newer therapies. One investigational approach is the use of ventricular support devices. These devices reduce ventricular wall stress leading to decreases in left ventricular (LV) volumes, dimensions, and mass. Ventricular support devices have been shown to reverse pathological ventricular remodeling, improve systolic function, and improve symptoms of heart failure...
November 2012: American Heart Journal
James C Fang, Teresa DeMarco, Michael M Givertz, Barry A Borlaug, Gregory D Lewis, J Eduardo Rame, Mardi Gomberg-Maitland, Srinivas Murali, Robert P Frantz, Dana McGlothlin, Evelyn M Horn, Raymond L Benza
Pulmonary hypertension associated with left heart disease is the most common form of pulmonary hypertension encountered in clinical practice today. Although frequently a target of therapy, its pathophysiology remains poorly understood and its treatment remains undefined. Pulmonary hypertension in the context of left heart disease is a marker of worse prognosis and disease severity, but whether its primary treatment is beneficial or harmful is unknown. An important step to the future study of this important clinical problem will be to standardize definitions across disciplines to facilitate an evidence base that is interpretable and applicable to clinical practice...
September 2012: Journal of Heart and Lung Transplantation
Joseph M Zullo, Ignacio A Demarco, Roger Piqué-Regi, Daniel J Gaffney, Charles B Epstein, Chauncey J Spooner, Teresa R Luperchio, Bradley E Bernstein, Jonathan K Pritchard, Karen L Reddy, Harinder Singh
A large fraction of the mammalian genome is organized into inactive chromosomal domains along the nuclear lamina. The mechanism by which these lamina associated domains (LADs) are established remains to be elucidated. Using genomic repositioning assays, we show that LADs, spanning the developmentally regulated IgH and Cyp3a loci contain discrete DNA regions that associate chromatin with the nuclear lamina and repress gene activity in fibroblasts. Lamina interaction is established during mitosis and likely involves the localized recruitment of Lamin B during late anaphase...
June 22, 2012: Cell
Maria Rosa Costanzo, Russell J Ivanhoe, Andrew Kao, Inder S Anand, Alan Bank, John Boehmer, Teresa Demarco, Cheryl M Hergert, Richard G Holcomb, Simon Maybaum, Benjamin Sun, Thomas A Vassiliades, Barry K Rayburn, William T Abraham
BACKGROUND: Left ventricular (LV) remodeling predicts poor outcomes in heart failure (HF) patients. The HeartNet(®) cardiac restraint device (Paracor Medical Inc., Sunnyvale, CA) may reduce LV remodeling and improve functional capacity, quality of life, and outcomes in HF patients. To evaluate the safety and efficacy of the HeartNet Ventricular Support System in HF patients receiving optimal medical therapy. METHODS AND RESULTS: Prospective, randomized, controlled, multicenter trial in patients with symptomatic HF and LV ejection fraction ≤35% on optimal medical and device therapy...
June 2012: Journal of Cardiac Failure
Marco Piccinini, Federica Scandroglio, Simona Prioni, Barbara Buccinnà, Nicoletta Loberto, Massimo Aureli, Vanna Chigorno, Elisa Lupino, Giovanni DeMarco, Annarosa Lomartire, Maria Teresa Rinaudo, Sandro Sonnino, Alessandro Prinetti
Sphingolipids are polar membrane lipids present as minor components in eukaryotic cell membranes. Sphingolipids are highly enriched in nervous cells, where they exert important biological functions. They deeply affect the structural and geometrical properties and the lateral order of cellular membranes, modulate the function of several membrane-associated proteins, and give rise to important intra- and extracellular lipid mediators. Sphingolipid metabolism is regulated along the differentiation and development of the nervous system, and the expression of a peculiar spatially and temporarily regulated sphingolipid pattern is essential for the maintenance of the functional integrity of the nervous system: sphingolipids in the nervous system participate to several signaling pathways controlling neuronal survival, migration, and differentiation, responsiveness to trophic factors, synaptic stability and synaptic transmission, and neuron-glia interactions, including the formation and stability of central and peripheral myelin...
