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https://read.qxmd.com/read/30877507/semaphorin-3f-promotes-transendothelial-migration-of-leukocytes-in-the-inflammatory-response-after-survived-cardiac-arrest
#1
Stephanie Reichert, Stefanie Scheid, Tina Roth, Marius Herkel, Diana Petrova, Alexandra Linden, Miki Weberbauer, Jennifer Esser, Philipp Diehl, Sebastian Grundmann, Hans-Jörg Busch, Katrin Fink, Christoph Bode, Martin Moser, Thomas Helbing
Leukocyte transmigration through the blood vessel wall is a fundamental step of the inflammatory response and requires expression of adhesion molecule PECAM-1. Accumulating evidence implicates that semaphorin (Sema) 3F and its receptor neuropilin (NRP) 2 are central regulators in vascular biology. Herein, we assess the role of Sema3F in leukocyte migration in vitro and in vivo. To determine the impact of Sema3F on leukocyte recruitment in vivo, we used the thioglycollate-induced peritonitis model. After the induction of peritonitis, C57BL/6 mice were intraperitoneally (i...
March 15, 2019: Inflammation
https://read.qxmd.com/read/30877479/the-2018-guidelines-for-the-diagnosis-and-treatment-of-osteoporosis-in-greece
#2
Polyzois Makras, Athanasios D Anastasilakis, George Antypas, Efstathios Chronopoulos, Evangelia G Kaskani, Aikaterini Matsouka, Dimos K Patrikos, Konstantinos D Stathopoulos, Symeon Tournis, George Trovas, Christos Kosmidis
We report the updated guidelines for the management of osteoporosis in Greece, which include guidance on fracture risk assessment, diagnosis-pharmacological treatment-follow-up of osteoporosis based on updated information, and national evidence from Greek clinical practice and the healthcare setting. PURPOSE: The purpose of this report was to update the Guidelines for the Management of Osteoporosis in Greece that was published in 2011. METHODS: In line with the GRADE system, the working group initially defined the main clinical questions that should be addressed when dealing with the diagnosis and management of osteoporosis in clinical practice in Greece...
March 15, 2019: Archives of Osteoporosis
https://read.qxmd.com/read/30876618/prevention-and-treatment-of-multidrug-resistant-organisms-in-end-stage-renal-disease
#3
REVIEW
John K Midturi, Sangeetha Ranganath
Chronic kidney disease patients are at high risk for infections because of multidrug-resistant organisms. Infections are the second most common cause of death in patients with ESRD. Patients with ESRD are prone to infections given alterations in immunity, increased rates of colonization with multidrug-resistant organisms, increased hospitalizations, and interactions with health care systems. Infections range from urinary tract infections, pneumonia, skin and soft tissue infections, central line-associated bloodstream infections to sepsis...
January 2019: Advances in Chronic Kidney Disease
https://read.qxmd.com/read/30876612/current-concepts-in-hemodialysis-vascular-access-infections
#4
REVIEW
Lalathaksha Kumbar, Jerry Yee
Infection-related causes are second only to cardiovascular events for mortality among end-stage renal disease patients. This review will provide an overview of hemodialysis catheter-, graft-, and fistula-related infections with emphasis on diagnosis and management in specific settings. Use of catheters at the initiation of dialysis has remained unchanged at 80%. Of all access-related bloodstream infections (BSIs), 70% occur in patients with catheters. The risk factors for BSIs in tunneled, cuffed catheters include the duration of the catheter, past catheter-related bacteremia, left-sided internal jugular vein catheters, hypoalbuminemia, and immunosuppression...
January 2019: Advances in Chronic Kidney Disease
https://read.qxmd.com/read/30875359/pediatric-central-line-associated-acute-deep-vein-thrombosis
#5
T Wesley Templeton, Shelly H Pecorella, Benjamin N Morris
No abstract text is available yet for this article.
April 2019: Anesthesiology
https://read.qxmd.com/read/30869576/multi-energy-x-ray-tomography-of-an-optical-fiber-the-role-of-spatial-averaging
#6
Zachary H Levine, Adele P Peskin, Edward J Garboczi, Andrew D Holmgren
Using a commercial X-ray tomography instrument, we have obtained reconstructions of a graded-index optical fiber with voxels of edge length 1.05 µm at 12 tube voltages. The fiber manufacturer created a graded index in the central region by varying the germanium concentration from a peak value in the center of the core to a very small value at the core-cladding boundary. Operating on 12 tube voltages, we show by a singular value decomposition that there are only two singular vectors with significant weight...
