Caterina Vivaldi, Virginia Genovesi, Clara Ugolini, Laura Bernardini, Andrea Casadei-Gardini, Vincenzo Formica, Francesca Salani, Giulia Orsi, Valentina Massa, Andrea Cacciato-Insilla, Miriam Caccese, Silvia Cesario, Kalliopi Andrikou, Jessica Graziani, Daniela Campani, Enrico Vasile, Gabriella Fontanini, Lorenzo Fornaro, Gianluca Masi
INTRODUCTION: Mismatch repair (MMR) deficiency represents a biomarker and therapeutic target in various neoplasms, but its role in biliary tract cancers (BTCs) remains misunderstood. METHODS: MMR status was retrospectively assessed using immunohistochemistry in 163-BTCs patients. We identified MMR proficiency (pMMR)/deficiency (dMMR) according to the loss of MMR proteins (MLH-1, PMS-2, MSH-2, MSH-6). The primary objective of the study was to assess the incidence of dMMR in BTCs; the secondary purpose was to explore its association with prognosis and clinical features...
September 12, 2023: Oncology