keyword
https://read.qxmd.com/read/38535218/importance-of-the-aspergillus-fumigatus-mismatch-repair-protein-msh6-in-antifungal-resistance-development
#1
JOURNAL ARTICLE
Jose Lucio, Irene Gonzalez-Jimenez, Alejandra Roldan, Jorge Amich, Laura Alcazar-Fuoli, Emilia Mellado
One of the systems responsible for the recognition and repair of mistakes occurring during cell replication is the DNA mismatch repair (MMR) system. Two major protein complexes constitute the MMR pathway: MutS and MutL. Here, we investigated the possible relation of four A. fumigatus MMR genes ( msh 2, msh 6, pms 1, and mlh 1) with the development of azole resistance related to the phenomenon of multi-drug resistance. We examined the MMR gene variations in 163 Aspergillus fumigatus genomes. Our analysis showed that genes msh 2, pms 1, and mlh 1 have low genetic variability and do not seem to correlate with drug resistance...
March 12, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38532150/exploring-the-combined-anti-cancer-effects-of-sodium-butyrate-and-celastrol-in-glioblastoma-cell-lines-a-novel-therapeutic-approach
#2
JOURNAL ARTICLE
Bahar Kartal, Farika Nur Denizler-Ebiri, Mustafa Güven, Filiz Taşpınar, Hande Canpınar, Sedat Çetin, Tuğçe Karaduman, Serkan Küççüktürk, Javier Castresana, Mehmet Taşpınar
Glioblastoma, a highly aggressive and lethal brain cancer, lacks effective treatment options and has a poor prognosis. In our study, we explored the potential anti-cancer effects of sodium butyrate (SB) and celastrol (CEL) in two glioblastoma cell lines. SB, a histone deacetylase inhibitor, and CEL, derived from the tripterygium wilfordii plant, act as mTOR and proteasome inhibitors. Both can cross the blood-brain barrier, and they exhibit chemo- and radiosensitive properties in various cancer models. GB cell lines LN-405 and T98G were treated with SB and CEL...
March 26, 2024: Medical Oncology
https://read.qxmd.com/read/38301222/effect-of-fungicide-and-timing-of-application-on-management-of-phoma-black-stem-of-cultivated-sunflowers-in-the-united-states
#3
JOURNAL ARTICLE
Bryan Hansen, Michelle A Gilley, Brandt G Berghuis, Jessica Halvorson, Andrew J Friskop, Blaine G Schatz, Herman Kandel, Scott Fitterer, David Carruth, Febina Merlin Mathew, Samuel G Markell
Phoma black stem (PBS), caused by Phoma macdonaldii Boerema (teleomorph Leptosphaeria lindquistii Frezzi), is the most common stem disease of sunflower ( Helianthus annuus L.) in the Northern Great Plains (NGP) region of the United States (US). However, the impact of PBS on sunflower yield in the US is unclear, and a near complete absence of information on the impact of fungicides on disease management exists. The objectives of this study were to determine the impact of PBS on sunflower yield, the efficacy of available fungicides, the optimal fungicide application timing, and the economic viability of fungicides as a management tool...
February 1, 2024: Plant Disease
https://read.qxmd.com/read/38279425/next-generation-sequencing-and-immunohistochemistry-approaches-for-microsatellite-instability-detection-in-endometrial-cancer
#4
JOURNAL ARTICLE
Azhin Saber Ali, Lana Sardar Alalem
The purpose was to determine the effectiveness of immunohistochemical observation, a quick and easy method for determining Microsatellite instability MSI and/or other types of endometrial cancer (EC) based on modern classification. As molecular study takes more cost we want to compare both methods and show the possibility of doing IHC instead of molecular study. This study was designed to establish a small gene panel of Next Generation Sequencing (NGS) of endometrial cancer patients targeting 4 mismatch repair genes; MSH6, MSH2, MLH1 and PMS2...