February 2019: Microscopy and Microanalysis
https://read.qxmd.com/read/30867333/an-essential-role-for-mirna167-in-maternal-control-of-embryonic-and-seed-development
#7
Xiaozhen Yao, Jilin Chen, Jie Zhou, Hanchuanzhi Yu, Chennan Ge, Min Zhang, Xiuhua Gao, Xinhua Dai, Zhong-Nan Yang, Yunde Zhao
Maternal cells play a critical role in ensuring the normal development of embryos, endosperms, and seeds. Mutations that disrupt the maternal control of embryogenesis and seed development are difficult to identify. Here, we completely deleted four MICRORNA167 (MIR167) genes in Arabidopsis thaliana using a clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing technology We found that plants with a deletion of MIR167A phenocopied plants overexpressing miRNA167-resistant versions of Auxin Response Factor 6 (ARF6) or ARF8, two miRNA167 targets...
March 13, 2019: Plant Physiology
https://read.qxmd.com/read/30865328/bloodstream-infection-caused-by-enteric-organisms-during-the-first-6-months-after-intestinal-transplant
#8
Jacques J Simkins, Jose A Morillas-Rodriguez, Michele I Morris, Lilian M Abbo, Jose F Camargo, Gennaro Selvaggi, Thiago Beduschi, Akin Tekin, Rodrigo Vianna
BACKGROUND: Data on bloodstream infection (BSI) due to enteric organisms is scarce. METHODS: This retrospective study (1/2009-5/2017) aimed to evaluate the incidence of BSI episodes due to enteric organisms during the first six months after ITx. Differences between the first (2009-2012) and second period (2013-2017) were evaluated as they differed from each other in the perioperative fungal prophylaxis and immunosuppressive regimen. RESULTS: Fifty-five adult patients were analyzed...
March 13, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30864945/impaired-abca1-abcg1-mediated-lipid-efflux-in-the-mouse-retinal-pigment-epithelium-rpe-leads-to-retinal-degeneration
#9
Federica Storti, Katrin Klee, Vyara Todorova, Regula Steiner, Alaa Othman, Saskia van der Velde-Visser, Marijana Samardzija, Isabelle Meneau, Maya Barben, Duygu Karademir, Valda Pauzuolyte, Sanford L Boye, Frank Blaser, Christoph Ullmer, Joshua L Dunaief, Thorsten Hornemann, Lucia Rohrer, Anneke I den Hollander, Arnold von Eckardstein, Jürgen Fingerle, Cyrille Maugeais, Christian Grimm
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transporter A1 ( ABCA1 ), have been associated with AMD risk. However, the significance of retinal lipid handling for AMD pathogenesis remains elusive. Here, we study the contribution of lipid efflux in the RPE by generating a mouse model lacking ABCA1 and its partner ABCG1 specifically in this layer...
March 13, 2019: ELife
https://read.qxmd.com/read/30864666/a-pilot-study-to-reduce-central-line-associated-bloodstream-infections-in-children-from-extremely-low-income-settings-with-intestinal-failure-meeting-the-challenge
#10
Inbal Fuchs, Dov Rosenbaum, Ilana Klein, Menachem Einhorn, Vered Pinsk, Yonat Shelef, Amir Sherf, Yan Press, Baruch Yerushalmi
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) are major sources of morbidity, death, and healthcare costs in patients who receive home parenteral nutrition (HPN). The majority of HPN-dependent children in southern Israel reside in poor communities with substandard living conditions, which creates significant challenges for the safe provision of HPN. We developed a pilot intervention that aimed to reduce the rates of CLABSI and central venous catheter (CVC) replacements in this vulnerable population in our region...
