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https://read.qxmd.com/read/30784189/polylactic-co-glycolic-acid-microspheres-added-to-fixative-cements-and-its-role-on-bone-infected-architecture
#1
Blanca Ibarra, Joaquin García-García, Galo Azuara, Blanca Vázquez-Lasa, Miguel A Ortega, Ángel Asúnsolo, Julio San Román, Julia Buján, Natalio García-Honduvilla, Basilio De la Torre
Joint prostheses are an essential element to improve quality of life. However, prostheses may fail due to several factors, including the most frequent cause, Staphylococcus aureus infection. The identification of new fixing bone cements with less reactivity on bone tissue and an adequate response to infection remains a primary challenge. The aim of this study is to evaluate the response of bone tissue in rabbits after introduction of a hydroxyapatite-coated titanium rod with a commercial fixative cement (Palacos®) compared to a modified experimental cement (EC) containing polylactic-co-glycolic acid (PLGA) microspheres in the presence or absence of contaminating germs...
February 19, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30783530/a-case-of-staphylococcus-lugdunensis-bacteremia-complicated-by-reactive-arthritis
#2
Daria Gaut, Kyle Muir, Antonio M Pessegueiro
Reactive arthritis has been described infrequently in association with staphylococcal infections, both those secondary to Staphylococcus aureus and coagulase-negative staphylococci. We present a case of a 51-year-old male undergoing chemotherapy for pancreatic cancer who presented with joint pain and fevers and was found to have Staphylococcus lugdunensis bacteremia. Transthoracic and transesophageal echocardiograms were negative for endocarditis. Arthrocentesis from one large joint revealed culture-negative inflammatory synovitis...
2019: SAGE Open Medical Case Reports
https://read.qxmd.com/read/30778724/high-incidence-of-early-periprosthetic-joint-infection-following-total-hip-arthroplasty-with-concomitant-or-previous-hardware-removal
#3
Ruben Scholten, Wout Füssenich, Matthijs P Somford, Job L C van Susante
INTRODUCTION: Hardware removal preceding total hip arthroplasty may increase the risk of prosthetic joint infection (PJI). Whether hardware removal and total hip arthroplasty (THA) should be performed in a single- or two-stage procedure remains controversial. In this comparative retrospective study, the incidence of PJI following either single- or two-stage THA with hardware removal was assessed in a consecutive series. PATIENTS AND METHODS: All patients that underwent THA preceded by hardware removal from January 2006 until March 2018 were retrospectively reviewed and checked for the occurrence of early PJI...
February 18, 2019: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/30778552/silver-nanoparticles-present-high-intracellular-and-extracellular-killing-against-staphylococcus-aureus
#4
Jason Kang, Matthew J Dietz, Krystal Hughes, Malcolm Xing, Bingyun Li
OBJECTIVES: Bone and joint infections caused by Staphylococcus aureus are becoming increasingly difficult to treat due to rising antibiotic resistance, resilient biofilms and intracellular survival of S. aureus. It has been challenging to identify and develop antimicrobial agents that can be used to kill extracellular and intracellular bacteria while having limited toxicity towards host cells. In addressing this challenge, this study investigates the antimicrobial efficacy and toxicity of silver nanoparticles (AgNPs)...
February 18, 2019: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/30777196/shoulder-osteoarthritis-in-a-european-saber-toothed-cat-homotherium-latidens-from-the-lower-palaeolithic-site-of-sch%C3%A3-ningen-germany
#5
Luc A A Janssens, Ivo K A Verheijen, Jordi Serangeli, Thijs van Kolfschoten
Evaluation of a right ventral scapula fragment from a mature Homotherium latidens from Schöningen, Germany (337-300 ka before present - MIS 9) revealed lesions consisting of an osteophyte at the caudal border of the glenoid cavity, and a large, multilobular, cystic feature in the medio-caudal glenoid cavity. Based on the type of lesions, their localization, their severity, and exclusion of several nutritional and other etiologies such as immune mediated disease, joint infection (septic arthritis), and joint tumors, we conclude that the lesion was caused by trauma or age-related shoulder osteoarthritis (or possibly both)...