December 20, 2023: Cellular and Molecular Biology
https://read.qxmd.com/read/38110279/-analysis-of-clinicopathological-features-and-prognosis-of-sporadic-synchronous-multiple-primary-colorectal-cancers
#5
JOURNAL ARTICLE
Z F Qin, G H Xu, S Q Zhou, P W Zheng, Y P Zhu, H X Ju, D C Li, D N Ma
Objective: To investigate the impact of relative locations of multiple foci and microsatellite status of sporadic, synchronous, multiple, primary, colorectal carcinomas on clinicopathological features and prognosis. Methods: The clinicopathologic and prognostic data of 278 patients with sporadic, synchronous, multiple, primary, colorectal carcinomas who had been admitted to the Department of Colorectal Surgery at Zhejiang Cancer Hospital from January 2008 to July 2022 were retrospectively collected. The patients were categorized into three groups based on the relative locations of their multiple cancer foci: (1) a right-sided group that comprised patients with multiple cancer foci in the cecum, ascending colon, hepatic flexure of the colon, and transverse colon; (2) a left-sided group that comprised patients with multiple cancer foci in the splenic flexure of the colon, descending colon, sigmoid colon, and rectum; and (3) a left- and right-sided group that comprised patients with multiple cancer foci in the right half of the colon and left half of the colon/rectum...
December 25, 2023: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38075831/cerium-doped-cufe-layered-catalyst-for-the-enhanced-oxidation-of-o-xylene-and-n-n-dimethylacetamide-insights-into-the-effects-of-temperature-and-space-velocity
#6
JOURNAL ARTICLE
Zehra Betul Ocal, Ramazan Keyikoglu, Ahmet Karagunduz, Yeojoon Yoon, Alireza Khataee
Volatile organic compounds (VOCs) are among the most potential pollutant groups that cause air quality degradation because of their toxic effects on human health. Although catalytic oxidation is an effective method for VOC removal, further studies are required to develop more efficient and affordable catalysts. In this study, cerium (Ce) was doped into a CuFe-layered material (Ce-CuFe) to improve the catalytic oxidation efficiencies of N , N -dimethylacetamide (DMAC) and o -xylene. The synthesized catalyst was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDS), Fourier-transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS) analysis...
December 5, 2023: ACS Omega
https://read.qxmd.com/read/38029026/expression-of-programmed-cell-death-ligand-1-and-mismatch-repair-status-in-endometrial-carcinomas
#7
JOURNAL ARTICLE
Madhubala Rajendran, Meenakshi Rao, Poonam Abhay Elhence, Jyotsna Naresh Bharti, Pratibha Singh, Garima Yadav, Aasma Nalwa, Akhil Dhanesh Goyal
BACKGROUND AND AIMS: Programmed death ligand-1 (PD-L1) is a co-regulatory molecule that suppresses local immunity, and mismatch repair (MMR) deficiency (dMMR) is reported to influence the response to anti-PD-L1-targeted therapy. This study was conducted to find the PD-L1 status, the occurrence of dMMR in endometrial carcinomas, and the association between them. MATERIALS AND METHODS: The study included 35 resected specimens of endometrial carcinomas represented on formalin-fixed paraffin-embedded sections from January 2016 to July 2020...
2023: Journal of Mid-life Health
https://read.qxmd.com/read/37884712/properties-of-the-mixing-layer-height-retrieved-from-ceilometer-measurements-in-slovakia-and-its-relationship-to-the-air-pollutant-concentrations
#8
JOURNAL ARTICLE
Duy-Hieu Nguyen, Dušan Štefánik, Tereza Šedivá, Chitsan Lin
Mixing layer height (MLH) is an important meteorological parameter for air quality since it significantly affects ground-level pollution in the atmosphere. This study examined the properties of the MLH on diurnal and seasonal timescales over a 3-year period (2020-2022) using high temporal resolution measurements from eight Vaisala CL31 ceilometers situated around Slovakia. Hourly averaged MLH data was retrieved from the BL-View software using merged method. The highest daily maxima for the MLH occurred mostly in summer and spring, while the lowest values occurred predominantly during winter and autumn...
