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Stepan Boitsov, Bjørn Einar Grøsvik, Guri Nesje, Ketil Malde, Jarle Klungsøyr
Liver samples of two gadoid species, Atlantic cod (Gadus morhua) and haddock (Melanogrammus aeglefinus), sampled in the southern Barents Sea in the period 1992-2015, were studied for the levels of six types of persistent organic pollutants (POPs): polychlorinated biphenyls (PCBs), chlorinated organic pesticides (DDTs, hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), trans-nonachlor (TNC)), and polybrominated diphenyl ethers (PBDEs). Higher average levels were found in cod than in haddock. Sampling approximately every third year allowed studies of temporal trends for all the compound groups except PBDEs...
February 8, 2019: Environmental Research
Md Imran Khan, Tai Yuan, Ruey-Hwang Chou, Chin Yu
The Ca2+-dependent human S100A4 (Mts1) protein is part of the S100 family. Here, we studied the interactions of S100A4 with S100A1 using nuclear magnetic resonance (NMR) spectroscopy. We used the chemical shift perturbed residues from HSQC to model S100A4 and S100A1 complex with HADDOCK software. We observed that S100A1 and the RAGE V domain have an analogous binding area in S100A4. We discovered that S100A4 acts as an antagonist among the RAGE V domain and S100A1, which inhibits tumorigenesis and cell proliferation...
2019: PloS One
Gillian Haddock, Daniel Pratt, Patricia A Gooding, Sarah Peters, Richard Emsley, Emma Evans, James Kelly, Charlotte Huggett, Ailsa Munro, Kamelia Harris, Linda Davies, Yvonne Awenat
BACKGROUND: Suicidal behaviour is common in acute psychiatric wards resulting in distress, and burden for patients, carers and society. Although psychological therapies for suicidal behaviour are effective in out-patient settings, there is little research on their effectiveness for in-patients who are suicidal.AimsOur primary objective was to determine whether cognitive-behavioural suicide prevention therapy (CBSP) was feasible and acceptable, compared with treatment as usual (TAU) for in-patients who are suicidal...
January 2019: BJPsych Open
Ashley N Haddock, Sydney A Labuzan, Amy E Haynes, Caleb S Hayes, Karina M Kakareka, David S Waddell
Skeletal muscle atrophy results from disparate physiological conditions, including denervation, corticosteroid treatment, and aging. The purpose of this study was to describe and characterize the function of dual-specificity phosphatase 4 (Dusp4) in skeletal muscle after it was found to be induced in response to neurogenic atrophy. qPCR and Western blot analysis revealed that Dusp4 is expressed during myoblast proliferation, but rapidly disappears as muscle cells differentiate. The Dusp4 regulatory region was cloned and found to contain a conserved E-box element that negatively regulates Dusp4 reporter gene activity in response to myogenic regulatory factor expression...
February 13, 2019: American Journal of Physiology. Cell Physiology
Christophe V F P Laurent, Erik Breslmayr, Daniel Tunega, Roland Ludwig, Chris Oostenbrink
Lytic polysaccharide monooxygenases (LPMOs) are ubiquitous oxidoreductases, facilitating the degradation of polymeric carbohydrates in biomass. Cellobiose dehydrogenase (CDH) is a biologically relevant electron donor in this process, with the electrons resulting from cellobiose oxidation being shuttled from the CDH dehydrogenase domain to its cytochrome domain and then to the LPMO catalytic site. In the current work, we investigate the interaction of four Neurospora crassa LPMOs and five CDH cytochrome domains from different species using computational methods...
February 4, 2019: Biochemistry
Thomas M Suszynski, Nicholas T Haddock, Sumeet S Teotia
No abstract text is available yet for this article.
February 1, 2019: Plastic and Reconstructive Surgery
David M Routman, Aurelie Garant, Scott C Lester, Courtney N Day, William S Harmsen, Cristobal T Sanheuza, Harry H Yoon, Michelle A Neben-Wittich, James A Martenson, Michael G Haddock, Christopher L Hallemeier, Kenneth W Merrell
Purpose: Grade 4 lymphopenia (G4L) during radiation therapy (RT) is associated with higher rates of distant metastasis and decreased overall survival in a number of malignancies, including esophageal cancer (EC). Through a reduction in integral radiation dose, proton RT (PRT) may reduce G4L relative to photon RT (XRT). The purpose of this study was to compare G4L in patients with EC undergoing PRT versus XRT. Methods and materials: Patients receiving curative-intent RT and concurrent chemotherapy for EC were identified...