March 13, 2019: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30863358/functional-neuroanatomy-of-vertical-visual-perception-in-humans
#11
Arnaud Saj, Liliane Borel, Jacques Honoré
Vertical representation is central to posture control, as well as to spatial perception and navigation. This representation has been studied for a long time in patients with vestibular disorders and more recently in patients with hemispheric damage, in particular in those with right lesions causing spatial or postural deficits. The aim of the study was to determine the brain areas involved in the visual perception of the vertical. Sixteen right-handed healthy participants were evaluated using fMRI while they were judging the verticality of lines or, in a control task, the color of the same lines...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30862871/three-dimensional-geometry-of-human-tibial-anterior-curvature-in-chronologically-distinct-population-samples-of-central-europeans-2900-bc-21-st-century-ad
#12
Hana Brzobohatá, Václav Krajíček, Petr Velemínský, Jana Velemínská
Several lines of bioarchaeological research have confirmed the gradual decline in lower limb loading among past human populations, beginning with the transition to agriculture. The goal of this study was to assess whether human tibial curvature reflects this decline, with a special emphasis on the time-span during which the pace of technological change has been the most rapid. Our study is the first (1) to apply longitudinal curvature analysis in the antero-posterior (A-P) and medio-lateral (M-L) planes to the human tibia, and (2) that incorporates a broad temporal population sample including the periods of intensification of agriculture, urbanization and industrialization (from 2900 BC to the 21st century AD; N = 435) within Czech territories...
March 12, 2019: Scientific Reports
https://read.qxmd.com/read/30862676/proteomic-analysis-reveals-that-sugar-and-fatty-acid-metabolism-play-a-central-role-in-sterility-of-the-male-sterile-line-1355a-of-cotton
#13
Yuanlong Wu, Yanlong Li, Yaoyao Li, Yizan Ma, Yunlong Zhao, Chaozhi Wang, Huabin Chi, Miao Chen, Yuanhao Ding, Xiaoping Guo, Ling Min, XianLong Zhang
Cotton (Gossypium spp.) is one of the most important economic crops and exhibits yield-improving heterosis in specific hybrid combinations. The genic male-sterility system is the main strategy used for producing heterosis in cotton. To better understand the mechanisms of male sterility in cotton, we carried out 2-dimensional electrophoresis (2-DE) and label-free quantitative proteomics analysis in the anthers of two near-isogenic lines, the male-sterile line 1355A and the male-fertile line 1355B. We identified 39 and 124 proteins that were significantly differentially expressed between these two lines in the anthers at the tetrad stage (stage 7) and uninucleate pollen stage (stage 8), respectively...
March 12, 2019: Journal of Biological Chemistry
https://read.qxmd.com/read/30861550/prevapix-all-apixaban-compared-to-standard-of-care-for-prevention-of-venous-thrombosis-in-paediatric-acute-lymphoblastic-leukaemia-all-rationale-and-design
#14
Sarah H O'Brien, Danshi Li, Lesley G Mitchell, Thomas Hess, Pamela Zee, Donald L Yee, Jane W Newburger, Lillian Sung, Vilmarie Rodriguez
Venous thromboembolic (VTE) complications in children and adolescents with acute lymphoblastic leukaemia (ALL) and T or B cell lymphoblastic lymphoma (T/B cell LL) can result not only in life-threatening acute complications but also contribute to significant long-term sequelae. The PREVAPIX-ALL study is an open-label randomized controlled study comparing outcomes of treatment with prophylactic dose apixaban versus no anticoagulation (standard of care) in children and adolescents with ALL and T/B cell LL receiving standard induction chemotherapy with asparaginase and the presence of a central venous access device...
March 12, 2019: Thrombosis and Haemostasis
https://read.qxmd.com/read/30859187/vascular-access-in-children-requiring-maintenance-haemodialysis-a-consensus-document-by-the-european-society-for-paediatric-nephrology-dialysis-working-group
#15
Rukshana Shroff, Francis Calder, Sevcan Bakkaloğlu, Evi V Nagler, Sam Stuart, Lynsey Stronach, Claus P Schmitt, Karl H Heckert, Pierre Bourquelot, Ann-Marie Wagner, Fabio Paglialonga, Sandip Mitra, Constantinos J Stefanidis
BACKGROUND: There are three principle forms of vascular access available for the treatment of children with end stage kidney disease (ESKD) by haemodialysis: tunnelled catheters placed in a central vein (central venous lines, CVLs), arteriovenous fistulas (AVF), and arteriovenous grafts (AVG) using prosthetic or biological material. Compared with the adult literature, there are few studies in children to provide evidence based guidelines for optimal vascular access type or its management and outcomes in children with ESKD...