March 2019: International Journal of Paleopathology
https://read.qxmd.com/read/30774531/validity-and-reliability-of-the-manchester-scale-used-in-the-orthopedic-emergency-department
#6
Fernando Brandão Andrade-Silva, Renan Lyuji Takemura, Renato Tavares Bellato, Marcos de Camargo Leonhardt, Kodi Edson Kojima, Jorge Dos Santos Silva
Objectives: To describe the clinical utility of the Manchester triage scale adapted for orthopedic emergency departments and to evaluate its validity in identifying patients with the need for hospital care and its reliability when reproduced by different professionals. Methods: Five triage flowcharts were developed based on the Manchester scale for the following orthopedic disorders: traumatic injuries, joint pain, vertebral pain, postoperative disorders, and musculoskeletal infections...
January 2019: Acta Ortopedica Brasileira
https://read.qxmd.com/read/30774255/-mycoplasma-bovis-arthritis-and-pneumonia-in-calves-in-jordan-an-emerging-disease
#7
Wael M Hananeh, Waleed M Al Momani, Mustafa M Ababneh, Sameeh M Abutarbush
Aim: Clinical, microbiological, molecular, and pathological assays were undertaken to characterize an outbreak of increasingly reported signs of unresponsive arthritis and pneumonia of Mycoplasma bovis infection in young calves in Jordan. Materials and Methods: Clinical history of the affected bovine herd was investigated for the presence of respiratory and/or joint problems. Two calves with such history were clinically examined and necropsied. Representative tissues were sent for microbiological, molecular, and pathological examinations for M...
December 2018: Veterinary World
https://read.qxmd.com/read/30772469/antibiotic-penetration-into-bone-and-joints-an-updated-review
#8
REVIEW
Abrar K Thabit, Dania F Fatani, Maryam S Bamakhrama, Ola A Barnawi, Lana O Basudan, Shahad F Alhejaili
Treatment of bone and joint infections can be challenging as antibiotics should penetrate through the rigid bone structure and into the synovial space. Several pharmacokinetic studies measured the extent of penetration of different antibiotics into bone and joint tissues. This review discusses the results of these studies and compares them with minimum inhibitory concentrations (MIC) of common pathogens implicated in bone and joint infections in order to determine which antibiotics may have a greater potential in the treatment of such infections...
February 14, 2019: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/30772001/abatacept-initiation-in-rheumatoid-arthritis-and-the-risk-of-serious-infection-a-population-based-cohort-study
#9
François Montastruc, Christel Renoux, Marie Hudson, Sophie Dell'Aniello, Teresa A Simon, Samy Suissa
OBJECTIVE: To assess whether abatacept as initial biologic disease-modifying antirheumatic drug (DMARD) in the treatment of rheumatoid arthritis is associated with an increased risk of serious infections, including bone and joint, gastrointestinal, respiratory tract, skin and soft tissue, and urinary tract, when compared with other biologic DMARDs. METHODS: We performed a population-based cohort study among patients newly-treated with biologic DMARDs within the US-based Truven MarketScan® population and Supplemental US Medicare from 2007 to 2014...
January 25, 2019: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/30769135/in-vitro-testing-of-a-first-in-class-tri-alkylnorspermidine-biaryl-antibiotic-in-an-anti-biofilm-silicone-coating
#10
Nicholas N Ashton, Gina Allyn, Scott T Porter, Travis J Haussener, Paul R Sebahar, Ryan E Looper, Dustin L Williams
Biofilm-related infection is among the worst complication to prosthetic joint replacement procedures; once established on the implant surface, biofilms show strong recalcitrance to clinical antibiotic therapy, frequently requiring costly revision procedures and prolonged systemic antibiotics for their removal. A well-designed active release coating might assist host immunity in clearing bacterial contaminants within the narrow perioperative window and ultimately prevent microbial colonization of the joint prosthesis...