January 2019: Advances in Radiation Oncology
Lindsey M Weiler, Ashley A Boat, Shelley A Haddock
Because program experiences are more amendable than mentor or mentee characteristics, they may be important factors to consider in buffering the negative impact of youth risk on the quality of the mentor-mentee bond. Data from 455 mentees (ages 11-18; 57% male) and their undergraduate student mentors (82.3% female) from the Campus Connections mentoring program were used to assess whether youth risk and mentors' program experiences (i.e., program structure, supportive relationships with staff, opportunities for skill building, support for efficacy and mattering, and opportunities to belong) were associated with mentoring relationship quality and whether mentors' experience within the program moderated the association between youth risk and mentoring relationship quality...
January 29, 2019: American Journal of Community Psychology
Nicholas T Haddock, Sumeet S Teotia
No abstract text is available yet for this article.
February 2019: Plastic and Reconstructive Surgery
Emmie de Wit, Friederike Feldmann, Eva Horne, Atsushi Okumura, Elisabetta Cameroni, Elaine Haddock, Greg Saturday, Dana Scott, Robin Gopal, Maria Zambon, Davide Corti, Heinz Feldmann
Effective antiviral treatments for MERS-CoV are urgently needed. LCA60 is a MERS-CoV-neutralizing monoclonal antibody isolated from a convalescent MERS patient. Previously, it was shown that treatment with LCA60 resulted in reduced disease and virus titers in mouse models of MERS-CoV infection. Here, we tested the prophylactic efficacy of LCA60 in the common marmoset model of MERS-CoV infection. Intravenous administration of LCA60 one day before virus challenge resulted in high levels of MERS-CoV-neutralizing activity in circulating blood...
January 24, 2019: Antiviral Research
Satyavani Kaliamurthi, Gurudeeban Selvaraj, Sathishkumar Chinnasamy, Qiankun Wang, Asma Sindhoo Nangraj, William Cs Cho, Keren Gu, Dong-Qing Wei
The human papillomavirus (HPV) 58 is considered to be the second most predominant genotype in cervical cancer incidents in China. HPV type-restriction, non-targeted delivery, and the highcost of existing vaccines necessitate continuing research on the HPV vaccine. We aimed to explore the papillomaviral proteome in order to identify potential candidates for a chimeric vaccine against cervix papilloma using computational immunology and structural vaccinology approaches. Two overlapped epitope segments (23⁻36) and (29⁻42) from the N-terminal region of the HPV58 minor capsid protein L2 are selected as capable of inducing both cellular and humoral immunity...
January 15, 2019: Viruses
Hayley Lowe, Gillian Haddock, Lee D Mulligan, Lynsey Gregg, Annabel Fuzellier-Hart, Lesley-Anne Carter, Simon D Kyle
Insomnia is recognised as the most prevalent sleep disorder. Untreated insomnia carries a heavy burden for patients and society. Exercise is proposed as a safe, inexpensive, and accessible non-pharmacological treatment. To the author's knowledge this is the first systematic review to investigate the sleep-enhancing effects of exercise by focusing exclusively on controlled trials comprising poor sleepers only and examining interventions consistent with national guidelines. Using a narrative synthesis, this review aimed to identify whether exercise improves objective and subjective sleep outcomes for people with insomnia...
November 16, 2018: Clinical Psychology Review
Victor M Lu, Anshit Goyal, Mohammed Ali Alvi, Panagiotis Kerezoudis, Michael G Haddock, Mohamad Bydon
The incidence of extraosseous Ewing's sarcoma, a highly malignant mesenchymal mass, is rare in the spinal cord and its clinical outcomes unknown. To date, few cases of primary intradural extramedullary Ewing's sarcoma (PIEES) have been reported, with varying follow-up. Herein, we aimed to perform a comprehensive review of all cases published in the literature and update previously reported cases from our institution. Institutional medical records were searched for cases of PIEES of the spine managed at our institution between the years 2005 and 2018...