March 11, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30858468/early-evolution-of-the-mitogen-activated-protein-kinase-family-in-the-plant-kingdom
#16
Balázs Kalapos, Monika Hlavová, Tímea V Nádai, Gábor Galiba, Kateřina Bišová, Róbert Dóczi
Mitogen-activated protein kinase (MAPK) pathways are central cellular signalling mechanisms in all eukaryotes. They are key regulators of the cell cycle and stress responses, yet evolution of MAPK families took markedly different paths in the animal and plant kingdoms. Instead of the characteristic divergence of MAPK types in animals, in plants an expanded network of ERK-like MAPKs has emerged. To gain insight into the early evolution of the plant MAPK family we identified and analysed MAPKs in 13 representative species across green algae, a large and diverse early-diverging lineage within the plant kingdom...
March 11, 2019: Scientific Reports
https://read.qxmd.com/read/30856515/growing-trends-of-contralateral-prophylactic-mastectomy-and-reconstruction-in-young-breast-cancer
#17
Hongliang Chen, Peng Zhang, Mingdi Zhang, Maoli Wang, Fang Bai, Kejin Wu
BACKGROUND: The aim of this study was to evaluate the trends of surgical treatments among young patients in T1 N0-1 M0 stage based on the Surveillance, Epidemiology, and End Results database. MATERIALS AND METHODS: Patients aged less than 40 y diagnosed between 1998 and 2015 were enrolled, with tumors in T1 N0-1 M0 stage and not located in the central area. Differences in clinical-pathological characteristics were evaluated using chi-square tests. Multivariate logistic regression was used to measure the various factors associated with contralateral prophylactic mastectomy (CPM)...
March 8, 2019: Journal of Surgical Research
https://read.qxmd.com/read/30853911/cycling-quiescence-in-temozolomide-resistant-glioblastoma-cells-is-partly-explained-by-microrna-93-and-193-mediated-decrease-of-cyclin-d
#18
Jessian L Munoz, Nykia D Walker, Satvik Mareedu, Sri Harika Pamarthi, Garima Sinha, Steven J Greco, Pranela Rameshwar
Glioblastoma multiforme (GBM) is a fatal malignancy of the central nervous system, commonly associated with chemoresistance. The alkylating agent Temozolomide (TMZ) is the front-line chemotherapeutic agent and has undergone intense studies on resistance. These studies reported on mismatch repair gene upregulation, ABC-targeted drug efflux, and cell cycle alterations. The mechanism by which TMZ induces cell cycle arrest has not been well-established. TMZ-resistant GBM cells have been linked to microRNA (miRNA) and exosomes...
2019: Frontiers in Pharmacology
https://read.qxmd.com/read/30853470/effects-of-estrogens-and-androgens-on-mitochondria-under-normal-and-pathological-conditions
#19
REVIEW
Mohammad Mohajeri, Cynthia Martín-Jiménez, George E Barreto, Amirhossein Sahebkar
Several lines of evidence have suggested that mitochondrial dysfunction plays a key role in neurodegeneration. The mitochondrial function is a potential target for steroid hormones, which could exert protective activities in the brain and other tissues. The decrease of some sex steroids with aging has been associated with deleterious effects on brain function and progression to neurodegenerative diseases. Recent in vitro and in vivo evidence provides the basis for this review on the interplay of sex steroids and mitochondrial defects in preventing or improving pathological events in the central nervous system (CNS)...
March 7, 2019: Progress in Neurobiology
https://read.qxmd.com/read/30853200/central-line-associated-blood-stream-infections-and-non-central-line-associated-blood-stream-infections-surveillance-in-canadian-tertiary-care-neonatal-intensive-care-units
#20
Amy R Zipursky, Eugene W Yoon, Julie Emberley, Valerie Bertelle, Jaideep Kanungo, Shoo K Lee, Prakesh S Shah
OBJECTIVE: To determine if the reported reduction in hospital-acquired infections is due to reduced central line-associated blood stream infections (CLABSI) or non-CLABSIs. STUDY DESIGN: A retrospective cohort study design was used to describe the change in organism pattern and incidence of hospital-acquired infections (CLABSIs and non-CLABSIs) in neonates <33 weeks of gestation admitted to tertiary neonatal intensive care units in the Canadian Neonatal Network between January 1, 2010, and December 31, 2016...
March 7, 2019: Journal of Pediatrics
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