June 2010: Molecular Neurobiology
Brian C Jensen, Philip M Swigart, Marie-Eve Laden, Teresa DeMarco, Charles Hoopes, Paul C Simpson
OBJECTIVES: The goal was to identify alpha-1-adrenergic receptor (AR) subtypes in human coronary arteries. BACKGROUND: The alpha1-ARs regulate human coronary blood flow. The alpha1-ARs exist as 3 molecular subtypes, alpha1A, alpha1B, and alpha1D, and the alpha1D subtype mediates coronary vasoconstriction in the mouse. However, the alpha1A is thought to be the only subtype in human coronary arteries. METHODS: We obtained human epicardial coronary arteries and left ventricular (LV) myocardium from 19 transplant recipients and 6 unused donors (age 19 to 70 years; 68% male; 32% with coronary artery disease)...
September 22, 2009: Journal of the American College of Cardiology
Jalal K Ghali, John Boehmer, Arthur M Feldman, Leslie A Saxon, Teresa Demarco, Peter Carson, Patrick Yong, Elizabeth G Galle, Jill Leigh, Fred L Ecklund, Michael R Bristow
OBJECTIVES: We performed a post hoc analysis to determine the influence of cardiac resynchronization therapy with a defibrillator (CRT-D) or without a defibrillator (CRT-P) on outcomes among diabetic patients with advanced heart failure (HF). BACKGROUND: In patients with systolic HF, diabetes is an independent predictor of morbidity and mortality. No data are available on its impact on CRT-D or CRT-P in advanced HF. METHODS: The database of the Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure trial was examined to determine the influence of CRT (CRT-D and CRT-P) on outcomes among diabetic patients...
November 2007: Journal of Cardiac Failure
Mihai Gheorghiade, Joseph S Rossi, William Cotts, David D Shin, Anne S Hellkamp, Ileana L Piña, Gregg C Fonarow, Teresa DeMarco, Daniel F Pauly, Joseph Rogers, Thomas G DiSalvo, Javed Butler, Joshua M Hare, Gary S Francis, Wendy Gattis Stough, Christopher M O'Connor
BACKGROUND: Mild hyponatremia is relatively common in patients hospitalized with heart failure (HF). To our knowledge, the association of hyponatremia with outcomes has not been evaluated in the context of in-hospital clinical course including central hemodynamics and changes in serum sodium level. METHODS: The ESCAPE trial (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) was a randomized, controlled study designed to evaluate the utility of a pulmonary artery catheter plus clinical assessment vs clinical assessment alone in guiding therapy in patients hospitalized with New York Heart Association class IV HF due to systolic dysfunction (left ventricular ejection fraction <30%)...
October 8, 2007: Archives of Internal Medicine
JoAnn Lindenfeld, Arthur M Feldman, Leslie Saxon, John Boehmer, Peter Carson, Jalal K Ghali, Inder Anand, Steve Singh, Jonathan S Steinberg, Brian Jaski, Teresa DeMarco, David Mann, Patrick Yong, Elizabeth Galle, Fred Ecklund, Michael Bristow
BACKGROUND: Cardiac resynchronization therapy (CRT) alone or combined with an implantable defibrillator (CRT-D) has been shown to improve exercise capacity and quality of life and to reduce heart failure (HF) hospitalizations and mortality in patients with New York Heart Association (NYHA) class III and IV HF. There is concern that the device procedure may destabilize these very ill class IV patients. We sought to examine the outcomes of NYHA class IV patients enrolled in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial to assess the potential benefits of CRT and CRT-D...