December 14, 2018: Clinical Neurology and Neurosurgery
Katharina Schütz, Diana Alecsandru, Bodo Grimbacher, Jamanda Haddock, Annemarie Bruining, Gertjan Driessen, Esther de Vries, Peter M van Hagen, Ieneke Hartmann, Francesco Fraioli, Cinzia Milito, Milica Mitrevski, Isabella Quinti, Goffredo Serra, Peter Kelleher, Michael Loebinger, Jiri Litzman, Vera Postranecka, Vojtech Thon, Judith Babar, Alison M Condliffe, Andrew Exley, Dinakantha Kumararatne, Nick Screaton, Alison Jones, Maria P Bondioni, Vassilios Lougaris, Alessandro Plebani, Annarosa Soresina, Cesare Sirignano, Giuseppe Spadaro, Nermeen Galal, Luis I Gonzalez-Granado, Sabine Dettmer, Robert Stirling, Helen Chapel, Mary Lucas, Smita Patel, Claire-Michele Farber, Isabelle Meyts, Arpan K Banerjee, Scott Hackett, John R Hurst, Klaus Warnatz, Benjamin Gathmann, Ulrich Baumann
Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency...
December 13, 2018: Journal of Clinical Immunology
Diana M Elizondo, Temesgen E Andargie, Naomi L Haddock, Ricardo L Louzada da Silva, Tatiana Rodrigues de Moura, Michael W Lipscomb
Allograft Inflammatory Factor-1 (AIF1) is a cytoplasmic scaffold protein that contains Ca2+ binding EF-hand and PDZ interaction domains important for mediating intracellular signaling complexes in immune cells. The protein plays a dominant role in both macrophage- and dendritic cell (DC)-mediated inflammatory responses. This study now reports that AIF1 expression in DC is important in directing CD8+ T cell effector responses. Silencing AIF1 expression in murine CD11c+ DC suppressed antigen-specific CD8+ T cell activation, marked by reduced CXCR3, IFNγ and Granzyme B expression, and restrained proliferation...
December 4, 2018: Journal of Leukocyte Biology
Katarina Elez, Alexandre M J J Bonvin, Anna Vangone
BACKGROUND: Study of macromolecular assemblies is fundamental to understand functions in cells. X-ray crystallography is the most common technique to solve their 3D structure at atomic resolution. In a crystal, however, both biologically-relevant interfaces and non-specific interfaces resulting from crystallographic packing are observed. Due to the complexity of the biological assemblies currently tackled, classifying those interfaces, i.e. distinguishing biological from crystal lattice interfaces, is not trivial and often prone to errors...
November 30, 2018: BMC Bioinformatics
Nicholas T Haddock, Sumeet T Teotia
No abstract text is available yet for this article.
December 2018: Plastic and Reconstructive Surgery
Jose L Garrido, Joseph Presscott, Mario Calvo, Felipe Bravo, Raymond Alvarez, Alexis Salas, Raul Riquelme, Maria L Rioseco, Brandi N Williamson, Elaine Haddock, Heinz Feldmann, Maria I Barria
Andes hantavirus (ANDV) is an etiologic agent of hantavirus cardiopulmonary syndrome (HCPS), a severe disease characterized by fever, headache, and gastrointestinal symptoms that may progress to hypotension, pulmonary failure, and cardiac shock that results in a 25 to 40% case-fatality rate. Currently, there is no specific treatment or vaccine; however, several studies have shown that the generation of neutralizing antibody (Ab) responses strongly correlates with survival from HCPS in humans. In this study, we screened 27 ANDV convalescent HCPS patient sera for their capacity to bind and neutralize ANDV in vitro...
November 21, 2018: Science Translational Medicine
Oleg Klykov, Barbara Steigenberger, Sibel Pektaş, Domenico Fasci, Albert J R Heck, Richard A Scheltema
Cross-linking mass spectrometry (XL-MS) has received considerable interest, owing to its potential to investigate protein-protein interactions (PPIs) in an unbiased fashion in complex protein mixtures. Recent developments have enabled the detection of thousands of PPIs from a single experiment. A unique strength of XL-MS, in comparison with other methods for determining PPIs, is that it provides direct spatial information for the detected interactions. This is accomplished by the use of bifunctional cross-linking molecules that link two amino acids in close proximity with a covalent bond...
December 2018: Nature Protocols
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