October 26, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/37868939/estimating-the-dose-response-relationship-for-ocular-pain-after-radiotherapy-of-head-and-neck-cancers-and-skull-base-tumors-based-on-the-lkb-radiobiological-model
#9
JOURNAL ARTICLE
Nastaran Momeni, Mohammad Ali Broomand, Zahra Roozmand, Nima Hamzian
BACKGROUND: Radiotherapy is considered a compromise between the amount of killed tumor cells and the damage caused to the healthy tissue. Regarding this, radiobiological modeling is performed to individualize and optimize treatment strategies. OBJECTIVE: This study aimed to determine the normal tissue complication probability (NTCP) of acute ocular pain following radiotherapy. MATERIAL AND METHODS: In this prospective observational study, the clinical data were collected from 45 patients with head and neck cancers and skull-base tumors, and dosimetric data were recorded after contouring the eye globe...
October 2023: Journal of Biomedical Physics & Engineering
https://read.qxmd.com/read/37699372/mismatch-repair-deficiency-in-biliary-tract-cancer-prognostic-implications-and-correlation-with-histology
#10
JOURNAL ARTICLE
Caterina Vivaldi, Virginia Genovesi, Clara Ugolini, Laura Bernardini, Andrea Casadei-Gardini, Vincenzo Formica, Francesca Salani, Giulia Orsi, Valentina Massa, Andrea Cacciato-Insilla, Miriam Caccese, Silvia Cesario, Kalliopi Andrikou, Jessica Graziani, Daniela Campani, Enrico Vasile, Gabriella Fontanini, Lorenzo Fornaro, Gianluca Masi
INTRODUCTION: Mismatch repair (MMR) deficiency represents a biomarker and therapeutic target in various neoplasms, but its role in biliary tract cancers (BTCs) remains misunderstood. METHODS: MMR status was retrospectively assessed using immunohistochemistry in 163-BTCs patients. We identified MMR proficiency (pMMR)/deficiency (dMMR) according to the loss of MMR proteins (MLH-1, PMS-2, MSH-2, MSH-6). The primary objective of the study was to assess the incidence of dMMR in BTCs; the secondary purpose was to explore its association with prognosis and clinical features...
September 12, 2023: Oncology
https://read.qxmd.com/read/37616604/a-healthcare-system-looks-within-to-improve-outcomes
#11
JOURNAL ARTICLE
Monica Wharton, Paula Jacobs
Healthcare organizations are facing exponential growth in change-not just to compete, but to survive. Amid the widening gap between expenses and reimbursements, hospitals must manage the adoption of expensive advanced technologies, continuous synthesis of emerging clinical knowledge, intensive regulatory readiness, and public ranking of quality outcomes. And they must handle all this as patient expectations grow. At Methodist Le Bonheur Healthcare (MLH), we have approached these challenges by nurturing an organizational mindset of transformational innovation...
October 2023: Frontiers of Health Services Management
https://read.qxmd.com/read/37590371/macrocyclic-1-2-hydroxypyridinone-based-chelators-as-potential-ligands-for-thorium-227-and-zirconium-89-radiopharmaceuticals
#12
JOURNAL ARTICLE
Joshua J Woods, Alexia G Cosby, Jennifer N Wacker, Luis M Aguirre Quintana, Appie Peterson, Stefan G Minasian, Rebecca J Abergel
Thorium-227 (227 Th) is an α-emitting radionuclide that has shown preclinical and clinical promise for use in targeted α-therapy (TAT), a type of molecular radiopharmaceutical treatment that harnesses high energy α particles to eradicate cancerous lesions. Despite these initial successes, there still exists a need for bifunctional chelators that can stably bind thorium in vivo. Toward this goal, we have prepared two macrocyclic chelators bearing 1,2-hydroxypyridinone groups. Both chelators can be synthesized in less than six steps from readily available starting materials, which is an advantage over currently available platforms...
