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Genme Editing

Florian Thibord, Claire Perret, Maguelonne Roux, Pierre Suchon, Marine Germain, Jean-Fran├žois Deleuze, Pierre-Emmanuel Morange, David-Alexandre Tregouet
Next-generation sequencing is an increasingly popular and efficient approach to characterize the full set of microRNAs (miRNAs) present in human biosamples. MiRNAs' detection and quantification still remain a challenge as they can undergo different post transcriptional modifications and might harbor genetic variations (polymiRs) that may impact on the alignment step. We present a novel algorithm, OPTIMIR, that incorporates biological knowledge on miRNA editing and genome-wide genotype data available in the processed samples to improve alignment accuracy...
February 28, 2019: RNA
Samantha L Ginn, Anais K Amaya, Ian E Alexander, Michael Edelstein, Mohammad R Abedi
To date, almost 2600 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. Our database brings together global information on gene therapy clinical activity from trial databases, official agency sources, published literature, conference presentations and posters kindly provided to us by individual investigators or trial sponsors. This review presents our analysis of clinical trials that, to the best of our knowledge, have been or are being performed worldwide. As of our November 2017 update, we have entries on 2597 trials undertaken in 38 countries...
May 2018: Journal of Gene Medicine
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