February 12, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30768655/antibody-responses-to-plasmodium-vivax-duffy-binding-and-erythrocyte-binding-proteins-predict-risk-of-infection-and-are-associated-with-protection-from-clinical-malaria
#11
Wen-Qiang He, Ahmad Rushdi Shakri, Rukmini Bhardwaj, Camila T França, Danielle I Stanisic, Julie Healer, Benson Kiniboro, Leanne J Robinson, Micheline Guillotte-Blisnick, Christèle Huon, Peter Siba, Alan Cowman, Christopher L King, Wai-Hong Tham, Chetan E Chitnis, Ivo Mueller
BACKGROUND: The Plasmodium vivax Duffy Binding Protein (PvDBP) is a key target of naturally acquired immunity. However, region II of PvDBP, which contains the receptor-binding site, is highly polymorphic. The natural acquisition of antibodies to different variants of PvDBP region II (PvDBPII), including the AH, O, P and Sal1 alleles, the central region III-V (PvDBPIII-V), and P. vivax Erythrocyte Binding Protein region II (PvEBPII) and their associations with risk of clinical P. vivax malaria are not well understood...
February 15, 2019: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/30768581/retained-foreign-objects-in-casts-in-children
#12
Gloria Hui Min Cheng, Claris Jia-Yi Shi, Beatrice Jia Ying Lee, Kevin Boon Leong Lim
Cast immobilization is a noninvasive and effective option in the treatment of fractures in children. However, its use can be associated with complications, such as pressure sores, skin infections, thermal injuries, and joint stiffness. In clinical practice, retained foreign objects in casts are not uncommon. This study aims to ascertain reasons for foreign objects being retained in casts and their effects on the skin. Eighteen children with retained foreign objects in their casts were identified and interviewed...
February 12, 2019: Journal of Pediatric Orthopedics. Part B
https://read.qxmd.com/read/30765287/management-of-patients-presenting-with-generalized-musculoskeletal-pain-and-a-suspicion-of-lyme-disease
#13
REVIEW
S Ranque-Garnier, C Eldin, C Sault, D Raoult, A Donnet
Lyme disease is caused by bacteria of the B. burgdorferi sensu lato complex, and can give polymorphic clinical manifestations that can affect several organs such as the skin, the central nervous system, or the joints. In recent years, patients' associations and physicians have been supporting the hypothesis that this infection would manifest as chronic generalized musculoskeletal pain symptoms, named "chronic Lyme disease". Fibromyalgia is a clinical presentation characterized by chronic generalized musculoskeletal pain with a major impact on quality of life and social and psychological functioning...
February 11, 2019: Médecine et Maladies Infectieuses
https://read.qxmd.com/read/30765230/the-lawrence-d-dorr-surgical-techniques-and-technologies-award-why-are-contemporary-revision-total-hip-arthroplasties-failing-an-analysis-of-2500-cases
#14
Ashton H Goldman, Rafael J Sierra, Robert T Trousdale, David G Lewallen, Daniel J Berry, Matthew P Abdel
BACKGROUND: As revision implants and techniques have evolved and improved, understanding why contemporary revision total hip arthroplasties (THAs) fail is important to direct further improvement and innovation. As such, the goals of this study are to determine the implant survivorship of contemporary revision THAs, as well as the most common indications for re-revision. METHODS: We retrospectively reviewed 2589 aseptic revision THAs completed at our academic institution between 2005 and 2015 through our total joint registry...
January 23, 2019: Journal of Arthroplasty
https://read.qxmd.com/read/30765229/longer-operative-time-results-in-a-higher-rate-of-subsequent-periprosthetic-joint-infection-in-patients-undergoing-primary-joint-arthroplasty
#15
Qiaojie Wang, Karan Goswami, Noam Shohat, Arash Aalirezaie, Jorge Manrique, Javad Parvizi
BACKGROUND: Whether prolonged operative time is an independent risk factor for subsequent surgical site infection (SSI) and periprosthetic joint infection (PJI) following total joint arthroplasty (TJA) remains a clinically significant and underexplored issue. The aim of this study is to investigate the association between operative time and the risk of subsequent SSI and PJI in patients undergoing primary TJA. METHODS: We retrospectively reviewed 17,342 primary unilateral total knee arthroplasty and total hip arthroplasty performed at a single institution between 2005 and 2016, with a minimum follow-up of 1 year...