August 17, 2023: Inorganic Chemistry
https://read.qxmd.com/read/37552166/population-structure-and-reproductive-biology-of-monilinia-vaccinii-corymbosi-in-vaccinium-angustifolium-in-maine
#13
JOURNAL ARTICLE
Katherine A Ashley, Seanna Annis
The fungus Monilinia vaccinii-corymbosi (Mvc) causes mummy berry disease in blueberries including lowbush blueberry, Vaccinium angustifolium , and is a significant pathogen of concern for Maine lowbush blueberry growers. This disease is typically managed with fungicides or by burning of plant debris containing overwintering pseudosclerotia. The population structure of Mvc in various fields in Maine was investigated using microsatellites and isolates collected from three stages in the Mvc lifecycle. The impacts of management strategies were also examined...
August 8, 2023: Plant Disease
https://read.qxmd.com/read/37545840/case-report-laparoscopic-nissen-sleeve-gastrectomy-in-a-young-adult-with-incidental-finding-of-morgagni-larrey-hernia
#14
Rossella Palma, Francesco Angrisani, Antonella Santonicola, Paola Iovino, Vittorio Maria Ormando, Roberta Maselli, Luigi Angrisani
Laparoscopic sleeve Gastrectomy (LSG) is the most performed bariatric procedure worldwide but it is associated with an increased incidence of de-novo or recurrent GERD. Recently a new technique consisting in LSG with associated fundoplication has been described. Morgagni-Larrey hernia is very rare and there is a lack of evidences on its correct surgical treatment. There are only rare cases of a MLH incidental diagnosis in patients submitted to bariatric surgery. We present our experience of Morgagni-Larrey Hernia (MLH) incidentally found intraoperatively in a patient with Gastroesophageal Reflux Disease (GERD) with Hiatal Hernia (HH) undergoing a bariatric surgical procedure...
2023: Frontiers in Surgery
https://read.qxmd.com/read/37516770/externally-validated-deep-learning-model-to-identify-prodromal-parkinson-s-disease-from-electrocardiogram
#15
JOURNAL ARTICLE
Ibrahim Karabayir, Fatma Gunturkun, Liam Butler, Samuel M Goldman, Rishikesan Kamaleswaran, Robert L Davis, Kalea Colletta, Lokesh Chinthala, John L Jefferies, Kathleen Bobay, G Webster Ross, Helen Petrovitch, Kamal Masaki, Caroline M Tanner, Oguz Akbilgic
Little is known about electrocardiogram (ECG) markers of Parkinson's disease (PD) during the prodromal stage. The aim of the study was to build a generalizable ECG-based fully automatic artificial intelligence (AI) model to predict PD risk during the prodromal stage, up to 5 years before disease diagnosis. This case-control study included samples from Loyola University Chicago (LUC) and University of Tennessee-Methodist Le Bonheur Healthcare (MLH). Cases and controls were matched according to specific characteristics (date, age, sex and race)...
July 29, 2023: Scientific Reports
https://read.qxmd.com/read/37492990/the-quest-for-good-genes-epigamic-traits-fitness-mhc-and-multilocus-heterozygosity-in-the-guppy
#16
JOURNAL ARTICLE
Karolina Przesmycka, Magdalena Herdegen-Radwan, Karl P Phillips, Ryan S Mohammed, Jacek Radwan
The 'good genes' hypothesis for the evolution of male secondary sexual traits poses that female preferences for such traits are driven by indirect genetic benefits. However, support for the hypothesis remains ambiguous, and, in particular, the genetic basis for the benefits has rarely been investigated. Here, we use seminatural populations of Trinidadian guppies to investigate whether sexually selected traits (orange, black and iridescent colouration, gonopodium length and body size) predict fitness measured as the number of grandoffspring, a metric that integrates across fitness components and sexes...