January 16, 2007: Circulation
Uri Elkayam, Gudaye Tasissa, Cynthia Binanay, Lynne W Stevenson, Mihai Gheorghiade, J Wayne Warnica, James B Young, Barry K Rayburn, Joseph G Rogers, Teresa DeMarco, Carl V Leier
BACKGROUND: Treatment of decompensated heart failure often includes the use of intravenous vasoactive medications, but the effect on outcome has not been clearly defined. METHODS: Data from 433 patients enrolled in the ESCAPE trial were analyzed to determine 6-month risks of all-cause mortality and all-cause mortality plus rehospitalization associated with the use of vasodilators, inotropes, and their combination. Patients had a mean left ventricular ejection fraction of 19%, 6-minute walk distance of 414 ft, and systolic blood pressure of 106 mm Hg...
January 2007: American Heart Journal
Aimee V Loladze, Malinda A Stull, Anne M Rowzee, Jean Demarco, James H Lantry, Clifford J Rosen, Derek Leroith, Kay-Uwe Wagner, Lothar Hennighausen, Teresa L Wood
Postnatal development of the mammary gland requires interactions between the epithelial and stromal compartments, which regulate actions of hormones and growth factors. IGF-I is expressed in both epithelial and stromal compartments during postnatal development of the mammary gland. However, little is known about how local expression of IGF-I in epithelium or stroma regulates mammary growth and differentiation during puberty and pregnancy-induced alveolar development. The goal of this study was to investigate the mechanisms of IGF-I actions in the postnatal mammary gland and test the hypothesis that IGF-I expressed in stromal and epithelial compartments has distinct functions...
November 2006: Endocrinology
Marie Galvao, Jill Kalman, Teresa DeMarco, Gregg C Fonarow, Catherine Galvin, Jalal K Ghali, Robert M Moskowitz
BACKGROUND: The impact of gender differences has not been well described in patients hospitalized with acute decompensated heart failure (ADHF). METHODS AND RESULTS: Through review of medical records, data on characteristics, treatments, and outcomes were analyzed on 105,388 patient records according to gender. Women accounted for 52% of these admissions and were older than men (74.5 versus 70.1 years,) and more commonly had preserved left ventricular function (51% versus 28%)...
March 2006: Journal of Cardiac Failure
Roberta K Oka, Teresa DeMarco, William L Haskell
BACKGROUND: Self-efficacy is a person's confidence in being able to successfully perform a specific activity or behavior. Self-efficacy has been shown to influence exercise capacity in patients post myocardial infarction, but has not been fully explored in patients with heart failure (HF). This study examined the impact of performance of a single treadmill exercise test and participation in a 3-month program of walking and resistance exercise on self-efficacy in HF patients. METHODS: 24 patients were randomized to either a home-based walking and resistance exercise program or usual care for 3 months...
September 2005: European Journal of Cardiovascular Nursing
Jayant Nath, Teresa Demarco, Lisa Hourigan, Paul A Heidenreich, Elyse Foster
The aim of this study was to evaluate which parameter of right ventricular (RV) echocardiographic best mirrors the clinical status of patients with pulmonary arterial hypertension. Patients with pulmonary arterial hypertension on epoprostenol therapy were identified via hospital registry. Twenty patients, (16 females, 4 males) were included in the study, 9 with primary pulmonary hypertension and 11 with other diseases. Echocardiograms before therapy and at 22.7 (+/-9.3) months into therapy were compared. The right ventricular myocardial performance index (RVMPI) was measured as the sum of the isometric contraction time and the isometric relaxation time divided by right ventricular ejection time...
May 2005: Echocardiography
Michael J Mann, Elaine Tseng, Mark Ratcliffe, Greg Strattman, Anil De Silva, Teresa Demarco, Nancy Achorn, William Moskalik, Charles Hoopes
Heparin-induced thrombocytopenia (HIT) is an increasingly common clinical finding in patients presenting for cardiac transplantation. Bivalrudin, a reversible direct thrombin inhibitor, is a molecular anti-coagulant with short half-life and the potential for removal by intraoperative hemofiltration. Herein we describe the dosing and intraoperative management of bivalrudin anti-coagulation in a patient undergoing urgent cardiac transplantation in the context of recently diagnosed HIT.
February 2005: Journal of Heart and Lung Transplantation
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