January 18, 2019: Journal of Arthroplasty
https://read.qxmd.com/read/30764840/calm-in-the-midst-of-cytokine-storm-a-collaborative-approach-to-the-diagnosis-and-treatment-of-hemophagocytic-lymphohistiocytosis-and-macrophage-activation-syndrome
#16
Olha Halyabar, Margaret H Chang, Michelle L Schoettler, Marc A Schwartz, Ezgi H Baris, Leslie A Benson, Catherine M Biggs, Mark Gorman, Leslie Lehmann, Mindy S Lo, Peter A Nigrovic, Craig D Platt, Gregory P Priebe, Jared Rowe, Robert P Sundel, Neeraj K Surana, Katja G Weinacht, Alison Mann, Jenny Chan Yuen, Patricia Meleedy-Rey, Amy Starmer, Taruna Banerjee, Fatma Dedeoglu, Barbara A Degar, Melissa M Hazen, Lauren A Henderson
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HLH/MAS independently, is needed. We leveraged quality improvement (QI) techniques in the form of an Evidence-Based Guideline (EBG) to build consensus across disciplines on the diagnosis and treatment of HLH/MAS...
February 14, 2019: Pediatric Rheumatology Online Journal
https://read.qxmd.com/read/30763047/acute-hand-infections
#17
Caitlyn M Rerucha, John T Ewing, Kathryn E Oppenlander, Wesley Charles Cowan
Acute hand infections are often caused by puncture wounds and are generally classified into superficial or deep infections. Superficial infections occur in the skin and subcutaneous tissues, whereas deep infections can involve the tendon sheaths, adjacent anatomic compartments, deep fascial planes, bursae, joint spaces, and bones. Superficial hand infections are more common than deep infections and are typically managed with elevation, warm soaks, splinting in the position of function, analgesics, and empiric antibiotics when indicated...
February 15, 2019: American Family Physician
https://read.qxmd.com/read/30762801/a-novel-computer-navigation-method-for-accurate-percutaneous-sacroiliac-screw-implantation-a-technical-note-and-literature-review
#18
Tong Yu, Shuang Zheng, Xiwen Zhang, Dongsheng Wang, Mingyang Kang, Rongpeng Dong, Yang Qu, Jianwu Zhao
The purpose of this study was to assess the accuracy of percutaneous sacroiliac screw (PSS) placement assisted by screw view model of navigation system for treatment of sacroiliac fractures.Data pertaining to 18 consecutive patients with posterior pelvic ring fracture who received sacroiliac screw fixation between January 2015 and July 2018 at the Second Hospital of Jilin University were retrospectively analyzed. Kirschner wires were placed under the guidance of navigation's screw view mode. The position of the screws was evaluated by computed tomography (CT) scan postoperatively...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762432/outcomes-of-secondary-combined-proximal-interphalangeal-joint-release-and-zone-ii-flexor-tenolysis
#19
Kevin J Zuo, Moaath Saggaf, Herbert P von Schroeder, Paul Binhammer
BACKGROUND: Tendon adhesions and capsular contractures following trauma to the proximal interphalangeal joint (PIPJ) may significantly reduce hand function. Traditional, staged surgical management prioritizes restoration of PIPJ passive range of motion with joint release prior to restoration of active range of motion (AROM) with tenolysis. This is expensive and burdensome for patients. Our objective was to evaluate functional outcomes of combined PIPJ release and zone II flexor tenolysis...
February 14, 2019: Hand: Official Journal of the American Association for Hand Surgery
https://read.qxmd.com/read/30762428/effects-of-antibiotics-on-%C3%AE-toxin-levels-during-staphylococcus-aureus-culture-implications-for-the-protection-of-chondrocytes-in-a-model-of-septic-arthritis
#20
Robbie P Miller, Marie E Berlouis, Alan G Hall, A Hamish R W Simpson, Innes D M Smith, Andrew C Hall
OBJECTIVE: Septic arthritis results from joint infection by Staphylococcus aureus, which produces potent α-toxin causing cell death, potentially leading to permanent cartilage damage. Treatment is by joint irrigation and antibiotics, although it is unclear if, following treatment with antibiotics which cause bacterial lysis, there is release of additional stored α-toxin. DESIGN: A rabbit erythrocyte hemolysis assay was optimised to assess biologically-active α-toxin from cultured S...
February 14, 2019: Cartilage
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