July 26, 2023: Molecular Ecology
https://read.qxmd.com/read/37427855/multi-locus-homozygosity-promotes-actuarial-senescence-in-a-wild-mammal
#17
JOURNAL ARTICLE
Dave W Hudson, Trevelyan J McKinley, Clare H Benton, Richard Delahay, Robbie A McDonald, Dave J Hodgson
Genome-wide homozygosity, caused for example by inbreeding, is expected to have deleterious effects on survival and/or reproduction. Evolutionary theory predicts that any fitness costs are likely to be detected in late life because natural selection will filter out negative impacts on younger individuals with greater reproductive value. Here we infer associations between multi-locus homozygosity (MLH), sex, disease and age-dependent mortality risks using Bayesian analysis of the life histories of wild European badgers Meles meles in a population naturally infected with Mycobacterium bovis (the causative agent of bovine tuberculosis [bTB])...
July 10, 2023: Journal of Animal Ecology
https://read.qxmd.com/read/37403006/the-antagonistic-effects-of-temozolomide-and-trichostatin-a-combination-on-mgmt-and-dna-mismatch-repair-pathways-in-glioblastoma
#18
JOURNAL ARTICLE
Mustafa Güven, Filiz Taşpınar, Farika Nur Denizler-Ebiri, Javier S Castresana, Mehmet Taşpınar
Glioblastoma is the most aggressive and fatal form of brain cancer. Despite new advancements in treatment, the desired outcomes have not been achieved. Temozolomide (TMZ) is the first-choice treatment for the last two decades and has improved survival rates. Emerging studies have shown that targeting epigenetics in glioblastoma can be beneficial when combined with clinically used treatments. Trichostatin A (TSA), a histone deacetylase inhibitor, has anti-cancer properties in various cancers. No data concerning the TMZ and TSA relationship was shown previously in glioblastoma therefore, we aimed to determine the likely therapeutic effect of the TMZ and TSA combination in glioblastoma...
July 5, 2023: Medical Oncology
https://read.qxmd.com/read/37182172/locally-advanced-rectal-cancer-patients-with-mismatch-repair-protein-deficiency-can-obtain-better-pathological-response-after-regional-chemoembolization
#19
JOURNAL ARTICLE
Yuchen Gao, Hualiang Xiao, Wenjun Meng, Juan Liao, Qi Chen, Guowei Zhao, Chunxue Li, Lian Bai
BACKGROUND AND OBJECTIVE: Preoperative transcatheter rectal arterial chemoembolization (TRACE) can enhance the pathological response rate in some patients with locally advanced rectal cancer (LARC). However, how to accurately identify patients who can benefit from this neoadjuvant modality therapy remains to be further studied. Deficient mismatch repair (dMMR) protein plays a crucial role in maintaining genome stability. A proportion of patients with rectal cancer are caused by the loss of mismatch repair (MMR) protein...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37133528/modelling-of-land-use-land-cover-changes-using-machine-learning-and-gis-techniques-a-case-study-in-el-fayoum-governorate-egypt
#20
JOURNAL ARTICLE
Islam Atef, Wael Ahmed, Ramadan H Abdel-Maguid
Land use/land cover (LULC) changes can occur naturally or due to human activities. In this study, the maximum likelihood algorithm (MLH) and machine learning (random forest algorithm (RF) and support vector machine (SVM)) were investigated for image classification to oversight spatio-temporal land use changes in El-Fayoum governorate, Egypt. The Google Earth Engine has been utilized to pre-process the Landsat imagery, and then upload it for classification. Each classification method was evaluated using field observations and high-resolution Google Earth imagery...
May 3, 2023: Environmental Monitoring and Assessment
keyword
keyword
171231
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.