Clara Bosbach, Luisa Maria Gatzemeier, Katja Ilme Bloch von Blottnitz, Annekatrin König, Ulf Diederichsen, Claudia Steinem, Tiago Fleming Outeiro
Advanced glycation end products (AGEs) arise from the Maillard reaction between dicarbonyls and proteins, nucleic acids, or specific lipids. Notably, AGEs are linked to aging and implicated in various disorders, spanning from cancer to neurodegenerative diseases. While dicarbonyls like methylglyoxal preferentially target arginine residues, lysine-derived AGEs, such as N (6)-(1-carboxymethyl)lysine (CML) and N (6)-(1-carboxyethyl)lysine (CEL), are also abundant. Predicting protein glycation in vivo proves challenging due to the intricate nature of glycation reactions...
March 14, 2024: Organic & Biomolecular Chemistry